PL3619215T3 - Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimus - Google Patents
Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimusInfo
- Publication number
- PL3619215T3 PL3619215T3 PL18723771T PL18723771T PL3619215T3 PL 3619215 T3 PL3619215 T3 PL 3619215T3 PL 18723771 T PL18723771 T PL 18723771T PL 18723771 T PL18723771 T PL 18723771T PL 3619215 T3 PL3619215 T3 PL 3619215T3
- Authority
- PL
- Poland
- Prior art keywords
- convert crude
- purified pimecrolimus
- crude ascomycin
- ascomycin
- pimecrolimus
- Prior art date
Links
- ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 title 1
- ZDQSOHOQTUFQEM-XCXYXIJFSA-N ascomycin Natural products CC[C@H]1C=C(C)C[C@@H](C)C[C@@H](OC)[C@H]2O[C@@](O)([C@@H](C)C[C@H]2OC)C(=O)C(=O)N3CCCC[C@@H]3C(=O)O[C@H]([C@H](C)[C@@H](O)CC1=O)C(=C[C@@H]4CC[C@@H](O)[C@H](C4)OC)C ZDQSOHOQTUFQEM-XCXYXIJFSA-N 0.000 title 1
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 title 1
- 229960005330 pimecrolimus Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762492394P | 2017-05-01 | 2017-05-01 | |
| PCT/EP2018/061235 WO2018202733A1 (en) | 2017-05-01 | 2018-05-02 | Process to convert crude ascomycin into purified pimecrolimus |
| EP18723771.4A EP3619215B1 (en) | 2017-05-01 | 2018-05-02 | Process to convert crude ascomycin into purified pimecrolimus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3619215T3 true PL3619215T3 (pl) | 2022-03-21 |
Family
ID=62148339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18723771T PL3619215T3 (pl) | 2017-05-01 | 2018-05-02 | Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimus |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10975097B2 (pl) |
| EP (1) | EP3619215B1 (pl) |
| KR (1) | KR102592374B1 (pl) |
| CN (1) | CN110741006B (pl) |
| CA (1) | CA3060330A1 (pl) |
| CL (1) | CL2019003118A1 (pl) |
| ES (1) | ES2906158T3 (pl) |
| HR (1) | HRP20220203T1 (pl) |
| PL (1) | PL3619215T3 (pl) |
| PT (1) | PT3619215T (pl) |
| SA (1) | SA519410421B1 (pl) |
| SI (1) | SI3619215T1 (pl) |
| WO (1) | WO2018202733A1 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102645011B1 (ko) * | 2023-10-17 | 2024-03-07 | 주식회사 라이프슈티컬 | 고상 추출법을 이용한 타크롤리무스의 정제방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737292A (en) | 1986-06-05 | 1988-04-12 | Separations Technology, Inc. | HPLC column and a column packing method |
| DK0427680T3 (da) | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
| GB9618952D0 (en) | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| GB0012383D0 (en) | 2000-05-22 | 2000-07-12 | Novartis Ag | Organic compounds |
| US7645876B2 (en) | 2004-12-01 | 2010-01-12 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | Processes for producing crystalline macrolides |
| TW200523266A (en) | 2003-07-24 | 2005-07-16 | Biogal Gyogyszergyar | Method of purifying macrolides |
| GT200500282A (es) * | 2004-10-12 | 2006-05-04 | Heteroatomos conteniendo compuestos triciclicos. | |
| CN101068818A (zh) * | 2004-12-01 | 2007-11-07 | 特瓦药厂私人有限公司 | 制备吡美莫司的方法 |
| CA2668134A1 (en) | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| IT1394309B1 (it) | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
| PL4108769T3 (pl) | 2015-05-29 | 2024-02-05 | CureVac Manufacturing GmbH | Sposób wytwarzania i oczyszczania rna obejmujący co najmniej jeden etap filtracji o przepływie stycznym |
-
2018
- 2018-05-02 PL PL18723771T patent/PL3619215T3/pl unknown
- 2018-05-02 WO PCT/EP2018/061235 patent/WO2018202733A1/en not_active Ceased
- 2018-05-02 PT PT187237714T patent/PT3619215T/pt unknown
- 2018-05-02 KR KR1020197032281A patent/KR102592374B1/ko active Active
- 2018-05-02 US US16/610,098 patent/US10975097B2/en active Active
- 2018-05-02 EP EP18723771.4A patent/EP3619215B1/en active Active
- 2018-05-02 CA CA3060330A patent/CA3060330A1/en active Pending
- 2018-05-02 CN CN201880028973.2A patent/CN110741006B/zh active Active
- 2018-05-02 ES ES18723771T patent/ES2906158T3/es active Active
- 2018-05-02 SI SI201830565T patent/SI3619215T1/sl unknown
- 2018-05-02 HR HRP20220203TT patent/HRP20220203T1/hr unknown
-
2019
- 2019-10-29 CL CL2019003118A patent/CL2019003118A1/es unknown
- 2019-10-30 SA SA519410421A patent/SA519410421B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110741006A (zh) | 2020-01-31 |
| CN110741006B (zh) | 2023-04-07 |
| WO2018202733A1 (en) | 2018-11-08 |
| ES2906158T3 (es) | 2022-04-13 |
| KR102592374B1 (ko) | 2023-10-25 |
| EP3619215A1 (en) | 2020-03-11 |
| HRP20220203T1 (hr) | 2022-05-27 |
| EP3619215B1 (en) | 2021-11-17 |
| US20200079792A1 (en) | 2020-03-12 |
| KR20200006529A (ko) | 2020-01-20 |
| US10975097B2 (en) | 2021-04-13 |
| CA3060330A1 (en) | 2018-11-08 |
| CL2019003118A1 (es) | 2020-02-21 |
| SA519410421B1 (ar) | 2022-03-03 |
| PT3619215T (pt) | 2022-02-11 |
| SI3619215T1 (sl) | 2022-05-31 |
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