SMT201700282T1 - Nuovi composti antagonisti selettivi del recetiore nk-3, composizione farmaceutica e metodi per l'uso in disturbi mediati dai recettori nk-3 - Google Patents

Nuovi composti antagonisti selettivi del recetiore nk-3, composizione farmaceutica e metodi per l'uso in disturbi mediati dai recettori nk-3

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Publication number
SMT201700282T1
SMT201700282T1 SM20170282T SMT201700282T SMT201700282T1 SM T201700282 T1 SMT201700282 T1 SM T201700282T1 SM 20170282 T SM20170282 T SM 20170282T SM T201700282 T SMT201700282 T SM T201700282T SM T201700282 T1 SMT201700282 T1 SM T201700282T1
Authority
SM
San Marino
Prior art keywords
novel
methods
pharmaceutical composition
mediated disorders
antagonist compounds
Prior art date
Application number
SM20170282T
Other languages
English (en)
Inventor
Guillaume Dutheuil
Marie-Odile Roy
Hamid Hoveyda
Graeme Lovat Fraser
Original Assignee
Ogeda Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ogeda Sa filed Critical Ogeda Sa
Publication of SMT201700282T1 publication Critical patent/SMT201700282T1/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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SM20170282T 2010-04-02 2011-04-04 Nuovi composti antagonisti selettivi del recetiore nk-3, composizione farmaceutica e metodi per l'uso in disturbi mediati dai recettori nk-3 SMT201700282T1 (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10305343 2010-04-02
US37902810P 2010-09-01 2010-09-01
PCT/EP2011/055218 WO2011121137A1 (en) 2010-04-02 2011-04-04 Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders
EP11711922.2A EP2552920B1 (en) 2010-04-02 2011-04-04 Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders

Publications (1)

Publication Number Publication Date
SMT201700282T1 true SMT201700282T1 (it) 2017-07-18

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SM20170282T SMT201700282T1 (it) 2010-04-02 2011-04-04 Nuovi composti antagonisti selettivi del recetiore nk-3, composizione farmaceutica e metodi per l'uso in disturbi mediati dai recettori nk-3

Country Status (21)

Country Link
US (4) US8871761B2 (it)
EP (2) EP2552920B1 (it)
JP (1) JP5822911B2 (it)
KR (1) KR101878888B1 (it)
CN (1) CN102906093B (it)
AU (1) AU2011234398B8 (it)
BR (1) BR112012025101B1 (it)
CA (1) CA2793313C (it)
DK (1) DK2552920T3 (it)
EA (1) EA023161B1 (it)
ES (1) ES2627688T3 (it)
HR (1) HRP20170712T1 (it)
HU (1) HUE032770T2 (it)
LT (1) LT2552920T (it)
MX (1) MX342161B (it)
PL (1) PL2552920T3 (it)
PT (1) PT2552920T (it)
RS (1) RS55997B1 (it)
SI (1) SI2552920T1 (it)
SM (1) SMT201700282T1 (it)
WO (1) WO2011121137A1 (it)

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