WO1991000019A1 - Process for the production of canned coffee - Google Patents
Process for the production of canned coffee Download PDFInfo
- Publication number
- WO1991000019A1 WO1991000019A1 PCT/JP1990/000828 JP9000828W WO9100019A1 WO 1991000019 A1 WO1991000019 A1 WO 1991000019A1 JP 9000828 W JP9000828 W JP 9000828W WO 9100019 A1 WO9100019 A1 WO 9100019A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coffee
- extract
- production
- canned
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F5/00—Coffee; Coffee substitutes; Preparations thereof
- A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F5/00—Coffee; Coffee substitutes; Preparations thereof
- A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
- A23F5/243—Liquid, semi-liquid or non-dried semi-solid coffee extract preparations; Coffee gels; Liquid coffee in solid capsules
Definitions
- the present invention relates to a process for the production of canned coffee drink. More particularly, it relates to a process for the production of canned coffee drink which has good flavor, taste and color of coffee and retains fresh-brewed aroma.
- Japanese Patent Publication (Kokai) No. Sho 51-85881 discloses a process for the prevention of putrefaction of a liquid content in a container by sealing a container filled with a liquid content in an atmosphere of steam to prevent the penetration of air and contamination of bacteria which exist in air as being entrained therein.
- 58-31939 discloses a process for the long-term retention of a coffee extract without deteriorating its aroma by incorporating carbon dioxide gas or dry ice in a container filled with a coffee extract to establish a carbon dioxide atmosphere and refrigerating the extract at a temperature of about 10°C.
- Japanese Patent Publication (Kokai) No. Sho 61-124361 discloses a process for the production of canned drink contained in a can in which negative pressure nitrogen gas is sealed, and which can has a degree of vacuum of no lower than 10 cmHg at 40°C after sealing and is suitable for tapping tests, by replacing at least a portion of oxygen in the head space of the can and in the drink with nitrogen gas.
- Japanese Patent Publication (Kokai) No. Sho 61-190403 discloses a process for the production of canned drink by filling spumous drink containing no carbon dioxide in a metal can at a temperature near room temperature and then replacing air in the head space of the can with carbon dioxide gas.
- 62-14777 discloses a process for the production of canned alcoholic drink containing 0.005 to 0.3% by weight of ascorbic acid, erythorbic acid or water-soluble salt thereof.
- Japanese Patent Publication (Kokai) No. Sho 62-44137 proposes the production of a coffee extract which has excellent aroma and storage stability by adding an alkali metal salt of L-ascorbic acid to a coffee extract.
- Japanese Patent Publication (Kokai) No. Sho 63-84466 discloses a process for filling food or drink in cans by filling contents in cans at a sterilization temperature such as 60 to 100°C, and then supplying a mixed gas comprising nitrogen gas and carbon dioxide gas in the head space in the cans, followed by sealing to obtain a desired degree of vacuum.
- a process for the production of canned coffee comprising: (1) preparing a cold extract of coffee by rapidly cooling a coffee extract at a temperature no higher than about 20°C;
- a mixed gas comprising at least two members selected from the group consisting of steam, carbon dioxide gas, and nitrogen gas.
- coffee powder of roasted and pulverized coffee beans is extracted with hot water to obtain coffee extract at a high temperature, which then is rapidly cooled down to a temperature no higher than about 20°C, for instance, usually at a temperature in the range of from 10 to 20°C.
- Any means may be used for the rapid cooling of the high temperature coffee extract.
- the rapid cooling can be performed efficiently by using a cooler which is called a "plate cooler".
- At least one antioxidant selected from the group consisting of erythorbic acid, ascorbic acid and water-soluble salts thereof is added to the cooled extract thus prepared.
- the cooled extract may if desired be diluted appropriately until its concentration reaches a level which is suitable for drinking. It is preferred that the antioxidant be added to the extract having a concentration suitable for drinking in a concentration of about 0.1 to 0.01% by weight.
- the coffee extract may contain various additives such as pH adjusters, sugar and milk, if desired.
- the additives, if added, can be added to the coffee extract advantageously in the same step as that in which the antioxidant is added in order to minimize complicated operations.
- a preferred example of the pH adjuster which can be used is sodium bicarbonate.
- the cooled extract thus adjusted and containing the antioxidant is then filled in a container for canning as it is without heating in contrast to ordinary filling techniques in which cooled extracts are heated again to elevated temperatures before filling.
- the container for canning filled with the coffee extract is then subjected to replacing of air therein with a mixed gas.
- the mixed gas comprises at least two members selected from the group consisting of steam, carbon dioxide gas and nitrogen gas.
- the use of the mixed gas enables reduction of the amount of air remaining in the hermetically seamed can to a level as low as possible, thereby preventing oxidation of the coffee extract with oxygen in the air remaining in the can.
- a portion of the mixed gas is dissolved in the coffee extract in the can to form appropriate negative pressure in the can, which makes it possible to perform tapping tests after the hermetical seaming advantageously.
- the replacement of air in the can with the mixed gas is performed by continuously passing containers for canning one after another under a nozzle which is spouting the mixed gas. Thereafter, the cans are tightly seamed rapidly.
- the tightly seamed cans containing coffee drink are usually subjected to sterilization treatment (for example, at 115°C for 20 minutes), cooled and shipped as final beverage products.
- Example 1 The present invention will be described in greater detail with reference to examples which should in no way be construed as limiting the present invention.
- Example 1
- Roasted, pulverized coffee (96 kg) was charged in an extractor and extracted with sprayed hot water at 98°C.
- the extract was rapidly cooled down to about 18°C and supplied to a mixing tank in which 1 kg of erythorbic acid, 1 kg of sodium bicarbonate and 15 kg of sugar and water were added to prepare 2,000 liters of coffee extract.
- the coffee extract was filled in a can (250 ml, three piece necked in TFS can) as it is without heating and air in the head space was replaced with either one of a mixed gas composed of nitrogen gas and steam, a mixed gas composed of nitrogen gas and carbon dioxide gas, or a mixed gas composed of carbon dioxide gas and steam.
- the can was sealed and sterilized by retorting at 115°C for 20 minutes, followed by cooling to produce canned coffee drink.
- the filling of the coffee extract, replacement of air with the mixed gas and sealing of the can were performed continuously at a speed of 515 cans/minute.
- Table 1 shows conditions of replacing air in the head space (kind and flow rate of mixed gases) and degree of pressure reduction (cmHg) immediately after the production of canned coffee drink (final beverage product) as well as the total amount (ml/100 ml) of oxygen in the can, in the case where mocha blend was used as the coffee.
- Table 2 shows conditions similar to those shown in Table 1 above and results obtained in the case where kirimanjaro blend was used as the coffee.
- Runs Nos. Mo-1 and Mo-11 in Table 1 and Runs Nos. Ki-1 and Ki-11 are comparative examples, respectively.
- Example 1 The degree of vacuum and pH of canned coffee drink corresponding to the respecitve run numbers obtained in Example 1 were examined chronologically.
- Example 1 The total amount of oxygen in the can and transmittance of canned coffee drink samples corresponding to the respective run numbers obtained in Example 1 were examined periodically.
- Tables 9 and 10 show results obtained on the canned coffee drink samples immediately after the production thereof.
- the above-described canned coffee drink samples were each in an incubator at 55°C for 1 week and at room temperature for 1 month and evaluated in the same manner as above in comparsion with a control sample which was stored in a refrigerator as a standard.
- the canned coffee drink of the present invention is superior in storage stability at elevated temperature (Tables 11 and 12) and also in stability after long-term retention at room temperature (Tables 13 and 14) to the comparison product filled with coffee extract at 88°C.
- the present invention provides an improved process for the production of canned coffee drink which has good flavor, taste and color of fresh-brewed coffee and retains intrinsic fresh-brewed aroma after long-term retention and which is suitable for impact testing for the examination of the degree of vacuum in the sealed cans.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Tea And Coffee (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Description
Claims
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69009702T DE69009702T2 (en) | 1989-06-27 | 1990-06-26 | METHOD FOR PRODUCING CANNED COFFEE. |
| CA002035040A CA2035040C (en) | 1989-06-27 | 1990-06-26 | Process for the production of canned coffee |
| BR909006831A BR9006831A (en) | 1989-06-27 | 1990-06-26 | PROCESS FOR THE PRODUCTION OF CANNED COFFEE |
| EP90909489A EP0431193B1 (en) | 1989-06-27 | 1990-06-26 | Process for the production of canned coffee |
| KR1019910700220A KR920700549A (en) | 1989-06-27 | 1990-06-26 | Method of making canned coffee |
| US08/083,315 US5384143A (en) | 1989-06-27 | 1993-06-29 | Process for the production of canned coffee |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1162807A JPH0712281B2 (en) | 1989-06-27 | 1989-06-27 | Coffee can beverage manufacturing method |
| JP1/162807 | 1989-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1991000019A1 true WO1991000019A1 (en) | 1991-01-10 |
Family
ID=15761596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1990/000828 Ceased WO1991000019A1 (en) | 1989-06-27 | 1990-06-26 | Process for the production of canned coffee |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5384143A (en) |
| EP (1) | EP0431193B1 (en) |
| JP (1) | JPH0712281B2 (en) |
| KR (1) | KR920700549A (en) |
| AT (1) | ATE106675T1 (en) |
| AU (1) | AU629366B2 (en) |
| BR (1) | BR9006831A (en) |
| CA (1) | CA2035040C (en) |
| DE (1) | DE69009702T2 (en) |
| DK (1) | DK0431193T3 (en) |
| ES (1) | ES2055913T3 (en) |
| WO (1) | WO1991000019A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0517424A1 (en) * | 1991-06-05 | 1992-12-09 | Kraft Foods, Inc. | Shelf-stable milk-containing beverage products |
| EP0628259A4 (en) * | 1992-02-27 | 1995-01-25 | Takuji Ono | PROCESS FOR PRODUCING PRESERVES. |
| US6024996A (en) * | 1995-05-29 | 2000-02-15 | Sara Lee/De N.V. | Packaged carbonated coffee beverage |
| US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
| US20160007626A1 (en) * | 2014-07-10 | 2016-01-14 | Paris Croissant Co., Ltd | Method of making coffe and apparatus of making coffee |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997018720A1 (en) * | 1995-11-24 | 1997-05-29 | Shepard Thomas R | Vitamin c enriched coffee, cocoa, and tea, and process for its production |
| KR100423587B1 (en) * | 1996-03-26 | 2004-08-25 | 폭카 코포레이션 | Method for producing high-quality drinks filled in containers and high-quality drinks produced by the method |
| US6093436A (en) * | 1998-02-04 | 2000-07-25 | Nestec S.A. | Beverage antioxidant system |
| US6352736B2 (en) * | 1998-07-23 | 2002-03-05 | Nestec S.A. | Liquid coffee product |
| US6228410B1 (en) | 1999-01-28 | 2001-05-08 | Gerry W. Zajac | Method and apparatus for extending the freshness of coffee and indicating its freshness |
| US5956151A (en) * | 1999-01-28 | 1999-09-21 | Zajac; Gerry W. | Beverage freshness monitor |
| US6756069B2 (en) | 1999-05-18 | 2004-06-29 | Nestec S.A. | System and method for dispensing a liquid beverage concentrate |
| US7597922B2 (en) * | 1999-05-18 | 2009-10-06 | Nestec S.A. | System for dispensing a liquid beverage concentrate |
| MY117222A (en) * | 1999-05-18 | 2004-05-31 | Nestle Sa | Stable coffee concentrate system |
| US6399136B1 (en) * | 1999-06-28 | 2002-06-04 | Arthur W. Watkins, Jr. | Coffee concentrate |
| US6808731B1 (en) | 1999-08-14 | 2004-10-26 | The Procter & Gamble Co. | Coffee extract and process for providing customized varieties and strengths of fresh-brewed coffee on demand |
| US6759072B1 (en) | 1999-08-14 | 2004-07-06 | The Procter + Gamble Co. | Methods and systems for utilizing delayed dilution, mixing and filtration for providing customized beverages on demand |
| US6726947B1 (en) * | 1999-08-14 | 2004-04-27 | The Procter & Gamble Co. | Process for providing customized varieties and strengths of fresh-brewed coffee on demand |
| MXPA02001620A (en) * | 1999-08-14 | 2002-07-02 | Procter & Gamble | Methods and systems for utilizing delayed dilution, mixing and filtering to provide customized varieties of fresh-brewed coffee on-demand. |
| US6622462B2 (en) * | 2000-01-24 | 2003-09-23 | Showa Tansan Co., Ltd. | Device for replacing air within a container headspace |
| EP1359812B1 (en) * | 2001-02-13 | 2007-05-16 | The Procter & Gamble Company | Coffee compositions with stable flavor characteristics and method of making |
| WO2002063971A2 (en) | 2001-02-15 | 2002-08-22 | The Procter & Gamble Company | Coffee compositions with enhanced flavor characteristics and method of making |
| US6841185B2 (en) * | 2001-10-19 | 2005-01-11 | The Procter & Gamble Co. | Flavored coffee compositions and methods of making the same |
| US20030180431A1 (en) * | 2001-10-22 | 2003-09-25 | The Procter Gamble Co. | Flavored coffee compositions with stable flavors and method of making |
| KR20050027992A (en) * | 2002-06-12 | 2005-03-21 | 더 코카콜라 컴파니 | Method of serving heated beverages |
| US20050031761A1 (en) * | 2003-08-05 | 2005-02-10 | Donald Brucker | Methods of producing a functionalized coffee |
| IL159990A (en) | 2004-01-21 | 2008-03-20 | Eyal Eliav | Device, method and system for the application of content onto the surface of a beverage |
| JP4503308B2 (en) * | 2004-02-13 | 2010-07-14 | 日本クラウンコルク株式会社 | Container lid for sheet metal container |
| CN101106908B (en) * | 2004-12-13 | 2010-09-15 | 三得利控股株式会社 | Method for producing coffee beverage using filtered extract |
| CA2660059A1 (en) * | 2006-09-15 | 2008-03-20 | Ito En, Ltd. | Coffee drink packed in container and method of producing the same |
| IL178519A (en) * | 2006-10-15 | 2016-04-21 | Shlomo Magdassi | Edible coloring composition |
| CA2705109C (en) * | 2007-11-13 | 2016-02-09 | Nestec S.A. | Use of thioester flavors to improve the flavor quality of ready-to-drink coffee upon retorting and storage |
| JP4898719B2 (en) * | 2008-02-13 | 2012-03-21 | カヤバ工業株式会社 | Front fork |
| JP2014090678A (en) * | 2012-11-01 | 2014-05-19 | Ito En Ltd | Packed vegetable juice and/or fruit juice containing beverage, manufacturing method thereof, and method for preventing taste deterioration of packed vegetable juice and/or fruit juice containing beverage |
| CH707314A1 (en) | 2012-12-06 | 2014-06-13 | Innoprax Ag | A process for the production of cold coffee milk drinks. |
| US20140322397A1 (en) * | 2013-04-27 | 2014-10-30 | David F. Mamo | Aseptic hot-brewed packaged coffee or espresso beverage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2089191A (en) * | 1980-12-10 | 1982-06-23 | Toyo Seikan Kaisha Ltd | Method and apparatus for making a hermetically sealed food container |
| DE3339839A1 (en) * | 1983-02-08 | 1984-08-09 | Asahi Breweries Ltd. | METHOD FOR FILLING CARBONIC-FREE DRINKS |
| DE3538810A1 (en) * | 1984-11-02 | 1986-05-22 | Jujo Paper Co. Ltd., Tokio/Tokyo | PAPER CONTAINER FOR LIQUID CLEARED IN THE UPPER SPACE WITH GAS AND A METHOD AND DEVICE FOR INJECTING THE GAS |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2291604A (en) * | 1939-10-21 | 1942-08-04 | American Can Co | Method of canning a liquid coffee beverage |
| US2333898A (en) * | 1941-10-07 | 1943-11-09 | Continental Can Co | Method of packaging fruit and vegetable juices |
| US2454510A (en) * | 1944-10-14 | 1948-11-23 | Wilbert A Heyman | Method of forming a coffee concentrate |
| US2497721A (en) * | 1948-08-12 | 1950-02-14 | Finer Foods Packing Corp | Canned liquid coffee and method of making same |
| US2626558A (en) * | 1949-01-07 | 1953-01-27 | Jacob R Stein | Method of preparing coffee |
| US2620276A (en) * | 1949-03-02 | 1952-12-02 | Wilbert A Heyman | Package coffee drink |
| US2759307A (en) * | 1953-08-31 | 1956-08-21 | Gerber Prod | Method and apparatus for filling containers |
| US2828684A (en) * | 1954-01-18 | 1958-04-01 | Phil R Graham | Coffee oxidation preventative apparatus |
| US3119695A (en) * | 1961-10-05 | 1964-01-28 | Glamorene Ind Factors Inc | Pressurized liquid instant coffee |
| US3261507A (en) * | 1963-07-01 | 1966-07-19 | Cornelius Co | Method and means for treating and handling coffee beverage |
| US3536496A (en) * | 1967-12-18 | 1970-10-27 | Armand M Paoloni | Method of making liquid coffee concentrate |
| DE2047861A1 (en) * | 1970-09-29 | 1972-03-30 | Fa. J. Eilles, 8000 München | Cold tea or coffee - stable during storage |
| US3830940A (en) * | 1972-06-07 | 1974-08-20 | M Sivetz | Preparation of aqueous beverage concentrate of coffee |
| US3987941A (en) * | 1973-12-14 | 1976-10-26 | Blessing Alfred V | Preserving container for liquid food substances |
| JPS5144655A (en) * | 1974-10-09 | 1976-04-16 | Ueshima Koohii Kk | Mitsupeiinshokubutsuno satsukinhoho |
| US3974758A (en) * | 1974-11-08 | 1976-08-17 | Stone Jr Wayne B | Apparatus for reducing oxidation of coffee |
| US4363262A (en) * | 1980-10-17 | 1982-12-14 | Pinckley Marion E | Apparatus for storage and dispensing coffee |
| US4526797A (en) * | 1981-02-11 | 1985-07-02 | Wood Manufacturing Co., Inc. | Decanter for reducing oxidation and evaporation of coffee |
| EP0092966B1 (en) * | 1982-04-22 | 1987-01-28 | Daiwa Can Company, Limited | Method of manufacturing gas-sealed containered food |
| US4618500A (en) * | 1985-08-20 | 1986-10-21 | Fulcrum Enterprises | Method for preparing an espresso-type coffee beverage |
| JPS63129955A (en) * | 1986-11-21 | 1988-06-02 | Ajinomoto General Foods Kk | Stabilization of coffee extract solution |
| US4980182A (en) * | 1989-06-21 | 1990-12-25 | Nestec S.A. | Beverages containing a beverage base and milk protein |
-
1989
- 1989-06-27 JP JP1162807A patent/JPH0712281B2/en not_active Expired - Fee Related
-
1990
- 1990-06-26 WO PCT/JP1990/000828 patent/WO1991000019A1/en not_active Ceased
- 1990-06-26 BR BR909006831A patent/BR9006831A/en not_active Application Discontinuation
- 1990-06-26 AT AT90909489T patent/ATE106675T1/en active
- 1990-06-26 AU AU58383/90A patent/AU629366B2/en not_active Ceased
- 1990-06-26 EP EP90909489A patent/EP0431193B1/en not_active Expired - Lifetime
- 1990-06-26 DK DK90909489.8T patent/DK0431193T3/en active
- 1990-06-26 KR KR1019910700220A patent/KR920700549A/en not_active Withdrawn
- 1990-06-26 DE DE69009702T patent/DE69009702T2/en not_active Expired - Lifetime
- 1990-06-26 CA CA002035040A patent/CA2035040C/en not_active Expired - Fee Related
- 1990-06-26 ES ES90909489T patent/ES2055913T3/en not_active Expired - Lifetime
-
1993
- 1993-06-29 US US08/083,315 patent/US5384143A/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2089191A (en) * | 1980-12-10 | 1982-06-23 | Toyo Seikan Kaisha Ltd | Method and apparatus for making a hermetically sealed food container |
| DE3339839A1 (en) * | 1983-02-08 | 1984-08-09 | Asahi Breweries Ltd. | METHOD FOR FILLING CARBONIC-FREE DRINKS |
| DE3538810A1 (en) * | 1984-11-02 | 1986-05-22 | Jujo Paper Co. Ltd., Tokio/Tokyo | PAPER CONTAINER FOR LIQUID CLEARED IN THE UPPER SPACE WITH GAS AND A METHOD AND DEVICE FOR INJECTING THE GAS |
Non-Patent Citations (2)
| Title |
|---|
| PATENT ABSTRACTS OF JAPAN, Vol. 11, No. 232 (C-437)(2679), 29 July 1987; & JP-A-6244137 (Meiji Milk Prod Co., Ltd) 26 February 1987 * |
| PATENT ABSTRACTS OF JAPAN, Vol. 7, No. 108 (C-165)(1253), 11 May 1983; & JP-A-5831939 (Kiyoudou Niyuugiyou K.K.) 24 February 1983 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0517424A1 (en) * | 1991-06-05 | 1992-12-09 | Kraft Foods, Inc. | Shelf-stable milk-containing beverage products |
| EP0628259A4 (en) * | 1992-02-27 | 1995-01-25 | Takuji Ono | PROCESS FOR PRODUCING PRESERVES. |
| US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
| US6024996A (en) * | 1995-05-29 | 2000-02-15 | Sara Lee/De N.V. | Packaged carbonated coffee beverage |
| US20160007626A1 (en) * | 2014-07-10 | 2016-01-14 | Paris Croissant Co., Ltd | Method of making coffe and apparatus of making coffee |
| US9386782B2 (en) * | 2014-07-10 | 2016-07-12 | Paris Croissant Co., Ltd | Method of making and dispensing nitrogen-charged coffee |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2035040A1 (en) | 1990-12-28 |
| CA2035040C (en) | 1999-12-07 |
| EP0431193B1 (en) | 1994-06-08 |
| DK0431193T3 (en) | 1994-07-04 |
| JPH0330633A (en) | 1991-02-08 |
| JPH0712281B2 (en) | 1995-02-15 |
| BR9006831A (en) | 1991-08-06 |
| ATE106675T1 (en) | 1994-06-15 |
| AU5838390A (en) | 1991-01-17 |
| DE69009702D1 (en) | 1994-07-14 |
| AU629366B2 (en) | 1992-10-01 |
| KR920700549A (en) | 1992-08-10 |
| DE69009702T2 (en) | 1994-11-03 |
| ES2055913T3 (en) | 1994-09-01 |
| EP0431193A1 (en) | 1991-06-12 |
| US5384143A (en) | 1995-01-24 |
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