MY172707A - Il-12/p40 binding proteins - Google Patents

Il-12/p40 binding proteins

Info

Publication number
MY172707A
MY172707A MYPI2010004296A MYPI2010004296A MY172707A MY 172707 A MY172707 A MY 172707A MY PI2010004296 A MYPI2010004296 A MY PI2010004296A MY PI2010004296 A MYPI2010004296 A MY PI2010004296A MY 172707 A MY172707 A MY 172707A
Authority
MY
Malaysia
Prior art keywords
hll
antibodies
activity
hil
antibody
Prior art date
Application number
MYPI2010004296A
Inventor
Roguska Michael
E Lacy Susan
Fung Emma
P Belk Jonathan
W Dixon Richard
R Hinton Paul
Kumar Shankar
Original Assignee
Abbott Lab
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Abbvie Inc filed Critical Abbott Lab
Priority to MYPI2010004296A priority Critical patent/MY172707A/en
Publication of MY172707A publication Critical patent/MY172707A/en

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  • Peptides Or Proteins (AREA)

Abstract

The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-] 2 (hlL- I 2) and/or human IL-23 (hlL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hlL-12 and/or hlL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or h!L-23 and for inhibiting hIL-12 and/or hlL-23 activity, e.g., in a human subject suffering from a disorder in which h!L-12 and/or hlL-23 activity is detrimental:
MYPI2010004296A 2010-09-14 2010-09-14 Il-12/p40 binding proteins MY172707A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI2010004296A MY172707A (en) 2010-09-14 2010-09-14 Il-12/p40 binding proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2010004296A MY172707A (en) 2010-09-14 2010-09-14 Il-12/p40 binding proteins

Publications (1)

Publication Number Publication Date
MY172707A true MY172707A (en) 2019-12-11

Family

ID=79169805

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2010004296A MY172707A (en) 2010-09-14 2010-09-14 Il-12/p40 binding proteins

Country Status (1)

Country Link
MY (1) MY172707A (en)

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