PE115699A1 - Co-inhibidores de proteasa - Google Patents

Co-inhibidores de proteasa

Info

Publication number: PE115699A1
Authority: PE; Peru
Prior art keywords: alkyl; protease; ch2cf3; compound; treat
Prior art date: 1997-09-04

Application number

PE1998000830A

Other languages

English (en)

Spanish (es)

Inventor

Renee Louise Desjarlais

Iv Sigfried Benjamin Christensen

Cornelia Jutta Forster

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-04

Filing date

1998-09-04

Publication date

2000-01-13

1998-09-04 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2000-01-13 Publication of PE115699A1 publication Critical patent/PE115699A1/es

Links

108091005804 Peptidases Proteins 0.000 title abstract 2
239000004365 Protease Substances 0.000 title abstract 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102000005927 Cysteine Proteases Human genes 0.000 abstract 1
108010005843 Cysteine Proteases Proteins 0.000 abstract 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
102000012479 Serine Proteases Human genes 0.000 abstract 1
108010022999 Serine Proteases Proteins 0.000 abstract 1
ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
210000000845 cartilage Anatomy 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
208000007565 gingivitis Diseases 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
201000001245 periodontitis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PE1998000830A 1997-09-04 1998-09-04 Co-inhibidores de proteasa PE115699A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5752797P	1997-09-04	1997-09-04

Publications (1)

Publication Number	Publication Date
PE115699A1 true PE115699A1 (es)	2000-01-13

Family

ID=22011125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE1998000830A PE115699A1 (es)	1997-09-04	1998-09-04	Co-inhibidores de proteasa

Country Status (10)

Country	Link
EP (1)	EP1015438A4 (fr)
JP (1)	JP2001514257A (fr)
AU (1)	AU9300298A (fr)
CA (1)	CA2302361A1 (fr)
CO (1)	CO4970736A1 (fr)
MA (1)	MA26540A1 (fr)
PE (1)	PE115699A1 (fr)
SA (1)	SA98190653A (fr)
WO (1)	WO1999011637A1 (fr)
ZA (1)	ZA988064B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030144175A1 (en)	1998-12-23	2003-07-31	Smithkline Beecham Corporation	Protease inhibitors
JP2003513971A (ja)	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
EP1229914A4 (fr)	1999-11-10	2004-06-23	Smithkline Beecham Corp	Inhibiteurs de protease
KR20020082896A (ko)	2000-03-21	2002-10-31	스미스클라인 비참 코포레이션	프로테아제 억제제
US6699866B2 (en)	2001-04-17	2004-03-02	Sepracor Inc.	Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
WO2003062192A1 (fr)	2002-01-17	2003-07-31	Smithkline Beecham Corporation	Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k
KR100962972B1 (ko)	2002-07-26	2010-06-09	주식회사유한양행	1-페닐피페리딘-3-온 유도체 및 그의 제조방법
DE102004008141A1 (de)	2004-02-19	2005-09-01	Abbott Gmbh & Co. Kg	Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225172A (ja) *	1983-06-03	1984-12-18	Yamanouchi Pharmaceut Co Ltd	新規グアニジノチアゾ−ル誘導体及びその製法

1998
- 1998-09-01 MA MA25238A patent/MA26540A1/fr unknown
- 1998-09-03 AU AU93002/98A patent/AU9300298A/en not_active Abandoned
- 1998-09-03 ZA ZA988064A patent/ZA988064B/xx unknown
- 1998-09-03 EP EP98945850A patent/EP1015438A4/fr not_active Withdrawn
- 1998-09-03 CO CO98050517A patent/CO4970736A1/es unknown
- 1998-09-03 CA CA002302361A patent/CA2302361A1/fr not_active Abandoned
- 1998-09-03 WO PCT/US1998/018289 patent/WO1999011637A1/fr not_active Ceased
- 1998-09-03 JP JP2000508676A patent/JP2001514257A/ja not_active Withdrawn
- 1998-09-04 PE PE1998000830A patent/PE115699A1/es not_active Application Discontinuation
- 1998-10-17 SA SA98190653A patent/SA98190653A/ar unknown

Also Published As

Publication number	Publication date
SA98190653A (ar)	2005-12-03
MA26540A1 (fr)	2004-12-20
EP1015438A4 (fr)	2000-11-08
AU9300298A (en)	1999-03-22
WO1999011637A1 (fr)	1999-03-11
CA2302361A1 (fr)	1999-03-11
ZA988064B (en)	1999-05-28
JP2001514257A (ja)	2001-09-11
EP1015438A1 (fr)	2000-07-05
CO4970736A1 (es)	2000-11-07

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Legal Events

Date	Code	Title	Description
2001-09-26	FC	Refusal