TN2012000473A1 - Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs - Google Patents

Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs

Info

Publication number
TN2012000473A1
TN2012000473A1 TNP2012000473A TN2012000473A TN2012000473A1 TN 2012000473 A1 TN2012000473 A1 TN 2012000473A1 TN P2012000473 A TNP2012000473 A TN P2012000473A TN 2012000473 A TN2012000473 A TN 2012000473A TN 2012000473 A1 TN2012000473 A1 TN 2012000473A1
Authority
TN
Tunisia
Prior art keywords
robo1
tumors
treatment
fusion protein
protein
Prior art date
Application number
TNP2012000473A
Other languages
English (en)
Inventor
Francis Blanche
Béatrice Cameron
Tarik Dabdoubi
Frédérique Dol-Gleizes
Pierre Fons
Jean-Pascal Herault
Catherine Prades
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2012000473(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of TN2012000473A1 publication Critical patent/TN2012000473A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne une protéine recombinante Robo1-Fc et son utilisation pour traiter les maladies dans lesquelles une protéine Slit est surexprimée, en particulier le cancer. Elle concerne également une composition comprenant une telle protéine recombinante. Un autre aspect de l'invention consiste en l'utilisation d'une molécule Robo1-Fc en tant qu'outil de diagnostic pour détecter la surexpression d'une molécule de la famille Slit chez un patient.
TNP2012000473A 2010-04-14 2012-09-28 Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs TN2012000473A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1052829A FR2958936A1 (fr) 2010-04-14 2010-04-14 Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
PCT/FR2011/050811 WO2011128561A1 (fr) 2010-04-14 2011-04-08 Protéine de fusion robo1-fc et son utilisation dans le traitement des tumeurs

Publications (1)

Publication Number Publication Date
TN2012000473A1 true TN2012000473A1 (fr) 2014-01-30

Family

ID=42830780

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2012000473A TN2012000473A1 (fr) 2010-04-14 2012-09-28 Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs

Country Status (27)

Country Link
US (1) US9493529B2 (fr)
EP (1) EP2558489A1 (fr)
JP (1) JP5858442B2 (fr)
KR (1) KR20130059329A (fr)
CN (1) CN102884076A (fr)
AR (1) AR080891A1 (fr)
AU (1) AU2011239839B2 (fr)
BR (1) BR112012026020A2 (fr)
CA (1) CA2796303A1 (fr)
CL (1) CL2012002879A1 (fr)
CR (1) CR20120508A (fr)
DO (1) DOP2012000265A (fr)
EA (1) EA201291044A1 (fr)
EC (1) ECSP12012230A (fr)
FR (1) FR2958936A1 (fr)
GT (1) GT201200275A (fr)
IL (1) IL222382A (fr)
MA (1) MA34221B1 (fr)
MX (1) MX338981B (fr)
NI (1) NI201200155A (fr)
PE (1) PE20130199A1 (fr)
PH (1) PH12012502044A1 (fr)
SG (1) SG184529A1 (fr)
TN (1) TN2012000473A1 (fr)
TW (1) TW201142024A (fr)
UY (1) UY33334A (fr)
WO (1) WO2011128561A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5562986A (en) 1993-04-05 1996-10-08 Daikin Industries, Ltd. Polytetrafluoroethylene fibers, polytetrafluoroethylene materials and process for preparation of the same
CN103703021A (zh) * 2010-12-23 2014-04-02 赛诺菲 用于治疗肝癌的Robo1-Fc融合蛋白
LT2800578T (lt) 2012-01-05 2019-02-11 Boston Medical Center Corporation Slit-robo signalo perdavimas, skirtas inkstų ligos diagnozavimui ir gydymui
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN107298715B (zh) * 2016-04-15 2021-05-04 阿思科力(苏州)生物科技有限公司 Slit2D2-嵌合抗原受体及其应用
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US11708390B2 (en) 2016-05-11 2023-07-25 Cytiva Bioprocess R&D Ab Method of storing a separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
JP6987424B2 (ja) 2016-05-11 2022-01-05 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックスを洗浄および／または消毒する方法
CN109071613A (zh) 2016-05-11 2018-12-21 通用电气医疗集团生物工艺研发股份公司 分离基质
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
BR112019024742A2 (pt) * 2017-06-02 2020-06-16 Pfizer Inc. Proteínas robo2 recombinantes, composições, métodos e usos das mesmas
WO2019038772A1 (fr) 2017-08-24 2019-02-28 Bar-Ilan University Inhibiteurs de récepteurs de la famille roundabout (robo) et utilisations correspondantes
EP3932430A4 (fr) * 2019-02-27 2023-02-01 Daewoong Pharmaceutical Co., Ltd. Composition liée à l'albumine comprenant le lrrd2 de la protéine slit3 pour la prévention ou le traitement de maladies osseuses
JP7696161B2 (ja) 2019-04-23 2025-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 乳汁産生の促進に有用な組成物および方法
WO2025056020A1 (fr) * 2023-09-14 2025-03-20 北京拓界生物医药科技有限公司 Protéine contenant un domaine robo et son utilisation médicale

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
AU729496B2 (en) * 1997-10-20 2001-02-01 Regents Of The University Of California, The Robo: a novel family of polypeptides and nucleic acids
WO1999051625A2 (fr) * 1998-04-02 1999-10-14 Rigel Pharmaceuticals, Inc. Peptides provoquant la formation de structures compactes
CA2416732C (fr) * 2000-08-02 2016-02-09 Brad St. Croix Profils d'expression de cellules endotheliales
SI1572169T1 (sl) 2002-03-08 2013-12-31 Shanghai Institutes For Biological Sciences, Cas Odkrivanje in modulacija slit in robo posredovane angiogeneze ter njuni načini uporabe
EP1652923B1 (fr) * 2003-08-08 2011-10-12 Perseus Proteomics Inc. Gene surexprime dans le cancer
JP2008504012A (ja) * 2004-01-28 2008-02-14 シントニックス・ファーマシューティカルズ・インコーポレーテッド 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Ｆｃ（ＦＳＨ−Ｆｃ）融合タンパク質
KR20140071452A (ko) * 2006-04-05 2014-06-11 애브비 바이오테크놀로지 리미티드 항체 정제
CL2007003411A1 (es) 2006-11-28 2008-07-04 Centelion Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu
TWI570135B (zh) * 2007-04-27 2017-02-11 建南德克公司 高效、穩定且非免疫抑制之抗－ｃｄ４抗體
CN111909273B (zh) 2007-08-29 2024-03-26 塞诺菲-安万特股份有限公司 人源化的抗-cxcr5抗体、其衍生物及它们的应用
EP2050764A1 (fr) * 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent

Also Published As

Publication number Publication date
FR2958936A1 (fr) 2011-10-21
AR080891A1 (es) 2012-05-16
JP5858442B2 (ja) 2016-02-10
PE20130199A1 (es) 2013-03-09
US20130039912A1 (en) 2013-02-14
PH12012502044A1 (en) 2017-07-26
NI201200155A (es) 2013-02-05
KR20130059329A (ko) 2013-06-05
BR112012026020A2 (pt) 2016-06-28
AU2011239839A1 (en) 2012-11-08
IL222382A0 (en) 2012-12-31
UY33334A (es) 2011-12-01
MA34221B1 (fr) 2013-05-02
MX2012011822A (es) 2012-11-12
WO2011128561A1 (fr) 2011-10-20
EA201291044A1 (ru) 2013-04-30
JP2013523172A (ja) 2013-06-17
GT201200275A (es) 2014-01-24
IL222382A (en) 2016-06-30
US9493529B2 (en) 2016-11-15
SG184529A1 (en) 2012-11-29
ECSP12012230A (es) 2012-11-30
MX338981B (es) 2016-05-06
CN102884076A (zh) 2013-01-16
CL2012002879A1 (es) 2013-03-22
AU2011239839B2 (en) 2015-08-20
DOP2012000265A (es) 2013-02-28
CA2796303A1 (fr) 2011-10-20
CR20120508A (es) 2012-11-01
EP2558489A1 (fr) 2013-02-20
TW201142024A (en) 2011-12-01

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