SE8004454L - PROCEDURE FOR MANUFACTURING OXIMORPHONE - Google Patents

PROCEDURE FOR MANUFACTURING OXIMORPHONE

Info

Publication number
SE8004454L
SE8004454L SE8004454A SE8004454A SE8004454L SE 8004454 L SE8004454 L SE 8004454L SE 8004454 A SE8004454 A SE 8004454A SE 8004454 A SE8004454 A SE 8004454A SE 8004454 L SE8004454 L SE 8004454L
Authority
SE
Sweden
Prior art keywords
oximorphone
procedure
manufacturing
utilizing
lewis base
Prior art date
Application number
SE8004454A
Other languages
Swedish (sv)
Inventor
M L Wilson
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of SE8004454L publication Critical patent/SE8004454L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polarising Elements (AREA)

Abstract

A process for producing oxymorphone by converting oxycodone utilizing a suitable boron reagent in the presence of a weak Lewis base attenuating agent.
SE8004454A 1978-10-19 1980-06-16 PROCEDURE FOR MANUFACTURING OXIMORPHONE SE8004454L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95305678A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
SE8004454L true SE8004454L (en) 1980-06-16

Family

ID=25493512

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8004454A SE8004454L (en) 1978-10-19 1980-06-16 PROCEDURE FOR MANUFACTURING OXIMORPHONE

Country Status (16)

Country Link
JP (1) JPS55501025A (en)
AU (1) AU5189779A (en)
BE (1) BE879494A (en)
CA (1) CA1108132A (en)
CS (1) CS211364B2 (en)
DK (1) DK258280A (en)
ES (1) ES485154A1 (en)
FI (1) FI793235A7 (en)
FR (1) FR2439201A1 (en)
GB (1) GB2049680A (en)
IL (1) IL58489A0 (en)
IT (1) IT7969032A0 (en)
NL (1) NL7920126A (en)
NO (1) NO793297L (en)
SE (1) SE8004454L (en)
WO (1) WO1980000841A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (en) * 1988-09-13 1990-11-30 Sanofi Sa PROCESS FOR THE PREPARATION OF MORPHINANE DERIVATIVES
ATE178329T1 (en) * 1989-10-16 1999-04-15 Us Health TOTAL SYNTHESIS OF NORTHEBAIN, NORMORPHINE, NOROXYMORPHONE ENANTIOMERS AND DERIVATIVES VIA N-NOR INTERMEDIATE COMPOUNDS
KR20030048026A (en) 2001-07-06 2003-06-18 펜웨스트 파머슈티칼즈 컴파니 Sustained release formulations of oxymorphone
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
CN1610551A (en) 2001-07-06 2005-04-27 恩德制药公司 Parenteral administration of 6-hydroxymorphone as an analgesic
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
DE102004032049A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
DE102005005449A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
MX2008010921A (en) 2006-03-02 2008-09-03 Mallinckrodt Inc Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds.
KR101616246B1 (en) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 Pharmaceutical dosage form
AU2009243681B2 (en) 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
TWI473628B (en) 2009-07-22 2015-02-21 Tamper-resistant dosage form for oxidation-sensitive opioids
WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
ES2648129T3 (en) 2011-07-29 2017-12-28 Grünenthal GmbH Tamper-proof tablet that provides immediate release of a medication
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (en) 2012-04-18 2018-12-31 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
JP6466417B2 (en) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング A tamper-resistant dosage form with a bimodal release profile
JP6449871B2 (en) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Anti-modified dosage form containing ethylene-vinyl acetate polymer
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (en) 2014-05-26 2017-05-31 Грюненталь Гмбх DOSAGE FORM AS PARTICLE MULTIPLE, PROTECTED AGAINST CALLED DOSE RESET BY ETHANOL
BR112017021475A2 (en) 2015-04-24 2018-07-10 Gruenenthal Gmbh tamper-resistant dosage form with immediate release and resistance to solvent extraction
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
NL7920126A (en) 1980-08-29
IT7969032A0 (en) 1979-10-18
NO793297L (en) 1980-04-22
IL58489A0 (en) 1980-01-31
BE879494A (en) 1980-02-15
GB2049680A (en) 1980-12-31
CA1108132A (en) 1981-09-01
CS211364B2 (en) 1982-02-26
ES485154A1 (en) 1980-06-16
AU5189779A (en) 1980-04-24
FR2439201A1 (en) 1980-05-16
DK258280A (en) 1980-06-17
FI793235A7 (en) 1981-01-01
WO1980000841A1 (en) 1980-05-01
JPS55501025A (en) 1980-11-27

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