TW201440799A - 色穩定的口腔護理組成物 - Google Patents
色穩定的口腔護理組成物 Download PDFInfo
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- TW201440799A TW201440799A TW102140612A TW102140612A TW201440799A TW 201440799 A TW201440799 A TW 201440799A TW 102140612 A TW102140612 A TW 102140612A TW 102140612 A TW102140612 A TW 102140612A TW 201440799 A TW201440799 A TW 201440799A
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- oral care
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- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
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Abstract
本發明係關於口腔護理組成物，其包括含有三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比由2：1至1：2之著色劑摻合物；及經取代或未經取代之苯基鏈烯香味劑。
Description
本發明係關於口腔護理組成物，其包括含有三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比由2：1至1：2之著色劑摻合物；及經取代或未經取代之苯基鏈烯香味劑。
為了讓消費者接受，很多口腔護理組成物，如漱口水(mouthwash)、漱口劑(mouth rinse)及潔牙劑業已添加香味劑(類)及著色劑(類)至該組成物之活性組份中，對該口腔護理組成物賦予想要的味道與顏色。對消費者很重要的是，每批次之顏色與味道恆定不變，且使得該顏色與味道，不管係於購買前於供應鏈之儲存條件下，或於購買後於使用及儲存條件的結果，不會被察覺到隨著時間而變化。
於某些情況中，該香味劑及著色劑組份可隨著時間而相互作用，導致很容易察覺該組成物之味道及/或顏色隨著時間改變。
因此，當特定顏色與特定味道合併時，有必要提供一種具有顏色穩定性之口腔護理組成物。
於此方面之技藝中，本發明之目的至少部分符合此種需求。本發明之進一步具體實例將由詳細說明及各實例而顯而易見。
於某些具體實例中，本發明係提供口腔護理組成物，其包括：三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比
由2：1至1：2；及經取代或未經取代之苯基鏈烯香味劑。
於其他具體實例中，本發明係提供口腔護理組成物，其包括含有三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比由2：1至1：2之著色劑摻合物以提供綠色之顏色至該口腔護理組成物，及香味劑摻合物包含經取代或未經取代之苯基鏈烯香味劑。
選擇性地，該三芳基甲烷綠色著色劑包含FD & C綠色3號著色劑。選擇性地，該萘磺酸鹽黃色著色劑包含FD & C黃色6號著色劑。
選擇性地，該三芳基甲烷綠色著色劑及該萘磺酸鹽黃色著色劑係呈由1.5：1至1：1.5，進一步選擇性由1.25：1至1：1，更進一步選擇性約1.2：1之重量比存在。
選擇性地，該三芳基甲烷綠色著色劑係呈由0.00025至0.00075重量%之量存在且該萘磺酸鹽黃色著色劑係呈由0.00025至0.00075重量%之量存在，各自係基於該組成物之總重量。進一步選擇性地，該三芳基甲烷綠色著色劑係呈由0.00035至0.00055重量%之量存在且該萘磺酸鹽黃色著色劑係呈由0.00030至0.00045重量%之量存在，各自係基於該組成物之總重量。更進一步選擇性地，該三芳基甲烷綠色著色劑係呈由0.00040至0.00050重量%之量存在且該萘磺酸鹽黃色著色劑係呈由0.00030至0.00040重量%之量存在，各自係基於該組成物之總重量。
選擇性地，該經取代或未經取代之苯基鏈烯香味劑包含不飽和之苯醚。典型地，該不飽和之苯醚包含茴香腦。
選擇性地，該經取代或未經取代之苯基鏈烯香味劑係相關於該著色劑摻合物呈由8：1至4：1，進一步選擇性約6：1之重量比存在。
選擇性地，該經取代或未經取代之苯基鏈烯香味劑係基於該組成物之總重量呈由0.003至0.007重量%，進一步選擇性由0.004至0.006重量%，更進一步選擇性由0.0045至0.0050重量%之量存在。
選擇性地，該口腔護理組成物可進一步包含pH調
整劑用來調整該組成物之pH且該組成物之pH為由4.60至5.60。典型地，該組成物之pH為約5.10。
典型地，該pH調整劑包括有機酸，例如檸檬酸。該有機酸係基於該組成物之總重量選擇性地呈由0.005至0.015重量%，進一步選擇性由0.008至0.012重量%之量存在。
選擇性地，當曝露於包括環境日光條件及溫度40℃達4週期間之加速老化試驗時，該綠色具有小於2之δ E。
選擇性地，該口腔護理組成物為漱口水(mouthwash)或漱口劑(mouthrinse)。
本發明進一步提供呈由2：1至1：2之重量比之三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑之用途，其係於基於本發明之口腔護理組成物且其包含提供綠色之顏色至該口腔護理組成物之著色劑摻合物、及包含經取代或未經取代之苯基鏈烯香味劑之香味劑摻合物中，當該口腔護理組成物曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，用於穩定該綠色且提供小於2之δ E。
應瞭解當指明本發明之具體實例時，該詳細說明及特定實例意欲僅用於闡明之目的且並非意欲用來限制本發明之範圍。
如全文中所使用者，範圍係以簡略方式使用來說明該範圍內之各個及每一個數值。於該範圍內之任何數值可選擇作為該範圍之終點。
如本文中所用之“選擇性地”、“典型地”、“較佳之”及“較佳地”詞語係指本發明之具體實例於某些情況下給予之特定利益。然而，其他具體實例亦可於相同或其他情況下為較佳者。此外，詳述一種或多種較佳之具體實例並非意指其他具體實例不可用，且並非意欲將其他具體實例從本發明之範圍中排除。
如本文中所用之“約”一詞，當應用於本發明之組成物或方法之參數值時，表示該值之計算或測量於該組成物或方法之化學或物理屬性上容許一些不具實質影響之輕微不精確性。若，由於某
種原因，所提供之“約”之不精確性並非另有於此方面技藝中所理解之一般意義，則如本文中所用之"約"表示於該值中可能之變化多至5%。
如本文中所指者，所有組成物之百分比係以該全部組成物之重量計，除非另有指明。
於某些具體實例中，本發明係提供口腔護理組成物，其包含：三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比由2：1至1：2；及經取代或未經取代之苯基鏈烯香味劑。
於某些具體實例中，本發明係提供口腔護理組成物，其包括口腔護理組成物含有三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈重量比由2：1至1：2之著色劑摻合物以提供綠色的顏色至該口腔護理組成物，及香味劑摻合物含有經取代或未經取代之苯基鏈烯香味劑。
本發明係關於口腔護理組成物，其通常係對使用者呈現綠色的外觀，但於特別具體實例中係關於漱口水及漱口劑。
如於下之進一步詳細討論者，本發明係基於本案發明者選擇特定之綠色與黃色著色劑組合物之發現，當其他著色劑或著色劑摻合物存在於包含易導致降低此等顏色褪色之特定香味劑於該口腔護理組成物中時，其可降低口腔護理組成物於延長儲存及使用時之褪色傾向。
於某些具體實例中，當曝露於包括環境日光條件及溫度40℃達4週期間之加速老化試驗時，該綠色的顏色具有小於2之δ E。如此低之δ E值其實際效果是人類的眼睛實質上察覺不到任何顏色的變化。
本發明相關地進一步提供呈由2：1至1：2之重量比三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑之用途，其係於根據本發明之口腔護理組成物且其包含提供綠色之顏色至該口腔護理組成物之著色劑摻合物、及包括經取代或未經取代之苯基鏈烯香味劑之香味劑摻合物中，當該口腔護理組成物曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，提供δ E小於2。
於某些具體實例中，該三芳基甲烷綠色著色劑包含
FD & C綠色3號著色劑及/或該萘磺酸鹽黃色著色劑包含FD & C黃色6號著色劑。典型地存有FD & C綠色3號及FD & C黃色6號著色劑二者。此等著色劑係廣泛市售可得。
FD & C綠色3號具有下式：乙基-[4-[[4-[乙基-[(3-磺苯基)甲基]胺基]苯基]-(4-羥基-2-磺苯基)亞甲烯]-1-環己-2,5-亞二烯(dienylidene)]-[(3-磺苯基)甲基]銨離子(azanium)。
該FD & C綠色3號之式為：
FD & C黃色6號具有下式：6-羥基-5-[(4-磺苯基)偶氮基]-2-萘磺酸二鈉。
該FD & C黃色6號之式為：
於某些具體實例中，該三芳基甲烷綠色著色劑及該萘磺酸鹽黃色著色劑係以由1.5：1至1：1.5，進一步選擇性由1.25：1至1：1，更進一步選擇性約1.2：1之重量比存在。藉由選擇重量比可實現所想要之綠色的顏色，特別是鮮薄荷綠。
於某些具體實例中，該三芳基甲烷綠色著色劑係以由0.00025至0.00075重量%之量存在且該萘磺酸鹽黃色著色劑係以由0.00025至0.00075重量%之量存在，各自基於該組成物之總重量，進一步選擇性地，該三芳基甲烷綠色著色劑係以由0.00035至0.00055重量%之量存在且該萘磺酸鹽黃色著色劑係以由0.00030至0.00045重量%之量存在，各自基於該組成物之總重量。更進一步選擇性地，該三芳基甲烷綠色著色劑係以由0.00040至0.00050重量%之量存在
且該萘磺酸鹽黃色著色劑係以由0.00030至0.00040重量%之量存在，各自基於該組成物之總重量。藉由選擇此等著色劑之量，可於該口腔護理組成物中實現所想要的綠色強度。
於某些具體實例中，於該組成物中該經取代或未經取代之苯基鏈烯香味劑係與其他香味劑組份合併存在，以提供香味劑摻合物傳遞想要之整體味道，例如新鮮之薄荷味，給消費者。例如，該香味劑摻合物亦可包括綠薄荷油，或任何其他薄荷香味劑，作為主要的組份。
於某些具體實例中，該經取代或未經取代之苯基鏈烯香味劑係包含不飽和之苯醚。典型地，該不飽和之苯醚係包含茴香腦，大多數典型地為反式-茴香腦。
於某些具體實例中，該經取代或未經取代之苯基鏈烯香味劑係以相關於該著色劑摻合物由8：1至4：1，進一步選擇性約6：1之重量比存在。藉由選擇苯基鏈烯香味劑及該著色劑摻合物之間的重量關係可方便地達到所想要的顏色穩定性。
該經取代或未經取代之苯基鏈烯香味劑係基於該組成物之總重量以選擇性由0.003至0.007重量%，進一步選擇性由0.004至0.006重量%，更進一步選擇性由0.0045至0.0050重量%之量存在。藉由苯基鏈烯組份，此等量提供該組成物貢獻所想要之香味態樣。
FD & C綠色3號著色劑具有625毫微米之最大吸收。該萘磺酸鹽黃色著色劑之最大吸收可為pH依賴。FD & C黃色6號著色劑，依該組成物之pH而定，具有介於480毫微米及500毫微米間之最大吸收。因此，為了“調整”該組成物之整體綠色至所期望的色調，其可存有pH調整劑以便該萘磺酸鹽黃色著色劑之最大吸收位於所需之值。
因此，於某些具體實例中，該口腔護理組成物可進一步包含pH調整劑用來調整該組成物之pH且該組成物之pH為由4.60至5.60。該組成物之pH為約5.10。
典型地，該pH調整劑包含有機酸，例如檸檬酸，然而任何其他口腔可接受之酸可以替代或另外採用。於某些具體實例
中，該有機酸係基於該組成物之總重量以由0.005至0.015重量%之量存在。於某些具體實例中，該有機酸係基於該組成物之總重量以由0.008至0.012重量%之量存在。
該口腔護理組成物可另外包含載體，特別是用於個別組成物之任何適當載體，不管該口腔護理組成物為，例如，漱口水、漱口劑或潔牙劑。
可選擇性包含於本發明組成物中之載體為稀釋劑、表面活化劑、泡沫調節劑、增稠劑、黏度調節劑、濕潤劑、甜味劑、抗齲齒劑，及抗結石或酒石控制劑。載體應予以選擇，使其彼此及與該組成物之其他組成份相容。
水為較佳之稀釋劑且於一些組成物如漱口水中，水通常伴隨著醇，例如，乙醇，或者該組成物為不含酒精者。於漱口水組成物中，水對醇之重量比一般為1：1至20：1，例如3：1至20：1或4：1至10：1。於美白液中，水對醇之重量比可於上述範圍內或較低，例如，1：10至2：1。
於又進一步之具體實例中，除了任何pH調整劑，本發明之組成物可包含至少一種緩衝劑以控制pH於想要之範圍內。任何pH調整劑或緩衝劑係選擇性地以有效維持該組成物於口腔可接受pH範圍中之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種表面活化劑。可使用任何口腔可接受之表面活化劑，其中大多數為陰離子性、非離子性或兩性的。適當之陰離子性表面活化劑無需限制包括：C8-20烷基硫酸鹽之水溶性鹽、C8-20脂肪酸之磺化甘油一酸酯、肌胺酸鹽、牛磺酸鹽等。此等及其他種類之闡明性實例包括：月桂基硫酸鈉、椰基(coconut)甘油一酸酯磺酸鈉、月桂基肌胺酸鈉、月桂基異乙二磺酸鈉、第十二烷基羧酸鈉及十二烷基苯磺酸鈉。適當之非離子性表面活化劑無需限制包括：聚羥亞烴(poloxamer)、聚氧化乙烯山梨糖醇酐酯、脂族醇乙氧酸酯、烷基苯酚乙氧酸酯、第三胺氧化物、第三膦氧化物、二烷基亞碸等。適當之兩性表面活化劑無需限制包括：具有陰離子基團如羧酸鹽、硫酸鹽、磺酸鹽、磷酸鹽或膦酸鹽
之C8-20脂族第二及第三胺衍生物。適當之實例為椰基醯胺基丙基甜菜鹼。一種或多種表面活化劑係基於該組成物之總重量選擇性地以約0.01重量%至約10重量%，例如，由約0.05重量%至約5重量%，或由約0.1重量%至約2重量%之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種泡沫調節劑，其有用於，例如，增加於攪拌該組成物後所產生之泡沫量、厚度或穩定性。可使用任何口腔可接受之泡沫調節劑，無需限制包括：聚乙二醇(PEGs)，亦稱為聚氧基乙烯。高分子量PEGs包括那些具有平均分子量200,000至7,000,000，例如500,000至5,000,000，或1,000,000至2,500,000者為適合。一種或多種PEGs係基於該組成物之總重量選擇性地以約0.1重量%至約10重量%，例如，由約0.2重量%至約5重量%，或由約0.25重量%至約2重量%之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種增稠劑，其有用於，例如，賦予想要之一致性及/或口感至該組成物。可使用任何口腔可接受之增稠劑，無需限制包括：碳聚物，亦稱為羧基乙烯基聚合物、角叉菜，亦稱為愛爾蘭青苔且更特別為ι-角叉菜(iota-carrageenan)、纖維質聚合物如羥基乙基纖維素、羧基甲基纖維素(CMC)及其鹽，例如，CMC鈉、天然樹膠如刺梧桐、黃原、阿拉伯樹膠及西黃蓍、膠態矽酸鋁鎂、膠態矽石等。增稠或膠凝劑之較佳種類係包括丙烯酸與季戊四醇之烷基醚或蔗糖之烷基醚交聯均聚物等級，或碳聚物(carbomer)。碳聚物市售可得自於B.F.古德里奇，如該卡波普(Carbopol)®系列。特別佳之卡波普包括卡波普934、940、941、956、974P，及其混合物。一種或多種增稠劑係基於該組成物之總重量選擇性地以由約0.01重量%至15重量%，例如，由約0.1重量%至約10重量%，或由約0.2重量%至約5重量%之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種黏度調節劑，其有用於，例如，抑制組成份於攪拌液態組成物後沉降或分離，或促進再分散。可使用任何口腔可接受之黏度調節劑，無需限制包括：礦物油、凡士林、黏土及有機改質黏土、矽石等。
一種或多種黏度調節劑係基於該組成物之總重量選擇性地以由約0.01重量%至約10重量%，例如，由約0.1重量%至約5重量%之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種濕潤劑。可使用任何口腔可接受之濕潤劑，無需限制包括：多元醇，如丙三醇、山梨糖醇、木糖醇或低分子量PEGs。大多數濕潤劑亦可作用如甜味劑。一種或多種濕潤劑係基於該組成物之總重量選擇性地以由約1重量%至約70重量%，例如，由約1重量%至約50重量%，由約2重量%至約25重量%，或由約5重量%至約15重量%之總量存在。
於又進一步之具體實例中，本發明之組成物包含至少一種甜味劑，其有用於，例如，增強該組成物之味道。可使用任何口腔可接受之天然或人工甜味劑，無需限制包括：右旋糖、蔗糖、麥芽糖、糊精、乾性轉化糖、甘露糖、木糖、核糖、果糖、左旋糖、半乳糖、玉米糖漿(包括高果糖玉米糖漿及玉米糖漿固體)、部分水解之澱粉、氫化澱粉水解物、山梨糖醇、甘露糖醇、木糖醇、麥芽糖醇、異麥芽酮糖醇、阿斯巴甜(aspartame)、紐甜(neotame)、糖精及其鹽，以二胜肽為底之強甜味劑、環己基磺醯胺酸鹽(cyclamate)等。一種或多種甜味劑係強烈地依所選擇之特定甜味劑(類)而定，選擇性地以總量，但典型地係基於該組成物之總重量以0.005重量%至5重量%存在。
於又進一步之具體實例中，本發明組成物之香味劑摻合物，除了苯基鏈烯香味劑，特別是茴香腦，可額外包含至少一種其他香味劑，其有用於，例如，增強該組成物之味道。可使用任何口腔可接受之天然或合成香味劑，無需限制包括：香草醛、鼠尾草、黑角蘭、歐芹油、綠薄荷油、肉桂油、鹿蹄草油(水楊酸甲酯)、薄荷油、丁子香油、月桂樹油、茴香油、桉樹油、柑橘類油、果實油及精油，其包括那些由檸檬、枊橙、萊姆、葡萄柚、杏桃、香蕉、葡萄、蘋果、草莓、櫻桃、鳳梨等所導生者，豆及堅果所導生之香味，如咖啡、可可、可樂、花生、扁桃仁等，吸附及包膠之香味劑等。亦涵括於本文
中之香味劑為於口中提供香氣及/或其他感官效果，包括清涼或溫熱效果之組成份。此等組成份闡明性地包括醇、醋酸酯、乳酸酯、樟腦、桉樹油、桉樹腦、丁子香酚、山扁豆、歐沙酮(oxanone)、α-紫羅蘭酮、丙烯基癒瘡木酚(propenyl guaiethol)、百里酚、里哪醇、苯甲醛、肉桂醛、N-乙基-對-烷-3-羧胺、N,2,3-三甲基-2-異丙基丁醯胺、3-(1-氧基)-丙烷-1,2-二醇、肉桂醛甘油縮醛(CGA)、酮甘油縮醛(MGA)等。一種或多種香味劑係基於該組成物之總重量選擇性地以由約0.01重量%至約5重量%，例如，由約0.1重量%至約2.5重量%之總量存在。
於又進一步之具體實例中，本發明組成物之著色劑摻合物可包含至少一種另外的著色劑。本文中之著色劑包括顏料、染料、沉澱色料及增添特別光澤或反射性之試劑如珠光劑。該著色劑摻合物係基於該組成物之總重量選擇性地以由約0.001重量%至約20重量%，例如，由約0.01重量%至約10重量%，或由約0.1重量%至約5重量%之總量存在。
於某些具體實例中，該組成物包含氟化物離子來源。氟化物離子來源包括，但非侷限於：氟化亞錫、氟化鈉、氟化鉀、一氟磷酸鉀、一氟磷酸鈉、一氟磷酸銨、矽酸氟鈉、矽酸氟銨、氟化胺如歐拉氟(olaflur)(N'-十八基三亞甲基二胺-N,N,N'-三(2-乙醇)-二氫氟化物)、氟化銨，及其組合物。於特定具體實例中，該氟化物離子來源包括氟化亞錫、氟化鈉、氟化胺、一氟磷酸鈉，以及其混合物。於特定具體實例中，本發明之口腔護理組成物亦可含有氟化物離子來源或提供氟之組成份，其係以足夠之量來供應約50至約5000ppm氟化物離子，例如，由約100至約1000，由約200至約500，或約250ppm氟化物離子。氟化物離子來源可以約0.001重量%至約10重量%，例如，由約0.003重量%至約5重量%，0.01重量%至約1重量%，或約0.05重量%之含量添加至本發明之組成物。然而，應理解用來提供適當氟化物離含量之氟化物鹽的重量明顯地係基於該鹽中之平衡離子的重量而變化，且精於此方面技藝之人士可容易地測定此等量。較佳之氟化物鹽可為氟化鈉。
本發明之組成物係選擇性地包含唾液刺激劑，其有用於，例如，改善口乾。可使用任何口腔可接受之唾液刺激劑，無需限制包括：食物酸如檸檬酸、乳酸、蘋果酸、琥珀酸、抗壞血酸、己二酸、反式丁烯二酸及酒石酸，及其混合物。一種或多種唾液刺激劑係選擇性地以唾液刺激有效之總量存在。
本發明之組成物係選擇性地合併一種或多種抗敏感性劑，例如，鉀鹽如硝酸鉀、碳酸氫鉀、氯化鉀、檸檬酸鉀，及草酸鉀；番椒辣素；丁子香酚；鍶鹽；鋅鹽；氯化物鹽及其組合物。此等試劑可以有效之量，例如，基於該組成物之總重量，以由約1重量%至約20重量%按重量添加，依所選擇之試劑而定。當施用於牙齒時，本發明之組成物亦可藉阻斷牙本質小管來治療敏感症。
於某些具體實例中，本發明之組成物進一步包含抗氧化劑。可使用任何口腔可接受之抗氧化劑，包括：丁基化羥基苯甲醚(BHA)、丁基化羥基甲苯(BHT)、維生素A、類胡蘿蔔素、維生素E、類黃酮、多酚、抗壞血酸、草藥抗氧化劑、葉綠素、褪黑激素，及其混合物。
於另一個具體實例中，該組成物包含口腔可接受之鋅離子來源，其有用於，例如，作為抗微生物、抗結石或口氣清新劑。可存有一種或多種此等來源。適當之鋅離子來源無需限制包括：醋酸鋅、檸檬酸鋅、葡糖酸鋅、甘胺酸鋅、氧化鋅、硫酸鋅、檸檬酸鋅鈉等。一種或多種鋅離子來源係基於該組成物之總重量選擇性且闡明性地以由約0.05重量%至約3重量%，例如，由約0.1重量%至約1重量%之總量存在。
該組成物可含有其他治療及非治療性組份，且亦可於各種方法之實行中利用，其之全部將包含於本發明之範圍內。本發明範圍內之組成物及方法可用於，例如，降低或消除哺乳類之牙齒敏感，改善/維持全身性健康，及/或封閉牙本質小管。
抗細菌劑可合併於本發明之口腔護理組成物中。使用於口腔護理中常見之抗細菌劑包括三氯生(triclosan)、氯己酊(chlorhexidine)、十六基鈚錠氯化物，及其他季胺。此等試劑，當存在
時，其係以實質上不會負面影響所想要性質及該組成物特性之有效量合併於該口腔護理組成物中。
本發明之組成物可額外選擇性地包含如下所提供之酒石控制(抗結石)劑。那些有用於本文中之酒石控制劑包括特定試劑，其包括鹼金屬鹽及銨鹽。該試劑包括：磷酸鹽及聚磷酸鹽(例如焦磷酸鹽)、聚胺基丙烷磺酸(AMPS)、聚烯烴磺酸鹽、聚烯烴磷酸鹽、二膦酸鹽如氮雜環烷-2,2-二膦酸鹽(例如，氮雜環庚烷-2,2-二膦酸)、N-甲基氮雜環戊烷-2,3-二膦酸、乙烷-1-羥基-1,1-二膦酸(EHDP)及乙烷-1-胺基-1,1-二膦酸鹽及膦酸基鏈烷羧酸。有用的無機磷酸鹽及聚磷酸鹽包括一鹼式、二鹼式及三鹼式磷酸鈉、三聚磷酸鈉、四聚磷酸鹽、焦磷酸一、二、三及四鈉、三偏磷酸鈉、六偏磷酸鈉及其混合物。其他有用的酒石控制劑包括多羧酸鹽聚合物及聚乙烯基甲基醚/順式丁烯二酸酐(PVM/MA)共聚物，如GANTREZ®。
於某些具體實例中，本發明之組成物進一步包含營養物。適當之營養物包括維生素、礦物質、胺基酸，及其混合物。維生素包括維生素C及D、硫胺素、核黃素、泛酸鈣、菸酸、葉酸、菸醯胺、吡哆醇、氰鈷胺、對-胺基苯甲酸、生物類黃酮，及其混合物。營養補充物包括胺基酸(如L-色胺酸、L-賴胺酸、蛋胺酸、蘇胺酸、左旋肉毒鹼(levocarnitine)及L-肉毒鹼)、肝營養素(lipotropics)(如膽鹼、肌醇、甜菜鹼，及亞麻油酸)，及其混合物。
基於本發明之組成物可投遞或施用於人類或其他動物個體。該組成物可適於投遞或施用至人類或動物個體之口腔。典型地，該組成物係用來治療或降低口腔細菌、治療、減少或溶解牙菌斑、美白牙齒及/或去除牙漬。
本發明係藉下列之非限制性實例而進一步闡明。
提供無酒精漱口水，其包括十六基鈚錠氯化物作為抗細菌活性組份。該漱口水之顏色為鮮薄荷綠且包含著色劑摻合物，其含有0.00040重量% FD & C綠色3號及0.00072重量% FD & C黃色5號，由酒石黃組成，各個重量%係基於該漱口水之總重量。該漱口水亦包含香味劑摻合物，其包括0.048重量%反式-茴香腦，以該漱口水之總重量計。
該漱口水之顏色坐標為L=85.90、a=-33.3及b=10.45。
當該漱口水曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，該綠色之顏色明顯褪色且容易被人的眼睛所察覺。將該褪色予以測定，且δ E為18.22。
因此，於加速老化試驗中，該顏色褪色為不可接受的高。
將如於比較實例1中之相同的無酒精漱口水使用於實例1中，除了將該著色劑摻合物之一種著色劑予以修改。
又，該漱口水之顏色為鮮薄荷綠，但於該實例中，其包括著色劑摻合物含有由0.00040重量% FD & C綠色3號及0.00072重量% FD & C黃色6號，各個重量%係基於該漱口水之總重量。該漱口水係包括相同之香味劑摻合物，其包括反式-茴香腦以基於該漱口水總重量之0.048重量%。該漱口水之pH為6.50。
該漱口水之顏色坐標為L=73.94、a=-5.28及b=10.6。於整體之色調中，由於顏色坐標a之負值較小，該綠色較不明顯。
當該漱口水曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，並未察覺到該綠色的顏色褪色。該δ E為1.13，表示顏色變化實質上於人類的眼睛係察覺不到的。
使用如於實例1中所用之相同的無酒精漱口水，除了將該著色劑摻合物關於該著色劑之量進一步改良，以及添加了包含檸檬酸之pH調整劑。
又，該漱口水之顏色為亮薄荷綠，但於該實例中其係包括含有0.00044重量% FD & C綠色3號及0.00036重量% FD & C黃色6號之著色劑摻合物，各個重量%係基於該漱口水之總重量。該漱口水亦包括香味劑摻合物，其包括反式-茴香腦，基於該漱口水總重量之0.048重量%。該檸檬酸係基於該漱口水之總重量以0.01重量%之量存在。該漱口水之pH為5.16。
漱口水之顏色坐標為L=45.41、a=-13.9及b=1.4。當被人眼所感知時，該綠色整體之色調實質上與比較實例1者相同。
當該漱口水曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，並未察覺到該綠色褪色。該δ E為1.82，表示顏色變化實質上於人類的眼睛係察覺不到的。
因此，各實例及比較實例顯示，當該組成物包括苯基鏈烯香味劑時，改變該著色劑摻合物可意外地克服於延長儲存過程中之褪色及使用該口腔護理組成物，尤其是漱口水或漱口劑之問題。
Claims (20)
- 一種口腔護理組成物，其包括：著色劑摻合物，其含有三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑呈由2：1至1：2之重量比；及經取代或未經取代之苯基鏈烯香味劑。
- 如申請專利範圍第1項之口腔護理組成物，其中，該三芳基甲烷綠色著色劑包含FD & C綠色3號著色劑且該萘磺酸鹽黃色著色劑包含FD & C黃色6號著色劑。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，該著色劑摻合物提供綠色的顏色至該口腔護理組成物。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，該三芳基甲烷綠色著色劑及該萘磺酸鹽黃色著色劑係呈由1.5：1至1：1.5之重量比存在。
- 如申請專利範圍第3項之口腔護理組成物，其中，該三芳基甲烷綠色著色劑及該萘磺酸鹽黃色著色劑係呈由1.25：1至1：1之重量比存在。
- 如申請專利範圍第1或2項之該口腔護理組成物，其中，該三芳基甲烷綠色著色劑係呈由0.00025至0.00075重量%之量存在且該萘磺酸鹽黃色著色劑係呈由0.00025至0.00075重量%之量存在，各自係基於該組成物之總重量。
- 如申請專利範圍第6項之口腔護理組成物，其中，該三芳基甲烷綠色著色劑係呈由0.00040至0.00050重量%之量存在且該萘磺酸 鹽黃色著色劑係呈由0.00030至0.00040重量%之量存在，各自係基於該組成物之總重量。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，該經取代或未經取代之苯基鏈烯香味劑係包含不飽和苯醚。
- 如申請專利範圍第7項之口腔護理組成物，其中，該不飽和苯醚係包含茴香腦。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，該經取代或未經取代之苯基鏈烯香味劑係以相對於該著色劑摻合物呈由8：1至4：1之重量比存在。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，該經取代或未經取代之苯基鏈烯香味劑係基於該組成物之總重量呈由0.003至0.007重量%之量存在。
- 如申請專利範圍第11項之口腔護理組成物，其中，該經取代或未經取代之苯基鏈烯香味劑係基於該組成物之總重量呈由0.004至0.006重量%之量存在。
- 如申請專利範圍第12項之口腔護理組成物，其中，該經取代或未經取代之苯基鏈烯香味劑係基於該組成物之總重量呈由0.0045至0.0050重量%之量存在。
- 如申請專利範圍第1或2項之口腔護理組成物，其進一步包括pH調整劑，其含有有機酸用來調整該組成物之pH且該組成物之pH為由4.60至5.60。
- 如申請專利範圍第14項之口腔護理組成物，其中，該有機酸為檸檬酸。
- 如申請專利範圍第14項之口腔護理組成物，其中，該有機酸係基於該組成物之總重量呈由0.005至0.015重量%之量存在。
- 如申請專利範圍第16項之口腔護理組成物，其中，該有機酸係基於該組成物之總重量呈由0.008至0.012重量%之量存在。
- 如申請專利範圍第1或2項之口腔護理組成物，其中，當曝露於包括環境日光條件及溫度40℃達4週期間之加速老化試驗時，該綠色的顏色具有小於2之δ E。
- 如申請專利範圍第1或2項中任一項之口腔護理組成物，其為漱口水(mouthwash)或漱口劑(mouthrinse)。
- 一種呈由2：1至1：2之重量比三芳基甲烷綠色著色劑及萘磺酸鹽黃色著色劑之用途，其係於如申請專利範圍第1至19項中任一項之口腔護理組成物且其包含提供綠色之顏色至該口腔護理組成物之著色劑摻合物、及包含經取代或未經取代之苯基鏈烯香味劑之香味劑摻合物中，當該口腔護理組成物曝露於包含環境日光條件及溫度40℃達4週期間之加速老化試驗時，用於穩定該綠色且提供小於2之δ E。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/067342 WO2014084851A1 (en) | 2012-11-30 | 2012-11-30 | Color-stable oral care compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201440799A true TW201440799A (zh) | 2014-11-01 |
| TWI559934B TWI559934B (en) | 2016-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102140612A TWI559934B (en) | 2012-11-30 | 2013-11-08 | Color-stable oral care compositions |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9427387B2 (zh) |
| EP (1) | EP2925818B1 (zh) |
| JP (1) | JP2016501216A (zh) |
| KR (1) | KR20150090126A (zh) |
| CN (1) | CN104812845B (zh) |
| AR (1) | AR093682A1 (zh) |
| AU (1) | AU2012395816B2 (zh) |
| BR (1) | BR112015012298B1 (zh) |
| CA (1) | CA2887820C (zh) |
| IL (1) | IL238010A0 (zh) |
| MX (1) | MX351253B (zh) |
| PH (1) | PH12015500889A1 (zh) |
| PL (1) | PL2925818T3 (zh) |
| RU (1) | RU2616517C2 (zh) |
| TW (1) | TWI559934B (zh) |
| WO (1) | WO2014084851A1 (zh) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1090706A (en) | 1976-06-30 | 1980-12-02 | Jordan B. Barth | Stable mouthwash containing sodium bicarbonate |
| EP0208009B1 (en) * | 1985-07-10 | 1991-06-12 | Richardson GmbH | Cleansing foam for teeth |
| US4891216A (en) * | 1987-04-14 | 1990-01-02 | Alcide Corporation | Disinfecting compositions and methods therefor |
| US4895720A (en) * | 1988-03-28 | 1990-01-23 | Pfizer Inc. | Compositions and methods for cleaning the gums |
| US5683679A (en) | 1995-12-12 | 1997-11-04 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Oral compositions containing peroxide with stable green colorant |
| US6582682B2 (en) | 2000-10-30 | 2003-06-24 | Noville, Inc. | Oral care compositions comprising stabilized chlorine dioxide |
| US20050163729A1 (en) | 2002-09-27 | 2005-07-28 | Zaidel Lynette A. | Oral compositions containing peroxide and methods for use |
| GB0303678D0 (en) | 2003-02-18 | 2003-03-19 | Quest Int | Improvements in or relating to flavour compositions |
| AU2005209271A1 (en) * | 2004-01-26 | 2005-08-11 | Colgate-Palmolive Company | Dental-bleaching compositions and methods with reduced peroxide concentration |
| US20060099550A1 (en) * | 2004-11-10 | 2006-05-11 | Ranir/Dcp Corporation | Device and method for delivering an oral care agent |
| US9682256B2 (en) * | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
| CN102652028A (zh) * | 2009-12-21 | 2012-08-29 | 高露洁-棕榄公司 | 含有光敏染料的试剂盒 |
| PH12013501155A1 (en) * | 2010-12-23 | 2019-06-14 | Colgate Palmolive Co | Aqueous oral care composition comprising xanthan gum, cellulose gum and carbomer |
| CA2826075C (en) | 2011-02-15 | 2017-02-14 | Colgate-Palmolive Company | Taste-masked oral care compositions |
-
2012
- 2012-11-30 US US14/647,306 patent/US9427387B2/en active Active
- 2012-11-30 CN CN201280077401.6A patent/CN104812845B/zh not_active Expired - Fee Related
- 2012-11-30 PL PL12799029T patent/PL2925818T3/pl unknown
- 2012-11-30 RU RU2015120571A patent/RU2616517C2/ru active
- 2012-11-30 WO PCT/US2012/067342 patent/WO2014084851A1/en not_active Ceased
- 2012-11-30 KR KR1020157016018A patent/KR20150090126A/ko not_active Withdrawn
- 2012-11-30 BR BR112015012298-1A patent/BR112015012298B1/pt not_active IP Right Cessation
- 2012-11-30 EP EP12799029.9A patent/EP2925818B1/en active Active
- 2012-11-30 MX MX2015006485A patent/MX351253B/es active IP Right Grant
- 2012-11-30 JP JP2015545017A patent/JP2016501216A/ja active Pending
- 2012-11-30 CA CA2887820A patent/CA2887820C/en active Active
- 2012-11-30 AU AU2012395816A patent/AU2012395816B2/en not_active Ceased
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2013
- 2013-11-08 TW TW102140612A patent/TWI559934B/zh not_active IP Right Cessation
- 2013-11-29 AR ARP130104428A patent/AR093682A1/es unknown
-
2015
- 2015-03-29 IL IL238010A patent/IL238010A0/en unknown
- 2015-04-21 PH PH12015500889A patent/PH12015500889A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014084851A1 (en) | 2014-06-05 |
| RU2616517C2 (ru) | 2017-04-17 |
| EP2925818B1 (en) | 2016-09-28 |
| US9427387B2 (en) | 2016-08-30 |
| MX351253B (es) | 2017-10-06 |
| PL2925818T3 (pl) | 2017-04-28 |
| JP2016501216A (ja) | 2016-01-18 |
| EP2925818A1 (en) | 2015-10-07 |
| CA2887820A1 (en) | 2014-06-05 |
| TWI559934B (en) | 2016-12-01 |
| BR112015012298B1 (pt) | 2021-03-16 |
| AR093682A1 (es) | 2015-06-17 |
| BR112015012298A2 (pt) | 2017-07-11 |
| CN104812845B (zh) | 2016-10-26 |
| AU2012395816A1 (en) | 2015-04-23 |
| PH12015500889A1 (en) | 2015-06-29 |
| MX2015006485A (es) | 2015-08-14 |
| CN104812845A (zh) | 2015-07-29 |
| RU2015120571A (ru) | 2017-01-11 |
| CA2887820C (en) | 2020-06-02 |
| IL238010A0 (en) | 2015-05-31 |
| US20150306000A1 (en) | 2015-10-29 |
| KR20150090126A (ko) | 2015-08-05 |
| AU2012395816B2 (en) | 2015-09-03 |
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