NL1007839C2 - Formulering en gebruik. - Google Patents

Formulering en gebruik. Download PDF

Info

Publication number: NL1007839C2
Authority: NL; Netherlands
Prior art keywords: formulation; dose; bamboo; measured; formulation according
Prior art date: 1996-12-20

Application number

NL1007839A

Other languages

English (en)

Dutch (nl)

Other versions

NL1007839A1 (nl

Inventor

Hans Nilsson

Carl-Axel Bauer

Staffan Annefors

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-20

Filing date

1997-12-18

Publication date

1998-08-31

1997-12-18 Application filed by Astra Ab filed Critical Astra Ab

1998-06-23 Publication of NL1007839A1 publication Critical patent/NL1007839A1/xx

1998-08-31 Application granted granted Critical

1998-08-31 Publication of NL1007839C2 publication Critical patent/NL1007839C2/nl

Links

238000009472 formulation Methods 0.000 title claims description 31
239000000203 mixture Substances 0.000 title claims description 31
235000017166 Bambusa arundinacea Nutrition 0.000 claims description 15
235000017491 Bambusa tulda Nutrition 0.000 claims description 15
241001330002 Bambuseae Species 0.000 claims description 15
235000015334 Phyllostachys viridis Nutrition 0.000 claims description 15
239000011425 bamboo Substances 0.000 claims description 15
ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims description 9
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 8
229960003060 bambuterol Drugs 0.000 claims description 8
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
235000016954 Ribes hudsonianum Nutrition 0.000 claims description 5
240000001890 Ribes hudsonianum Species 0.000 claims description 5
235000001466 Ribes nigrum Nutrition 0.000 claims description 5
235000003599 food sweetener Nutrition 0.000 claims description 5
230000002335 preservative effect Effects 0.000 claims description 5
239000000243 solution Substances 0.000 claims description 5
239000003765 sweetening agent Substances 0.000 claims description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
229940079593 drug Drugs 0.000 claims description 4
239000013011 aqueous formulation Substances 0.000 claims description 3
229940124630 bronchodilator Drugs 0.000 claims description 3
239000006172 buffering agent Substances 0.000 claims description 3
239000003755 preservative agent Substances 0.000 claims description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
208000006673 asthma Diseases 0.000 description 4
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 4
235000010234 sodium benzoate Nutrition 0.000 description 4
239000004299 sodium benzoate Substances 0.000 description 4
239000000600 sorbitol Substances 0.000 description 4
HWAXMFYECKQLDX-UHFFFAOYSA-N 5-[[(4-chlorobenzoyl)amino]methyl]thiophene-2-sulfonyl chloride Chemical compound C1=CC(Cl)=CC=C1C(=O)NCC1=CC=C(S(Cl)(=O)=O)S1 HWAXMFYECKQLDX-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
229960003416 bambuterol hydrochloride Drugs 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
235000019634 flavors Nutrition 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
235000019658 bitter taste Nutrition 0.000 description 2
-1 e.g. Substances 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
230000009747 swallowing Effects 0.000 description 2
229960000195 terbutaline Drugs 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000001800 adrenalinergic effect Effects 0.000 description 1
229940125388 beta agonist Drugs 0.000 description 1
102000016966 beta-2 Adrenergic Receptors Human genes 0.000 description 1
108010014499 beta-2 Adrenergic Receptors Proteins 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000000168 bronchodilator agent Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229920001903 high density polyethylene Polymers 0.000 description 1
239000004700 high-density polyethylene Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
230000037323 metabolic rate Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
239000008213 purified water Substances 0.000 description 1
229940044601 receptor agonist Drugs 0.000 description 1
239000000018 receptor agonist Substances 0.000 description 1
229940127558 rescue medication Drugs 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NL1007839A 1996-12-20 1997-12-18 Formulering en gebruik. NL1007839C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9604752A SE9604752D0 (sv)	1996-12-20	1996-12-20	Formulation and use
SE9604752		1996-12-20

Publications (2)

Publication Number	Publication Date
NL1007839A1 NL1007839A1 (nl)	1998-06-23
NL1007839C2 true NL1007839C2 (nl)	1998-08-31

Family

ID=20405108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL1007839A NL1007839C2 (nl)	1996-12-20	1997-12-18	Formulering en gebruik.

Country Status (24)

Country	Link
US (1)	US6075048A (el)
EP (1)	EP0921795A1 (el)
JP (1)	JP2001501225A (el)
KR (1)	KR19990082274A (el)
CN (1)	CN1210464A (el)
AU (1)	AU7871398A (el)
BE (1)	BE1011395A5 (el)
BR (1)	BR9707574A (el)
CA (1)	CA2243085A1 (el)
CZ (1)	CZ243898A3 (el)
ES (1)	ES2131482B1 (el)
FR (1)	FR2757398B1 (el)
GR (1)	GR1003207B (el)
HU (1)	HUP9901792A3 (el)
ID (1)	ID23693A (el)
IE (1)	IE970899A1 (el)
IL (1)	IL125535A0 (el)
NL (1)	NL1007839C2 (el)
NO (1)	NO983556D0 (el)
PL (1)	PL328334A1 (el)
SE (1)	SE9604752D0 (el)
TR (1)	TR199801500T1 (el)
WO (1)	WO1998027981A1 (el)
ZA (1)	ZA9711047B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9604752D0 (sv) *	1996-12-20	1996-12-20	Astra Ab	Formulation and use
SE9903995D0 (sv) *	1999-11-03	1999-11-03	Astra Ab	New combination
WO2006081986A1 (en) *	2005-02-07	2006-08-10	F.Hoffmann-La Roche Ag	Bambuterol and integrin inhibitor combination
CN104784106A (zh) *	2014-01-17	2015-07-22	南京瑞尔医药有限公司	一种盐酸班布特罗口服溶液的制备方法
CN104784108A (zh) *	2014-01-17	2015-07-22	南京瑞尔医药有限公司	一种盐酸班布特罗口服溶液组合物
CN110898003A (zh) *	2019-12-09	2020-03-24	岳阳新华达制药有限公司	一种新型盐酸班布特罗口服溶液及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4086363A (en) *	1977-03-16	1978-04-25	Usv Pharmaceutical Corporation	Treatment of asthma
DE3163871D1 (en) *	1980-07-09	1984-07-05	Draco Ab	1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates
US4499108A (en) *	1983-06-08	1985-02-12	Schering Corporation	Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
GB2289842B (en) *	1991-04-05	1996-01-31	Sepracor Inc	Improved use of ß2 bronchodilator drugs
GB9107196D0 (en) *	1991-04-05	1991-05-22	Sandoz Ag	Improvements in or relating to organic compounds
SE9604752D0 (sv) *	1996-12-20	1996-12-20	Astra Ab	Formulation and use

1996
- 1996-12-20 SE SE9604752A patent/SE9604752D0/xx unknown
1997
- 1997-12-03 FR FR9715245A patent/FR2757398B1/fr not_active Expired - Fee Related
- 1997-12-09 EP EP97949302A patent/EP0921795A1/en not_active Withdrawn
- 1997-12-09 HU HU9901792A patent/HUP9901792A3/hu unknown
- 1997-12-09 AU AU78713/98A patent/AU7871398A/en not_active Abandoned
- 1997-12-09 CA CA002243085A patent/CA2243085A1/en not_active Abandoned
- 1997-12-09 JP JP10528671A patent/JP2001501225A/ja active Pending
- 1997-12-09 CN CN97192077A patent/CN1210464A/zh active Pending
- 1997-12-09 US US09/011,172 patent/US6075048A/en not_active Expired - Fee Related
- 1997-12-09 KR KR1019980706003A patent/KR19990082274A/ko not_active Withdrawn
- 1997-12-09 WO PCT/SE1997/002053 patent/WO1998027981A1/en not_active Ceased
- 1997-12-09 BR BR9707574A patent/BR9707574A/pt unknown
- 1997-12-09 CZ CZ982438A patent/CZ243898A3/cs unknown
- 1997-12-09 IL IL12553597A patent/IL125535A0/xx unknown
- 1997-12-09 PL PL97328334A patent/PL328334A1/xx unknown
- 1997-12-09 TR TR1998/01500T patent/TR199801500T1/xx unknown
- 1997-12-09 ID IDW980046D patent/ID23693A/id unknown
- 1997-12-09 ZA ZA9711047A patent/ZA9711047B/xx unknown
- 1997-12-10 GR GR970100486A patent/GR1003207B/el not_active IP Right Cessation
- 1997-12-10 ES ES009702568A patent/ES2131482B1/es not_active Expired - Lifetime
- 1997-12-17 BE BE9701030A patent/BE1011395A5/fr not_active IP Right Cessation
- 1997-12-18 NL NL1007839A patent/NL1007839C2/nl not_active IP Right Cessation
- 1997-12-18 IE IE970899A patent/IE970899A1/en unknown
1998
- 1998-08-03 NO NO983556A patent/NO983556D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR19990082274A (ko)	1999-11-25
BR9707574A (pt)	1999-07-27
HUP9901792A2 (hu)	1999-10-28
PL328334A1 (en)	1999-01-18
BE1011395A5 (fr)	1999-08-03
HUP9901792A3 (en)	2000-04-28
EP0921795A1 (en)	1999-06-16
FR2757398B1 (fr)	2000-09-01
JP2001501225A (ja)	2001-01-30
SE9604752D0 (sv)	1996-12-20
ES2131482A1 (es)	1999-07-16
US6075048A (en)	2000-06-13
WO1998027981A1 (en)	1998-07-02
CN1210464A (zh)	1999-03-10
CZ243898A3 (cs)	1998-11-11
FR2757398A1 (fr)	1998-06-26
ID23693A (id)	2000-05-11
NL1007839A1 (nl)	1998-06-23
NO983556L (no)	1998-08-03
TR199801500T1 (xx)	1999-02-22
GR970100486A (el)	1998-08-31
ES2131482B1 (es)	2000-03-01
IE970899A1 (en)	1998-10-07
AU7871398A (en)	1998-07-17
IL125535A0 (en)	1999-03-12
CA2243085A1 (en)	1998-07-02
ZA9711047B (en)	1998-06-22
NO983556D0 (no)	1998-08-03
GR1003207B (el)	1999-09-14

Legal Events

Date	Code	Title	Description
1998-08-03	AD1B	A search report has been drawn up
1998-11-02	PD2B	A search report has been drawn up
2004-09-01	VD1	Lapsed due to non-payment of the annual fee	Effective date: 20040701

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AU2002347948A1 (en)	2003-07-10	Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
KR960011772B1 (ko)	1996-08-30	개선된 디데옥시 퓨린 뉴클레오사이드 경구 투여 제제
SK74496A3 (en)	1997-04-09	Organoleptically acceptable oral pharmaceutical compositions
WO2008013929A2 (en)	2008-01-31	Anti-migraine oral spray formulations and methods
McCarron et al.	1991	Diphenoxylate-atropine (Lomotil) overdose in children: an update (report of eight cases and review of the literature)
KR19990008253A (ko)	1999-01-25	아목시실린 및 클라불란산을 함유하는 조성물
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NL1007839C2 (nl)	1998-08-31	Formulering en gebruik.
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DE60112584T2 (de)	2006-06-01	Verfahren zur Herstellung einer flüssigen Dosierungseinheit und Kit
WO2020155507A1 (zh)	2020-08-06	一种不含防腐剂的固体剂型氨己烯酸药物组合物
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US20050175544A1 (en)	2005-08-11	Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
Dawson et al.	1991	Guidelines for compounding oral medications for pediatric patients
KR20060128926A (ko)	2006-12-14	소비자 맞춤식 투여형
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AU2019224850A1 (en)	2020-08-13	Treatment of allergic rhinitis in pediatric subjects using a combination of mometasone and olopatadine
CA2464660C (en)	2011-12-20	Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
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