PL327443A1 - Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration - Google Patents

Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration

Info

Publication number: PL327443A1
Authority: PL; Poland
Prior art keywords: dioxolanic; nucleosides; compositions; methods; beta configuration
Prior art date: 1995-12-14

Application number

PL96327443A

Other versions

PL188447B1 (en

Inventor

Tarek Mansour

Alex Cimpoia

Krzystof Bednarski

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-14

Filing date

1996-12-13

Publication date

1998-12-07

1996-12-13 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

1998-12-07 Publication of PL327443A1 publication Critical patent/PL327443A1/en

2005-02-28 Publication of PL188447B1 publication Critical patent/PL188447B1/en

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
125000003835 nucleoside group Chemical group 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL96327443A 1995-12-14 1996-12-13 Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration PL188447B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9525606.1A GB9525606D0 (en)	1995-12-14	1995-12-14	Method and compositions for the synthesis of dioxolane nucleosides with - configuration
PCT/CA1996/000845 WO1997021706A1 (en)	1995-12-14	1996-12-13	METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (2)

Publication Number	Publication Date
PL327443A1 true PL327443A1 (en)	1998-12-07
PL188447B1 PL188447B1 (en)	2005-02-28

Family

ID=10785435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL96327443A PL188447B1 (en)	1995-12-14	1996-12-13	Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration

Country Status (27)

Country	Link
US (4)	US5922867A (en)
EP (1)	EP0970074B1 (en)
JP (1)	JP3229990B2 (en)
KR (1)	KR100406159B1 (en)
CN (1)	CN1080263C (en)
AP (1)	AP879A (en)
AT (1)	ATE214699T1 (en)
AU (1)	AU706328B2 (en)
BR (1)	BR9612351A (en)
CA (1)	CA2237730C (en)
DE (1)	DE69620042T2 (en)
DK (1)	DK0970074T3 (en)
EA (1)	EA000844B1 (en)
ES (1)	ES2172697T3 (en)
GB (1)	GB9525606D0 (en)
HU (1)	HU224076B1 (en)
IL (3)	IL144155A (en)
IN (1)	IN187349B (en)
MX (1)	MX9804701A (en)
NO (1)	NO309901B1 (en)
NZ (1)	NZ323855A (en)
OA (1)	OA11094A (en)
PL (1)	PL188447B1 (en)
PT (1)	PT970074E (en)
TW (1)	TW341574B (en)
WO (1)	WO1997021706A1 (en)
ZA (1)	ZA9610544B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0986375A2 (en)	1997-04-07	2000-03-22	Triangle Pharmaceuticals Inc.	Use of mkc-442 in combination with other antiviral agents
CA2340214C (en)	1998-08-12	2007-10-30	Triangle Pharmaceuticals, Inc.	Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en)	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
PT1140937E (en)	1998-12-23	2004-04-30	Shire Biochem Inc	ANALOGS OF ANTIVIRAL NUCLEOSIDES
AU2653200A (en) *	1999-02-11	2000-08-29	Biochem Pharma Inc.	Stereoselective synthesis of nucleoside analogues
DE60011637T2 (en) *	1999-09-24	2004-11-11	Shire Biochem Inc., Laval	DIOXOLAN NUCLEOSIDE ANALOGS FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS
US6566365B1 (en) *	1999-11-04	2003-05-20	Biochem Pharma Inc.	Method for the treatment of Flaviviridea viral infection using nucleoside analogues
WO2001058920A2 (en) *	2000-02-10	2001-08-16	Mitsui Chemicals, Inc.	Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
EP1265890B1 (en)	2000-02-11	2007-04-18	Shire BioChem Inc.	Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (en) *	2000-12-27	2002-07-04	Mitsui Chemicals, Inc.	Process for producing nonnatural saccharide derivative
KR101150250B1 (en) *	2001-03-01	2012-06-12	아보트 래버러토리즈	Polymorphic and other crystalline forms of cis-ftc
AU2002329970A1 (en) *	2001-09-04	2003-03-18	Isis Pharmaceuticals, Inc.	Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
CA2465682A1 (en) *	2001-11-02	2003-05-08	Shire Biochem Inc.	Methods of treating leukemia
EP1569652A4 (en) *	2001-12-14	2008-07-02	Pharmasset Inc	N sp 4 /sp-acylcytosine nucleosides for treatment of viral iinfections
CA2473736C (en)	2002-01-25	2011-10-11	Shire Biochem Inc.	Process for producing dioxolane nucleoside analogues
EP1534255B1 (en)	2002-08-06	2011-01-19	Pharmasset, Inc.	Processes for preparing 1,3-dioxolane nucleosides
ES2394304T3 (en)	2002-10-15	2013-01-30	Exxonmobil Chemical Patents, Inc.	Multiple catalyst system for the polymerization of olefins and polymers produced from them
DE10335061B4 (en)	2003-07-31	2005-11-17	Wacker-Chemie Gmbh	Process for the preparation of OH-protected [4- (2,6-damino-9H-purin-9-yl) -1,3-dioxolan-2-yl] methanol derivatives
BRPI0507363A (en)	2004-02-03	2007-07-03	Univ Emory	Methods for Manufacturing Nucleoside 1,3-Dioxolane
US7749531B2 (en) *	2005-06-08	2010-07-06	Indicator Systems International	Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (en) *	2007-07-30	2017-10-24	Rfs Pharma Llc	stereoselective process for preparing purine dioxolane nucleoside derivatives.
CN101862676B (en) *	2009-04-17	2012-01-25	中国石油化工股份有限公司	Large-aperture SBA-15 mesoporous material-copper trifluoromethanesulfonate composite catalyst, preparation method and application
CN103288806A (en) *	2013-07-02	2013-09-11	山东大学	Synthesis method of troxacitabine
WO2018022263A1 (en)	2016-07-29	2018-02-01	Exxonmobil Chemical Patents Inc.	Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en)	2018-06-21	2019-12-26	Medivir Ab	Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (en)	2018-06-21	2023-09-04	メディヴィル・アクチエボラーグ	Base-Modified Cytidine Nucleotides for Leukemia Therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
JPH0673086A (en) *	1992-06-22	1994-03-15	Eli Lilly & Co	Stereoselective anionic glycosylation method

1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
1996
- 1996-12-13 BR BR9612351A patent/BR9612351A/en not_active Application Discontinuation
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/en unknown
- 1996-12-13 TW TW085115392A patent/TW341574B/en active
- 1996-12-13 EA EA199800555A patent/EA000844B1/en not_active IP Right Cessation
- 1996-12-13 PT PT96941539T patent/PT970074E/en unknown
- 1996-12-13 IL IL14415596A patent/IL144155A/en not_active IP Right Cessation
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 CN CN96199879A patent/CN1080263C/en not_active Expired - Lifetime
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 DK DK96941539T patent/DK0970074T3/en active
- 1996-12-13 PL PL96327443A patent/PL188447B1/en not_active IP Right Cessation
- 1996-12-13 HU HU9901050A patent/HU224076B1/en active IP Right Grant
- 1996-12-13 AT AT96941539T patent/ATE214699T1/en not_active IP Right Cessation
- 1996-12-13 ES ES96941539T patent/ES2172697T3/en not_active Expired - Lifetime
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/en not_active Expired - Fee Related
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 DE DE69620042T patent/DE69620042T2/en not_active Expired - Lifetime
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 NZ NZ323855A patent/NZ323855A/en unknown
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
- 1996-12-13 JP JP52157397A patent/JP3229990B2/en not_active Expired - Lifetime
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/en unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/en unknown
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/en unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned

Also Published As

Publication number	Publication date
GB9525606D0 (en)	1996-02-14
MX9804701A (en)	1998-10-31
CA2237730C (en)	2001-12-04
EP0970074A1 (en)	2000-01-12
EA000844B1 (en)	2000-06-26
PT970074E (en)	2002-09-30
NO982716D0 (en)	1998-06-12
AU1089397A (en)	1997-07-03
AU706328B2 (en)	1999-06-17
IL144155A (en)	2003-07-06
IL124663A (en)	2001-10-31
HUP9901050A3 (en)	2001-05-28
OA11094A (en)	2003-03-13
IL124663A0 (en)	1998-12-06
ZA9610544B (en)	1997-07-29
DE69620042T2 (en)	2002-10-17
HK1017886A1 (en)	1999-12-03
NO309901B1 (en)	2001-04-17
CN1208414A (en)	1999-02-17
ATE214699T1 (en)	2002-04-15
KR100406159B1 (en)	2004-11-16
US20020058670A1 (en)	2002-05-16
IL144155A0 (en)	2002-05-23
ES2172697T3 (en)	2002-10-01
EA199800555A1 (en)	1999-02-25
US6069250A (en)	2000-05-30
JP2000501714A (en)	2000-02-15
DE69620042D1 (en)	2002-04-25
IN187349B (en)	2002-03-30
AP9801252A0 (en)	1998-06-30
PL188447B1 (en)	2005-02-28
KR19990072141A (en)	1999-09-27
AP879A (en)	2000-10-02
NO982716L (en)	1998-06-12
WO1997021706A1 (en)	1997-06-19
EP0970074B1 (en)	2002-03-20
JP3229990B2 (en)	2001-11-19
TW341574B (en)	1998-10-01
US5922867A (en)	1999-07-13
BR9612351A (en)	1999-07-13
CA2237730A1 (en)	1997-06-19
HU224076B1 (en)	2005-05-30
DK0970074T3 (en)	2002-07-15
NZ323855A (en)	1999-11-29
US20030060476A1 (en)	2003-03-27
HUP9901050A2 (en)	2001-04-28
CN1080263C (en)	2002-03-06

Legal Events

Date	Code	Title	Description
2009-02-27	LAPS	Decisions on the lapse of the protection rights	Effective date: 20071213

Publication	Publication Date	Title
PL327443A1 (en)	1998-12-07	Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration
HUT77516A (en)	1998-05-28	Sugar modified nucleosides and their use for synthesis of oligonucleotides
HUT76642A (en)	1997-10-28	Process for synthesis of substituted sulphoxides
IL113432A0 (en)	1995-07-31	Diastereoselective synthesis of nucleoside analogues
PL322277A1 (en)	1998-01-19	Derivatives of pyrazol-4-ylobenzoyl
HU9700076D0 (en)	1997-02-28	Anti-helicobacter acyl derivatives of azolones
HU9603081D0 (en)	1996-12-30	Process for selective synthesis of sylil-alkyl-disulfides
PL324451A1 (en)	1998-05-25	Derivatives of diphenylmethylenepiperidine
IL118294A0 (en)	1996-09-12	Preparation of 4-aryl-piperidine derivatives
IL114887A0 (en)	1995-12-08	Oxypurine nucleosides and their congeners and acyl derivatives thereof for improvement of hematopoiesis
GB9508791D0 (en)	1995-06-21	Compositions of matter
GB9507297D0 (en)	1995-05-31	New composition of matter
PL316985A1 (en)	1997-03-03	Derivatives of adenosine
HUP9801576A3 (en)	2000-07-28	Process for the synthesis of nucleoside analogues and the intermediers
AU4980097A (en)	1998-05-15	Efficient synthesis of nucleosides
GB9510222D0 (en)	1995-07-19	Compositions of matter
AU7706191A (en)	1991-11-28	Synthesis of nucleotide and nucleoside derivatives
GB2393957B (en)	2004-09-29	Synthesis of hexaazaisowurtzitane derivatives
IL118238A0 (en)	1996-09-12	Synthesis of benzoquinolinones
LT95123A (en)	1996-06-25	Diaprojector for investigating of microobjectives
PL318280A1 (en)	1997-06-09	Novel polymorphous modifications of lesopitrone dihydrochloride and theirhydrogenated forms, methods of obtaining them and compositions containing them
IL117639A0 (en)	1996-07-23	Preparation of cis-4-0-protected-2- cyclopentenol derivatives
GB9515058D0 (en)	1995-09-20	New compositions of matter
GB9515729D0 (en)	1995-10-04	New compositions of matter
GB9503223D0 (en)	1995-04-05	New compositions of matter