PT88373A - Procede de preparation d'imidazo <1,2-b> pyridazines et de compositions pharmaceutiques les contenant - Google Patents

Procede de preparation d'imidazo <1,2-b> pyridazines et de compositions pharmaceutiques les contenant

Info

Publication number: PT88373A
Authority: PT; Portugal
Prior art keywords: pyridazines; imidazo; alkyl group; procede; preparation
Prior art date: 1987-09-01

Application number

PT88373A

Other languages

English (en)

Other versions

PT88373B (pt

Inventor

Jean-Jacques Bourguignon

Camille Georges Wermuth

Paul Worms

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-01

Filing date

1988-08-30

Publication date

1989-07-31

1988-08-30 Application filed by Sanofi Sa filed Critical Sanofi Sa

1989-07-31 Publication of PT88373A publication Critical patent/PT88373A/pt

1992-10-30 Publication of PT88373B publication Critical patent/PT88373B/pt

Links

239000000203 mixture Substances 0.000 title 1
150000004892 pyridazines Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
230000001054 cortical effect Effects 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000004942 imidazo[1,2-b]pyridazines Chemical class 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT88373A 1987-09-01 1988-08-30 Processo para a preparacao de imidazo{1,2-b}piridazinas e de composicoes farmaceuticas que as contem PT88373B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8712167A FR2619818B1 (fr)	1987-09-01	1987-09-01	Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number	Publication Date
PT88373A true PT88373A (pt)	1989-07-31
PT88373B PT88373B (pt)	1992-10-30

Family

ID=9354553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88373A PT88373B (pt)	1987-09-01	1988-08-30	Processo para a preparacao de imidazo{1,2-b}piridazinas e de composicoes farmaceuticas que as contem

Country Status (8)

Country	Link
US (1)	US4910199A (pt)
EP (1)	EP0306408B1 (pt)
JP (1)	JPS6471877A (pt)
AT (1)	ATE73803T1 (pt)
CA (1)	CA1310318C (pt)
DE (1)	DE3869286D1 (pt)
FR (1)	FR2619818B1 (pt)
PT (1)	PT88373B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601011B1 (fr) *	1986-07-03	1988-10-28	Sanofi Sa	Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant
FR2625201B1 (fr) *	1987-12-24	1990-06-15	Sanofi Sa	Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant
EP0809642A1 (en) *	1995-02-15	1997-12-03	PHARMACIA & UPJOHN COMPANY	Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
US6013654A (en) *	1997-08-14	2000-01-11	Pharmacia & Upjohn Company	Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
TWI312347B (en) *	2001-02-08	2009-07-21	Eisai R&D Man Co Ltd	Bicyclic nitrogen-containing condensed ring compounds
US7723336B2 (en)	2005-09-22	2010-05-25	Bristol-Myers Squibb Company	Fused heterocyclic compounds useful as kinase modulators
US20070078136A1 (en) *	2005-09-22	2007-04-05	Bristol-Myers Squibb Company	Fused heterocyclic compounds useful as kinase modulators
WO2009100375A1 (en)	2008-02-06	2009-08-13	Bristol-Myers Squibb Company	Substituted imidazopyridazines useful as kinase inhibitors
PE20091468A1 (es) *	2008-02-28	2009-10-22	Novartis Ag	DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA
RS52561B (sr) *	2008-04-15	2013-04-30	Eisai R&D Management Co., Ltd.	Jedinjenje 3-fenilpirazolo[5,1-b]tiazol
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
JPWO2011043387A1 (ja) *	2009-10-08	2013-03-04	エーザイ・アール・アンド・ディー・マネジメント株式会社	ピラゾロオキサゾール化合物
AR078521A1 (es) *	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
UA117092C2 (uk)	2011-09-06	2018-06-25	Байєр Інтеллектуал Проперті Гмбх	Амінозаміщені імідазопіридазини
ES2646916T3 (es)	2012-11-19	2017-12-18	Bayer Pharma Aktiengesellschaft	Aminoimidazopiridazinas como inhibidores de MKNK1 cinasa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3489755A (en) *	1966-08-03	1970-01-13	Pfizer & Co C	Imidazo (1,2-b) pyridazines
US3828041A (en) *	1971-02-24	1974-08-06	American Cyanamid Co	6-substituted 3-nitroimidazo(1,2-b)pyridazines and method of preparing same
FR2473522A1 (fr) *	1980-01-16	1981-07-17	Synthelabo	Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
US4464372A (en) *	1982-08-16	1984-08-07	Schering Corporation	Imidazo[1,2-b]pyridazines
US4569934A (en) *	1984-10-09	1986-02-11	American Cyanamid Company	Imidazo[1,2-b]pyridazines

1987
- 1987-09-01 FR FR8712167A patent/FR2619818B1/fr not_active Expired - Fee Related
1988
- 1988-08-30 PT PT88373A patent/PT88373B/pt not_active IP Right Cessation
- 1988-08-31 US US07/238,488 patent/US4910199A/en not_active Expired - Fee Related
- 1988-08-31 CA CA000576243A patent/CA1310318C/en not_active Expired - Fee Related
- 1988-09-01 EP EP88402199A patent/EP0306408B1/fr not_active Expired - Lifetime
- 1988-09-01 DE DE8888402199T patent/DE3869286D1/de not_active Expired - Fee Related
- 1988-09-01 AT AT88402199T patent/ATE73803T1/de not_active IP Right Cessation
- 1988-09-01 JP JP63219591A patent/JPS6471877A/ja active Pending

Also Published As

Publication number	Publication date
FR2619818A1 (fr)	1989-03-03
JPS6471877A (en)	1989-03-16
ATE73803T1 (de)	1992-04-15
PT88373B (pt)	1992-10-30
DE3869286D1 (de)	1992-04-23
EP0306408B1 (fr)	1992-03-18
EP0306408A1 (fr)	1989-03-08
FR2619818B1 (fr)	1990-01-12
US4910199A (en)	1990-03-20
CA1310318C (en)	1992-11-17

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Legal Events

Date

Code

Title

Description

1992-10-30

FG3A

Patent granted, date of granting

Effective date: 19920413

1994-03-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19931031