WO1991011014A1 - Method and apparatus for sample injection into ion mobility spectrometer - Google Patents

Method and apparatus for sample injection into ion mobility spectrometer Download PDF

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Publication number
WO1991011014A1
WO1991011014A1 PCT/CA1991/000005 CA9100005W WO9111014A1 WO 1991011014 A1 WO1991011014 A1 WO 1991011014A1 CA 9100005 W CA9100005 W CA 9100005W WO 9111014 A1 WO9111014 A1 WO 9111014A1
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WO
WIPO (PCT)
Prior art keywords
sample
receptacle
septum
ims
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1991/000005
Other languages
French (fr)
Inventor
John Alfred Stone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pylon Electronic Development Co Ltd
Pylon Electronics Inc
Original Assignee
Pylon Electronic Development Co Ltd
Pylon Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pylon Electronic Development Co Ltd, Pylon Electronics Inc filed Critical Pylon Electronic Development Co Ltd
Publication of WO1991011014A1 publication Critical patent/WO1991011014A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Definitions

  • This invention relates to a method and apparatus for injecting a sample of material to be tested into an ion mobility sensor (IMS).
  • IMS ion mobility sensor
  • Various methods are known for injecting a sample into an IMS.
  • One method involves injecting sample material with a syringe by passing the needle of the syringe through a septum covering an opening in a sample receptacle from where it is taken by a carrier gas into the IMS.
  • An arrangement of this type although for a mass spectrometer, is disclosed in Canadian patent No. 1,045,253 of McLafferty, et al, issued December 26, 1978.
  • a method for injecting a sample of material to be tested into an ion mobility sensor comprising arranging an outlet tube projecting from one end of a sample receptacle into a sample inlet of said IMS, said sample receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said method further comprising placing a sample of said material into a syringe, said syringe having a hollow needle passing through a septum, placing said septum against the open end of said sample receptacle so that said septum closes the end of said sample receptacle and said needle enters said outlet tube, passing carrier gas into said sample receptacle to thereby convey at least part of said sample into the IMS, and then removing said syringe and septum.
  • IMS ion mobility sensor
  • apparatus for injecting a sample of material to be tested into an ion mobility sensor comprising a sample receptacle having an outlet tube projecting from one end and adapted to be inserted into a sample inlet of an IMS, said receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said apparatus further comprising a syringe for injecting sample material into said receptacle, said syringe having a needle projecting through a septum adapted to close said other end of said receptacle whereby said sample receptacle can be closed only long enough for sample injection after which it is open so that it does not receive contaminants from said septum.
  • IMS ion mobility sensor
  • the drawing shows the reaction region 12 of an IMS 10 which is provided with a sample inlet 14.
  • An outlet tube 15 of a sample receptacle 16 is received in the sample inlet 14 of the IMS.
  • the sample receptacle 16 has an open end 18.
  • a syringe 20 having a needle 21 provided with a septum 22 is placed so that the septum covers the end 18 of receptacle 16.
  • the needle 21 of the syringe projects into the outlet tube 15.
  • Sample material is injected into the receptacle using the syringe 20 and is taken by carrier gas introduced at 25 through outlet tube 15 and into IMS 10. The syringe and septum are then removed.
  • the sample receptacle 16 and tube 15 may be made of glass and the receptacle may be heated to, for example, 150°C by any suitable heat source (not shown).
  • the septum may be made of resilient material. Preferably it is made of Teflon (trade mark) or may be a Teflon facing on any suitable backing support member.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Disclosed is a method and apparatus for injecting a sample of material to be tested into an ion mobility sensor (IMS). A syringe needle is provided with a septum, preferably of TeflonR. In use, the septum closes an open end of a sample receptacle, sample material is injected and is taken into the IMS by a carrier gas, after which the syringe and septum are removed. This minimizes the change of contaminants in or on the septum reaching the IMS.

Description

METHOD AND APPARATUS FOR SAMPLE INJECTION INTO ION MOBILITY SPECTROMETER
BACKGROUND OF THE INVENTION
This invention relates to a method and apparatus for injecting a sample of material to be tested into an ion mobility sensor (IMS). Various methods are known for injecting a sample into an IMS. One method involves injecting sample material with a syringe by passing the needle of the syringe through a septum covering an opening in a sample receptacle from where it is taken by a carrier gas into the IMS. An arrangement of this type, although for a mass spectrometer, is disclosed in Canadian patent No. 1,045,253 of McLafferty, et al, issued December 26, 1978. However, it has been found that, when used with an IMS, particularly if the sample receptacle is heated, all septa tried give background ions which remain while the septa are in place, and indeed long after the septa are removed. Septa were preconditioned in a vacuum oven but to no avail. A Teflon (trade mark) faced septum gave the fewest background peaks but the spectrum was still unacceptable. SUMMARY OF THE INVENTION
I have discovered that this problem can be solved by placing a septum (preferably Teflon or Teflon faced) on to a syringe needle and holding it in place over the end of the sample receptacle only during sample injection. This actually achieved two objectives: firstly peaks due to the septum were not observed and secondly flow of gas out of the reaction region swept out any gas which adsorbed on the inner walls of the central tube of the injector and thus reduced "clear-out" time between samples.
Thus, in accordance with a broad aspect of the invention, there is provided a method for injecting a sample of material to be tested into an ion mobility sensor (IMS) comprising arranging an outlet tube projecting from one end of a sample receptacle into a sample inlet of said IMS, said sample receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said method further comprising placing a sample of said material into a syringe, said syringe having a hollow needle passing through a septum, placing said septum against the open end of said sample receptacle so that said septum closes the end of said sample receptacle and said needle enters said outlet tube, passing carrier gas into said sample receptacle to thereby convey at least part of said sample into the IMS, and then removing said syringe and septum.
In accordance with another broad aspect of the invention there is provided apparatus for injecting a sample of material to be tested into an ion mobility sensor (IMS) comprising a sample receptacle having an outlet tube projecting from one end and adapted to be inserted into a sample inlet of an IMS, said receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said apparatus further comprising a syringe for injecting sample material into said receptacle, said syringe having a needle projecting through a septum adapted to close said other end of said receptacle whereby said sample receptacle can be closed only long enough for sample injection after which it is open so that it does not receive contaminants from said septum.
BRIEF DESCRIPTION OF THE DRAWING The sole drawing figure illustrates a preferred embodiment of the invention. DESCRIPTION OF THE PREFERRED EMBODIMENT
The drawing shows the reaction region 12 of an IMS 10 which is provided with a sample inlet 14. An outlet tube 15 of a sample receptacle 16 is received in the sample inlet 14 of the IMS. The sample receptacle 16 has an open end 18. For sample injection, a syringe 20 having a needle 21 provided with a septum 22 is placed so that the septum covers the end 18 of receptacle 16. The needle 21 of the syringe projects into the outlet tube 15. Sample material is injected into the receptacle using the syringe 20 and is taken by carrier gas introduced at 25 through outlet tube 15 and into IMS 10. The syringe and septum are then removed. Gas flow out of the reaction region sweeps out any gas which adsorbed on the inner walls of the tube 15 of the injector, thus reducing "clear-out" time between samples. The sample receptacle 16 and tube 15 may be made of glass and the receptacle may be heated to, for example, 150°C by any suitable heat source (not shown).
The septum may be made of resilient material. Preferably it is made of Teflon (trade mark) or may be a Teflon facing on any suitable backing support member.

Claims

1. A method for injecting a sample of material to be tested into an ion mobility sensor (IMS) comprising arranging an outlet tube projecting from one end of a sample receptacle into a sample inlet of said IMS, said sample receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said method further comprising placing a sample of said material into a syringe, said syringe having a hollow needle passing through a septum, placing said septum against the open end of said sample receptacle so that said septum closes the end of said sample receptacle and said needle enters said- outlet tube, passing carrier gas into said sample receptacle to thereby convey at least part of said sample into the IMS, and then removing said syringe and septum.
2. A method as claimed in claim 1 and further comprising heating said sample receptacle.
3. A method as claimed in claim 2 wherein said sample receptacle is heated to about 150 C.
4. A method as claimed in claim 1, 2 or 3 wherein said sample receptacle and outlet tube are made of glass.
5. A method as claimed in claim 1, 2 or 3, wherein said septum is formed of a resilient material.
6. A method as claimed in claim 5 wherein said resilient material is Teflon (trade mark).
7. Apparatus for injecting a sample of material to be tested into an ion mobility sensor (IMS) comprising a sample receptacle having an outlet tube projecting from one end and adapted to be inserted into a sample inlet of an IMS, said receptacle enclosing a portion of said outlet tube and having an open other end opposite said one end and an inlet for a carrier gas, said apparatus further comprising a syringe for injecting sample material into said receptacle, said syringe having a needle projecting through a septum adapted to close said other end of said receptacle whereby said sample receptacle can be closed only long enough for sample injection after which it is open so that it does not receive contaminants from said septum.
8. Apparatus as claimed in claim 7 wherein said receptacle and outlet tube are made of glass.
9. Apparatus as claimed in claim 7 or 8 wherein said septum is formed of resilient material.
10. Apparatus as claimed in claim 7 or 8 wherein said septum is formed of Teflon (trade mark).
PCT/CA1991/000005 1990-01-09 1991-01-08 Method and apparatus for sample injection into ion mobility spectrometer Ceased WO1991011014A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,007,372 1990-01-09
CA002007372A CA2007372A1 (en) 1990-01-09 1990-01-09 Method and apparatus for sample injection into ion mobility spectrometer

Publications (1)

Publication Number Publication Date
WO1991011014A1 true WO1991011014A1 (en) 1991-07-25

Family

ID=4143968

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1991/000005 Ceased WO1991011014A1 (en) 1990-01-09 1991-01-08 Method and apparatus for sample injection into ion mobility spectrometer

Country Status (3)

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EP (1) EP0510025A1 (en)
CA (1) CA2007372A1 (en)
WO (1) WO1991011014A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558630B1 (en) 1997-10-20 2003-05-06 Hans Degn Dosing unit and a method of continuous introduction of liquid solution samples into a system
EP2163891A1 (en) * 2008-09-15 2010-03-17 C & C Ingescience Vorrichtung und Verfahren zur Kalibrierung eines Ionisierungssensors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3581573A (en) * 1967-12-27 1971-06-01 Perkin Elmer Corp Sample injection arrangement for an analytical instrument
US4239967A (en) * 1979-04-13 1980-12-16 International Business Machines Corporation Trace water measurement
EP0198154A2 (en) * 1985-02-15 1986-10-22 Environmental Technologies Group, Inc. Selective ionization of gas constituents using electrolytic reactions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3581573A (en) * 1967-12-27 1971-06-01 Perkin Elmer Corp Sample injection arrangement for an analytical instrument
US4239967A (en) * 1979-04-13 1980-12-16 International Business Machines Corporation Trace water measurement
EP0198154A2 (en) * 1985-02-15 1986-10-22 Environmental Technologies Group, Inc. Selective ionization of gas constituents using electrolytic reactions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Analytical Chemistry, vol. 54, no. 9, August 1982, American Chemical Society; (Easton, Penns., US), J. Greter et al.: "Septumless injection port for capillary gas chromatography"; pages 1646-1647 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558630B1 (en) 1997-10-20 2003-05-06 Hans Degn Dosing unit and a method of continuous introduction of liquid solution samples into a system
EP2163891A1 (en) * 2008-09-15 2010-03-17 C & C Ingescience Vorrichtung und Verfahren zur Kalibrierung eines Ionisierungssensors
FR2936059A1 (en) * 2008-09-15 2010-03-19 C & C Ingescience DEVICE AND METHOD FOR CALIBRATING AN IONIZATION SENSOR

Also Published As

Publication number Publication date
CA2007372A1 (en) 1991-07-09
EP0510025A1 (en) 1992-10-28

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