PL2768821T3 - Stałe postacie (1,1-diokso-4-tiomorfolinylo)-[6-[[3-(4-fluorofenylo)-5-metylo-4-izoksazolilo]metoksy]-3-pirydynylo]metanonu - Google Patents
Stałe postacie (1,1-diokso-4-tiomorfolinylo)-[6-[[3-(4-fluorofenylo)-5-metylo-4-izoksazolilo]metoksy]-3-pirydynylo]metanonuInfo
- Publication number
- PL2768821T3 PL2768821T3 PL12772789T PL12772789T PL2768821T3 PL 2768821 T3 PL2768821 T3 PL 2768821T3 PL 12772789 T PL12772789 T PL 12772789T PL 12772789 T PL12772789 T PL 12772789T PL 2768821 T3 PL2768821 T3 PL 2768821T3
- Authority
- PL
- Poland
- Prior art keywords
- methanone
- thiomorpholinyl
- dioxo
- isoxazolyl
- pyridinyl
- Prior art date
Links
- VCGRFBXVSFAGGA-UHFFFAOYSA-N (1,1-dioxo-1,4-thiazinan-4-yl)-[6-[[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone Chemical compound CC=1ON=C(C=2C=CC(F)=CC=2)C=1COC(N=C1)=CC=C1C(=O)N1CCS(=O)(=O)CC1 VCGRFBXVSFAGGA-UHFFFAOYSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11185993 | 2011-10-20 | ||
| EP12772789.9A EP2768821B1 (en) | 2011-10-20 | 2012-10-17 | Solid forms of (1,1-dioxo-4-thiomorpholinyl)-[6-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2768821T3 true PL2768821T3 (pl) | 2017-05-31 |
Family
ID=47019027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12772789T PL2768821T3 (pl) | 2011-10-20 | 2012-10-17 | Stałe postacie (1,1-diokso-4-tiomorfolinylo)-[6-[[3-(4-fluorofenylo)-5-metylo-4-izoksazolilo]metoksy]-3-pirydynylo]metanonu |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8785435B2 (pl) |
| EP (1) | EP2768821B1 (pl) |
| JP (1) | JP5918856B2 (pl) |
| KR (1) | KR20140079503A (pl) |
| CN (1) | CN103889971B (pl) |
| AR (1) | AR088359A1 (pl) |
| AU (1) | AU2012318294B2 (pl) |
| BR (1) | BR112014009288A8 (pl) |
| CA (1) | CA2850441A1 (pl) |
| DK (1) | DK2768821T3 (pl) |
| ES (1) | ES2606547T3 (pl) |
| HU (1) | HUE030298T2 (pl) |
| IL (1) | IL231532A0 (pl) |
| MX (1) | MX341492B (pl) |
| PL (1) | PL2768821T3 (pl) |
| RU (1) | RU2618524C2 (pl) |
| SG (1) | SG11201401591WA (pl) |
| SI (1) | SI2768821T1 (pl) |
| WO (1) | WO2013057124A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
| KR102927199B1 (ko) * | 2017-08-28 | 2026-02-12 | 유니버시티 오브 매릴랜드, 발티모어 | 기분장애를 위한 신규한 감마 아미노부티르산 타입 a 수용체 모듈레이터 |
| WO2019238633A1 (en) | 2018-06-13 | 2019-12-19 | F. Hoffmann-La Roche Ag | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| CA3195702A1 (en) | 2020-10-13 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Process of reworking |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE352505C (de) | 1918-03-01 | 1922-04-27 | Metallbank | Verfahren zur Verarbeitung von Salmiakschlacken |
| DE3525205A1 (de) | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
| GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
| EP1102755B1 (en) | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
| US6297256B1 (en) | 1999-06-15 | 2001-10-02 | Neurogen Corporation | Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands |
| US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| CN1390217A (zh) | 1999-11-12 | 2003-01-08 | 神经原公司 | 二环和三环杂芳族化合物 |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| EP1411942A4 (en) | 2001-07-05 | 2005-01-26 | Synaptic Pharma Corp | SUBSTITUTED ANILINPIPERIDINES AS MCH-SELECTIVE ANTAGONISTS |
| ATE381542T1 (de) | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
| AU2002353844A1 (en) | 2001-11-20 | 2003-06-10 | Eli Lilly And Company | Beta 3 adrenergic agonists |
| GB0128160D0 (en) | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
| GB0128499D0 (en) | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004048349A1 (en) | 2002-11-22 | 2004-06-10 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
| GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
| BRPI0511099A (pt) | 2004-05-14 | 2007-12-26 | Irm Llc | compostos e composições como moduladores de ppar |
| EP1756086B1 (en) | 2004-06-01 | 2008-06-04 | F.Hoffmann-La Roche Ag | Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists |
| WO2005123672A2 (en) | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Kinase inhibitors |
| JP4620123B2 (ja) | 2004-10-01 | 2011-01-26 | エフ．ホフマン−ラ ロシュ アーゲー | ヘキサフルオロイソプロパノール置換エーテル誘導体 |
| US7351724B2 (en) | 2004-10-15 | 2008-04-01 | The Scripps Research Institute | Oxadiazole ketone inhibitors of fatty acid amide hydrolase |
| US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
| WO2006095822A1 (ja) | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| EP1904338B1 (de) | 2005-07-20 | 2011-11-09 | Prospective Concepts AG | Pneumatische kissenstrukturen |
| CN101263139A (zh) | 2005-09-19 | 2008-09-10 | 弗·哈夫曼-拉罗切有限公司 | 作为GABA Aα5逆激动剂的异唑衍生物 |
| AU2006301376A1 (en) | 2005-10-11 | 2007-04-19 | F. Hoffmann-La Roche Ag | Isoxazole derivatives |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| ATE507222T1 (de) * | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
| WO2007076260A2 (en) | 2005-12-19 | 2007-07-05 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
| WO2007071476A1 (en) * | 2005-12-20 | 2007-06-28 | International Business Machines Corporation | Method, system and computer program for distributing software products based on an e-mail service |
| CA2640476A1 (en) | 2006-02-03 | 2007-08-16 | Eli Lilly And Company | Compounds and methods for modulating fx-receptors |
| JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
| AU2007267183B2 (en) | 2006-05-31 | 2011-10-20 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| US8546394B2 (en) | 2007-04-17 | 2013-10-01 | Bristol-Myers Squibb Company | Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors |
| KR101237576B1 (ko) | 2007-12-04 | 2013-03-04 | 에프. 호프만-라 로슈 아게 | 아이속사졸로-피리딘 유도체 |
| KR101175859B1 (ko) | 2007-12-04 | 2012-08-24 | 에프. 호프만-라 로슈 아게 | 이속사졸로-피라진 유도체 |
-
2012
- 2012-10-12 US US13/650,159 patent/US8785435B2/en active Active
- 2012-10-17 CN CN201280051089.3A patent/CN103889971B/zh active Active
- 2012-10-17 AR ARP120103860A patent/AR088359A1/es unknown
- 2012-10-17 RU RU2014118968A patent/RU2618524C2/ru not_active IP Right Cessation
- 2012-10-17 HU HUE12772789A patent/HUE030298T2/en unknown
- 2012-10-17 PL PL12772789T patent/PL2768821T3/pl unknown
- 2012-10-17 WO PCT/EP2012/070522 patent/WO2013057124A1/en not_active Ceased
- 2012-10-17 BR BR112014009288A patent/BR112014009288A8/pt not_active IP Right Cessation
- 2012-10-17 ES ES12772789.9T patent/ES2606547T3/es active Active
- 2012-10-17 JP JP2014536209A patent/JP5918856B2/ja active Active
- 2012-10-17 SI SI201230792A patent/SI2768821T1/sl unknown
- 2012-10-17 EP EP12772789.9A patent/EP2768821B1/en active Active
- 2012-10-17 KR KR1020147013555A patent/KR20140079503A/ko not_active Ceased
- 2012-10-17 SG SG11201401591WA patent/SG11201401591WA/en unknown
- 2012-10-17 DK DK12772789.9T patent/DK2768821T3/en active
- 2012-10-17 CA CA2850441A patent/CA2850441A1/en not_active Abandoned
- 2012-10-17 AU AU2012318294A patent/AU2012318294B2/en not_active Ceased
- 2012-10-17 MX MX2014004678A patent/MX341492B/es active IP Right Grant
-
2014
- 2014-03-13 IL IL231532A patent/IL231532A0/en active IP Right Grant
- 2014-06-04 US US14/295,535 patent/US8975397B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8785435B2 (en) | 2014-07-22 |
| CN103889971B (zh) | 2016-08-31 |
| US20130172329A1 (en) | 2013-07-04 |
| NZ622215A (en) | 2016-06-24 |
| HUE030298T2 (en) | 2017-04-28 |
| AU2012318294B2 (en) | 2015-10-01 |
| RU2618524C2 (ru) | 2017-05-04 |
| MX341492B (es) | 2016-08-23 |
| IL231532A0 (en) | 2014-04-30 |
| RU2014118968A (ru) | 2015-11-27 |
| US20140329806A1 (en) | 2014-11-06 |
| SG11201401591WA (en) | 2014-05-29 |
| BR112014009288A8 (pt) | 2020-04-22 |
| EP2768821A1 (en) | 2014-08-27 |
| AU2012318294A1 (en) | 2013-05-09 |
| WO2013057124A1 (en) | 2013-04-25 |
| MX2014004678A (es) | 2014-05-28 |
| BR112014009288A2 (pt) | 2017-06-13 |
| US8975397B2 (en) | 2015-03-10 |
| HK1193611A1 (zh) | 2014-09-26 |
| KR20140079503A (ko) | 2014-06-26 |
| CN103889971A (zh) | 2014-06-25 |
| SI2768821T1 (sl) | 2017-01-31 |
| AR088359A1 (es) | 2014-05-28 |
| ES2606547T3 (es) | 2017-03-24 |
| EP2768821B1 (en) | 2016-11-16 |
| CA2850441A1 (en) | 2013-04-25 |
| JP5918856B2 (ja) | 2016-05-18 |
| JP2014530832A (ja) | 2014-11-20 |
| DK2768821T3 (en) | 2017-01-23 |
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