NO177318C - Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen - Google Patents

Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen

Info

Publication number: NO177318C
Authority: NO; Norway
Prior art keywords: lipolytica; heterologous; xpr2; plasmids; preparation
Prior art date: 1985-10-18

Application number

NO864148A

Other languages

English (en)

Other versions

NO177318B (no

NO864148D0 (no

NO864148L (no

Inventor

Lance Steven Davidow

John Robert Dezeeuw

Arthur Ernest Franke

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-18

Filing date

1986-10-17

Publication date

1995-08-23

1986-10-17 Application filed by Pfizer filed Critical Pfizer

1986-10-17 Publication of NO864148D0 publication Critical patent/NO864148D0/no

1987-04-21 Publication of NO864148L publication Critical patent/NO864148L/no

1992-09-17 Priority to NO923616A priority Critical patent/NO178793C/no

1995-05-15 Publication of NO177318B publication Critical patent/NO177318B/no

1995-08-23 Publication of NO177318C publication Critical patent/NO177318C/no

Links

241000235015 Yarrowia lipolytica Species 0.000 title abstract 7
239000013612 plasmid Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 7
102000004169 proteins and genes Human genes 0.000 abstract 4
108091005658 Basic proteases Proteins 0.000 abstract 2
108020004414 DNA Proteins 0.000 abstract 2
101100215634 Yarrowia lipolytica (strain CLIB 122 / E 150) XPR2 gene Proteins 0.000 abstract 2
230000003248 secreting effect Effects 0.000 abstract 2
230000028327 secretion Effects 0.000 abstract 2
239000013598 vector Substances 0.000 abstract 2
108091026890 Coding region Proteins 0.000 abstract 1
108700007698 Genetic Terminator Regions Proteins 0.000 abstract 1
108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
101150023108 XPR2 gene Proteins 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
238000010367 cloning Methods 0.000 abstract 1
239000002299 complementary DNA Substances 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000012163 sequencing technique Methods 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Mycology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Treatment Of Sludge (AREA)
Magnetic Ceramics (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Paper (AREA)
Fodder In General (AREA)
Noodles (AREA)
Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)

NO864148A 1985-10-18 1986-10-17 Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen NO177318C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78920685A	1985-10-18	1985-10-18
US06/841,121 US4937189A (en)	1985-10-18	1986-03-18	Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants

Publications (4)

Publication Number	Publication Date
NO864148D0 NO864148D0 (no)	1986-10-17
NO864148L NO864148L (no)	1987-04-21
NO177318B NO177318B (no)	1995-05-15
NO177318C true NO177318C (no)	1995-08-23

Family

ID=27120892

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO864148A NO177318C (no)	1985-10-18	1986-10-17	Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO923616A NO178793C (no)	1985-10-18	1992-09-17	Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Country Status (24)

Country	Link
US (1)	US4937189A (no)
EP (1)	EP0220864B1 (no)
JP (1)	JP3096297B2 (no)
KR (1)	KR900008950B1 (no)
CN (3)	CN1034428C (no)
AT (1)	ATE86302T1 (no)
AU (1)	AU586041B2 (no)
CA (1)	CA1340837C (no)
DD (7)	DD276886A5 (no)
DE (1)	DE3687878T2 (no)
DK (1)	DK496886A (no)
EG (1)	EG18142A (no)
ES (1)	ES2038966T3 (no)
FI (1)	FI90352C (no)
HU (1)	HU209150B (no)
IE (1)	IE59774B1 (no)
IL (7)	IL99894A (no)
NO (2)	NO177318C (no)
NZ (1)	NZ217985A (no)
PH (3)	PH27026A (no)
PL (2)	PL154427B1 (no)
PT (1)	PT83562B (no)
RU (2)	RU2069694C1 (no)
YU (2)	YU46412B (no)

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FR2626584B1 (fr) *	1988-01-28	1990-07-13	Agronomique Inst Nat Rech	Sequence ars efficace chez yarrowia lipolytica et procede pour sa preparation
EP0382332A3 (en) *	1989-01-06	1990-11-14	Collaborative Research Inc.	Improved supersecreting mutants of saccharomyces cerevisiae
JPH0669365B2 (ja) *	1989-05-22	1994-09-07	株式会社ミドリ十字	アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法
EP0402226A1 (en) *	1989-06-06	1990-12-12	Institut National De La Recherche Agronomique	Transformation vectors for yeast yarrowia
EP0716704A1 (en) *	1993-09-02	1996-06-19	Pfizer Inc.	MULTIPLE INTEGRATIVE VECTORS AND $i(YARROWIA LIPOLYTICA) TRANSFORMANTS
US5807824A (en) *	1993-12-06	1998-09-15	Ciba-Geigy Corporation	C5A receptor antagonists having substantially no agonist activity
US5837499A (en) *	1993-12-06	1998-11-17	Ciba-Geigy Corporation	DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
DE19513152A1 (de) *	1995-04-07	1996-10-10	Bundesrep Deutschland	Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren
EP0832223A1 (en) *	1995-06-05	1998-04-01	Novartis AG	C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION
EP0747484A1 (en)	1995-06-08	1996-12-11	Institut National De La Recherche Agronomique (Inra)	Upstream activator sequences and recombinant promoter sequences functional in yarrowia and vectors containing them
WO1997044470A1 (en)	1996-05-21	1997-11-27	Novo Nordisk A/S	Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
FR2782733B1 (fr)	1998-09-01	2002-02-08	Agronomique Inst Nat Rech	Procede de transformation non-homologue de yarrowia lipolytica
US7459546B2 (en)	2003-06-25	2008-12-02	E.I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
US20110059496A1 (en) *	2003-06-25	2011-03-10	E. I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7259255B2 (en) *	2003-06-25	2007-08-21	E. I. Du Pont De Nemours And Company	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7202356B2 (en) *	2003-11-14	2007-04-10	E. I. Du Pont De Nemours And Company	Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7264949B2 (en) *	2004-09-15	2007-09-04	E.I. Du Pont De Nemours And Company	Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
US20060094102A1 (en) *	2004-11-04	2006-05-04	Zhixiong Xue	Ammonium transporter promoter for gene expression in oleaginous yeast
EP1866428A2 (en) *	2005-03-18	2007-12-19	Microbia, Inc.	Production of carotenoids in oleaginous yeast and fungi
EP2078092A2 (en)	2006-09-28	2009-07-15	Microbia, Inc.	Production of carotenoids in oleaginous yeast and fungi
FR2927089B1 (fr) *	2008-02-05	2011-03-25	Inst Nat De La Rech Agronomique Inra	Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia
US8597931B2 (en) *	2008-07-11	2013-12-03	Institut National De La Recherche Agronomique (Inra)	Mutant yeast strains capable of accumulating a large quantity of lipids
RU2388823C1 (ru) *	2008-08-21	2010-05-10	Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика)	Интегративный плазмидный вектор для экспрессии генов в дрожжах
FR2962133B1 (fr)	2010-07-01	2014-09-12	Agronomique Inst Nat Rech	Optimisation de la synthese et de l'accumulation de lipides
CA2824584A1 (en) *	2010-12-30	2012-07-05	E. I. Du Pont De Nemours And Company	Use of saccharomyces cerevisiae suc2 gene in yarrowia lipolytica for sucrose utilization
WO2012135773A1 (en)	2011-03-31	2012-10-04	E. I. Du Pont De Nemours And Company	Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
WO2012138613A1 (en)	2011-04-05	2012-10-11	E. I. Du Pont De Nemours And Company	Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
WO2012138612A1 (en)	2011-04-07	2012-10-11	E. I. Du Pont De Nemours And Company	Yarrowia peroxisomal 2,4-dienoyl-coa reductase promoter regions for gene expression in yeast
GB201106188D0 (en)	2011-04-12	2011-05-25	Csir	Production of extracellular polypeptides
FR3002774A1 (fr)	2013-03-04	2014-09-05	Agronomique Inst Nat Rech	Levures mutantes ayant une production accrue de lipides et d'acide citrique
FR3005317B1 (fr)	2013-05-02	2016-03-18	Agronomique Inst Nat Rech	Levures mutantes capables de produire un acide gras inhabituel
BR112016017468A2 (pt)	2014-01-31	2017-10-10	Dsm Ip Assets Bv	promotores adequados para a expressão de genes heterólogos em leveduras
EP3155094A1 (en)	2014-06-11	2017-04-19	Institut National De La Recherche Agronomique (INRA)	Improved lipid accumulation in yarrowia lipolytica strains by overexpression of hexokinase and new strains thereof
WO2016075314A1 (fr)	2014-11-13	2016-05-19	Institut National De La Recherche Agronomique	Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
FR3028527A1 (fr)	2014-11-13	2016-05-20	Pivert	Identification de facteurs de transcription de yarrowia lipolytica
EP3387134B1 (en)	2015-12-11	2020-10-14	Danisco US Inc.	Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
EP3708665A1 (en)	2015-12-18	2020-09-16	Danisco US Inc.	Methods and compositions for t-rna based guide rna expression
US20190136278A1 (en)	2016-05-10	2019-05-09	Institut National De La Recherche Agronomique	Mutant yeast strains with enhanced production of erythritol or erythrulose
EP3348647A1 (en)	2017-01-13	2018-07-18	Institut National De La Recherche Agronomique	Mutant yeast strain capable of producing medium chain fatty acids

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NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
US4628033A (en) *	1983-10-06	1986-12-09	Pfizer Inc.	Novel host strain for transformation of Yarrowia lipolytica
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DE3572688D1 (en) *	1984-06-26	1989-10-05	Agronomique Inst Nat Rech	Transformation vector for yeast yarrowia lipolytica, transformation process and transformed yeast

1986
- 1986-03-18 US US06/841,121 patent/US4937189A/en not_active Expired - Lifetime
- 1986-10-10 DE DE8686307839T patent/DE3687878T2/de not_active Expired - Lifetime
- 1986-10-10 AT AT86307839T patent/ATE86302T1/de not_active IP Right Cessation
- 1986-10-10 ES ES198686307839T patent/ES2038966T3/es not_active Expired - Lifetime
- 1986-10-10 EP EP86307839A patent/EP0220864B1/en not_active Expired - Lifetime
- 1986-10-14 IL IL99894A patent/IL99894A/xx not_active IP Right Cessation
- 1986-10-14 IL IL99892A patent/IL99892A/xx not_active IP Right Cessation
- 1986-10-14 IL IL80297A patent/IL80297A/xx not_active IP Right Cessation
- 1986-10-14 IL IL99893A patent/IL99893A/xx not_active IP Right Cessation
- 1986-10-16 EG EG652/86A patent/EG18142A/xx active
- 1986-10-16 CA CA000520577A patent/CA1340837C/en not_active Expired - Lifetime
- 1986-10-16 PT PT83562A patent/PT83562B/pt unknown
- 1986-10-17 PL PL1986261912A patent/PL154427B1/pl unknown
- 1986-10-17 DD DD29535886A patent/DD276886A5/de not_active IP Right Cessation
- 1986-10-17 RU SU864028319A patent/RU2069694C1/ru active
- 1986-10-17 NO NO864148A patent/NO177318C/no unknown
- 1986-10-17 YU YU177386A patent/YU46412B/sh unknown
- 1986-10-17 DD DD31347186A patent/DD269396A5/de unknown
- 1986-10-17 NZ NZ217985A patent/NZ217985A/en unknown
- 1986-10-17 HU HU864332A patent/HU209150B/hu unknown
- 1986-10-17 PH PH34383A patent/PH27026A/en unknown
- 1986-10-17 DK DK496886A patent/DK496886A/da not_active Application Discontinuation
- 1986-10-17 CN CN86106522A patent/CN1034428C/zh not_active Expired - Lifetime
- 1986-10-17 PL PL1986288208A patent/PL155850B1/pl unknown
- 1986-10-17 KR KR1019860008726A patent/KR900008950B1/ko not_active Expired
- 1986-10-17 FI FI864206A patent/FI90352C/fi not_active IP Right Cessation
- 1986-10-17 IE IE275486A patent/IE59774B1/en not_active IP Right Cessation
- 1986-10-17 DD DD31347286A patent/DD269397A5/de unknown
- 1986-10-17 DD DD31347586A patent/DD267998A5/de unknown
- 1986-10-17 DD DD31347086A patent/DD267995A5/de unknown
- 1986-10-17 DD DD31347386A patent/DD267996A5/de unknown
- 1986-10-17 RU SU5010596/13A patent/RU2157845C2/ru active
- 1986-10-17 AU AU64161/86A patent/AU586041B2/en not_active Expired
- 1986-10-17 DD DD31347486A patent/DD267997A5/de unknown
- 1986-10-18 JP JP61248263A patent/JP3096297B2/ja not_active Expired - Lifetime
1988
- 1988-05-06 PH PH36896A patent/PH27171A/en unknown
- 1988-05-06 PH PH36903A patent/PH27198A/en unknown
- 1988-06-27 YU YU124588A patent/YU46571B/sh unknown
1991
- 1991-10-29 IL IL99894A patent/IL99894A0/xx unknown
- 1991-10-29 IL IL99892A patent/IL99892A0/xx unknown
- 1991-10-29 IL IL99893A patent/IL99893A0/xx unknown
1992
- 1992-09-17 NO NO923616A patent/NO178793C/no unknown
1996
- 1996-01-15 CN CN96101527A patent/CN1069346C/zh not_active Expired - Lifetime
- 1996-01-15 CN CN96100922A patent/CN1141339A/zh active Pending

Also Published As

Publication number	Publication date
FI90352C (fi)	1994-01-25
EP0220864B1 (en)	1993-03-03
KR900008950B1 (ko)	1990-12-15
DD267996A5 (de)	1989-05-17
PH27198A (en)	1993-04-16
DD267997A5 (de)	1989-05-17
PL154427B1 (en)	1991-08-30
IL99892A (en)	1993-02-21
RU2157845C2 (ru)	2000-10-20
YU124588A (en)	1989-08-31
NO177318B (no)	1995-05-15
HU209150B (en)	1994-03-28
IL99894A (en)	1993-02-21
FI864206A0 (fi)	1986-10-17
AU6416186A (en)	1987-05-14
JPS63164889A (ja)	1988-07-08
DD267998A5 (de)	1989-05-17
PL261912A1 (en)	1987-10-19
DD276886A5 (de)	1990-03-14
IL99892A0 (en)	1992-08-18
PH27026A (en)	1993-02-01
NO864148D0 (no)	1986-10-17
DE3687878T2 (de)	1993-07-15
ATE86302T1 (de)	1993-03-15
NO178793B (no)	1996-02-26
IL99893A0 (en)	1992-08-18
PH27171A (en)	1993-04-02
CN1034428C (zh)	1997-04-02
AU586041B2 (en)	1989-06-29
CN1069346C (zh)	2001-08-08
YU46412B (sh)	1993-10-20
PL155850B1 (en)	1992-01-31
DD269396A5 (de)	1989-06-28
IL80297A (en)	1993-02-21
PT83562B (pt)	1989-05-31
IE59774B1 (en)	1994-04-06
NZ217985A (en)	1991-06-25
ES2038966T3 (es)	1993-08-16
CN1138632A (zh)	1996-12-25
CA1340837C (en)	1999-12-07
CN86106522A (zh)	1987-09-16
JP3096297B2 (ja)	2000-10-10
IL99893A (en)	1993-02-21
DK496886A (da)	1987-06-11
FI864206A7 (fi)	1987-04-19
FI90352B (fi)	1993-10-15
DD267995A5 (de)	1989-05-17
RU2069694C1 (ru)	1996-11-27
DD269397A5 (de)	1989-06-28
IL80297A0 (en)	1987-01-30
EP0220864A1 (en)	1987-05-06
NO923616D0 (no)	1992-09-17
IL99894A0 (en)	1992-08-18
EG18142A (en)	1992-08-30
NO178793C (no)	1996-06-05
DE3687878D1 (de)	1993-04-08
NO923616L (no)	1987-04-21
IE862754L (en)	1987-04-18
KR870004138A (ko)	1987-05-07
YU177386A (en)	1989-04-30
US4937189A (en)	1990-06-26
PT83562A (en)	1986-11-01
CN1141339A (zh)	1997-01-29
YU46571B (sh)	1993-11-16
DK496886D0 (da)	1986-10-17
HUT43632A (en)	1987-11-30
NO864148L (no)	1987-04-21

Publication	Publication Date	Title
NO177318C (no)	1995-08-23	Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen
CA1340547C (en)	1999-05-18	Novel secretory leader sequences for yeasts
IL80022A (en)	1993-06-10	Cloned human basic fibroblast growth factor, methods for its preparation, compositions containing it, dna sequences encoding therefor and vectors and host cells containing said dna
EP0196864A3 (en)	1988-03-23	Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences
DE3072070D1 (en)	1988-02-25	Plasmid vectors, plasmids containing genes for alkaline phosphatases and bacteria containing the latter, their preparation and use
EP0206783A3 (en)	1988-10-05	Expression and secretion of polypeptides from saccharomyces cerevisiae
Chung et al.	1996	Highly efficient secretion of heterologous proteins from Saccharomyces cerevisiae using inulinase signal peptides
Hiramatsu et al.	1990	The prepro-peptide of Mucor rennin directs the secretion of human growth hormone by Saccharomyces cerevisiae
ES8800721A1 (es)	1987-11-16	Un metodo para producir un granulo intracelular de la hormona bovina del crecimiento, altamente homogeneo.
EP0266057A3 (en)	1989-11-08	Plasmid containing an eucaryotic secretory signal sequence and process for secreting encoded proteins
Oshima et al.	1986	Expression of Chemically Synthesized α-Neo-endorphin Genes under the Control of the PH05 Gene of Saccharomyces cerevisiae
RU92004585A (ru)	1996-09-20	Промотор, днк-последовательность, вектор, клетки, способ экспрессии днк
LTIP237A (en)	1994-07-15	Po438, a new calcium-regulated promotor
ES8705040A1 (es)	1987-04-16	Un procedimiento para la preparacion de un vector de expre- sion de una recombinante
ULMANEN et al.	1985	Recombinant DNA Laboratory, University of Helsinki, Valimotie 7, SF-00380 Helsinki, Finland
WO1990005186A1 (en)	1990-05-17	Somatotropin expression using a serratia promoter