US2155504A - Disinfecting means - Google Patents

Description

Patented Apr. 25, 1939 UNITED STATES PATENT OFFICE msmmc'rmc MEANS Wilhelm Neugebauer, Wiesbaden-Biebrich, Germany, assignor, by mesne assignments, to Alba Pharmaceutical Company, Inc.,

New York,

N. Y., a corporation of New York No Drawing. Application May 2, 1936, Serial No. 77,545. In Germany May 2, 1935 Claims.

- 5 of this kind which contain one or more higher aliphatic or cyclo aliphatic, respectively, residues linked to the sulphur, can be employed with very great advantage as disinfecting means. The term aliphatic whenever used in the specification is, therefore, to be understood to include cyclo-aliphatic compounds. Sulphonium hydroxides and also the salts thereof may be employed. These compounds may, for example, be produced in the manner described in the French patent specification 773,254. One object of the invention is, therefore, a disinfecting and sterilizlng agent which comprises a higher molecular sulphonium compound.

Compounds which contain higher molecular aliphatic or cycloaliphatic residues having more than six carbon atoms, such as dodecyl-, decylor hexadecyl residues, are particularly suitable. Residues which contain more than ten and less than twenty carbon atoms are most particularly Q5 suitable. The higher molecular residues may also be of an unsaturated nature. Moreover, they may carry substituents.

As suitable compounds there may be named by way of example: dodecyl-benzyl-methyl-sulpho- 30 nium-methylsulphate, hexadecyl-ethyl-methylsulphonium ethylsulphate, 2,6 dichlorbenzyl decyl-methyl-sulphonium-methylsulphate, oleylethyl-methyl-sulphonium-bromide, [(diisobutyl) phenyl] benzyl-methyl-sulphonium-methylsul 35 phate.

Salts of the following substances may also be used: o-chlorbenzyl-dodecyl-methyl-sulphoniumhydroxide, tetradecyl-dimethyl-sulphonium-hydroxide, a-napththomethyl-dodecyl-methyl-sul- 4o phonium-hydroxide, dodecyl-ethyl-methyl-sul phonium hydroxide, didodecyl methyl-sulphomum-hydroxide, abietinyl-dimethyl-aulphoniumhydroxide.

The compounds are characterized not only by possessing particularly high disinfecting properties but also by the fact that they only possess very slight poisoning action and that they are soluble in fats. Pathogenic bacteria, such as 5 C011 and typhus bacteria, as also staphylococci are killed by highly diluted solutions of the sulphonium compounds.

e new compounds can be employed for the disinfection of the hands, for the disinfection of 10 medical appliances and of skins, for the sterilization of adhesive substances and for all purposes for which other antiseptic or disinfecting means are customarily used. The disinfecting operation is preferably carried out by treating the objects 15 to be disinfected for some time with dilute solutions of the sulphonium compounds. In this manner, for example, by means of a solution of dodecyl dimethyl sulphonium methylsulphate (1:1000) coll bacilli or typhus bacilli are killed 20 within a few minutes. For killing staphylococci or diphtheria bacilli an aqueous solution of dodecyl benzyl methyl-sulphonium-methylsulphate (1:10000) may, for example, be employed.

I claim:

1. A disinfecting and sterilizing agent comprising a higher molecular sulphonium compound.

2. A disinfecting and sterilizing agent comprising a sulphonium compound containing an aliphatic residue having more than six carbon atoms.

3. A disinfecting and sterilizing agent comprising a sulphonium compound containing an allphatic residue having more than ten and less than twenty carbon atoms.

4. A disinfecting and sterilizing agent comprising dodecyl-benzyl-methyl-sulphonium-methylsulfate.

5. A disinfecting and sterilizing agent comprising 2,6-dichlorbenzyl-decyl-methyl-sulphoniummethylsulfate.

WIH-IELM NEUGEBAUER.