NO304885B1 - Nipectoin syrederivater som antitrombe forbindelser - Google Patents

Nipectoin syrederivater som antitrombe forbindelser

Info

Publication number
NO304885B1
NO304885B1 NO954609A NO954609A NO304885B1 NO 304885 B1 NO304885 B1 NO 304885B1 NO 954609 A NO954609 A NO 954609A NO 954609 A NO954609 A NO 954609A NO 304885 B1 NO304885 B1 NO 304885B1
Authority
NO
Norway
Prior art keywords
nipectoin
acid derivatives
antithrombotic compounds
compounds
antithrombotic
Prior art date
Application number
NO954609A
Other languages
English (en)
Norwegian (no)
Other versions
NO954609L (no
NO954609D0 (no
Inventor
Mary Pat Beavers
Patricia Andrade-Gordon
William J Hoekstra
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of NO954609D0 publication Critical patent/NO954609D0/no
Publication of NO954609L publication Critical patent/NO954609L/no
Publication of NO304885B1 publication Critical patent/NO304885B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
NO954609A 1994-03-16 1995-11-15 Nipectoin syrederivater som antitrombe forbindelser NO304885B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US36489694A 1994-12-27 1994-12-27
PCT/US1995/003145 WO1995025091A2 (en) 1994-03-16 1995-03-14 Nipecotic acid derivatives as antithrombic compounds

Publications (3)

Publication Number Publication Date
NO954609D0 NO954609D0 (no) 1995-11-15
NO954609L NO954609L (no) 1996-01-05
NO304885B1 true NO304885B1 (no) 1999-03-01

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954609A NO304885B1 (no) 1994-03-16 1995-11-15 Nipectoin syrederivater som antitrombe forbindelser

Country Status (20)

Country Link
US (1) US5770575A (ja)
EP (1) EP0746545B1 (ja)
JP (1) JPH09510453A (ja)
KR (1) KR100328287B1 (ja)
CN (1) CN1083834C (ja)
AT (1) ATE180470T1 (ja)
AU (1) AU703397B2 (ja)
CA (1) CA2163027A1 (ja)
DE (1) DE69509875T2 (ja)
DK (1) DK0746545T3 (ja)
ES (1) ES2131313T3 (ja)
FI (1) FI113763B (ja)
GR (1) GR3030566T3 (ja)
HU (1) HUT74871A (ja)
MX (1) MX9504800A (ja)
NO (1) NO304885B1 (ja)
NZ (1) NZ283209A (ja)
RU (1) RU2135470C1 (ja)
TW (1) TW318179B (ja)
WO (1) WO1995025091A2 (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW401414B (en) * 1993-09-22 2000-08-11 Fujisawa Pharmaceutical Co <beta>-alanine derivative and a process for the preparation thereof
CA2215106A1 (en) * 1995-03-17 1996-09-26 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iiia antagonists and fibrinogen-blood platelets binding inhibitors
JP2000506524A (ja) * 1996-03-13 2000-05-30 藤沢薬品工業株式会社 フィブリノーゲン受容体拮抗剤であるＮ―［（Ｒ）―１―｛３―（４―ピペリジル）プロピオニル｝―３―ピペリジルカルボニル］―２（Ｓ）―アセチルアミノ―β―アラニン
SI0923555T1 (en) * 1996-05-01 2005-10-31 Ortho-Mcneil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
EP0923555B1 (en) * 1996-05-01 2005-06-15 Ortho-McNeil Pharmaceutical, Inc. Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
AU1415099A (en) * 1997-11-18 1999-06-07 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
CA2368024A1 (en) * 1999-03-22 2000-09-28 Ortho-Mcneil Pharmaceutical, Inc. Process for preparing [s-(r*,s*)]-.beta.-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives
AUPQ570100A0 (en) * 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
EP1719529A4 (en) 2004-02-25 2008-05-21 Astellas Pharma Inc CONTRASTING FOR THROMBUS EDUCATION
RU2349304C1 (ru) * 2007-08-10 2009-03-20 Закрытое Акционерное Общество "Канонфарма Продакшн" Таблетированная лекарственная форма клопидогрела или его фармацевтически приемлемой соли, способ ее получения и применение
EP3184149A1 (en) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Soluble glycoprotein v for treating thrombotic diseases
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (ja) * 1990-07-05 1993-03-01 Hoffmann La Roche
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
ATE158589T1 (de) * 1991-11-22 1997-10-15 Yeda Res & Dev Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
JP3401005B2 (ja) * 1992-12-11 2003-04-28 ユニバーシティ オブ フロリダ 有害生物の防除のための材料および方法
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
NZ283209A (en) 1998-04-27
DK0746545T3 (da) 1999-11-08
NO954609L (no) 1996-01-05
RU2135470C1 (ru) 1999-08-27
EP0746545B1 (en) 1999-05-26
CN1128022A (zh) 1996-07-31
WO1995025091A2 (en) 1995-09-21
US5770575A (en) 1998-06-23
MX9504800A (es) 1997-05-31
NO954609D0 (no) 1995-11-15
HUT74871A (en) 1997-02-28
CN1083834C (zh) 2002-05-01
ES2131313T3 (es) 1999-07-16
CA2163027A1 (en) 1995-09-21
KR100328287B1 (ko) 2002-10-11
FI113763B (fi) 2004-06-15
TW318179B (en) 1997-10-21
JPH09510453A (ja) 1997-10-21
AU703397B2 (en) 1999-03-25
AU2119195A (en) 1995-10-03
DE69509875T2 (de) 1999-12-09
DE69509875D1 (de) 1999-07-01
WO1995025091A3 (en) 1995-10-12
ATE180470T1 (de) 1999-06-15
FI955498A0 (fi) 1995-11-15
FI955498L (fi) 1996-01-15
GR3030566T3 (en) 1999-10-29
HU9503270D0 (en) 1996-05-28
EP0746545A1 (en) 1996-12-11

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