WO1994012625A3 - LIGAND BINDING VARIABLE DOMAIN (V-MIN) COMPRISING A FRAMEWORK REGION WITH A CYCLICALLY PERMUTED CENTRAL β-BARREL - Google Patents

LIGAND BINDING VARIABLE DOMAIN (V-MIN) COMPRISING A FRAMEWORK REGION WITH A CYCLICALLY PERMUTED CENTRAL β-BARREL Download PDF

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Publication number
WO1994012625A3
WO1994012625A3 PCT/GB1993/002375 GB9302375W WO9412625A3 WO 1994012625 A3 WO1994012625 A3 WO 1994012625A3 GB 9302375 W GB9302375 W GB 9302375W WO 9412625 A3 WO9412625 A3 WO 9412625A3
Authority
WO
WIPO (PCT)
Prior art keywords
barrel
ligand binding
central
framework region
variable domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1993/002375
Other languages
French (fr)
Other versions
WO1994012625A2 (en
Inventor
Anthony Michael Slater
David Timms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929224588A external-priority patent/GB9224588D0/en
Priority claimed from GB929227189A external-priority patent/GB9227189D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to GB9509600A priority Critical patent/GB2287247B/en
Priority to EP94900226A priority patent/EP0673417B1/en
Priority to AT94900226T priority patent/ATE242804T1/en
Priority to AU55303/94A priority patent/AU5530394A/en
Priority to DE69333044T priority patent/DE69333044T2/en
Publication of WO1994012625A2 publication Critical patent/WO1994012625A2/en
Publication of WO1994012625A3 publication Critical patent/WO1994012625A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

The invention relates to ligand binding variable domains (V-mins) having structural rearrangement of the binding domain of immunoglobulins and other ligand binding members of the immunoglobulin superfamily. The minimal elements necessary to retain good antigen binding affinity, the complementarity determining region (CDRs) and the central beta barrel structure for the Fv fragment, may be retained positioned appropriately in space by cyclic permutation of the central beta barrel structure and leaving the strands of the β barrel intact. The invention is also independently based on recognising that after cyclic permutation of the central beta barrel the framework region which supports the CDRs can be pared down through creation of novel linkages in the structure.
PCT/GB1993/002375 1992-11-23 1993-11-19 LIGAND BINDING VARIABLE DOMAIN (V-MIN) COMPRISING A FRAMEWORK REGION WITH A CYCLICALLY PERMUTED CENTRAL β-BARREL Ceased WO1994012625A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB9509600A GB2287247B (en) 1992-11-23 1993-11-19 Ligand binding variable domain (V-min) comprising a framework region with a cyclically permuted central beta-barrel
EP94900226A EP0673417B1 (en) 1992-11-23 1993-11-19 LIGAND BINDING VARIABLE DOMAIN (V-MIN) COMPRISING A FRAMEWORK REGION WITH A CYCLICALLY PERMUTED CENTRAL $g(b)-BARREL
AT94900226T ATE242804T1 (en) 1992-11-23 1993-11-19 LIGAND-BINDING VARIABLE DOMANE (V-MIN) CONTAINING A ßFRAMEWORKß REGION WITH A CYCLICALLY PERMUTATED CENTRAL $G(B) TUBUS
AU55303/94A AU5530394A (en) 1992-11-23 1993-11-19 Ligand binding variable domain (v-min) comprising a framework region with a cyclically permuted central beta -barrel
DE69333044T DE69333044T2 (en) 1992-11-23 1993-11-19 LIGAND-BINDING VARIABLE DOMANE (V-MIN), WHICH CONTAINS A "FRAMEWORK" REGION WITH A CYCLICALLY PERMUTED CENTRAL $ g (b) TUBE

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9224588.5 1992-11-23
GB929224588A GB9224588D0 (en) 1992-11-23 1992-11-23 Proteins
GB9227189.9 1992-12-31
GB929227189A GB9227189D0 (en) 1992-12-31 1992-12-31 Proteins

Publications (2)

Publication Number Publication Date
WO1994012625A2 WO1994012625A2 (en) 1994-06-09
WO1994012625A3 true WO1994012625A3 (en) 1994-07-21

Family

ID=26302037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/002375 Ceased WO1994012625A2 (en) 1992-11-23 1993-11-19 LIGAND BINDING VARIABLE DOMAIN (V-MIN) COMPRISING A FRAMEWORK REGION WITH A CYCLICALLY PERMUTED CENTRAL β-BARREL

Country Status (8)

Country Link
EP (1) EP0673417B1 (en)
AT (1) ATE242804T1 (en)
AU (1) AU5530394A (en)
DE (1) DE69333044T2 (en)
GB (2) GB9323648D0 (en)
IL (1) IL107708A0 (en)
MX (1) MX9307316A (en)
WO (1) WO1994012625A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof

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Also Published As

Publication number Publication date
GB2287247A (en) 1995-09-13
MX9307316A (en) 1994-06-30
EP0673417A1 (en) 1995-09-27
DE69333044T2 (en) 2004-04-29
GB9509600D0 (en) 1995-07-05
EP0673417B1 (en) 2003-06-11
AU5530394A (en) 1994-06-22
GB9323648D0 (en) 1994-01-05
ATE242804T1 (en) 2003-06-15
IL107708A0 (en) 1994-02-27
WO1994012625A2 (en) 1994-06-09
DE69333044D1 (en) 2003-07-17
GB2287247B (en) 1996-08-14

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