NO20045373L - Cyanoguanidinprodroger - Google Patents
CyanoguanidinprodrogerInfo
- Publication number
- NO20045373L NO20045373L NO20045373A NO20045373A NO20045373L NO 20045373 L NO20045373 L NO 20045373L NO 20045373 A NO20045373 A NO 20045373A NO 20045373 A NO20045373 A NO 20045373A NO 20045373 L NO20045373 L NO 20045373L
- Authority
- NO
- Norway
- Prior art keywords
- cyanoguanidinprodroger
- prodrugs
- cancers
- pyridyl
- human
- Prior art date
Links
- CPFPCHSTLBKFPH-UHFFFAOYSA-N 1-cyano-1-pyridin-2-ylguanidine Chemical class NC(=N)N(C#N)C1=CC=CC=N1 CPFPCHSTLBKFPH-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38085602P | 2002-05-17 | 2002-05-17 | |
| PCT/DK2003/000319 WO2003097602A1 (en) | 2002-05-17 | 2003-05-15 | Cyanoguanidine produgs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20045373L true NO20045373L (no) | 2004-12-08 |
Family
ID=29550027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045373A NO20045373L (no) | 2002-05-17 | 2004-12-08 | Cyanoguanidinprodroger |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20060014804A1 (is) |
| EP (1) | EP1507759A1 (is) |
| JP (1) | JP2005531560A (is) |
| KR (1) | KR20040111626A (is) |
| CN (1) | CN1662502A (is) |
| AU (1) | AU2003223932A1 (is) |
| BR (1) | BR0309988A (is) |
| CA (1) | CA2484671A1 (is) |
| IL (1) | IL164986A0 (is) |
| IS (1) | IS7563A (is) |
| MX (1) | MXPA04011324A (is) |
| NO (1) | NO20045373L (is) |
| PL (1) | PL372761A1 (is) |
| RU (1) | RU2004136989A (is) |
| WO (1) | WO2003097602A1 (is) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2485351C (en) * | 2002-05-17 | 2011-12-06 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| US7253193B2 (en) * | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| US7262334B2 (en) * | 2002-11-13 | 2007-08-28 | Regents Of The University Of Minnesota | Catalytic partial oxidation of hydrocarbons |
| JP5189367B2 (ja) | 2004-12-22 | 2013-04-24 | レオ ファーマ アクティーゼルスカブ | 新規シアノグアニジン化合物 |
| CA2701071C (en) | 2007-09-26 | 2018-03-27 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| WO2009089053A1 (en) * | 2008-01-11 | 2009-07-16 | Nektar Therapeutics Al, Corporation | Oligomer-guanidine class conjugates |
| JP5688367B2 (ja) | 2008-08-29 | 2015-03-25 | トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ | 新規なウレアおよびチオウレア誘導体 |
| EP2394649A4 (en) | 2009-02-06 | 2012-08-15 | Tianjin Hemay Bio Tech Co Ltd | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL-CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF |
| CA2768338A1 (en) | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| TWI835714B (zh) | 2016-10-18 | 2024-03-21 | 美商思進公司 | 菸鹼醯胺腺嘌呤二核苷酸補救合成(salvage pathway)抑制劑之靶向投遞 |
| WO2018201087A1 (en) | 2017-04-27 | 2018-11-01 | Seattle Genetics, Inc. | Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates |
| CN121085842A (zh) * | 2021-12-22 | 2025-12-09 | 杭州濡湜生物科技有限公司 | 吡啶氰基胍衍生物及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU4076500A (en) * | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | (n)-substituted cyanoguanidine compounds |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
-
2003
- 2003-05-15 CA CA002484671A patent/CA2484671A1/en not_active Abandoned
- 2003-05-15 BR BR0309988-1A patent/BR0309988A/pt not_active IP Right Cessation
- 2003-05-15 WO PCT/DK2003/000319 patent/WO2003097602A1/en not_active Ceased
- 2003-05-15 CN CN038140950A patent/CN1662502A/zh active Pending
- 2003-05-15 JP JP2004505335A patent/JP2005531560A/ja not_active Withdrawn
- 2003-05-15 PL PL03372761A patent/PL372761A1/xx not_active Application Discontinuation
- 2003-05-15 RU RU2004136989/04A patent/RU2004136989A/ru not_active Application Discontinuation
- 2003-05-15 MX MXPA04011324A patent/MXPA04011324A/es not_active Application Discontinuation
- 2003-05-15 EP EP03720293A patent/EP1507759A1/en not_active Withdrawn
- 2003-05-15 US US10/514,498 patent/US20060014804A1/en not_active Abandoned
- 2003-05-15 KR KR10-2004-7018524A patent/KR20040111626A/ko not_active Withdrawn
- 2003-05-15 AU AU2003223932A patent/AU2003223932A1/en not_active Abandoned
-
2004
- 2004-11-02 IL IL16498604A patent/IL164986A0/xx unknown
- 2004-11-29 IS IS7563A patent/IS7563A/is unknown
- 2004-12-08 NO NO20045373A patent/NO20045373L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005531560A (ja) | 2005-10-20 |
| EP1507759A1 (en) | 2005-02-23 |
| WO2003097602A1 (en) | 2003-11-27 |
| IS7563A (is) | 2004-11-29 |
| RU2004136989A (ru) | 2005-06-27 |
| IL164986A0 (en) | 2005-12-18 |
| AU2003223932A1 (en) | 2003-12-02 |
| CN1662502A (zh) | 2005-08-31 |
| MXPA04011324A (es) | 2005-02-17 |
| KR20040111626A (ko) | 2004-12-31 |
| PL372761A1 (en) | 2005-08-08 |
| CA2484671A1 (en) | 2003-11-27 |
| BR0309988A (pt) | 2005-02-22 |
| US20060014804A1 (en) | 2006-01-19 |
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