WO1989011154A1 - Encapsulated superparamagnetic particles - Google Patents

Encapsulated superparamagnetic particles Download PDF

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Publication number
WO1989011154A1
WO1989011154A1 PCT/US1989/001901 US8901901W WO8911154A1 WO 1989011154 A1 WO1989011154 A1 WO 1989011154A1 US 8901901 W US8901901 W US 8901901W WO 8911154 A1 WO8911154 A1 WO 8911154A1
Authority
WO
WIPO (PCT)
Prior art keywords
magnetite particles
coacervate
particle size
superparamagnetic particles
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1989/001901
Other languages
French (fr)
Inventor
Joseph Samuel Yudelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Kodak Co
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Publication of WO1989011154A1 publication Critical patent/WO1989011154A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
    • H01F1/445—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids the magnetic component being a compound, e.g. Fe3O4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/84—Polymer coating, e.g. gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Power Engineering (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Soft Magnetic Materials (AREA)
  • Hard Magnetic Materials (AREA)

Abstract

Stable, encapsulated superparamagnetic magnetite particles having a narrow particle size distribution with average particle diameters in the range of from 50 to 350 are prepared by forming an aqueous dispersion of magnetite particles having the above particle size characteristics in the presence of a surfactant, coacervating a mixture of gelatin and a carboxyl containing hydrophilic polymer such as gum arabic to form a thin coating of coacervate on the magnetite particles and crosslinking the coacervate coating with a gelatin hardener such as glutaraldehyde.
PCT/US1989/001901 1988-05-10 1989-05-05 Encapsulated superparamagnetic particles Ceased WO1989011154A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US192,753 1988-05-10
US07/192,753 US4965007A (en) 1988-05-10 1988-05-10 Encapsulated superparamagnetic particles

Publications (1)

Publication Number Publication Date
WO1989011154A1 true WO1989011154A1 (en) 1989-11-16

Family

ID=22710920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/001901 Ceased WO1989011154A1 (en) 1988-05-10 1989-05-05 Encapsulated superparamagnetic particles

Country Status (4)

Country Link
US (1) US4965007A (en)
EP (1) EP0414805A1 (en)
JP (1) JPH03504303A (en)
WO (1) WO1989011154A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428412A3 (en) * 1989-11-16 1992-02-26 Ortho Diagnostic Systems Inc. Method of producing a metal sol reagent containing colloidal metal particles of a preselected size
DE4117782A1 (en) * 1991-05-28 1992-12-03 Diagnostikforschung Inst NANOCRYSTALLINE MAGNETIC IRON OXIDE PARTICLES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICAL DIAGNOSTICS AND THERAPY
WO1997035200A1 (en) * 1996-03-18 1997-09-25 Silica Gel Gmbh Super-paramagnetic particles with increased r1 relaxivity, processes for producing said particles and use thereof
US6123920A (en) * 1996-01-10 2000-09-26 Nycomed Imaging As Superparamagnetic contrast media coated with starch and polyalkylene oxides
WO1995003128A3 (en) * 1993-07-23 2001-05-03 Ikosta Gmbh Inst Fur Korrosion Process and device for separating non-magnetic materials and objects by using ferrohydrodynamic fluid
US6713173B2 (en) 1996-11-16 2004-03-30 Nanomagnetics Limited Magnetizable device
US6815063B1 (en) 1996-11-16 2004-11-09 Nanomagnetics, Ltd. Magnetic fluid
US6896957B1 (en) 1996-11-16 2005-05-24 Nanomagnetics, Ltd. Magnetizable device
US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
DE102007059939A1 (en) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Noncovalently crosslinked spherical polymer particles for separating biological substances and cells can be dissolved by heating or adding a metal-complexing agent

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US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
US5358702A (en) * 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5240640A (en) * 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5062991A (en) * 1990-06-04 1991-11-05 Coulter Corporation In situ use of gelatin in the preparation of uniform ferrite particles
JPH0466125A (en) * 1990-07-04 1992-03-02 Nippon Zeon Co Ltd Water-absorbing agent, method for producing water-absorbing agent, and method for reducing moisture in powder or granular material using water-absorbing agent
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US5169754A (en) * 1990-10-31 1992-12-08 Coulter Corporation Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same
US5466609A (en) * 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
JP2901787B2 (en) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 Nuclear magnetic resonance contrast agent
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5532006A (en) * 1993-04-23 1996-07-02 The Board Of Trustees Of The University Of Illinois Magnetic gels which change volume in response to voltage changes for MRI
DE69428445T2 (en) * 1993-07-08 2002-05-29 Fujirebio Inc., Tokio/Tokyo MAGNETIC GELATINE-COVERED PARTICLES AND IMMUNOASSAY USING THEM
WO1995003789A1 (en) * 1993-07-28 1995-02-09 The Johns Hopkins University School Of Medicine Controlled release of pharmaceutically active substances from coacervate microcapsules
EP0692137B1 (en) * 1994-01-27 2002-04-10 Loctite (Ireland) Limited Compositions and methods for providing anisotropic conductive pathways and bonds between two sets of conductors
US5531913A (en) * 1995-03-10 1996-07-02 Eastman Kodak Company Haze-free transparent film-forming aqueous coating compositions for magnetic recording layers
US7709115B2 (en) * 1994-08-25 2010-05-04 University Of Iowa Research Foundation Methods for forming magnetically modified electrodes and articles produced thereby
US6322676B1 (en) 1998-03-25 2001-11-27 University Of Iowa Research Foundation Magnetic composites exhibiting distinct flux properties due to gradient interfaces
US6001248A (en) 1994-08-25 1999-12-14 The University Of Iowa Research Foundation Gradient interface magnetic composites and systems therefor
US5871625A (en) 1994-08-25 1999-02-16 University Of Iowa Research Foundation Magnetic composites for improved electrolysis
US6355166B1 (en) 1994-08-25 2002-03-12 The University Of Iowa Research Foundation Magnetically enhanced composite materials and methods for making and using the same
US6949179B2 (en) * 1994-08-25 2005-09-27 University Of Iowa Research Foundation Methods for forming magnetically modified electrodes and articles produced thereby
US20050213187A1 (en) * 1994-08-25 2005-09-29 University Of Iowa Research Foundation Methods for forming magnetically modified electrodes and articles produced thereby
US5817221A (en) * 1994-08-25 1998-10-06 University Of Iowa Research Foundation Composites formed using magnetizable material, a catalyst and an electron conductor
US5741714A (en) * 1995-07-18 1998-04-21 Immunivest Corporation Detection of bound analyte by magnetic partitioning and masking
US5851644A (en) * 1995-08-01 1998-12-22 Loctite (Ireland) Limited Films and coatings having anisotropic conductive pathways therein
US5660990A (en) * 1995-08-18 1997-08-26 Immunivest Corporation Surface immobilization of magnetically collected materials
KR970061942A (en) * 1996-02-09 1997-09-12 무또 미노루 Composite particle aqueous suspension and preparation method thereof
US5916641A (en) * 1996-08-01 1999-06-29 Loctite (Ireland) Limited Method of forming a monolayer of particles
EP0855049B1 (en) 1996-08-01 2005-11-09 Loctite (Ireland) Limited A method of forming a monolayer of particles, and products formed thereby
US6977025B2 (en) * 1996-08-01 2005-12-20 Loctite (R&D) Limited Method of forming a monolayer of particles having at least two different sizes, and products formed thereby
US6402876B1 (en) 1997-08-01 2002-06-11 Loctite (R&D) Ireland Method of forming a monolayer of particles, and products formed thereby
WO1999019000A1 (en) * 1997-10-11 1999-04-22 The Research Foundation Of State University Of New York Controlled size polymeric microspheres with superparamagnetic cores
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US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
US20040009614A1 (en) * 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
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US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7276254B2 (en) * 2002-05-07 2007-10-02 Xerox Corporation Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same
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EP0184710A2 (en) * 1984-12-08 1986-06-18 Bayer Ag Magnetic microspheres

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428412A3 (en) * 1989-11-16 1992-02-26 Ortho Diagnostic Systems Inc. Method of producing a metal sol reagent containing colloidal metal particles of a preselected size
GR900100804A (en) * 1989-11-16 1992-04-17 Ortho Diagnostic Systems Inc Method of producing a metal for reagent containingmethod of producing a metal for reagent containing colloidal metal particles of a preselected size colloidal metal particles of a preselected size
DE4117782A1 (en) * 1991-05-28 1992-12-03 Diagnostikforschung Inst NANOCRYSTALLINE MAGNETIC IRON OXIDE PARTICLES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICAL DIAGNOSTICS AND THERAPY
US5427767A (en) * 1991-05-28 1995-06-27 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy
WO1995003128A3 (en) * 1993-07-23 2001-05-03 Ikosta Gmbh Inst Fur Korrosion Process and device for separating non-magnetic materials and objects by using ferrohydrodynamic fluid
US6123920A (en) * 1996-01-10 2000-09-26 Nycomed Imaging As Superparamagnetic contrast media coated with starch and polyalkylene oxides
WO1997035200A1 (en) * 1996-03-18 1997-09-25 Silica Gel Gmbh Super-paramagnetic particles with increased r1 relaxivity, processes for producing said particles and use thereof
US6638494B1 (en) 1996-03-18 2003-10-28 Herbert Pilgrimm Super-paramagnetic particles with increased R1 relaxivity, process for producing said particles and use thereof
US6713173B2 (en) 1996-11-16 2004-03-30 Nanomagnetics Limited Magnetizable device
US6815063B1 (en) 1996-11-16 2004-11-09 Nanomagnetics, Ltd. Magnetic fluid
US6896957B1 (en) 1996-11-16 2005-05-24 Nanomagnetics, Ltd. Magnetizable device
US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
DE102007059939A1 (en) 2007-12-12 2009-06-18 Müller-Schulte, Detlef, Dr. Noncovalently crosslinked spherical polymer particles for separating biological substances and cells can be dissolved by heating or adding a metal-complexing agent

Also Published As

Publication number Publication date
JPH03504303A (en) 1991-09-19
EP0414805A1 (en) 1991-03-06
US4965007A (en) 1990-10-23

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