SE8006669L - E-5-(halogenovinyl)-2'-deoxicytidiner och sett for framstellning derav - Google Patents

E-5-(halogenovinyl)-2'-deoxicytidiner och sett for framstellning derav

Info

Publication number: SE8006669L
Authority: SE; Sweden
Prior art keywords: halogenovinyl; deoxycytidine; deoxicytidines; preparing; sets
Prior art date: 1979-10-03

Application number

SE8006669A

Other languages

English (en)

Other versions

SE445740B (sv

Inventor

A S Jones

R T Walker

Clercq E De

G A Verhelst

Original Assignee

Univ Birmingham

Stichting Rega V Z W

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-03

Filing date

1980-09-24

Publication date

1981-04-04

1980-09-24 Application filed by Univ Birmingham, Stichting Rega V Z W filed Critical Univ Birmingham

1981-04-04 Publication of SE8006669L publication Critical patent/SE8006669L/sv

1986-07-14 Publication of SE445740B publication Critical patent/SE445740B/sv

Links

230000000840 anti-viral effect Effects 0.000 abstract 2
CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 abstract 1
JUYRSVVLNGQWBD-PIXDULNESA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(e)-2-iodoethenyl]pyrimidin-2-one Chemical compound C1=C(\C=C\I)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 JUYRSVVLNGQWBD-PIXDULNESA-N 0.000 abstract 1
AKVDSWDYVDOWDW-PIXDULNESA-N 4-amino-5-[(e)-2-bromoethenyl]-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound C1=C(\C=C\Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 AKVDSWDYVDOWDW-PIXDULNESA-N 0.000 abstract 1
CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 abstract 1
241000700584 Simplexvirus Species 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
229940104302 cytosine Drugs 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

SE8006669A 1979-10-03 1980-09-24 E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin SE445740B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7934248A GB2060604B (en)	1979-10-03	1979-10-03	E15-(2-halogenovinyl)-2'-deoxycytidines

Publications (2)

Publication Number	Publication Date
SE8006669L true SE8006669L (sv)	1981-04-04
SE445740B SE445740B (sv)	1986-07-14

Family

ID=10508255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8006669A SE445740B (sv)	1979-10-03	1980-09-24	E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin

Country Status (11)

Country	Link
US (1)	US4382925A (sv)
JP (1)	JPS5695198A (sv)
BE (1)	BE885415A (sv)
CA (1)	CA1173438A (sv)
CH (1)	CH647245A5 (sv)
DE (1)	DE3036131A1 (sv)
FR (1)	FR2466472A1 (sv)
GB (1)	GB2060604B (sv)
IT (1)	IT1209758B (sv)
NL (1)	NL8005336A (sv)
SE (1)	SE445740B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199764A (en) *	1981-03-20	1984-08-24	Beecham Group Plc	5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) *	1981-09-07	1984-05-28	Mta Koezponti Kemiai Kutato In	Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) *	1981-09-09	1983-03-14	Yamasa Shoyu Co Ltd	１−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (en) *	1981-11-19	1983-06-01	Beecham Group Plc	Antiviral 2'-deoxyuridines, their preparation and use
EP0082668A1 (en) *	1981-12-18	1983-06-29	Beecham Group Plc	5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
US4782142A (en) *	1982-01-05	1988-11-01	The Research Foundation Of State University Of New York	Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
FI832884A7 (sv) *	1982-08-17	1984-02-18	Sandoz Ag	Desoxiuridinderivat, deras framställningsförfaranden och användning som farmaceutiska medel.
EP0104066B1 (en) *	1982-09-17	1988-08-10	Glaxo Group Limited	5-halovinyl-2'-deoxyuridine derivatives
AU575918B2 (en) *	1984-03-06	1988-08-11	Sloan-Kettering Institute For Cancer Research	Hepatitis treatment with pyrimidine nucleoside compounds
US4666892A (en) *	1984-03-06	1987-05-19	Sloan-Kettering Memorial Cancer Center	Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
US4762823A (en) *	1985-10-16	1988-08-09	Sloan-Kettering Institute For Cancer Research	Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US5215971A (en) *	1986-12-19	1993-06-01	Medivir Ab	Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
SE8605503D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel medicinal use
EP0428623A4 (en) *	1988-08-10	1993-12-08	Stephen Leslie Sacks	Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
IL151981A0 (en) *	2000-03-29	2003-04-10	Univ Georgetown	Method of treating hepatitis delta viral infection
AU2002360697B2 (en) *	2001-12-20	2009-04-23	Beth Israel Deaconess Medical Center	Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
JP2008174524A (ja) *	2007-01-22	2008-07-31	Nippon Shinyaku Co Ltd	リボ核酸化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3354160A (en) *	1965-07-22	1967-11-21	Hoffmann La Roche	Tri-lower alkyl-silyl-5-fluoropyrimidines
US4000260A (en) *	1974-08-29	1976-12-28	Research Corporation	Anti herpes simplex viral compounds and their synthesis
US4024143A (en) *	1976-03-11	1977-05-17	Pcr, Inc.	Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
US4267171A (en) *	1979-07-02	1981-05-12	The Regents Of The University Of California	C-5 Substituted cytosine nucleosides

1979
- 1979-10-03 GB GB7934248A patent/GB2060604B/en not_active Expired
1980
- 1980-09-24 NL NL8005336A patent/NL8005336A/nl not_active Application Discontinuation
- 1980-09-24 SE SE8006669A patent/SE445740B/sv not_active IP Right Cessation
- 1980-09-25 CH CH7181/80A patent/CH647245A5/de not_active IP Right Cessation
- 1980-09-25 DE DE19803036131 patent/DE3036131A1/de active Granted
- 1980-09-26 BE BE1/9967A patent/BE885415A/nl not_active IP Right Cessation
- 1980-10-02 US US06/193,251 patent/US4382925A/en not_active Expired - Lifetime
- 1980-10-02 JP JP13861580A patent/JPS5695198A/ja active Granted
- 1980-10-02 IT IT8009551A patent/IT1209758B/it active
- 1980-10-02 FR FR8021170A patent/FR2466472A1/fr active Granted
- 1980-10-03 CA CA000361953A patent/CA1173438A/en not_active Expired

Also Published As

Publication number	Publication date
DE3036131A1 (de)	1981-04-16
IT8009551A0 (it)	1980-10-02
DE3036131C2 (sv)	1989-07-06
JPS637199B2 (sv)	1988-02-15
FR2466472A1 (fr)	1981-04-10
GB2060604B (en)	1983-11-23
US4382925A (en)	1983-05-10
SE445740B (sv)	1986-07-14
FR2466472B1 (sv)	1983-12-23
JPS5695198A (en)	1981-08-01
CH647245A5 (de)	1985-01-15
BE885415A (nl)	1981-03-26
CA1173438A (en)	1984-08-28
IT1209758B (it)	1989-08-30
GB2060604A (en)	1981-05-07
NL8005336A (nl)	1981-04-07

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1995-01-31

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