WO1987007273A3 - Monobactams ayant un substituant en c-4 et ayant un groupe sulfonylaminocarbonyle substitue en n-1 - Google Patents

Monobactams ayant un substituant en c-4 et ayant un groupe sulfonylaminocarbonyle substitue en n-1 Download PDF

Info

Publication number
WO1987007273A3
WO1987007273A3 PCT/US1987/001047 US8701047W WO8707273A3 WO 1987007273 A3 WO1987007273 A3 WO 1987007273A3 US 8701047 W US8701047 W US 8701047W WO 8707273 A3 WO8707273 A3 WO 8707273A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
compounds
sulfonylaminocarbonyl
monobactams
imidazolidone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1987/001047
Other languages
English (en)
Other versions
WO1987007273A2 (fr
Inventor
Kyoung S Kim
Barney J Magerlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to KR1019880700073A priority Critical patent/KR880701238A/ko
Publication of WO1987007273A2 publication Critical patent/WO1987007273A2/fr
Publication of WO1987007273A3 publication Critical patent/WO1987007273A3/fr
Priority to DK030988A priority patent/DK30988A/da
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Les nouveaux composés 2-azetidinone de la formule (I) sont utiles comme agents antibactériens pour faire disparaître ou réguler d'éventuels microbes. Ces composés ont un groupe (5-hydroxy-4-pyridone-2-yl)carbonylamino-1-(2-imidazolidone-3-yl)sulfonylaminocarbonyl en position N-1, ainsi qu'un substituant de type carbonate ou un dérivé d'amino-acide en position C-4 via une liaison ester. Des intermédiaires et des procédés de production de ces composés sont également décrits.
PCT/US1987/001047 1986-05-23 1987-05-08 Monobactams ayant un substituant en c-4 et ayant un groupe sulfonylaminocarbonyle substitue en n-1 Ceased WO1987007273A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019880700073A KR880701238A (ko) 1986-05-23 1987-05-08 N-1 치환 설포닐아미노카르보닐,c-4 치환 모노박탐
DK030988A DK30988A (da) 1986-05-23 1988-01-22 2-azetidinon-forbindelser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86679286A 1986-05-23 1986-05-23
US866,792 1986-05-23

Publications (2)

Publication Number Publication Date
WO1987007273A2 WO1987007273A2 (fr) 1987-12-03
WO1987007273A3 true WO1987007273A3 (fr) 1987-12-17

Family

ID=25348424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/001047 Ceased WO1987007273A2 (fr) 1986-05-23 1987-05-08 Monobactams ayant un substituant en c-4 et ayant un groupe sulfonylaminocarbonyle substitue en n-1

Country Status (6)

Country Link
EP (2) EP0246786A1 (fr)
JP (1) JPH01502660A (fr)
KR (1) KR880701238A (fr)
AU (1) AU7541487A (fr)
DK (1) DK30988A (fr)
WO (1) WO1987007273A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
JPH02502378A (ja) * 1987-02-11 1990-08-02 ジ・アップジョン・カンパニー 抗生物質としての新規なＮ‐１置換β‐ラクタム
JPH02502455A (ja) * 1987-02-27 1990-08-09 ジ・アップジョン・カンパニー ピリドンカルボン酸または酸誘導体を含有する抗生物質β‐ラクタム
CA1317298C (fr) * 1987-03-03 1993-05-04 Upjohn Company (The) .beta.-lactames antibiotiques activees par des groupes sulfonylaminocar bonyles
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US4889930A (en) * 1987-12-21 1989-12-26 E. R. Squibb & Sons, Inc. Process for making 2-oxo-1-((substituted sulfonyl)amino)carbonzyl)azetidines and intermediates used therein
EP0336369A1 (fr) * 1988-04-04 1989-10-11 E.R. Squibb & Sons, Inc. 3-Acylamino-1-[[[(substituées sulfonyl)amino]carbonyl]amino]2-azétidinones
AU2011336209B2 (en) * 2010-11-29 2015-03-19 Pfizer Inc. Monobactams

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0062876A1 (fr) * 1981-04-09 1982-10-20 E.R. Squibb & Sons, Inc. 2-Oxo-1 (((sulfonyl substitué)amino)-carbonyl) azétidines
EP0085291A1 (fr) * 1982-01-04 1983-08-10 E.R. Squibb & Sons, Inc. 2-Oxo-1-(aminocarbonylaminosulfonylaminocarbonyl)-azétidines
GB2181130A (en) * 1985-09-26 1987-04-15 Squibb & Sons Inc 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0062876A1 (fr) * 1981-04-09 1982-10-20 E.R. Squibb & Sons, Inc. 2-Oxo-1 (((sulfonyl substitué)amino)-carbonyl) azétidines
EP0085291A1 (fr) * 1982-01-04 1983-08-10 E.R. Squibb & Sons, Inc. 2-Oxo-1-(aminocarbonylaminosulfonylaminocarbonyl)-azétidines
GB2181130A (en) * 1985-09-26 1987-04-15 Squibb & Sons Inc 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

Also Published As

Publication number Publication date
DK30988D0 (da) 1988-01-22
WO1987007273A2 (fr) 1987-12-03
EP0308416A1 (fr) 1989-03-29
EP0246786A1 (fr) 1987-11-25
KR880701238A (ko) 1988-07-26
DK30988A (da) 1988-01-22
JPH01502660A (ja) 1989-09-14
AU7541487A (en) 1987-12-22

Similar Documents

Publication Publication Date Title
WO1998028268A3 (fr) CYCLOALKYLE, LACTAME ET COMPOSES ASSOCIES, COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES, ET PROCEDES D'INHIBITION DE LA LIBERATION DU PEPTIDE β-AMYLOIDE ET/OU DE SA SYNTHESE AU MOYEN DE TELS COMPOSES
AU1973997A (en) Pentafluorobenzenesulfonamides and analogs
EP1004578A3 (fr) Dérivés d'hydroxamide de l'acide 5-oxo-pyrrolidine-2-carboxylique
MY102741A (en) Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms
EP0807633A3 (fr) (5,6)-Pyrimidin-4-ones condensées à hétéroaryle, substituées en 2,3
CA2325045A1 (fr) Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe
IL111843A (en) Crystalline 3,4,4-trisubstituted piperidinyl-N-(3-phenylprop-2-YL) carboxylic acid derivatives pharmaceutical compositions containing them and processes for their preparation
WO2001017973A3 (fr) Nouveaux herbicides
WO1999002497A3 (fr) Derives de pyridine
CA2245124A1 (fr) 2-methoxybenzophenones fongicides
IE870134L (en) 1, 4-dihydropyridines
CA2348735A1 (fr) Inhibiteurs heterocycliques de canaux potassiques
AU9744298A (en) Substituted tetrahydronaphthaline and analogous compounds
NO20001169L (no) 6,9-bro erythromycinderivater
WO1987007273A3 (fr) Monobactams ayant un substituant en c-4 et ayant un groupe sulfonylaminocarbonyle substitue en n-1
AU1887292A (en) Pyridonecarboxylic acid derivative
EP0825197A3 (fr) Nouveaux dérivés 6-hydroxy et 6-oxo-androstanes cardioactifs et compositions pharmaceutiques les renfermant
CA2266759A1 (fr) Derives 3-mercaptoacetylamino-1,5-substitue-2-oxo-azepane, utilises comme inhibiteurs de metalloproteinase matrice
AU662409B2 (en) A method for preparing low free formaldehyde methylolhydantoins and compositions thereof
IE872745L (en) Herbicidal compositions
CA2164918A1 (fr) Thiols
WO2000033788A3 (fr) Composes heterocycliques azotes substitues et leur utilisation therapeutique
WO1999048851A3 (fr) Procedes de preparation d'intermediaires
AU7381991A (en) Hydroxymethyl-indolizidines and quinolizidines
CA2302669A1 (fr) Derive de piperidinylmethyloxazolidinone

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1987903769

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1987903769

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1987903769

Country of ref document: EP