TR201815254T4 - Tl1a'ya bağlanan anti̇korlar ve bunlarin kullanimlari - Google Patents

Tl1a'ya bağlanan anti̇korlar ve bunlarin kullanimlari

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Publication number
TR201815254T4
TR201815254T4 TR2018/15254T TR201815254T TR201815254T4 TR 201815254 T4 TR201815254 T4 TR 201815254T4 TR 2018/15254 T TR2018/15254 T TR 2018/15254T TR 201815254 T TR201815254 T TR 201815254T TR 201815254 T4 TR201815254 T4 TR 201815254T4
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TR
Turkey
Prior art keywords
seq
amino acid
acid sequence
tl1a
light chain
Prior art date
Application number
TR2018/15254T
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English (en)
Inventor
Attinger Antoine
Albert Back Jonathan
Blein Stanislas
Lissilaa Rami
Skegro Darko
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Glenmark Pharmaceuticals Sa
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Publication date
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Publication of TR201815254T4 publication Critical patent/TR201815254T4/tr

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Mevcut buluş, TL1A'ya bağlanan antikorlar veya bunların fragmanları ile ilgilidir. Daha özel olarak, mevcut buluş, SEQ ID NO: 51'in amino asit dizisini içeren bir ağır zincir CDR1?i ve/veya SEQ ID NO: 52?nin amino asit dizisini içeren bir ağır zincir CDR2'yi ve/veya SEQ ID NO: 53'ün amino asit dizisini içeren bir ağır zincir CDR3?ü ve/veya SEQ ID NO: 54'ün amino asit dizisini içeren bir hafif zincir CDR1?i ve/veya SEQ ID NO: 55'in amino asit dizisini içeren bir hafif zincir CDR2?yi ve/veya SEQ ID NO: 56'nın amino asit dizisini içeren bir hafif zincir CDR3?ü içeren, TL1A'ya bağlanan bir antikor veya bunun fragmanı ile ilgilidir.
TR2018/15254T 2013-01-02 2013-12-23 Tl1a'ya bağlanan anti̇korlar ve bunlarin kullanimlari TR201815254T4 (tr)

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US201361748201P 2013-01-02 2013-01-02

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US (3) US9290576B2 (tr)
EP (1) EP2941302B1 (tr)
JP (2) JP2016503818A (tr)
KR (1) KR20150117259A (tr)
CN (1) CN105102067B (tr)
AP (1) AP2015008605A0 (tr)
AU (2) AU2013371957B2 (tr)
CA (1) CA2896894A1 (tr)
CL (1) CL2015001895A1 (tr)
DK (1) DK2941302T3 (tr)
EA (1) EA201591153A1 (tr)
ES (1) ES2689080T3 (tr)
IL (2) IL239634B (tr)
MX (1) MX360155B (tr)
MY (1) MY173334A (tr)
PE (1) PE20151289A1 (tr)
PH (1) PH12015501505B1 (tr)
SG (1) SG11201505186SA (tr)
TR (1) TR201815254T4 (tr)
UA (1) UA118961C2 (tr)
WO (1) WO2014106602A1 (tr)
ZA (1) ZA201505488B (tr)

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