NO20073958L - Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer - Google Patents

Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer

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Publication number
NO20073958L
NO20073958L NO20073958A NO20073958A NO20073958L NO 20073958 L NO20073958 L NO 20073958L NO 20073958 A NO20073958 A NO 20073958A NO 20073958 A NO20073958 A NO 20073958A NO 20073958 L NO20073958 L NO 20073958L
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NO
Norway
Prior art keywords
compounds
relates
disorders
phosphodiesterase inhibitors
heteroaromatic compounds
Prior art date
Application number
NO20073958A
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English (en)
Inventor
Thomas Allen Chappie
John Michael Humphrey
Original Assignee
Pfizer Prod Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36046318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20073958(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20073958L publication Critical patent/NO20073958L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår nye pyrrolidylderivater av benzosammensmeltede azaheteroaromatiske forbindelser som tjener som effektive fosfodiesterase (PDE)-inhibitorer. Oppfinnelsen angår også forbindelser som er selektive inhibitorer av PDE-IO. Oppfinnelsen angår videre intermediater for fremstilling av slike forbindelser; farmasøytiske sammensetninger som innbefatter slike forbindelser; og anvendelse av slike forbindelser i fremgangsmåter for behandling av visse sentralnervesystem (CNS) og andre forstyrrelser. Oppfinnelsen angår også fremgangsmåter for behandling av neurodegenerative og psykiatriske forstyrrelser, for eksempel psykose og forstyrrelser som innbefatter svekket kognisjon som et symptom.
NO20073958A 2004-12-31 2007-07-27 Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer NO20073958L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64040504P 2004-12-31 2004-12-31
PCT/IB2005/003989 WO2006070284A1 (en) 2004-12-31 2005-12-19 Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
NO20073958L true NO20073958L (no) 2007-09-27

Family

ID=36046318

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073958A NO20073958L (no) 2004-12-31 2007-07-27 Pyrrolidylderivater av heteroaromatiske forbindelser som fosfodiesteraseinhibitorer

Country Status (23)

Country Link
US (1) US20060183763A1 (no)
EP (1) EP1838702A1 (no)
JP (1) JP2008526726A (no)
KR (1) KR20070086841A (no)
CN (1) CN101087778A (no)
AP (1) AP2007004004A0 (no)
AR (1) AR055298A1 (no)
AU (1) AU2005321015A1 (no)
BR (1) BRPI0519760A2 (no)
CA (1) CA2594251A1 (no)
CR (1) CR9135A (no)
EA (1) EA200701118A1 (no)
GT (1) GT200500367A (no)
IL (1) IL183188A0 (no)
MA (1) MA29119B1 (no)
MX (1) MX2007006301A (no)
NL (1) NL1030819C2 (no)
NO (1) NO20073958L (no)
PE (1) PE20060775A1 (no)
TN (1) TNSN07248A1 (no)
TW (1) TW200637851A (no)
UY (1) UY29317A1 (no)
WO (1) WO2006070284A1 (no)

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Also Published As

Publication number Publication date
JP2008526726A (ja) 2008-07-24
TW200637851A (en) 2006-11-01
KR20070086841A (ko) 2007-08-27
TNSN07248A1 (fr) 2008-11-21
CR9135A (es) 2007-08-14
IL183188A0 (en) 2007-08-19
EA200701118A1 (ru) 2007-12-28
AR055298A1 (es) 2007-08-15
MA29119B1 (fr) 2007-12-03
PE20060775A1 (es) 2006-09-01
NL1030819A1 (nl) 2006-07-03
MX2007006301A (es) 2007-06-15
WO2006070284A1 (en) 2006-07-06
AP2007004004A0 (en) 2007-06-30
EP1838702A1 (en) 2007-10-03
NL1030819C2 (nl) 2007-01-04
UY29317A1 (es) 2006-07-31
BRPI0519760A2 (pt) 2009-03-10
US20060183763A1 (en) 2006-08-17
CA2594251A1 (en) 2006-07-06
CN101087778A (zh) 2007-12-12
AU2005321015A1 (en) 2006-07-06
GT200500367A (es) 2006-08-16

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