NL8900943A - Protease inhibitor. - Google Patents

Protease inhibitor. Download PDF

Info

Publication number: NL8900943A
Authority: NL; Netherlands
Prior art keywords: protease; substance according; gelin; inhibitor; chymotrypsin
Prior art date: 1989-04-14

Application number

NL8900943A

Other languages

English (en)

Dutch (nl)

Original Assignee

Euro Biopharm Technology B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-14

Filing date

1989-04-14

Publication date

1990-11-01

1989-04-14 Application filed by Euro Biopharm Technology B V filed Critical Euro Biopharm Technology B V

1989-04-14 Priority to NL8900943A priority Critical patent/NL8900943A/nl

1990-04-12 Priority to AT90907508T priority patent/ATE157989T1/de

1990-04-12 Priority to KR1019910701325A priority patent/KR0167344B1/ko

1990-04-12 Priority to PCT/NL1990/000046 priority patent/WO1990012808A1/en

1990-04-12 Priority to EP90907508A priority patent/EP0466833B1/en

1990-04-12 Priority to DK90907508.7T priority patent/DK0466833T3/da

1990-04-12 Priority to ES90907508T priority patent/ES2108694T3/es

1990-04-12 Priority to DE69031424T priority patent/DE69031424T2/de

1990-04-12 Priority to AU55492/90A priority patent/AU648252B2/en

1990-04-12 Priority to CA002053242A priority patent/CA2053242C/en

1990-04-12 Priority to US07/768,226 priority patent/US5397694A/en

1990-04-12 Priority to JP02506704A priority patent/JP3101629B2/ja

1990-11-01 Publication of NL8900943A publication Critical patent/NL8900943A/nl

Links

229940124158 Protease/peptidase inhibitor Drugs 0.000 title abstract description 11
239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract description 11
239000002537 cosmetic Substances 0.000 claims abstract description 6
238000002360 preparation method Methods 0.000 claims abstract description 6
230000002401 inhibitory effect Effects 0.000 claims description 13
239000000126 substance Substances 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 10
241000545744 Hirudinea Species 0.000 claims description 8
102100022712 Alpha-1-antitrypsin Human genes 0.000 claims description 6
101000823116 Homo sapiens Alpha-1-antitrypsin Proteins 0.000 claims description 6
101001010513 Homo sapiens Leukocyte elastase inhibitor Proteins 0.000 claims description 6
241000500851 Poecilobdella manillensis Species 0.000 claims description 6
230000002764 anti-chymotrypsin effect Effects 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
201000010099 disease Diseases 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
208000024693 gingival disease Diseases 0.000 claims description 2
230000002829 reductive effect Effects 0.000 claims description 2
241000894007 species Species 0.000 claims description 2
108091005804 Peptidases Proteins 0.000 claims 9
239000004365 Protease Substances 0.000 claims 9
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 9
229920001184 polypeptide Polymers 0.000 claims 3
102000004196 processed proteins & peptides Human genes 0.000 claims 3
108090000765 processed proteins & peptides Proteins 0.000 claims 3
125000003275 alpha amino acid group Chemical group 0.000 claims 1
230000002255 enzymatic effect Effects 0.000 claims 1
230000035784 germination Effects 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
108010067372 Pancreatic elastase Proteins 0.000 abstract description 12
102000016387 Pancreatic elastase Human genes 0.000 abstract description 12
108090000317 Chymotrypsin Proteins 0.000 abstract description 8
229960002376 chymotrypsin Drugs 0.000 abstract description 8
239000003112 inhibitor Substances 0.000 abstract description 7
229940122644 Chymotrypsin inhibitor Drugs 0.000 abstract description 5
101710137926 Chymotrypsin inhibitor Proteins 0.000 abstract description 5
239000003541 chymotrypsin inhibitor Substances 0.000 abstract description 5
230000003115 biocidal effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
238000000746 purification Methods 0.000 description 8
239000000872 buffer Substances 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
229940122858 Elastase inhibitor Drugs 0.000 description 5
150000001413 amino acids Chemical group 0.000 description 5
239000000243 solution Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
238000002835 absorbance Methods 0.000 description 4
238000003556 assay Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000003602 elastase inhibitor Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
229920005654 Sephadex Polymers 0.000 description 3
239000012507 Sephadex™ Substances 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
229960000583 acetic acid Drugs 0.000 description 3
239000012362 glacial acetic acid Substances 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
102000007625 Hirudins Human genes 0.000 description 2
108010007267 Hirudins Proteins 0.000 description 2
241000237902 Hirudo medicinalis Species 0.000 description 2
ALSPKRWQCLSJLV-UHFFFAOYSA-N azanium;acetic acid;acetate Chemical compound [NH4+].CC(O)=O.CC([O-])=O ALSPKRWQCLSJLV-UHFFFAOYSA-N 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003593 chromogenic compound Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 2
229940006607 hirudin Drugs 0.000 description 2
239000008188 pellet Substances 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
238000004007 reversed phase HPLC Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
239000005695 Ammonium acetate Substances 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
229940122079 Cathepsin G inhibitor Drugs 0.000 description 1
PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
206010014561 Emphysema Diseases 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
229940043376 ammonium acetate Drugs 0.000 description 1
235000019257 ammonium acetate Nutrition 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
239000007788 liquid Substances 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000005204 segregation Methods 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NL8900943A 1989-04-14 1989-04-14 Protease inhibitor. NL8900943A (nl)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
NL8900943A NL8900943A (nl)	1989-04-14	1989-04-14	Protease inhibitor.
AT90907508T ATE157989T1 (de)	1989-04-14	1990-04-12	Proteasehemmer
KR1019910701325A KR0167344B1 (ko)	1989-04-14	1990-04-12	프로테아제 억제제
PCT/NL1990/000046 WO1990012808A1 (en)	1989-04-14	1990-04-12	Protease inhibitor
EP90907508A EP0466833B1 (en)	1989-04-14	1990-04-12	Protease inhibitor
DK90907508.7T DK0466833T3 (da)	1989-04-14	1990-04-12	Insekticide og synergistiske miticide midler
ES90907508T ES2108694T3 (es)	1989-04-14	1990-04-12	Inhibidor de proteasa.
DE69031424T DE69031424T2 (de)	1989-04-14	1990-04-12	Proteasehemmer
AU55492/90A AU648252B2 (en)	1989-04-14	1990-04-12	Protease inhibitor
CA002053242A CA2053242C (en)	1989-04-14	1990-04-12	Protease inhibitor
US07/768,226 US5397694A (en)	1989-04-14	1990-04-12	Protease inhibitor
JP02506704A JP3101629B2 (ja)	1989-04-14	1990-04-12	プロテアーゼインヒビター

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8900943		1989-04-14
NL8900943A NL8900943A (nl)	1989-04-14	1989-04-14	Protease inhibitor.

Publications (1)

Publication Number	Publication Date
NL8900943A true NL8900943A (nl)	1990-11-01

Family

ID=19854482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8900943A NL8900943A (nl)	1989-04-14	1989-04-14	Protease inhibitor.

Country Status (12)

Country	Link
US (1)	US5397694A (es)
EP (1)	EP0466833B1 (es)
JP (1)	JP3101629B2 (es)
KR (1)	KR0167344B1 (es)
AT (1)	ATE157989T1 (es)
AU (1)	AU648252B2 (es)
CA (1)	CA2053242C (es)
DE (1)	DE69031424T2 (es)
DK (1)	DK0466833T3 (es)
ES (1)	ES2108694T3 (es)
NL (1)	NL8900943A (es)
WO (1)	WO1990012808A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ270194A (en) *	1994-01-07	1996-05-28	Ciba Geigy Ag	Hirustasin, a serine protease inhibitor from hirudo medicinalis
EP0662514A1 (en) *	1994-01-07	1995-07-12	Ciba-Geigy Ag	Hirustasin, an antistasin type serine proteinase inhibitor from Hiruda
KR0137519B1 (ko) *	1995-04-27	1998-04-30	심상철	한국산 흡혈종 거머리(Hirudo nipponia)로 부터 분리한 일래스테이즈 억제 단백질 및 그의 제조방법
GB2304048A (en) *	1995-08-12	1997-03-12	John William Carson	Medicament containing saliva extract
KR100224383B1 (ko)	1996-09-09	1999-10-15	윤덕용	거머린에서 유도된 단백질분해효소 억제활성을지닌 펩타이드
FR2755015B1 (fr) *	1996-10-25	1998-12-24	Sod Conseils Rech Applic	Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait
FR2763944B1 (fr) *	1997-06-03	2000-12-15	Centre Nat Rech Scient	Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
AT406120B (de) *	1997-08-28	2000-02-25	Immuno Ag	Gewebekleber
CA2385488C (en) *	1999-09-24	2015-07-07	Proteon Therapeutics, Inc.	Systems and methods for opening obstructed biological conduits
US7632494B2 (en) *	1999-09-24	2009-12-15	Proteon Therapeutics, Inc.	Methods for enlarging the diameter of a biological conduit in a human subject
US7063838B1 (en) *	1999-09-24	2006-06-20	Proteon Therapeutics Llc	Methods for treating an artery or vein in a human subject
US20080025966A1 (en) *	2004-01-30	2008-01-31	Currie Mark G	Methods And Compositions For The Treatment Of Gastrointestinal disorders
US20110034396A1 (en) *	2005-09-28	2011-02-10	Biovascular, Inc.	Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US7691839B2 (en) *	2005-09-28	2010-04-06	Biovascular, Inc.	Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
EP2316465A1 (en) *	2009-10-15	2011-05-04	Centre National De La Recherche Scientifique	Use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositons

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2808396C2 (de) *	1978-02-27	1984-04-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Protease-Inhibitoren
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

1989
- 1989-04-14 NL NL8900943A patent/NL8900943A/nl not_active Application Discontinuation
1990
- 1990-04-12 CA CA002053242A patent/CA2053242C/en not_active Expired - Lifetime
- 1990-04-12 AU AU55492/90A patent/AU648252B2/en not_active Expired
- 1990-04-12 WO PCT/NL1990/000046 patent/WO1990012808A1/en not_active Ceased
- 1990-04-12 JP JP02506704A patent/JP3101629B2/ja not_active Expired - Lifetime
- 1990-04-12 EP EP90907508A patent/EP0466833B1/en not_active Expired - Lifetime
- 1990-04-12 DE DE69031424T patent/DE69031424T2/de not_active Expired - Lifetime
- 1990-04-12 US US07/768,226 patent/US5397694A/en not_active Expired - Lifetime
- 1990-04-12 AT AT90907508T patent/ATE157989T1/de not_active IP Right Cessation
- 1990-04-12 DK DK90907508.7T patent/DK0466833T3/da active
- 1990-04-12 KR KR1019910701325A patent/KR0167344B1/ko not_active Expired - Fee Related
- 1990-04-12 ES ES90907508T patent/ES2108694T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2053242A1 (en)	1990-10-15
DE69031424D1 (de)	1997-10-16
JPH04507238A (ja)	1992-12-17
ATE157989T1 (de)	1997-09-15
WO1990012808A1 (en)	1990-11-01
DK0466833T3 (da)	1998-04-14
CA2053242C (en)	2000-09-19
AU648252B2 (en)	1994-04-21
DE69031424T2 (de)	1998-04-09
EP0466833B1 (en)	1997-09-10
KR920701247A (ko)	1992-08-11
EP0466833A1 (en)	1992-01-22
ES2108694T3 (es)	1998-01-01
US5397694A (en)	1995-03-14
JP3101629B2 (ja)	2000-10-23
AU5549290A (en)	1990-11-16
KR0167344B1 (ko)	1999-01-15

Legal Events

Date	Code	Title	Description
1990-11-01	A1B	A search report has been drawn up
1991-12-02	BV	The patent application has lapsed

Publication	Publication Date	Title
Bagdy et al.	1976	[54] Hirudin
DK171824B1 (da)	1997-06-23	Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem
Grob	1949	PROTEOLYTIC ENZYMES: III. Further Studies on Protein, Polypeptide, and Other Inhibitors of Serum Proteinase, Leucoproteinase, Trypsin, and Papain
CA1299126C (en)	1992-04-21	Hirudin-pa and its derivatives
NL8900943A (nl)	1990-11-01	Protease inhibitor.
US5472942A (en)	1995-12-05	Anti-thrombins
JP2520131B2 (ja)	1996-07-31	セリンプロテア−ゼ阻害剤
IE61569B1 (en)	1994-11-16	Novel polypeptides with a blood coagulation-inhibiting action, proceses for their preparation and isolation, their use and agents containing them
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