NO20030471L - Carboxamide compounds and their use as antagonists for an 11CBY receptor - Google Patents

Carboxamide compounds and their use as antagonists for an 11CBY receptor

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Publication number
NO20030471L
NO20030471L NO20030471A NO20030471A NO20030471L NO 20030471 L NO20030471 L NO 20030471L NO 20030471 A NO20030471 A NO 20030471A NO 20030471 A NO20030471 A NO 20030471A NO 20030471 L NO20030471 L NO 20030471L
Authority
NO
Norway
Prior art keywords
optionally substituted
antagonists
heterocyclic ring
carboxamide compounds
hydroxyl
Prior art date
Application number
NO20030471A
Other languages
Norwegian (no)
Other versions
NO20030471D0 (en
Inventor
Christopher Norbert Johnson
Martin Jones
Catherine Anne O'toole
Geoffrey Stemp
Kevin Michael Thewlis
David Witty
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0018758.3A external-priority patent/GB0018758D0/en
Priority claimed from GB0112544A external-priority patent/GB0112544D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO20030471D0 publication Critical patent/NO20030471D0/en
Publication of NO20030471L publication Critical patent/NO20030471L/en

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract

Forbindelser med formel (1) hvor: hver A uavhengig er hydrogen, Ci-6 alkyl eventuelt substituert med hydroksyl, Ci-6 alkoksy, Ci.6 alkenyl eller Ci.6 acyl eller et halogenatom eller hydroksyl, CN eller CF; R3 er hydrogen, metyl eller etyl, R4 er en eventuelt substituert aromatisk karbocyklisk eller heterocyklisk ring, Z er et O- eller S-atom, eller en NH- eller CH-gruppe eller en enkeltbinding, i 3- eller 4-stilling av R4 i forhold til karbonylgruppen, R5 er en eventuelt substituert aromatisk karbocyklisk eller heterocyklisk ring eller en i eventuelt substituert, mettet eller umettet, karbocyklisk eller heterocyklisk ring; og Q er (a) hvor X, Y, RI og R2 er som definert i krav 1, er antagonister av en human 1 lCBy-reseptor.Compounds of formula (1) wherein: each A is independently hydrogen, C 1-6 alkyl optionally substituted with hydroxyl, C 1-6 alkoxy, C 1-6 alkenyl or C 1-6 acyl or a halogen atom or hydroxyl, CN or CF; R 3 is hydrogen, methyl or ethyl, R 4 is an optionally substituted aromatic carbocyclic or heterocyclic ring, Z is an O or S atom, or an NH or CH group or a single bond, in the 3- or 4-position of R 4 relative to the carbonyl group, R 5 is an optionally substituted aromatic carbocyclic or heterocyclic ring or an optionally substituted, saturated or unsaturated, carbocyclic or heterocyclic ring; and Q is (a) wherein X, Y, R 1 and R 2 are as defined in claim 1, are antagonists of a human 11CBy receptor.

NO20030471A 2000-07-31 2003-01-30 Carboxamide compounds and their use as antagonists for an 11CBY receptor NO20030471L (en)

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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7229987B2 (en) 2002-05-13 2007-06-12 Eli Lilly And Company Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes
US7141561B2 (en) 2002-07-25 2006-11-28 Sanofi-Aventis Deutschland Gmbh Substituted diaryl heterocycles, process for their preparation and their use as medicaments
DE10233817A1 (en) * 2002-07-25 2004-02-12 Aventis Pharma Deutschland Gmbh Substituted diaryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (en) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituted N-aryl heterocycles, processes for their preparation and their use as pharmaceuticals
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
EP2385041B1 (en) * 2003-05-01 2013-09-18 Bristol-Myers Squibb Company Pyrazole-amine compounds useful as kinase inhibitors
CA2532965C (en) 2003-07-22 2013-05-14 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
US7037927B2 (en) * 2003-10-16 2006-05-02 Abbott Laboratories Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
US7241787B2 (en) 2004-01-25 2007-07-10 Sanofi-Aventis Deutschland Gmbh Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
JP2007526332A (en) * 2004-03-02 2007-09-13 ニューロジェン・コーポレーション Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogs
DE102004010893A1 (en) * 2004-03-06 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New β-ketoamide compounds having MCH antagonist activity and medicaments containing these compounds
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
TW200613272A (en) 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
DE102004039789A1 (en) 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Aryl-substituted polycyclic amines, process for their preparation and their use as pharmaceuticals
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (en) 2005-01-21 2007-06-27 Astex Therapeutics Ltd PIPERIDIN ADDITION SALTS 4-IL-ACID AMID 4- (2,6-DICLORO-BENZOILAMINO) 1H-PIRAZOL-3-CARBOXILICO.
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
AR056155A1 (en) 2005-10-26 2007-09-19 Bristol Myers Squibb Co ANTAGONISTS OF NON-BASIC MELANINE CONCENTRATION HORMONE RECEIVER 1
US7553836B2 (en) 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
KR20080094699A (en) 2006-02-15 2008-10-23 사노피-아벤티스 Novel aminoalcohol-substituted aryldihydroisoquinolinones, methods for their preparation and use as drugs
GB0625523D0 (en) * 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
TWI417100B (en) 2007-06-07 2013-12-01 Astrazeneca Ab Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
PE20091928A1 (en) 2008-05-29 2009-12-31 Bristol Myers Squibb Co HAVE HYDROXYSUSTITUTED PYRIMIDINES AS NON-BASIC MELANIN-CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
US7790760B2 (en) 2008-06-06 2010-09-07 Astrazeneca Ab Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
AR072297A1 (en) 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
CA2739488A1 (en) 2008-10-15 2010-04-22 Boehringer Ingelheim International Gmbh Fused heteroaryl diamide compounds useful as mmp-13 inhibitors
CA2738929A1 (en) 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
AR075401A1 (en) 2009-02-13 2011-03-30 Sanofi Aventis SUBSTITUTED INDANS, PROCESSES FOR THEIR PREPARATION AND USE OF THE SAME AS A MEDICINAL PRODUCT
UY32443A (en) 2009-02-13 2010-09-30 Sanofi Aventis NEW TETRAHYDRONAFTALENES, PROCESSES FOR THE PREPARATION AND USE OF THE SAME AS A MEDICINAL PRODUCT.
WO2013130968A1 (en) * 2012-03-01 2013-09-06 University Of Cincinnati Ros-activated compounds as selective anti-cancer therapeutics
WO2020140054A1 (en) 2018-12-28 2020-07-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
FI4225753T3 (en) * 2020-10-08 2024-08-29 Leukos Biotech S L Potent and selective compounds as serotonin 1b receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA985542B (en) * 1997-07-03 1999-04-07 Smithkline Beecham Corp Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
JP2002521436A (en) * 1998-07-28 2002-07-16 スミスクライン・ビーチャム・コーポレイション Substituted anilide compounds and methods
MXPA01008142A (en) * 1999-02-10 2003-07-21 Welfide Corp Amide compounds and medicinal use thereof.

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