WO1982002829A1 - Cardiac valvular bioprosthesis and the proceeding of achievement - Google Patents

Cardiac valvular bioprosthesis and the proceeding of achievement Download PDF

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Publication number
WO1982002829A1
WO1982002829A1 PCT/RO1981/000009 RO8100009W WO8202829A1 WO 1982002829 A1 WO1982002829 A1 WO 1982002829A1 RO 8100009 W RO8100009 W RO 8100009W WO 8202829 A1 WO8202829 A1 WO 8202829A1
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WIPO (PCT)
Prior art keywords
support
basis
aortic
biologic
prosthesis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RO1981/000009
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French (fr)
Inventor
Clinic Fundeni Spitalul
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE8282900160T priority Critical patent/DE3174117D1/en
Publication of WO1982002829A1 publication Critical patent/WO1982002829A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue

Definitions

  • She present invention relates to a cardiac valvular bioprosthe- tics,used in cardiac valvular replacements and to the proceeding of achievement.
  • Mettallic valvular prosthetic of different constructions are known.
  • bioprosthetics made from a pericardium of calf,human dura mater and broad fascia are more known.
  • the biologic material contains: an aortic valva of wild boar,bear or other animal,taked with the aortic wall and interventricular septum,immediately after the animal sacrifice.
  • the support for the valva is made from a basis and a superstructure.
  • the basis has a circular form with the diameter depending the valva diameter which must be replaced(between.1-2mm),interrupted by resistence pillars from which someones,disposed in the middle of flankeies basis and.the others,in the middle of curve between two flankeies.
  • the burelat ring can be made from knited textile material,plastic material or siliconal material.
  • the proceeding of achievement of cardiac valvular bioprosthetic consists in taking the biologic material from the wild boar,immediately after sacrifice.They take the aortic valva with the aortic wall and a side of the interventricular septum,it is washed in physio- logic serum in a view to eliminate the blood,the muscular fibres are eliminated from the septal cuspa and,from the aorta,the surplus of tissue.Swabs are introduced in cuspae for maintaining the form and they are introduced in keeping solutions and sterilization, they are stored in containers at 6-12° and after 48h,the biologic material is pulled and prepared for mounting on tho metallic suppor
  • the preparing consists in eliminating all muscular fibres from the cuspae surface and cutting the aortic wall in concordance with the form of superior edge of metallic support,dressed with a textile stratum.
  • the support 2 for the prosthesis 1 is made from a basis A and superstructure B.
  • the basis A has a circular form with a diameter depending of prosthesis diameter which must be replaced(betv/een 15-33mm)and on the circumference,it presents a tube b,1-2mm,interrupted by some resictence pills c from which someones in the middle of the flankeies d and the others in the middle of the curve between two flankeies.
  • the proceeding of achievement of cardiac valvular bioprosthetics consists in taking the aortic prosthesis l with the aortic wall j and a side from interventricular septum k of the wild boar, they wash it in physiologic serum for blood removing,the muscular fibres of septal cuspae are eliminated and, also,the tissue suprplus of the aorta.
  • the swabs are introduced in cuspae for the form maintaining and they are introduced in keeping solutions and sterilization with glutaraldehida 0,625,tamponed with phosphat at Ph 7,27,4.They are deposited in containers at 5-12° G,after 48h,the biologic material is taken and prepared for its mounting on the support 2 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Une bioprothese valvulaire cardiaque est fabriquee a partir d'un materiau biologique (valvule aortique de sanglier, ours ou autre animal) d'une structure speciale qui est applique sur un support metallique (2) ou un materiau plastique au moyen d'une couche de liaison (3) en un materiau textile tricote, la fixation sur le coeur s'effectuant a l'aide d'un anneau (4) en materiau textile, en plastique ou en caoutchouc au silicone. Le support (2) de la prothese est constitue d'une base (A) et d'une superstructure (B). La base (A) possede une forme circulaire avec un diametre dependant du diametre de la prothese qui doit etre remplacee et, sur la circonference, elle presente un tube (b) de 1-2 nm, interrompu par des billes de resistance (c), certaines placees au milieu des flancs (d), les autres au milieu de la courbe entre les deux flancs. Un procede d'obtention d'une bioprothese valvulaire cardiaque est egalement decrit.A cardiac valve bioprosthesis is made from a biological material (aortic valve of boar, bear or other animal) of a special structure which is applied to a metallic support (2) or a plastic material by means of a layer of connection (3) in a knitted textile material, the attachment to the core being effected by means of a ring (4) in textile material, plastic or silicone rubber. The support (2) of the prosthesis consists of a base (A) and a superstructure (B). The base (A) has a circular shape with a diameter depending on the diameter of the prosthesis which must be replaced and, on the circumference, it presents a tube (b) of 1-2 nm, interrupted by resistance balls (c) , some placed in the middle of the flanks (d), others in the middle of the curve between the two flanks. A method of obtaining a heart valve bioprosthesis is also described.

Description

Cardiac valvular bioprosthesis and the proceeding of achievement
1. TECHNlCAL FIELD
She present invention relates to a cardiac valvular bioprosthe- tics,used in cardiac valvular replacements and to the proceeding of achievement.
2. BACKGROUND OF PRIOR ART
Mettallic valvular prosthetic of different constructions are known.
The drawback of these prosthesis that the beares are obligatory submited to a chronical anticoagulant treatment.
The bioprosthetics made from a pericardium of calf,human dura mater and broad fascia are more known.
The drawback of these prosthesis is;their cuspa does not. present an adequate anatomical form and their resistence is reduced.
The valvular bioprosthetics from an aorta of domestic pig are also known.The drawback of these bioprosthetics is that,due to the short fibres with great fibrilar spaces for the fat storehouse, they present a more reduced resistence in time.
3. BRIEF SUMMARY OF INVENTION
The cardiac valvular bioprosthetics, in accordance with the invention,remove the above drawback,in a view to obtain a great resistence by using as biological material, an aortic valva from wild boar, bear or other animal,with a special structure of the tissues,applied on a metallic support or plastic material by agency of a relation stratum from knited textile material and the heart fixation making by agency of a burclat ring.
The biologic material contains: an aortic valva of wild boar,bear or other animal,taked with the aortic wall and interventricular septum,immediately after the animal sacrifice.
The aortic valva of wild boar is a valva with three depth cuspae which achieve some nests which much proIabe under the horizontal plan which passes through the valvular ring.To transligh the cuspae appear semitransparent,the maximum tranparence being to the center cuspae.Also,the presence of dense fascicolae of fibres is observed in length of cuspa,between ccmisures,.approximately parallel with the cuspa edge which is free,the length of these fibres and the parallel sitting(small spaces between the fibres) giving to the tissue an incresed resistence and elasticity,tissue submited to a very intensive mechanic requirement.
The support for the valva is made from a basis and a superstructure.The basis has a circular form with the diameter depending the valva diameter which must be replaced(between.1-2mm),interrupted by resistence pillars from which someones,disposed in the middle of flankeies basis and.the others,in the middle of curve between two flankeies.
The superstructure is formed from three flankeies like an isosoel triangle,disposed at 120 ,between the superior tips.
The passing from a tip to the other,is formed on a curve which fidelly follows the natural form of biologic valva which must be mounted on the support.
Each triangle flankeies is disposed with the small side on the support basis, the opposite tip to basis is rounded and,in interior has a window of the same form and a prominence for fixing the seam.
The burelat ring can be made from knited textile material,plastic material or siliconal material. The proceeding of achievement of cardiac valvular bioprosthetic consists in taking the biologic material from the wild boar,immediately after sacrifice.They take the aortic valva with the aortic wall and a side of the interventricular septum,it is washed in physio- logic serum in a view to eliminate the blood,the muscular fibres are eliminated from the septal cuspa and,from the aorta,the surplus of tissue.Swabs are introduced in cuspae for maintaining the form and they are introduced in keeping solutions and sterilization, they are stored in containers at 6-12° and after 48h,the biologic material is pulled and prepared for mounting on tho metallic suppor
The preparing consists in eliminating all muscular fibres from the cuspae surface and cutting the aortic wall in concordance with the form of superior edge of metallic support,dressed with a textile stratum.
The metallic support is separately prepared by dressing with knited textile material with a tubular form, introduced from down- wards to upwards through the metallic support and after,the superior edge of the tube(textile material) is bended over the flankeies tips and is pulled under the inferior edge of support with 8-10mm shorter than the other edge of inferior textile tube. Further on,the surplus of textile material is remove,comprised between flankeies and the edge must be cut with thread from the exterior to the interior of edges for being plugged.
The exterior cylinder is fixed in few points(six) of the basis of metallic support,the surplus is cut and bended over its edge, the burelat ring is applied and fixed in few points on the support basic(through the textile stratum and the tube of support basis) . The edge of the interior cylinder must be bended over the burelet ring and cut around with a permanent thread. Further on, the biologic material,previously prepared on the dressed support is mounted by cutting with two threads and its introduction being made through the support interior.! seam is made between the aortic valvular ring and the inferior edge of the dressed metallic support, the second seam is made between the prepare aortic wall and the superior edge of the support.After ail these, a band from the same knited textile material is applied on the superior edge of dressed support and the biologic material thus sewed so that it covers the seam between the biologic material and support for protecting the seam.
Until its using, all make procedeeing is kept in keeping solution and sterilization , accomplishing a sterile medium.
4.MEANS OF INDUSTRlAL ACHIEVEMENT
The cardiac valvular bioprosthetics, in accordance with the invention, can be achieved on an industrial or semiindustrial way providing,first at all, the source of biologic material as well as the means necessary for its make.For obtaining the prosthesis replacements in man,it is necessary to make their tests by some apparatus which determine their resistence and their hidrodynamic performances..
5.SHORT PRESENTAION OF THΕ FIGURSS
We illustrate an achievement also regarding the figures 1-4 representing:
-fig.1-sight with section through bioprosthetics -fig.2-sight with section through the flankey tip A-A -fig.3-sight with section B-3
-fig.4-sight from face of metallic support
6.DETAILED DESCRIPTION OF INVENTION
The cardiac valvular bioprosthetics,in accordance with the invention,is made from a biologic material 1(aortic valva of wild boar,bear or other animal) with a special structure which is applied on metallic support 2 or plastic material by agency of a stratum 3 for contact from knited textile material and the fixation on the heart accomplishing by agency of a burelat ring 4 from textile material,plastic material or siliccnic rubber.
The aortic valva of wild boar is a prosthesis with three deep cuspae a,formed from dense fascicolae of fibres on the cuspa length between comisures approximately parallel with the free edge of it.
The support 2 for the prosthesis 1 is made from a basis A and superstructure B. The basis A has a circular form with a diameter depending of prosthesis diameter which must be replaced(betv/een 15-33mm)and on the circumference,it presents a tube b,1-2mm,interrupted by some resictence pills c from which someones in the middle of the flankeies d and the others in the middle of the curve between two flankeies.
The superstructure B is formed by three flankeies d with an isoscel triangle form, disposed at 120° between the superior tips The passing from a tip to the other is made on a curve f which fidelly follows the natural form of the biologic prosthesis which must be mounted on the support.
Each flankey d is set with the small side g on the basis A, the tip opposite to the basis,is rounded and,in interior ,presents a window h of the same form and a prominence i for fixing the seam material.
The proceeding of achievement of cardiac valvular bioprosthetics consists in taking the aortic prosthesis l with the aortic wall j and a side from interventricular septum k of the wild boar, they wash it in physiologic serum for blood removing,the muscular fibres of septal cuspae are eliminated and, also,the tissue suprplus of the aorta.The swabs are introduced in cuspae for the form maintaining and they are introduced in keeping solutions and sterilization with glutaraldehida 0,625,tamponed with phosphat at Ph 7,27,4.They are deposited in containers at 5-12° G,after 48h,the biologic material is taken and prepared for its mounting on the support 2 .
The preparing consists in eliminating the muscular fibres of the cuspae surface a and in cutting the aortic wall j in accordance with the superior edge of the dressed support 2 with the stratum 3 from textile material.The metallic support 2 is separately prepared by dressing with knited textile material 3 of tubular form,introduced from downwards to upwards through the support 2.
The material 3 is bended over the tips e and the tube 1 pull under the inferior edge of a support 2 with 8-10mm shorter than the end m of a material 3.Further on,the material surplus comprise between the flankeies d and the edges are cut with thred from the exterior to the interior of the edges for being plugged. The cylinder 1 is fixed in few points(six) on the basis A,the surplus is cut and it is bended over the edge,the burelat ring 4 is applied and fixed in few points on the basis A.The cylinder edge m is bended over the ring 4 and they cut around with a permanent thread.
Further on,the biologic material 1 is mounted and previously prepared on the support 2 by sewing with two threads,its introduction being made through the interior of the support 2.
A seam is made between the aortic valvular ring and thevinferior edge of the support 2 and the second seam,between the prepared aorti wall j and the superior edge of the support 2.After all these,a band 5 from the same knited textile material is applied on the super or edge of the dressed support 2 and the biologic material j so cut that it covers the seam from the biologic material j and the support 2 for its protection.
All proceeding of achievemnt is made in sterile medium.
Until its utilisation,tho prosthesis must be kept in keeping solution and sterilisation.
7. ADVANTAGES
The cardiac valvular prosthesis and the proceeding of its achievement present the following advantages;
-a greater resistsnee in time
-no requires a permanent anticoagulant treatment
-the employment of this prosthesis is indicated specially for certain categories of patients as: young women,ulcer,with disorders of sanguine chrasa, special social circumstances (braάipsychics, difficult access to medical assistence) ,hypertensive patients(to whom the prosthesis of pig are unadvisable).

Claims

1.Cardiac valvular bioprosthetics,characterised by the employment as biologic material of an aortic valva(l) of wild boar,bear or other animal(for obtaining a greater resistence in time) with dense faccicola-i of fibres on the cuspa length(a) 'between comisures, appro- ximately parallel with the free edge of this,the length of these fibres and the parallel dispersion giving to the tissue,an incresed resistence and elasticity which can resist to mechanic demands of a great intensity,the prosthesis being applied on a metallic support(2) or plastic material by agency of a conection stratum(3) from knited textile, material and the fixation on the heart being made by agency of a burelat ring(4) from textile material,plastic or siliconic rubber
2.Bioprosthetic,in accordance with the claim l,is characterized by; a metallic support(2) formed from a basis (A) and a suprestructure (B) from which the basis(A) has a circular form with a diameter according to the prosthesis diameter which must be replaced and,on the circumference,it presents a tube(b) of 1-2mm,interrupted by some resistence pills(e),the superstructure(B) of a support(2) being formed from three flankeies(d) in an isoscel triangle form,disposed at 120º between the superior tips(e),the coupling between the tips bein on a curve(f) similar to natural biologic valva, each triangle flankey being set with the small side(g) on the support basis,the tip(e) , opposite to basis,is rounded and,in interior presenting a window(4) with a same form and prominence(i) for fixing the material of seaming
3.The achievement proceeding of cardiac valvular bioprosthetics, according with claims 1,2 is characterized by:for its make,the aortic valva(l) is taken, also an aortic wall(j) and a side of interventriculy septum, immediately after the animal sacrifice,it is washed with physic logic serum for blood removing,the muscular fibres being eliminated from the septal cuspa and the tissue surplus from the aorta, swabs are introduced in cuspae,after,theyare introduced in a keeping solu- tion and sterilization,they are deposed in containers at 6-12ºC and after 48 h,the biologic material must be pulled and the aortic wall(j) peeled,the metallic support(2) is separately dressed with a tubular knited textile material(3) which bends over the flankeies tips(d) ,they cut and sew,the exterior cylin- der must fixed,the burelat ring(4) is applied,over which the interior cyIinder(m) bends and it is sewed on the support thus achieved,they applied with two seams the prepared biologic material(l) after which,on the superior edge of support,dressed with a fixed biologic material (j),a band(5) from knited textile material,is applied for the seam protection.
PCT/RO1981/000009 1981-02-04 1981-12-02 Cardiac valvular bioprosthesis and the proceeding of achievement Ceased WO1982002829A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8282900160T DE3174117D1 (en) 1981-02-04 1981-12-02 Cardiac valvular bioprosthesis and the method of manufacture thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RO81103294A RO78309A2 (en) 1981-02-04 1981-02-04 CARDIAC VALVULAR BIOPROTHESIS AND METHOD OF MAKING THE SAME
RO103294810204 1981-02-04

Publications (1)

Publication Number Publication Date
WO1982002829A1 true WO1982002829A1 (en) 1982-09-02

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PCT/RO1981/000009 Ceased WO1982002829A1 (en) 1981-02-04 1981-12-02 Cardiac valvular bioprosthesis and the proceeding of achievement

Country Status (4)

Country Link
EP (1) EP0071610B1 (en)
IT (1) IT1140088B (en)
RO (1) RO78309A2 (en)
WO (1) WO1982002829A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0143246A3 (en) * 1983-09-23 1986-02-05 Christian Weinhold Heart valve prosthesis
WO1990011738A1 (en) * 1989-04-05 1990-10-18 Alexander Bernhard Heart valve prosthesis for replacement of the aortic valve
US5755783A (en) * 1996-07-29 1998-05-26 Stobie; Robert Suture rings for rotatable artificial heart valves
US5880242A (en) * 1996-03-04 1999-03-09 Baxter International Inc. Nonpolymeric epoxy compounds for cross linking biological tissue and bioprosthetic grafts prepared thereby
EP1023879A3 (en) * 1999-01-29 2001-06-27 Medtronic, Inc. Implantable medical device with enhanced biocompatibility and biostability
GB2388524A (en) * 2002-04-23 2003-11-19 Sunhing Millennium Ltd A digital media rack and dividers
DE10327904B3 (en) * 2003-06-20 2004-07-29 Universitätsklinikum Schleswig-Holstein Production of a heart valve prosthesis comprises pulsing a nutrient solution through a section of vein containing a valve in a bioreactor
WO2005007017A3 (en) * 2003-07-16 2005-02-24 David Peter Shaw Prosthetic valves for medical application
EP1554990A3 (en) * 1999-01-29 2008-08-06 Medtronic, Inc. Implantable medical device with enhanced biocompatibility and biostability
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928281A (en) * 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves

Citations (6)

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Publication number Priority date Publication date Assignee Title
FR2038843A5 (en) * 1969-03-31 1971-01-08 Dassault Electronique Aortic valve support
US3570014A (en) * 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve
GB1253442A (en) * 1968-05-03 1971-11-10 Cutter Lab Surgical graft support ring
FR2355492A1 (en) * 1976-01-01 1978-01-20 Liotta Domingo LOW HEIGHT BIOLOGICAL PROSTHESIS CARRIED OUT FROM A PORK AORTIC VALVE
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
FR2451189A1 (en) * 1979-03-16 1980-10-10 Liotta Domingo SUPPORT FOR CARDIAC VALVES OF ORGANIC TISSUES

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GB1264471A (en) * 1968-01-12 1972-02-23
GB1264472A (en) * 1969-09-25 1972-02-23
US3755823A (en) * 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US3983581A (en) * 1975-01-20 1976-10-05 William W. Angell Heart valve stent
US4035849A (en) * 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
US4172295A (en) * 1978-01-27 1979-10-30 Shiley Scientific, Inc. Tri-cuspid three-tissue prosthetic heart valve

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253442A (en) * 1968-05-03 1971-11-10 Cutter Lab Surgical graft support ring
US3570014A (en) * 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve
FR2038843A5 (en) * 1969-03-31 1971-01-08 Dassault Electronique Aortic valve support
FR2355492A1 (en) * 1976-01-01 1978-01-20 Liotta Domingo LOW HEIGHT BIOLOGICAL PROSTHESIS CARRIED OUT FROM A PORK AORTIC VALVE
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
FR2451189A1 (en) * 1979-03-16 1980-10-10 Liotta Domingo SUPPORT FOR CARDIAC VALVES OF ORGANIC TISSUES

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0143246A3 (en) * 1983-09-23 1986-02-05 Christian Weinhold Heart valve prosthesis
WO1990011738A1 (en) * 1989-04-05 1990-10-18 Alexander Bernhard Heart valve prosthesis for replacement of the aortic valve
US5880242A (en) * 1996-03-04 1999-03-09 Baxter International Inc. Nonpolymeric epoxy compounds for cross linking biological tissue and bioprosthetic grafts prepared thereby
US5755783A (en) * 1996-07-29 1998-05-26 Stobie; Robert Suture rings for rotatable artificial heart valves
US6143025A (en) * 1996-07-29 2000-11-07 Edwards Lifesciences Corporation Suture rings for rotatable artificial heart valves
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
EP1554990A3 (en) * 1999-01-29 2008-08-06 Medtronic, Inc. Implantable medical device with enhanced biocompatibility and biostability
EP1023879A3 (en) * 1999-01-29 2001-06-27 Medtronic, Inc. Implantable medical device with enhanced biocompatibility and biostability
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring
US9439762B2 (en) 2000-06-01 2016-09-13 Edwards Lifesciences Corporation Methods of implant of a heart valve with a convertible sewing ring
US10238486B2 (en) 2000-06-01 2019-03-26 Edwards Lifesciences Corporation Heart valve with integrated stent and sewing ring
GB2388524B (en) * 2002-04-23 2005-01-26 Sunhing Millennium Ltd Divider for cd rack
GB2388524A (en) * 2002-04-23 2003-11-19 Sunhing Millennium Ltd A digital media rack and dividers
DE10327904B3 (en) * 2003-06-20 2004-07-29 Universitätsklinikum Schleswig-Holstein Production of a heart valve prosthesis comprises pulsing a nutrient solution through a section of vein containing a valve in a bioreactor
WO2005007017A3 (en) * 2003-07-16 2005-02-24 David Peter Shaw Prosthetic valves for medical application
US9017396B2 (en) 2003-07-16 2015-04-28 David Peter Shaw Prosthetic valves for medical application

Also Published As

Publication number Publication date
EP0071610A1 (en) 1983-02-16
RO78309B1 (en) 1983-01-30
IT8125358A0 (en) 1981-11-30
IT1140088B (en) 1986-09-24
RO78309A2 (en) 1983-02-01
EP0071610B1 (en) 1986-03-12

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