SG10201701140WA - Recombinant clostridium botulinum neurotoxins - Google Patents

Recombinant clostridium botulinum neurotoxins

Info

Publication number: SG10201701140WA
Authority: SG; Singapore
Prior art keywords: clostridium botulinum; botulinum neurotoxins; recombinant clostridium; recombinant; neurotoxins
Prior art date: 2012-10-31

Application number

SG10201701140WA

Other languages

English (en)

Inventor

Aimee Cossins

Matthew Beard

Marks Philip

Original Assignee

Syntaxin Ltd

Ipsen Biopharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-10-31

Filing date

2013-10-31

Publication date

2017-04-27

2013-10-31 Application filed by Syntaxin Ltd, Ipsen Biopharm Ltd filed Critical Syntaxin Ltd

2017-04-27 Publication of SG10201701140WA publication Critical patent/SG10201701140WA/en

Links

108030001720 Bontoxilysin Proteins 0.000 title 1
241000193155 Clostridium botulinum Species 0.000 title 1
231100001103 botulinum neurotoxin Toxicity 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG10201701140WA 2012-10-31 2013-10-31 Recombinant clostridium botulinum neurotoxins SG10201701140WA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB201219602A GB201219602D0 (en)	2012-10-31	2012-10-31	Recombinant clostridium botulinum neurotoxins

Publications (1)

Publication Number	Publication Date
SG10201701140WA true SG10201701140WA (en)	2017-04-27

Family

ID=47358958

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG11201502372SA SG11201502372SA (en)	2012-10-31	2013-10-31	Recombinant clostridium botulinum neurotoxins
SG10201701140WA SG10201701140WA (en)	2012-10-31	2013-10-31	Recombinant clostridium botulinum neurotoxins

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SG11201502372SA SG11201502372SA (en)	2012-10-31	2013-10-31	Recombinant clostridium botulinum neurotoxins

Country Status (26)

Country	Link
US (1)	US10030238B2 (2)
EP (3)	EP3326644B1 (2)
JP (2)	JP2019068823A (2)
KR (2)	KR102264478B1 (2)
CN (2)	CN104755098A (2)
AR (2)	AR093309A1 (2)
AU (3)	AU2013340610B2 (2)
BR (1)	BR112015005384A2 (2)
CA (1)	CA2885519A1 (2)
DK (2)	DK2914282T3 (2)
EA (1)	EA201590794A8 (2)
ES (2)	ES2662402T3 (2)
GB (1)	GB201219602D0 (2)
HU (2)	HUE048802T2 (2)
IL (1)	IL237623B (2)
IN (1)	IN2015MN00436A (2)
MX (2)	MX367080B (2)
NO (1)	NO2914282T3 (2)
NZ (1)	NZ705575A (2)
PL (2)	PL2914282T3 (2)
PT (2)	PT2914282T (2)
SG (2)	SG11201502372SA (2)
TW (3)	TWI673361B (2)
UA (1)	UA118837C2 (2)
WO (1)	WO2014068317A1 (2)
ZA (1)	ZA201501449B (2)

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GB201219602D0 (en) *	2012-10-31	2012-12-12	Syntaxin Ltd	Recombinant clostridium botulinum neurotoxins
PT3274364T (pt) *	2015-03-26	2021-11-05	Harvard College	Neurotoxina botulínica manipulada
WO2017063743A1 (en)	2015-10-14	2017-04-20	Merz Pharma Gmbh & Co. Kgaa	Improvements to ultrasound-based therapy of photoaged tissue
CN108463242A (zh)	2016-03-02	2018-08-28	梅尔兹制药公司	包含肉毒杆菌毒素的组合物
EP3263710A1 (en) *	2016-07-01	2018-01-03	Ipsen Biopharm Limited	Production of activated clostridial neurotoxins
EP3504226A1 (en)	2016-08-24	2019-07-03	President and Fellows of Harvard College	Engineered botulinum neurotoxin
KR102480965B1 (ko)	2016-09-13	2022-12-26	알레간 인코포레이티드	안정화된 비단백질 클로스트리듐 독소 조성물
WO2018233813A1 (en)	2017-06-20	2018-12-27	Merz Pharma Gmbh & Co. Kgaa	NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
EP3649143B1 (en)	2017-07-06	2022-08-31	Merz Pharma GmbH & Co. KGaA	Novel recombinant botulinum neurotoxins with increased duration of effect
MY210233A (en)	2017-10-11	2025-09-04	Illustris Pharmaceuticals Inc	Methods and compositions for topical delivery
TWI822723B (zh) *	2018-01-29	2023-11-21	英商艾普森生物製藥有限公司	非神經元性 SNARE 裂解的肉毒桿菌神經毒素、裂解 hSNAP-23 之活體外方法、及經修飾 BoNT/A L 鏈蛋白酶之用途
US11707510B2 (en) *	2018-02-16	2023-07-25	Preclinics Discovery Gmbh	Nucleic acid-based botulinum neurotoxin for therapeutic use
GB201815844D0 (en)	2018-09-28	2018-11-14	Ipsen Biopharm Ltd	Therapeutic & comestic uses of botulinum neurotoxin serotype e
GB202011055D0 (en)	2020-07-17	2020-09-02	Ipsen Bioinnovation Ltd	Treatment of post-operative pain
GB202015618D0 (en)	2020-10-01	2020-11-18	Ipsen Biopharm Ltd	Method for producing beta-trypsin
CN115819526A (zh) *	2022-12-02	2023-03-21	海雅美生物技术(珠海)有限公司	一种重组肉毒杆菌神经毒素及其制备方法和应用

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NZ308772A (en) *	1995-05-17	1999-04-29	Du Pont	Recombinant baculovirus insecticides
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ATE348178T1 (de)	1999-08-25	2007-01-15	Allergan Inc	Aktivierbare rekombinante neurotoxine
US7374896B2 (en)	2001-08-28	2008-05-20	Allergan, Inc.	GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US7514088B2 (en) *	2005-03-15	2009-04-07	Allergan, Inc.	Multivalent Clostridial toxin derivatives and methods of their use
WO2006011966A1 (en) *	2004-06-30	2006-02-02	Allergan, Inc.	Optimizing expression of active botulinum toxin type e
US20110111483A1 (en)	2004-06-30	2011-05-12	Allergan, Inc.	Optimizing Expression of Active Botulinum Toxin Type E
GB2416122A (en) *	2004-07-12	2006-01-18	Ipsen Ltd	Botulinum neurotoxin composition
DE102004043009A1 (de) *	2004-09-06	2006-03-23	Toxogen Gmbh	Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
DE102005002978B4 (de)	2005-01-21	2013-04-25	Merz Pharma Gmbh & Co. Kgaa	Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
ES2509872T3 (es) *	2005-03-03	2014-10-20	Allergan, Inc.	Procedimientos para obtener una toxina clostrídica
ATE518882T1 (de) *	2005-09-19	2011-08-15	Allergan Inc	Mit clostridientoxin aktivierbare clostridientoxine
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CN105833254A (zh) *	2008-12-10	2016-08-10	阿勒根公司	梭菌毒素药物组合物
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GB201219602D0 (en) *	2012-10-31	2012-12-12	Syntaxin Ltd	Recombinant clostridium botulinum neurotoxins
GB201407525D0 (en) *	2014-04-29	2014-06-11	Syntaxin Ltd	Manufacture of recombinant clostridium botulinum neurotoxins
EP3504226A1 (en) *	2016-08-24	2019-07-03	President and Fellows of Harvard College	Engineered botulinum neurotoxin

2012
- 2012-10-31 GB GB201219602A patent/GB201219602D0/en not_active Ceased
2013
- 2013-10-31 PL PL13811605T patent/PL2914282T3/pl unknown
- 2013-10-31 US US14/427,234 patent/US10030238B2/en active Active
- 2013-10-31 DK DK13811605.8T patent/DK2914282T3/en active
- 2013-10-31 HU HUE17201198A patent/HUE048802T2/hu unknown
- 2013-10-31 AU AU2013340610A patent/AU2013340610B2/en not_active Ceased
- 2013-10-31 EP EP17201198.3A patent/EP3326644B1/en active Active
- 2013-10-31 MX MX2015005156A patent/MX367080B/es active IP Right Grant
- 2013-10-31 EA EA201590794A patent/EA201590794A8/ru unknown
- 2013-10-31 KR KR1020207026658A patent/KR102264478B1/ko active Active
- 2013-10-31 HU HUE13811605A patent/HUE036764T2/hu unknown
- 2013-10-31 IN IN436MUN2015 patent/IN2015MN00436A/en unknown
- 2013-10-31 NZ NZ705575A patent/NZ705575A/en not_active IP Right Cessation
- 2013-10-31 KR KR1020157010099A patent/KR102188539B1/ko active Active
- 2013-10-31 ES ES13811605.8T patent/ES2662402T3/es active Active
- 2013-10-31 AR ARP130103981A patent/AR093309A1/es active IP Right Grant
- 2013-10-31 EP EP20153122.5A patent/EP3673914B1/en active Active
- 2013-10-31 SG SG11201502372SA patent/SG11201502372SA/en unknown
- 2013-10-31 PT PT138116058T patent/PT2914282T/pt unknown
- 2013-10-31 CA CA2885519A patent/CA2885519A1/en not_active Abandoned
- 2013-10-31 DK DK17201198.3T patent/DK3326644T3/da active
- 2013-10-31 ES ES17201198T patent/ES2788199T3/es active Active
- 2013-10-31 UA UAA201502159A patent/UA118837C2/uk unknown
- 2013-10-31 WO PCT/GB2013/052845 patent/WO2014068317A1/en not_active Ceased
- 2013-10-31 BR BR112015005384A patent/BR112015005384A2/pt not_active Application Discontinuation
- 2013-10-31 SG SG10201701140WA patent/SG10201701140WA/en unknown
- 2013-10-31 TW TW107110108A patent/TWI673361B/zh not_active IP Right Cessation
- 2013-10-31 PT PT172011983T patent/PT3326644T/pt unknown
- 2013-10-31 CN CN201380047542.8A patent/CN104755098A/zh active Pending
- 2013-10-31 EP EP13811605.8A patent/EP2914282B1/en active Active
- 2013-10-31 TW TW108125708A patent/TW202012622A/zh unknown
- 2013-10-31 NO NO13811605A patent/NO2914282T3/no unknown
- 2013-10-31 TW TW102139558A patent/TWI626307B/zh not_active IP Right Cessation
- 2013-10-31 PL PL17201198T patent/PL3326644T3/pl unknown
- 2013-10-31 CN CN201910795176.3A patent/CN110499321A/zh active Pending
2015
- 2015-03-03 ZA ZA2015/01449A patent/ZA201501449B/en unknown
- 2015-03-08 IL IL237623A patent/IL237623B/en active IP Right Grant
- 2015-04-23 MX MX2019009222A patent/MX2019009222A/es unknown
2018
- 2018-05-21 AU AU2018203556A patent/AU2018203556B2/en not_active Ceased
- 2018-12-10 JP JP2018230980A patent/JP2019068823A/ja not_active Ceased
2019
- 2019-12-26 AR ARP190103867A patent/AR117738A2/es unknown
2020
- 2020-02-05 JP JP2020017612A patent/JP2020078321A/ja active Pending
- 2020-09-30 AU AU2020244481A patent/AU2020244481A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ705575A (en)	2019-08-30
PT2914282T (pt)	2018-03-13
US10030238B2 (en)	2018-07-24
GB201219602D0 (en)	2012-12-12
BR112015005384A2 (pt)	2017-08-08
TW202012622A (zh)	2020-04-01
JP2020078321A (ja)	2020-05-28
HK1208359A1 (en)	2016-03-04
UA118837C2 (uk)	2019-03-25
DK3326644T3 (da)	2020-05-11
EA201590794A8 (ru)	2016-01-29
JP2019068823A (ja)	2019-05-09
DK2914282T3 (en)	2018-02-26
CN110499321A (zh)	2019-11-26
AU2018203556A1 (en)	2018-06-07
PL3326644T3 (pl)	2020-08-24
ZA201501449B (en)	2016-08-31
US20150247139A1 (en)	2015-09-03
AU2013340610B2 (en)	2018-02-22
EP3673914B1 (en)	2021-10-27
TW201825680A (zh)	2018-07-16
AU2020244481A1 (en)	2020-10-29
EP2914282A1 (en)	2015-09-09
SG11201502372SA (en)	2015-05-28
KR102188539B1 (ko)	2020-12-09
WO2014068317A1 (en)	2014-05-08
CA2885519A1 (en)	2014-05-08
AR117738A2 (es)	2021-08-25
EP3326644B1 (en)	2020-03-04
AU2018203556B2 (en)	2020-08-20
TW201435084A (zh)	2014-09-16
TWI673361B (zh)	2019-10-01
AU2013340610A1 (en)	2015-03-19
KR102264478B1 (ko)	2021-06-15
NO2914282T3 (2)	2018-05-19
PT3326644T (pt)	2020-05-29
KR20200110470A (ko)	2020-09-23
PL2914282T3 (pl)	2018-07-31
CN104755098A (zh)	2015-07-01
EA201590794A1 (ru)	2015-08-31
EP2914282B1 (en)	2017-12-20
HUE048802T2 (hu)	2020-08-28
IL237623A0 (en)	2015-04-30
KR20150094590A (ko)	2015-08-19
TWI626307B (zh)	2018-06-11
MX367080B (es)	2019-08-05
ES2788199T3 (es)	2020-10-20
EP3673914A1 (en)	2020-07-01
ES2662402T3 (es)	2018-04-06
HUE036764T2 (hu)	2018-07-30
EP3326644A1 (en)	2018-05-30
MX2015005156A (es)	2015-09-23
IL237623B (en)	2019-05-30
IN2015MN00436A (2)	2015-09-04
MX2019009222A (es)	2019-11-21
AR093309A1 (es)	2015-05-27

Publication	Publication Date	Title
IL237623A0 (en)	2015-04-30	Clostridium botulinum recombinant neurotoxins
ZA201408757B (en)	2018-05-30	Engineered botulinum neurotoxin
DK3584317T3 (en)	2022-01-03	Clostridium histolyticum enzym
EP2807186A4 (en)	2016-01-27	DIFFICULT CLOSTRIDIUM VACCINES COMPRISING RECOMBINANT TOXINS
SG11201607400VA (en)	2016-11-29	Manufacture of recombinant clostridium botulinum neurotoxins
IL237132B (en)	2021-05-31	Variant of the fc region specific to fcгriib
HUE050037T2 (hu)	2020-11-30	Liofilizált botulinum toxin készítmény
FR2988733B1 (fr)	2016-02-05	Microorganisme recombinant
SG11201500980WA (en)	2015-04-29	Clostridium difficile polypeptides as vaccine
AP3655A (en)	2016-04-03	Improved injections
SG10201507721SA (en)	2015-10-29	CHO-GMT Recombinant Protein Expression
HK40023045A (en)	2020-11-27	Solid compositions comprising recombinant clostridium botulinum neurotoxins
GB201215440D0 (en)	2012-10-17	Improved handover control
GB201210286D0 (en)	2012-07-25	Recombinant polypeptide
SG11201504096RA (en)	2015-07-30	Recombinant protein