SE9503924D0 - Novel opioid peptides - Google Patents

Novel opioid peptides

Info

Publication number
SE9503924D0
SE9503924D0 SE9503924A SE9503924A SE9503924D0 SE 9503924 D0 SE9503924 D0 SE 9503924D0 SE 9503924 A SE9503924 A SE 9503924A SE 9503924 A SE9503924 A SE 9503924A SE 9503924 D0 SE9503924 D0 SE 9503924D0
Authority
SE
Sweden
Prior art keywords
peptides
pain
opioid
preparation
treatment
Prior art date
Application number
SE9503924A
Other languages
English (en)
Swedish (sv)
Inventor
John Dimaio
Wuyi Wang
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9502877A external-priority patent/SE9502877D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9503924A priority Critical patent/SE9503924D0/xx
Publication of SE9503924D0 publication Critical patent/SE9503924D0/xx
Priority to ARP960103900A priority patent/AR003475A1/es
Priority to DE69617699T priority patent/DE69617699T2/de
Priority to EP96927978A priority patent/EP0845003B1/de
Priority to KR1019980701156A priority patent/KR19990037677A/ko
Priority to EE9800048A priority patent/EE9800048A/xx
Priority to NZ315809A priority patent/NZ315809A/xx
Priority to CA002229797A priority patent/CA2229797A1/en
Priority to JP9509209A priority patent/JPH11512086A/ja
Priority to CZ1998401A priority patent/CZ287299B6/cs
Priority to PCT/SE1996/001011 priority patent/WO1997007130A1/en
Priority to AU67600/96A priority patent/AU711862B2/en
Priority to AT96927978T priority patent/ATE210148T1/de
Priority to ES96927978T priority patent/ES2171224T3/es
Priority to DK96927978T priority patent/DK0845003T3/da
Priority to IL12325896A priority patent/IL123258A/xx
Priority to SK203-98A priority patent/SK282469B6/sk
Priority to TR1998/00258T priority patent/TR199800258T1/xx
Priority to HU9901209A priority patent/HUP9901209A3/hu
Priority to BR9610248A priority patent/BR9610248A/pt
Priority to CN96197625A priority patent/CN1200127A/zh
Priority to US08/718,585 priority patent/US6337319B1/en
Priority to PL96325113A priority patent/PL325113A1/xx
Priority to RU98104253/04A priority patent/RU2165432C2/ru
Priority to TW085109918A priority patent/TW424095B/zh
Priority to IS4664A priority patent/IS4664A/is
Priority to NO980592A priority patent/NO980592L/no
Priority to US09/994,078 priority patent/US20030032774A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE9503924A 1994-02-21 1995-11-07 Novel opioid peptides SE9503924D0 (sv)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE9503924A SE9503924D0 (sv) 1995-08-18 1995-11-07 Novel opioid peptides
ARP960103900A AR003475A1 (es) 1995-08-18 1996-08-06 Nuevos peptidos opiaceos, composiciones farmaceuticas que los contienen, el uso de los mismos en la preparacion de formulaciones y un metodo para su preparacion.
PL96325113A PL325113A1 (en) 1995-08-18 1996-08-14 Novell opiodic peptides
RU98104253/04A RU2165432C2 (ru) 1995-08-18 1996-08-14 Новые опиоидоподобные пептиды, способ их получения, фармацевтическая композиция
AU67600/96A AU711862B2 (en) 1995-08-18 1996-08-14 Novel opioid peptides
IL12325896A IL123258A (en) 1995-08-18 1996-08-14 PEPTIDES SELECTIVE FOR mu-OPIOID RECEPTORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
KR1019980701156A KR19990037677A (ko) 1995-08-18 1996-08-14 신규 오피오이드 펩티드
EE9800048A EE9800048A (et) 1995-08-18 1996-08-14 Uudsed opioidpeptiidid
NZ315809A NZ315809A (en) 1995-08-18 1996-08-14 Opiate tetrapeptides with a tyr (or 2',6'-dimethyl tyr) at one terminus and an optionally substituted amino at the other terminus
CA002229797A CA2229797A1 (en) 1995-08-18 1996-08-14 Novel opioid peptides
JP9509209A JPH11512086A (ja) 1995-08-18 1996-08-14 新規なオピオイドペプチド
CZ1998401A CZ287299B6 (en) 1995-08-18 1996-08-14 Opioidal peptide, pharmaceutical preparation containing thereof and use of this peptide
PCT/SE1996/001011 WO1997007130A1 (en) 1995-08-18 1996-08-14 Novel opioid peptides
DE69617699T DE69617699T2 (de) 1995-08-18 1996-08-14 Neuartige opioid-peptide
AT96927978T ATE210148T1 (de) 1995-08-18 1996-08-14 Neuartige opioid-peptide
ES96927978T ES2171224T3 (es) 1995-08-18 1996-08-14 Nuevos peptidos opioides.
DK96927978T DK0845003T3 (da) 1995-08-18 1996-08-14 Hidtil ukendte opioid-peptider
EP96927978A EP0845003B1 (de) 1995-08-18 1996-08-14 Neuartige opioid-peptide
SK203-98A SK282469B6 (sk) 1995-08-18 1996-08-14 Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie
TR1998/00258T TR199800258T1 (xx) 1995-08-18 1996-08-14 Yeni opioid peptidler.
HU9901209A HUP9901209A3 (en) 1995-08-18 1996-08-14 Opioid-like peptide compounds, process for producing them and pharmaceutical compositions containing them
BR9610248A BR9610248A (pt) 1995-08-18 1996-08-14 Composto composição farmacêutica processos para o tratamento da dor e para a preparação de um composto e uso do composto
CN96197625A CN1200127A (zh) 1995-08-18 1996-08-14 新的阿片样肽
US08/718,585 US6337319B1 (en) 1995-08-18 1996-08-14 μ-Selective opioid peptides
TW085109918A TW424095B (en) 1995-08-18 1996-08-15 Novel opioid peptides
IS4664A IS4664A (is) 1995-08-18 1998-02-04 Ný peptíð-ópíóíð
NO980592A NO980592L (no) 1995-08-18 1998-02-11 Nye opioidpeptider
US09/994,078 US20030032774A1 (en) 1994-02-21 2001-11-26 Novel opioid peptides for the treatment of pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502877A SE9502877D0 (sv) 1995-08-18 1995-08-18 Novel opioid peptides
SE9503924A SE9503924D0 (sv) 1995-08-18 1995-11-07 Novel opioid peptides

Publications (1)

Publication Number Publication Date
SE9503924D0 true SE9503924D0 (sv) 1995-11-07

Family

ID=26662362

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9503924A SE9503924D0 (sv) 1994-02-21 1995-11-07 Novel opioid peptides

Country Status (27)

Country Link
US (1) US6337319B1 (de)
EP (1) EP0845003B1 (de)
JP (1) JPH11512086A (de)
KR (1) KR19990037677A (de)
CN (1) CN1200127A (de)
AR (1) AR003475A1 (de)
AT (1) ATE210148T1 (de)
AU (1) AU711862B2 (de)
BR (1) BR9610248A (de)
CA (1) CA2229797A1 (de)
CZ (1) CZ287299B6 (de)
DE (1) DE69617699T2 (de)
DK (1) DK0845003T3 (de)
EE (1) EE9800048A (de)
ES (1) ES2171224T3 (de)
HU (1) HUP9901209A3 (de)
IL (1) IL123258A (de)
IS (1) IS4664A (de)
NO (1) NO980592L (de)
NZ (1) NZ315809A (de)
PL (1) PL325113A1 (de)
RU (1) RU2165432C2 (de)
SE (1) SE9503924D0 (de)
SK (1) SK282469B6 (de)
TR (1) TR199800258T1 (de)
TW (1) TW424095B (de)
WO (1) WO1997007130A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030032774A1 (en) * 1994-02-21 2003-02-13 Astrazeneca Ab Novel opioid peptides for the treatment of pain
US5885958A (en) 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
SE9701718D0 (sv) * 1997-05-07 1997-05-07 Astra Ab Analgesic peptidomimetic compounds
SE9800865D0 (sv) * 1998-03-16 1998-03-16 Astra Ab New Process
AU6730500A (en) * 1999-08-25 2001-03-19 Daiichi Fine Chemical Co., Ltd. Medicinal composition for percutaneous/permucosal absorption
WO2001036006A1 (en) * 1999-11-19 2001-05-25 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
EP1303186B1 (de) 2000-07-18 2011-01-26 Cornell Research Foundation, Inc. Medizinische verwendung von agonisten des mu-opioid rezeptors
JP2002069059A (ja) * 2000-08-28 2002-03-08 Teikoku Seiyaku Co Ltd ピラジノン環を含む新規なオピオイドペプチド誘導体
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7825231B2 (en) 2005-06-01 2010-11-02 Darren P. Wolfe Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
EP1782819A1 (de) 2005-11-03 2007-05-09 Cognis IP Management GmbH Oligopeptide und deren Verwendung
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
MX2009005000A (es) 2006-11-10 2009-10-12 Cara Therapeutics Inc Amidas de peptidos sinteticos.
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
AU2009243681B2 (en) * 2008-05-09 2013-12-19 Grunenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
TWI473628B (zh) * 2009-07-22 2015-02-21 用於對氧化敏感之類鴉片藥劑之抗破壞劑型
WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
US9579285B2 (en) * 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
AU2012289764B2 (en) 2011-07-29 2017-03-02 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CN102964279B (zh) * 2012-12-12 2014-05-07 中国药科大学 一类具有外周镇痛作用的κ阿片受体激动剂
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP3073994A1 (de) 2013-11-26 2016-10-05 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350221B1 (de) * 1988-06-30 1996-04-17 Astra Aktiebolag Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge
PT644772E (pt) * 1992-11-12 2003-08-29 Conseils De Rec Appl Scient S Peptidos opioides
SE9300012D0 (sv) * 1993-01-05 1993-01-05 Astra Ab New peptides
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra

Also Published As

Publication number Publication date
DE69617699D1 (de) 2002-01-17
DK0845003T3 (da) 2002-07-15
IL123258A (en) 2003-03-12
CZ287299B6 (en) 2000-10-11
CZ40198A3 (cs) 1998-08-12
TR199800258T1 (xx) 1998-05-21
SK20398A3 (en) 1998-12-02
HUP9901209A3 (en) 2000-12-28
CN1200127A (zh) 1998-11-25
EP0845003B1 (de) 2001-12-05
EP0845003A1 (de) 1998-06-03
AU6760096A (en) 1997-03-12
SK282469B6 (sk) 2002-02-05
AR003475A1 (es) 1998-08-05
RU2165432C2 (ru) 2001-04-20
NO980592D0 (no) 1998-02-11
JPH11512086A (ja) 1999-10-19
HUP9901209A2 (hu) 1999-08-30
ATE210148T1 (de) 2001-12-15
NZ315809A (en) 1999-05-28
BR9610248A (pt) 1999-07-06
CA2229797A1 (en) 1997-02-27
EE9800048A (et) 1998-08-17
AU711862B2 (en) 1999-10-21
IS4664A (is) 1998-02-04
ES2171224T3 (es) 2002-09-01
US6337319B1 (en) 2002-01-08
NO980592L (no) 1998-02-11
PL325113A1 (en) 1998-07-06
DE69617699T2 (de) 2003-08-07
WO1997007130A1 (en) 1997-02-27
KR19990037677A (ko) 1999-05-25
TW424095B (en) 2001-03-01
IL123258A0 (en) 1998-09-24

Similar Documents

Publication Publication Date Title
SE9503924D0 (sv) Novel opioid peptides
HU9602281D0 (en) Novel opioid peptides for the treatment of pain and use thereof
AU2002225772A1 (en) Therapeutic agents and methods of use thereof for treating an amyloidogenic disease
BG106095A (bg) Нови лекарствени състави на базата на антихолинергично активни съединения и бета-миметици
CA2375908A1 (en) Highly selective norepinephrine reuptake inhibitors and methods of using the same
AU2005202257C1 (en) Azacyclic compounds for use in the treatment of serotonin related diseases
HU9602522D0 (en) Heterocyclic compounds, their preparation and use
FI935847A0 (fi) L-DOPA-esterkompositioner
DK0668863T3 (da) Quinuclidinderivat som substans P-antagonist
PT1200103E (pt) Xénon como antagonista de nmda para neuroprotecção
BR9910130A (pt) Derivados de cubana como antagonistas de receptor de glutamato metabotrópico e processo para a sua preparação
SE9502877D0 (sv) Novel opioid peptides
WO2001002340A3 (en) Novel aminoindanes
YU24603A (sh) Novi farmaceutski preparati koji sadrže epinastin i pseudoefedrin
EP1164141A3 (de) Opioid-Peptide und ihre Verwendung zur Behandlung von Schmerz
MY133957A (en) "compounds useful for the treatment or prevention of a disease mediated by the alpha-2b-adrenoceptor"
MX9705820A (es) El uso de (s)-oxibutinina y (s)-desetiloxibutinina en la preparacion de composiciones para el tratamiento de incontinencia urinaria, las composiciones obtenidas y el procedimiento para preparar desetiloxibitinina.
CA2532330A1 (en) Highly selective norepinephrine reuptake inhibitors and methods of using the same