PT3819302T - Oligossacárido de sulfato de condroitina fucosilado, método de preparação correspondente, sua composição e sua utilização - Google Patents

Oligossacárido de sulfato de condroitina fucosilado, método de preparação correspondente, sua composição e sua utilização

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Publication number
PT3819302T
PT3819302T PT198383473T PT19838347T PT3819302T PT 3819302 T PT3819302 T PT 3819302T PT 198383473 T PT198383473 T PT 198383473T PT 19838347 T PT19838347 T PT 19838347T PT 3819302 T PT3819302 T PT 3819302T
Authority
PT
Portugal
Prior art keywords
preparation
composition
chondroitin sulfate
corresponding method
sulfate oligosaccharide
Prior art date
Application number
PT198383473T
Other languages
English (en)
Original Assignee
Yantai Dongcheng Biochemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yantai Dongcheng Biochemicals Co Ltd filed Critical Yantai Dongcheng Biochemicals Co Ltd
Publication of PT3819302T publication Critical patent/PT3819302T/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06Aminosugars
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/14Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT198383473T 2018-07-16 2019-07-15 Oligossacárido de sulfato de condroitina fucosilado, método de preparação correspondente, sua composição e sua utilização PT3819302T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810778733 2018-07-16

Publications (1)

Publication Number Publication Date
PT3819302T true PT3819302T (pt) 2022-12-23

Family

ID=69163991

Family Applications (1)

Application Number Title Priority Date Filing Date
PT198383473T PT3819302T (pt) 2018-07-16 2019-07-15 Oligossacárido de sulfato de condroitina fucosilado, método de preparação correspondente, sua composição e sua utilização

Country Status (7)

Country Link
US (1) US12421270B2 (pt)
EP (1) EP3819302B1 (pt)
JP (1) JP7166450B2 (pt)
CN (1) CN110724209B (pt)
ES (1) ES2934583T3 (pt)
PT (1) PT3819302T (pt)
WO (1) WO2020015612A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111471120B (zh) * 2020-06-16 2021-02-26 北京赫尔默技术有限公司 一种硫酸软骨素的制备方法及应用
CN115381844B (zh) * 2021-09-29 2024-03-22 北京大学 一种细菌荚膜寡糖衍生物及其制备方法、药物组合物和用途
CN114990175B (zh) * 2021-10-22 2023-03-31 岩唐生物科技(杭州)有限责任公司 一种岩藻糖衍生物的合成方法
WO2025157248A1 (zh) * 2024-01-26 2025-07-31 烟台东诚药业集团股份有限公司 一种岩藻糖基化硫酸软骨素寡糖衍生物及其应用
CN119708287B (zh) * 2024-11-28 2025-11-18 复旦大学 一种用于治疗心肌梗塞的化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101735336B (zh) 2009-11-06 2012-07-18 深圳海王药业有限公司 低聚岩藻糖化糖胺聚糖及其制备方法
CN104558070B (zh) 2013-10-14 2017-10-24 北京大学 新芒果苷的化学合成方法及中间体化合物
CN106467563B (zh) 2015-08-21 2019-08-06 北京大学 硫酸软骨素四糖的合成方法及其中间体化合物
JP6147322B2 (ja) * 2015-10-01 2017-06-14 ゼリアヘルスウエイ株式会社 サーチュイン1活性化剤
CN106349407A (zh) 2016-08-29 2017-01-25 中国海洋大学 一种低分子量岩藻糖化硫酸软骨素及其制备方法和在制备抗特鲁索综合征的药物中的应用
CN106645483B (zh) 2016-12-26 2019-05-21 大连工业大学 一种定量检测海参多糖的方法
CN108794653B (zh) * 2017-05-05 2020-07-17 烟台东诚药业集团股份有限公司 岩藻糖基化硫酸软骨素寡糖糖簇及其制备方法
CN107261147A (zh) * 2017-05-29 2017-10-20 钟术光 一种稳定活体生物活性材料的组合物
CN109912668B (zh) * 2019-01-17 2022-06-14 中国科学院昆明植物研究所 岩藻糖化硫酸软骨素三糖的制备方法、中间体和用途

Also Published As

Publication number Publication date
WO2020015612A1 (zh) 2020-01-23
JP2021529877A (ja) 2021-11-04
JP7166450B2 (ja) 2022-11-07
EP3819302B1 (en) 2022-10-19
EP3819302A1 (en) 2021-05-12
CN110724209B (zh) 2021-11-19
ES2934583T3 (es) 2023-02-23
CN110724209A (zh) 2020-01-24
EP3819302A4 (en) 2021-10-13
US12421270B2 (en) 2025-09-23
US20230029252A1 (en) 2023-01-26

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