TH96043A - Pyrimidone compounds - Google Patents

Abstract

DC60 (26/12/48) A compound represented by formula (I), its optically active isomer, or its pharmaceutically acceptable salt (chemical formula) (I), where R1 represents a C1-C12 alkyl, R2 represents a hydrogen atom or the like, R3 represents a halogen or the like, q represents an integer from 1 to 7, R4 represents a halogen or the like, p represents 0 or an integer from 1 to 5, R5 represents a C6-C10 aryl heterocycle or the like, and X represents an oxygen, NH , or the like, used for the prevention and/or treatment of diseases caused by overactivity of tau protein kinase 1, such as dementia (e.g., Alzheimer's disease). A compound represented by formula (I), its optically active isomer, or its salt. Its pharmaceutically acceptable (chemical formula) (I) where R1 represents a C1-C12 alkyl, R2 represents a hydrogen atom or similar, R3 represents a halogen or similar, q represents an integer from 1 to 7, R4 represents a halogen or similar, p represents 0 or an integer from 1 to 5, R5 represents a C6-C10 aryl heterocycle or similar, and X represents an oxygen, NH or similar, which is used for the prevention and/or treatment of diseases caused by overactivity of tau protein kinase 1, such as dementia (e.g., Alzheimer's disease). Drug patents.

Claims (1)

1. Compounds represented by the formula (I), isomers with its optics or salts. Its pharmacologically acceptable (chemical formula) (I), where each symbol is, as defined below, R1 represents C1-C12 alkyl, which may be substituted for R2 instead of a hydrogen atom, a halogen or C1-C6 Al. Kills, which may be replaced, R3 may be identical or different, and replace the hydroxyl halogen, nitro cyanano, C1-C6 alkyl, which may be replaced by C2-C6 alkylines, which May be replaced C2-C6-Alchinyl which may Tag: Drug Patents