SG52739A1 - Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds - Google Patents

Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds

Info

Publication number: SG52739A1
Authority: SG; Singapore
Prior art keywords: compounds; selenopyrimidinone; thiapyrimidinone; disclosed; antiproliferative
Prior art date: 1992-12-16

Application number

SG1996008590A

Other languages

English (en)

Inventor

Michael D Varney

William H Romines

Cynthia L Palmer

Judith G Deal

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-16

Filing date

1993-12-10

Publication date

1998-09-28

1993-12-10 Application filed by Agouron Pharma filed Critical Agouron Pharma

1998-09-28 Publication of SG52739A1 publication Critical patent/SG52739A1/en

Links

150000001875 compounds Chemical class 0.000 title abstract 4
230000001028 anti-proliverative effect Effects 0.000 title abstract 2
HUTLODTYVWHFRI-UHFFFAOYSA-N 1,3,5-thiadiazin-4-one Chemical class O=C1N=CSC=N1 HUTLODTYVWHFRI-UHFFFAOYSA-N 0.000 title 1
101000606741 Homo sapiens Phosphoribosylglycinamide formyltransferase Proteins 0.000 abstract 2
NOTGFIUVDGNKRI-UUOKFMHZSA-N AICA ribonucleotide Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 NOTGFIUVDGNKRI-UUOKFMHZSA-N 0.000 abstract 1
108010072462 Hydroxymethyl and Formyl Transferases Proteins 0.000 abstract 1
102000006933 Hydroxymethyl and Formyl Transferases Human genes 0.000 abstract 1
102100039654 Phosphoribosylglycinamide formyltransferase Human genes 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SG1996008590A 1992-12-16 1993-12-10 Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds SG52739A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US99125992A	1992-12-16	1992-12-16

Publications (1)

Publication Number	Publication Date
SG52739A1 true SG52739A1 (en)	1998-09-28

Family

ID=25537030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996008590A SG52739A1 (en)	1992-12-16	1993-12-10	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds

Country Status (13)

Country	Link
US (5)	US5739141A (de)
EP (1)	EP0674516B1 (de)
JP (1)	JPH08504765A (de)
AT (1)	ATE189390T1 (de)
AU (1)	AU5846494A (de)
CA (1)	CA2151588C (de)
DE (1)	DE69327796T2 (de)
DK (1)	DK0674516T3 (de)
ES (1)	ES2145122T3 (de)
GR (1)	GR3033314T3 (de)
PT (1)	PT674516E (de)
SG (1)	SG52739A1 (de)
WO (1)	WO1994013295A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT674516E (pt)	1992-12-16	2000-05-31	Agouron Pharma	Compostos de 5-tiapirimidinona e 5-selenopirimidinona substituidos antiproliferativos
US5945427A (en) *	1995-06-07	1999-08-31	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5594139A (en) *	1993-01-29	1997-01-14	Agouron Pharmaceuticals, Inc.	Processes for preparing antiproliferative garft-inhibiting compounds
ES2201079T3 (es) *	1994-07-28	2004-03-16	Agouron Pharmaceuticals, Inc.	Compuestos utiles como agentes antiproliferativos e inhibidores de garft.
CN1053448C (zh) *	1994-07-28	2000-06-14	阿格罗尼制药公司	用作抗增殖药物及garft抑制剂的化合物
US5608082A (en) *	1994-07-28	1997-03-04	Agouron Pharmaceuticals, Inc.	Compounds useful as antiproliferative agents and GARFT inhibitors
US5831100A (en) *	1995-06-07	1998-11-03	Agouron Pharmaceuticals, Inc.	Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
AUPO227896A0 (en) *	1996-09-13	1996-10-03	Fujisawa Pharmaceutical Co., Ltd.	Novel compounds and their preparation
HUP0101587A3 (en) *	1998-03-27	2003-03-28	Genentech Inc	Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
WO2000013688A1 (en)	1998-09-04	2000-03-16	Agouron Pharmaceuticals, Inc.	Compounds useful as aicarft inhibitors
US6423720B1 (en)	2001-02-01	2002-07-23	Duquesne University Of The Holy Ghost	Pyrimidine compounds and methods for making and using the same
US20040043959A1 (en) *	2002-03-04	2004-03-04	Bloom Laura A.	Combination therapies for treating methylthioadenosine phosphorylase deficient cells
US7700307B2 (en)	2003-03-08	2010-04-20	Auvation Limited	Mitochondrial stress-70 protein markers for colorectal cancer
WO2006105167A2 (en)	2005-03-28	2006-10-05	Pericor Therapeutics, Inc.	Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
US20070082859A1 (en) *	2005-10-07	2007-04-12	Stover Richard R	Formulations of AICA riboside
WO2008086341A1 (en) *	2007-01-09	2008-07-17	Pericor Therapeutics, Inc.	Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
US8063033B2 (en)	2008-01-18	2011-11-22	Allergan, Inc.	Therapeutic beta-lactams
US7956051B2 (en)	2008-01-24	2011-06-07	Allergan, Inc.	Therapeutic amides and related compounds
US7705001B2 (en)	2008-03-18	2010-04-27	Allergan, Inc	Therapeutic substituted gamma lactams
JP2011519937A (ja)	2008-05-09	2011-07-14	アラーガンインコーポレイテッド	治療用ｎ‐アリールまたはｎ‐ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体
US7985765B2 (en)	2008-08-20	2011-07-26	Allergan, Inc.	Therapeutic substituted pyrroles
EP3269374B1 (de) *	2008-10-03	2020-08-26	ViCardia Therapeutics, Inc.	Aica riboside analoges zur behandlung von akuter dekompensierter herzinsuffizienz
US9090584B2 (en) *	2010-01-26	2015-07-28	Allergan, Inc.	Therapeutic agents for treatment of ocular hypertension
ES2718175T3 (es) *	2014-12-02	2019-06-28	Lilly Co Eli	Compuestos de 1-oxo-1,2-dihidroisoquinolin-7-il-(tiofen-2-il-5-sustituido)-sulfonamida, formulaciones que contienen esos compuestos, y su uso como inhibidores de AICARFT en el tratamiento de cánceres
DE102017221259A1 (de) *	2017-11-28	2019-05-29	Evonik Degussa Gmbh	Silanmischungen und Verfahren zu deren Herstellung
CN112321425B (zh) *	2020-10-23	2022-08-09	上海毕得医药科技股份有限公司	一种4-(3-溴丙基)苯甲酸甲酯的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3222914A1 (de) *	1982-06-18	1983-12-22	Beiersdorf Ag, 2000 Hamburg	Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8625019D0 (en) *	1986-10-18	1986-11-19	Wellcome Found	Compounds
US4871743A (en) *	1988-01-19	1989-10-03	The Trustees Of Princeton University	L-glutamic acid derivatives
JPH029869A (ja) *	1988-04-15	1990-01-12	Wellcome Found Ltd:The	新規化合物
US4921836A (en) *	1989-05-17	1990-05-01	Burroughs Wellcome Co.	Substituted glutamic acids
US4971973A (en) *	1989-05-17	1990-11-20	Burroughs Wellcome Co.	Glutamic acid derivatives
US4920125A (en) *	1989-08-29	1990-04-24	The Trustees Of Princeton University	L-glutamic acid derivatives
US5013738A (en) *	1990-04-18	1991-05-07	The Trustees Of Princeton University	L-glutamic acid derivatives
US5262385A (en) *	1990-07-24	1993-11-16	Mitsubishi Petrochemical Co., Ltd.	Halogen-containing compounds, herbicidal composition containing the same as an active ingredient, and intermediary compounds therefor
PT674516E (pt)	1992-12-16	2000-05-31	Agouron Pharma	Compostos de 5-tiapirimidinona e 5-selenopirimidinona substituidos antiproliferativos
US5945427A (en)	1995-06-07	1999-08-31	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5426110A (en) *	1993-10-06	1995-06-20	Eli Lilly And Company	Pyrimidinyl-glutamic acid derivatives

1993
- 1993-12-10 PT PT94904399T patent/PT674516E/pt unknown
- 1993-12-10 CA CA002151588A patent/CA2151588C/en not_active Expired - Fee Related
- 1993-12-10 US US08/448,556 patent/US5739141A/en not_active Expired - Fee Related
- 1993-12-10 EP EP94904399A patent/EP0674516B1/de not_active Expired - Lifetime
- 1993-12-10 ES ES94904399T patent/ES2145122T3/es not_active Expired - Lifetime
- 1993-12-10 AT AT94904399T patent/ATE189390T1/de not_active IP Right Cessation
- 1993-12-10 SG SG1996008590A patent/SG52739A1/en unknown
- 1993-12-10 DE DE69327796T patent/DE69327796T2/de not_active Expired - Fee Related
- 1993-12-10 DK DK94904399T patent/DK0674516T3/da active
- 1993-12-10 AU AU58464/94A patent/AU5846494A/en not_active Abandoned
- 1993-12-10 WO PCT/US1993/011795 patent/WO1994013295A1/en not_active Ceased
- 1993-12-10 JP JP6514288A patent/JPH08504765A/ja active Pending
1995
- 1995-05-24 US US08/449,602 patent/US5726312A/en not_active Expired - Fee Related
2000
- 2000-04-26 GR GR20000400998T patent/GR3033314T3/el not_active IP Right Cessation
- 2000-06-07 US US09/588,654 patent/US6207670B1/en not_active Expired - Fee Related
2001
- 2001-02-14 US US09/782,284 patent/US6323210B2/en not_active Expired - Fee Related
- 2001-10-23 US US10/047,935 patent/US20020173515A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0674516A4 (de)	1995-10-25
DK0674516T3 (da)	2000-07-24
US5739141A (en)	1998-04-14
PT674516E (pt)	2000-05-31
DE69327796D1 (de)	2000-03-09
EP0674516A1 (de)	1995-10-04
ES2145122T3 (es)	2000-07-01
US6323210B2 (en)	2001-11-27
US6207670B1 (en)	2001-03-27
ATE189390T1 (de)	2000-02-15
AU5846494A (en)	1994-07-04
GR3033314T3 (en)	2000-09-29
CA2151588C (en)	2002-03-19
US20020173515A1 (en)	2002-11-21
WO1994013295A1 (en)	1994-06-23
DE69327796T2 (de)	2000-06-21
US5726312A (en)	1998-03-10
CA2151588A1 (en)	1994-06-23
EP0674516B1 (de)	2000-02-02
US20010018443A1 (en)	2001-08-30
JPH08504765A (ja)	1996-05-21

Publication	Publication Date	Title
SG52739A1 (en)	1998-09-28	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
IE840302L (en)	1984-08-10	3-(5-aminopentyl)amino-1-benzazepin-2-one-1-alkanoic acids.
PL322249A1 (en)	1998-01-19	1,4,5-substituted derivatives of imidazole useful as cytokin inhibitors
PL318595A1 (en)	1997-06-23	Derivatives of phenyloacetic acid, method of and intermediate products for obtaining them and agents containing such derivatives
ZA955466B (en)	1996-12-30	Stereochemical wortmannin derivatives
HUT63419A (en)	1993-08-30	Process for producing mercaptoacetamide derivatives of pyrrolo-, pyrido- and oxazinobenzazepine having encephalinase- and angiotensin-converting enzyme-inhibiting activity
BG101833A (bg)	1998-04-30	Гуаниново производно
TW327172B (en)	1998-02-21	Novel mercaptoacetylamide bicyclic lactam derivatives
TW225534B (de)	1994-06-21
HRP990167B1 (en)	2002-08-31	Sulphinic acid derivatives, method for producing them, and their use
AU2769995A (en)	1996-01-04	Bicyclic lactam inhibitors of interleukin-1-beta converting enzyme
HU9601857D0 (en)	1996-08-28	New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
IE840301L (en)	1984-08-10	Benzazocinone and benzazoninone derivatives
IL125285A0 (en)	1999-03-12	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and pharmaceutical compositions containing the same
EP0123950A3 (de)	1986-12-30	Zwischenstoffe für Thymosin alpha 1 und Desacetylthymosin alpha 1
HU9500559D0 (en)	1995-04-28	New mercapto-acetamide tricyclic derivatives as enkephalinase-inhibitors
MX9801190A (es)	1998-04-30	Inhibidores de prolil endopeptidasa.
GR3029454T3 (en)	1999-05-28	Novel 9-n-bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
MX9500363A (es)	1998-04-30	Monohiddrato de (e)-2'-desoxi-2'- (fluorometilen) citidina.
CA2154668A1 (en)	1994-08-04	Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
ES8205126A1 (es)	1982-06-01	Un procedimiento para la preparacion de un inhibidor del enzima convertidor de la angiotensina.
FI970318A0 (fi)	1997-01-24	Antiproliferatiivisina aineina ja Garft-inhibiitoreina käyttökelpoisia yhdisteitä
HU9201134D0 (en)	1992-07-28	Process for the production of an anti-metastatic substance
IL107242A0 (en)	1994-01-25	Derivatives of benzeneborinic acid, preparation thereof and use thereof as synthetic intermediates
AP9400608A0 (en)	1995-07-12	"New nicotinic acid derivative".