NO884989L - Fremgangsmaate for opploeseliggjoering av amfifile medisinske preparater/forbindelser. - Google Patents

Fremgangsmaate for opploeseliggjoering av amfifile medisinske preparater/forbindelser.

Info

Publication number: NO884989L
Authority: NO; Norway
Prior art keywords: solubilizing; organic solvent; amfifile; compounds; procedure
Prior art date: 1987-11-12

Application number

NO88884989A

Other languages

English (en)

Other versions

NO178484B (no

NO884989D0 (no

NO178484C (no

Inventor

Richard Thomas Proffitt

Jill Adler-Moore

Su-Ming Chiang

Original Assignee

Vestar Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-12

Filing date

1988-11-09

Publication date

1989-05-16

1988-11-09 Application filed by Vestar Inc filed Critical Vestar Inc

1988-11-09 Publication of NO884989D0 publication Critical patent/NO884989D0/no

1989-05-16 Publication of NO884989L publication Critical patent/NO884989L/no

1996-01-02 Publication of NO178484B publication Critical patent/NO178484B/no

1996-04-10 Publication of NO178484C publication Critical patent/NO178484C/no

Links

238000000034 method Methods 0.000 title abstract 2
230000003381 solubilizing effect Effects 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
229940079593 drug Drugs 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
239000002502 liposome Substances 0.000 abstract 3
239000003960 organic solvent Substances 0.000 abstract 3
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 2
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 2
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 2
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 2
229960003942 amphotericin b Drugs 0.000 abstract 2
239000012062 aqueous buffer Substances 0.000 abstract 1
230000000887 hydrating effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nanotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Oncology (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medical Informatics (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
External Artificial Organs (AREA)
Materials For Medical Uses (AREA)

NO884989A 1987-11-12 1988-11-09 Fremgangsmåte for å opplöseliggjöre et polyenantibiotika samt for fremstilling av liposomer inneholdende et polyenantibiotika NO178484C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11951887A	1987-11-12	1987-11-12

Publications (4)

Publication Number	Publication Date
NO884989D0 NO884989D0 (no)	1988-11-09
NO884989L true NO884989L (no)	1989-05-16
NO178484B NO178484B (no)	1996-01-02
NO178484C NO178484C (no)	1996-04-10

Family

ID=22384831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO884989A NO178484C (no)	1987-11-12	1988-11-09	Fremgangsmåte for å opplöseliggjöre et polyenantibiotika samt for fremstilling av liposomer inneholdende et polyenantibiotika

Country Status (14)

Country	Link
US (2)	US6770290B1 (no)
EP (1)	EP0317120B1 (no)
JP (1)	JP2958774B2 (no)
KR (1)	KR970007187B1 (no)
AT (1)	ATE66598T1 (no)
AU (1)	AU598958B2 (no)
CA (1)	CA1339008C (no)
DE (1)	DE3864495D1 (no)
DK (1)	DK175052B1 (no)
ES (1)	ES2029330T3 (no)
GR (1)	GR3003050T3 (no)
HK (1)	HK119893A (no)
IE (1)	IE62110B1 (no)
NO (1)	NO178484C (no)

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NZ223660A (en)	1987-03-05	1990-11-27	Liposome Co Inc	Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity
US4950432A (en) *	1987-10-16	1990-08-21	Board Of Regents, The University Of Texas System	Polyene microlide pre-liposomal powders

1988
- 1988-10-24 AU AU24161/88A patent/AU598958B2/en not_active Expired
- 1988-11-01 AT AT88310278T patent/ATE66598T1/de not_active IP Right Cessation
- 1988-11-01 ES ES198888310278T patent/ES2029330T3/es not_active Expired - Lifetime
- 1988-11-01 EP EP88310278A patent/EP0317120B1/en not_active Expired - Lifetime
- 1988-11-01 DE DE8888310278T patent/DE3864495D1/de not_active Expired - Lifetime
- 1988-11-05 KR KR1019880014547A patent/KR970007187B1/ko not_active Expired - Lifetime
- 1988-11-09 NO NO884989A patent/NO178484C/no unknown
- 1988-11-10 CA CA000582730A patent/CA1339008C/en not_active Expired - Lifetime
- 1988-11-10 JP JP63284828A patent/JP2958774B2/ja not_active Expired - Lifetime
- 1988-11-11 DK DK198806293A patent/DK175052B1/da not_active IP Right Cessation
- 1988-11-11 IE IE339488A patent/IE62110B1/en not_active IP Right Cessation
1990
- 1990-10-19 US US07/600,154 patent/US6770290B1/en not_active Expired - Lifetime
1991
- 1991-10-31 GR GR91401643T patent/GR3003050T3/el unknown
1993
- 1993-11-04 HK HK1198/93A patent/HK119893A/en not_active IP Right Cessation
1995
- 1995-06-06 US US08/469,251 patent/US5965156A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA1339008C (en)	1997-03-25
IE883394L (en)	1989-05-12
JPH01160915A (ja)	1989-06-23
NO178484B (no)	1996-01-02
DE3864495D1 (de)	1991-10-02
ATE66598T1 (de)	1991-09-15
DK175052B1 (da)	2004-05-10
US6770290B1 (en)	2004-08-03
IE62110B1 (en)	1994-12-14
US5965156A (en)	1999-10-12
DK629388D0 (da)	1988-11-11
NO884989D0 (no)	1988-11-09
JP2958774B2 (ja)	1999-10-06
KR890007718A (ko)	1989-07-05
KR970007187B1 (ko)	1997-05-07
HK119893A (en)	1993-11-12
AU2416188A (en)	1989-05-18
EP0317120B1 (en)	1991-08-28
DK629388A (da)	1989-05-13
EP0317120A1 (en)	1989-05-24
ES2029330T3 (es)	1992-08-01
NO178484C (no)	1996-04-10
GR3003050T3 (en)	1993-02-17
AU598958B2 (en)	1990-07-05

Publication	Publication Date	Title
NO884989L (no)	1989-05-16	Fremgangsmaate for opploeseliggjoering av amfifile medisinske preparater/forbindelser.
DK0580817T3 (da)	1996-08-05	Farmaceutisk præparat og fremgangsmåde til fremstilling deraf
CA2033725A1 (en)	1991-07-25	Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
NO166448C (no)	1991-07-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner.
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
GR1001503B (el)	1994-02-28	Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
FI883249A0 (fi)	1988-07-07	Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
NO891415L (no)	1989-10-09	Fremstilling av substituerte flavonoidforbindelser og salter og farmasoeytiske preparater derav.
TW234691B (no)	1994-11-21
RU94029667A (ru)	1996-06-27	ПРОИЗВОДНЫЕ 11β -БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ЛЕКАРСТВЕННЫЕ СРЕДСТВА
NO306762B1 (no)	1999-12-20	Anvendelse av lanolinderivater sammen med polyetylenglykoletere, blanding derav og transdermalt terapeutisk system
IE873367L (en)	1988-06-12	Ranitidine-ethanol formulation
FI884240A0 (fi)	1988-09-15	Menetelmä paikalliseen käyttöön tarkoitetun farmaseuttisen valmisteen valmistamiseksi
DK627987A (da)	1988-06-03	Farmaceutiske praeparater
ATE116849T1 (de)	1995-01-15	Pharmazeutische verwendung von fettsäuren.
DK623888A (da)	1989-07-25	9a-allyl- og propargylderivater af 9-deoxo-9a-aza-9a-homoerythromycin a, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af antibakterielle laegemidler
NO175637C (no)	1994-11-09	Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-fluor-3,5-dihydroksykarboksylsyrer og derivater derav
DK0437225T3 (da)	1994-06-27	Topiske præparater
DE69016719D1 (de)	1995-03-23	Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
ATE112679T1 (de)	1994-10-15	Wässrige bereitung von liposomenzusammensetzungen.
AU1022688A (en)	1988-07-21	Antibacterial lyophilized preparation
ATE135708T1 (de)	1996-04-15	Derivate von 10,11,12,13-tetra-hydrodesmycosin, verfahren zu ihrer herstellung, und ihre verwendung zur herstellung von arzneimitteln
DK192487D0 (da)	1987-04-14	Carbiovasculaere farmaceutiske praeparater, som er egnet til topisk indgivning
EP0389773A3 (de)	1991-07-24	Verfahren zur Herstellung einer Galenischen Zubereitung mit optimaler Bioverfügbarkeit des Wirkstoffs 2-Hydroxy-5-methyllaurophenonoxime (HMLO)
FR2592653A1 (fr)	1987-07-10	Derives de chromene, procede d'obtention et compositions pharmaceutiques.