WO1994012670A3 - Process for typing of hcv isolates - Google Patents

Process for typing of hcv isolates Download PDF

Info

Publication number
WO1994012670A3
WO1994012670A3 PCT/EP1993/003325 EP9303325W WO9412670A3 WO 1994012670 A3 WO1994012670 A3 WO 1994012670A3 EP 9303325 W EP9303325 W EP 9303325W WO 9412670 A3 WO9412670 A3 WO 9412670A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
probe
nucleotide
isolate
hcv isolates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1993/003325
Other languages
French (fr)
Other versions
WO1994012670A2 (en
Inventor
Geert Maertens
Lieven Stuyver
Rudi Rossau
Heuverswyn Hugo Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26132445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1994012670(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP51276794A priority Critical patent/JP4251407B2/en
Priority to EP94901891A priority patent/EP0637342B1/en
Priority to US08/256,568 priority patent/US5846704A/en
Priority to DK94901891T priority patent/DK0637342T3/en
Priority to CA2128528A priority patent/CA2128528C/en
Priority to AU56282/94A priority patent/AU681612B2/en
Priority to DE69324678T priority patent/DE69324678T2/en
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Publication of WO1994012670A2 publication Critical patent/WO1994012670A2/en
Publication of WO1994012670A3 publication Critical patent/WO1994012670A3/en
Anticipated expiration legal-status Critical
Priority to GR990401727T priority patent/GR3030641T3/en
Priority to US09/899,302 priority patent/US6887985B2/en
Priority to US09/899,044 priority patent/US6548244B2/en
Priority to US09/899,082 priority patent/US6891026B2/en
Priority to US10/822,711 priority patent/US7258982B2/en
Priority to US11/826,099 priority patent/US8101351B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position -291 to nucleotide at position -66 of the 5' untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes; detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
PCT/EP1993/003325 1992-11-27 1993-11-26 Process for typing of hcv isolates Ceased WO1994012670A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP51276794A JP4251407B2 (en) 1992-11-27 1993-11-26 HCV isolate typing method
EP94901891A EP0637342B1 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
US08/256,568 US5846704A (en) 1992-11-27 1993-11-26 Process for typing of HCV isolates
DK94901891T DK0637342T3 (en) 1992-11-27 1993-11-26 Method for typing HCV isolates
CA2128528A CA2128528C (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
AU56282/94A AU681612B2 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
DE69324678T DE69324678T2 (en) 1992-11-27 1993-11-26 METHOD FOR TYPING HCV ISOLATES
GR990401727T GR3030641T3 (en) 1992-11-27 1999-06-30 Process for typing of hcv isolates.
US09/899,082 US6891026B2 (en) 1992-11-27 2001-07-06 Process for typing of HCV isolates
US09/899,044 US6548244B2 (en) 1992-11-27 2001-07-06 Process for typing HCV isolates
US09/899,302 US6887985B2 (en) 1992-11-27 2001-07-06 Process for typing of HCV isolates
US10/822,711 US7258982B2 (en) 1992-11-27 2004-04-13 Process for typing of HCV isolates
US11/826,099 US8101351B2 (en) 1992-11-27 2007-07-12 Process for typing of HCV isolates

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP92403222 1992-11-27
EP92403222.0 1992-11-27
EP93402129 1993-08-31
EP93402129.6 1993-08-31

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US08256568 A-371-Of-International 1993-11-26
US08/256,568 A-371-Of-International US5846704A (en) 1992-11-27 1993-11-26 Process for typing of HCV isolates
US09/038,369 Continuation US6171784B1 (en) 1992-11-27 1998-03-10 Process for typing of HCV isolates
US09/044,665 Division US6051696A (en) 1992-11-27 1998-03-19 Process for typing of HCV isolates

Publications (2)

Publication Number Publication Date
WO1994012670A2 WO1994012670A2 (en) 1994-06-09
WO1994012670A3 true WO1994012670A3 (en) 1994-07-21

Family

ID=26132445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/003325 Ceased WO1994012670A2 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates

Country Status (13)

Country Link
US (8) US5846704A (en)
EP (3) EP0905258A3 (en)
JP (2) JP4251407B2 (en)
AT (2) ATE507312T1 (en)
AU (1) AU681612B2 (en)
CA (1) CA2128528C (en)
DE (2) DE69324678T2 (en)
DK (1) DK0637342T3 (en)
ES (1) ES2133529T3 (en)
GR (1) GR3030641T3 (en)
HK (1) HK1047961A1 (en)
SG (1) SG46456A1 (en)
WO (1) WO1994012670A2 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69324678T2 (en) * 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent METHOD FOR TYPING HCV ISOLATES
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
CN1071977C (en) * 1993-03-05 2001-09-26 杰姆斯达发展公司 Apparatus and method using compressed codes for television program record scheduling
EP0984068B1 (en) * 1993-04-27 2012-03-28 Innogenetics N.V. Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US5830635A (en) * 1995-03-31 1998-11-03 Agnello; Vincent Method of detecting hepatitis C virus in tissues
US20020081577A1 (en) * 1995-06-06 2002-06-27 Robert L. Kilkuskie Oligonucleotides speciific for hepatitis c virus
BR9704637A (en) * 1996-01-26 1998-06-09 Innogenetics Nv Process for detecting drug-induced mutations in the reverse transcription gene
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
FR2750505B1 (en) * 1996-06-27 1998-10-16 Appligene Oncor PROCESS FOR THE PREPARATION OF ANALYSIS MEDIA FOR CHEMICAL OR BIOLOGICAL SUBSTANCES HAVING ORDERED SET OF REACTION AREAS
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
IL122299A (en) * 1997-11-25 2003-11-23 Broadcom Corp Video encoding device
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
WO1999060158A1 (en) * 1998-05-19 1999-11-25 Laboratory Of Molecular Biophotonics Solid phase for detecting nucleic acid and method for detecting nucleic acid
AR019932A1 (en) 1998-07-17 2002-03-27 United Video Properties Inc A PROVISION OF INTERACTIVE TELEVISION PROGRAMMING GUIDES THAT HAVE MULTIPLE DEVICES WITHIN A RESIDENCE OF A FAMILY GROUP AND A METHOD THAT USES IT
AR020608A1 (en) 1998-07-17 2002-05-22 United Video Properties Inc A METHOD AND A PROVISION TO SUPPLY A USER REMOTE ACCESS TO AN INTERACTIVE PROGRAMMING GUIDE BY A REMOTE ACCESS LINK
US6638714B1 (en) * 1999-02-03 2003-10-28 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
AU2006203092B2 (en) * 1999-02-03 2009-11-12 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
US6623919B1 (en) * 1999-02-03 2003-09-23 Ortho-Clinical Diagnostics, Inc Oligonucleotide primers for efficient multiplex detection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and methods of use thereof
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
KR100461715B1 (en) * 2001-03-27 2004-12-17 가부시끼가이샤 도시바 Detection of Nucleic Acid Associated with Disease
WO2002090572A2 (en) * 2001-05-09 2002-11-14 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
US7196183B2 (en) * 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US7877273B2 (en) * 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
FR2855832B1 (en) 2003-06-03 2007-09-14 Biomerieux Sa DIAGNOSTIC AND / OR PROGNOSTIC METHOD OF SEPTIC SYNDROME
FR2857375B1 (en) 2003-07-10 2007-11-09 Biomerieux Sa PROCESS FOR THE DETECTION AND / OR IDENTIFICATION OF STAPHYLOCOCCUS GENE BACTERIA
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
EP1536024B1 (en) * 2003-08-29 2016-08-17 Fujirebio Europe N.V. New hepatitis c virus clade and phototype sequences thereof
CA2552949C (en) 2004-01-07 2012-10-02 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
US20090209432A1 (en) * 2004-04-06 2009-08-20 Flinders Technologies Pty. Ltd. Detecting targets using nucleic acids having both a variable region and a conserved region
US8806533B1 (en) 2004-10-08 2014-08-12 United Video Properties, Inc. System and method for using television information codes
FR2881437B1 (en) 2005-01-31 2010-11-19 Biomerieux Sa METHOD FOR THE DIAGNOSIS / PROGNOSIS OF A SEPTIC SYNDROME
US8927208B2 (en) 2005-03-30 2015-01-06 Labo Bio-Medical Investments B.V. Identification of beta-papillomavirus DNA by type-specific reverse hybridization
US7919242B2 (en) * 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
WO2007087310A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
FR2906537A1 (en) 2006-09-28 2008-04-04 Biomerieux Sa METHOD FOR IN VITRO DIAGNOSIS OF BRONCHO-PULMONARY CANCER BY DETECTION OF ALTERNATIVE MAJORITY TRANSCRIPTS OF KLK8 GENE ENCODING KALLICREIN 8 AND USE THEREOF FOR THE PROGNOSIS OF SURVIVAL
EP2527474A1 (en) 2006-10-20 2012-11-28 Innogenetics N.V. Methodology for analysis of sequence variations within the HCV NS3/4A genomic region
EP2463390A1 (en) 2006-10-20 2012-06-13 Innogenetics N.V. Methodology for analysis of sequence variations within the HCV NS5B genomic region
US8418206B2 (en) 2007-03-22 2013-04-09 United Video Properties, Inc. User defined rules for assigning destinations of content
WO2009022939A1 (en) * 2007-08-09 2009-02-19 Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im. V.A. Engelgardta Ran (Imb Ran) Method for identifying the genotype and subtype of hepatitis c virus on a biological microchip
US8601526B2 (en) 2008-06-13 2013-12-03 United Video Properties, Inc. Systems and methods for displaying media content and media guidance information
KR101755037B1 (en) 2008-12-29 2017-07-19 주식회사 엘지화학 Method for detection of HCV at the real time PCR with intercalating dye
US20100240049A1 (en) * 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
CN102301008B (en) 2009-01-19 2015-05-13 生物梅里埃公司 Method for determining susceptibility of patients to developing nosocomial infections and establishing prognosis for progression of septic syndrome
US20100323344A1 (en) * 2009-06-18 2010-12-23 Ferguson Monique R Detection of hepatitis C virus RNA
US9204193B2 (en) 2010-05-14 2015-12-01 Rovi Guides, Inc. Systems and methods for media detection and filtering using a parental control logging application
US9422598B2 (en) 2010-06-04 2016-08-23 Biomerieux Method and kit for the prognosis of colorectal cancer
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
FR2970975B1 (en) 2011-01-27 2016-11-04 Biomerieux Sa METHOD AND KIT FOR DETERMINING IN VITRO THE IMMUNE STATUS OF AN INDIVIDUAL
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
ES2640570T3 (en) * 2012-10-18 2017-11-03 F. Hoffmann-La Roche Ag Double probe assay for HCV detection
FR3000966B1 (en) 2013-01-11 2016-10-28 Biomerieux Sa METHOD FOR ESTABLISHING IN VITRO A PROGNOSIS OF SEVERITY IN A SEPTIC SHOCK PATIENT
CN104178562B (en) 2013-05-21 2018-11-09 生物梅里埃股份公司 A kind of colorectal cancer prognosis kit
WO2018075633A2 (en) * 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
EP3643792B1 (en) 2018-10-24 2021-09-15 Fujirebio Europe N.V. Detection and analysis of sequence variations in a target nucleic acid
CN117947214A (en) * 2024-01-18 2024-04-30 圣湘生物科技股份有限公司 Composition, kit and use thereof for detecting and typing hepatitis C
WO2025172242A1 (en) 2024-02-13 2025-08-21 bioMérieux Method of assessing the risk of death of a patient

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461863A1 (en) * 1990-06-12 1991-12-18 Immuno Japan Inc. Oligonucleotide primers, and their application for high-fidelity detection of non-A, non-B hepatitis virus
EP0469348A2 (en) * 1990-07-11 1992-02-05 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. cDNA sequence and detection of hepatits C virus
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
WO1992019743A2 (en) * 1991-05-08 1992-11-12 Chiron Corporation Hcv genomic sequences for diagnostics and therapeutics

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
JPH02167081A (en) * 1988-12-21 1990-06-27 Tetsuo Nakamura Genome rna of hepatitis virus of non-a, non-b type, cdna and viral antigen protein
US5176994A (en) * 1988-12-21 1993-01-05 Immuno Japan Inc. Non-A, Non-B hepatitis virus genome RNA, cDNA and virus antigen protein
US5629158A (en) 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
JP2802125B2 (en) * 1989-06-23 1998-09-24 キヤノン株式会社 Nucleic acid detection method
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5620852A (en) 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
EP0834575B1 (en) * 1990-12-06 2001-11-28 Affymetrix, Inc. (a Delaware Corporation) Identification of nucleic acids in samples
EP0511559A1 (en) * 1991-04-30 1992-11-04 F.Hoffmann-La Roche & Co. Aktiengesellschaft Oligonucleotide probe reagent
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
ES2111589T3 (en) * 1991-08-27 1998-03-16 Hoffmann La Roche METHODS AND REAGENTS FOR THE DETECTION OF HEPATITIS C.
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
JPH06502770A (en) 1991-09-12 1994-03-31 シーダーズ−サイナイ・メディカル・センター Direct detection method for hepatitis C virus RNA
US5173994A (en) * 1992-01-14 1992-12-29 The United States Of America As Represented By The Secretary Of Agriculture Fiber cleaning apparatus with air flow deflector
EP0642589A4 (en) * 1992-05-11 1997-05-21 Ribozyme Pharm Inc Method and reagent for inhibiting viral replication.
JPH06153961A (en) 1992-11-27 1994-06-03 Imuno Japan:Kk Partial gene of hepatitis c virus and method for detecting gene of hepatitis c virus in high sensitivity
DE69324678T2 (en) 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent METHOD FOR TYPING HCV ISOLATES
US5820852A (en) * 1996-11-26 1998-10-13 The Proctor & Gamble Company Oral compositions containing fluoride, pyrophosphate, and peroxide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461863A1 (en) * 1990-06-12 1991-12-18 Immuno Japan Inc. Oligonucleotide primers, and their application for high-fidelity detection of non-A, non-B hepatitis virus
EP0469348A2 (en) * 1990-07-11 1992-02-05 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. cDNA sequence and detection of hepatits C virus
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
WO1992019743A2 (en) * 1991-05-08 1992-11-12 Chiron Corporation Hcv genomic sequences for diagnostics and therapeutics

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BUKH, J. ET AL: "sequence analysis of the noncoding region of hepatitis c virus", PROC. NATL. ACAD. SCI USA, vol. 89, June 1992 (1992-06-01), WASHINGTON, pages 4942 - 4946 *
HU, K-Q. ET AL: "direct detection of circulating hepatitis c virus rna.", JOURNAL OF CLINICAL INVESTIGATION, vol. 89, June 1992 (1992-06-01), NEW YORK US, pages 2040 - 2045 *
LEE, C-H. ET AL: "identification of hepatitis c virus with a nonconserved sequence of the 5' untranslated region.", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 30, no. 6, June 1992 (1992-06-01), WASHINGTON USA, pages 1602 - 1604 *
OKAMOTO, H. ET AL: "typing hepatitis c virus by polymerase chain reaction", JOURNAL OF GENERAL VIROLOGY, vol. 73, no. 3, March 1992 (1992-03-01), GB, pages 673 - 679 *

Also Published As

Publication number Publication date
US6891026B2 (en) 2005-05-10
EP1197568A2 (en) 2002-04-17
US20030036053A1 (en) 2003-02-20
AU681612B2 (en) 1997-09-04
ATE507312T1 (en) 2011-05-15
EP0637342A1 (en) 1995-02-08
US5846704A (en) 1998-12-08
US6548244B2 (en) 2003-04-15
EP1197568A3 (en) 2004-04-14
CA2128528C (en) 2012-02-14
HK1047961A1 (en) 2003-03-14
ATE179459T1 (en) 1999-05-15
US7258982B2 (en) 2007-08-21
EP1197568B1 (en) 2011-04-27
US6887985B2 (en) 2005-05-03
US6495670B1 (en) 2002-12-17
WO1994012670A2 (en) 1994-06-09
JP4251407B2 (en) 2009-04-08
EP0905258A2 (en) 1999-03-31
GR3030641T3 (en) 1999-10-29
DE69324678D1 (en) 1999-06-02
ES2133529T3 (en) 1999-09-16
EP0637342B1 (en) 1999-04-28
US6051696A (en) 2000-04-18
US6171784B1 (en) 2001-01-09
US20020168626A1 (en) 2002-11-14
DE69334357D1 (en) 2011-06-09
SG46456A1 (en) 1998-02-20
DE69324678T2 (en) 1999-12-09
AU5628294A (en) 1994-06-22
CA2128528A1 (en) 1994-06-09
US20020106638A1 (en) 2002-08-08
US20040191768A1 (en) 2004-09-30
DK0637342T3 (en) 1999-11-01
JPH07503143A (en) 1995-04-06
EP0905258A3 (en) 2001-01-31
JP2005040145A (en) 2005-02-17

Similar Documents

Publication Publication Date Title
WO1994012670A3 (en) Process for typing of hcv isolates
Viazov et al. Typing of hepatitis C virus isolates by DNA enzyme immunoassay
DE69435023D1 (en) SEQUENCES OF THE GENOTYPE OF HEPATITIS C-VIRUS AND THEIR USE AS MEDICAMENTS AND DIAGNOSTICS
Stuyver et al. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay
DE69126617T2 (en) NANBV DIAGNOSTICS: POLYNUCLEOTIDES USED FOR THE HEPATITIS C EXAMINATION
WO1996013590A3 (en) New sequences of hepatitis c virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
EP0465603A4 (en) Methods of detecting picornaviruses in biological fluids and tissues
IL93764A (en) Polynucleotides capable of hybridizing to a genomic sequence of hepatitis c virus, polypeptides encoded thereby and methods and kits using said polynucleotides or polypeptides
Tisminetzky et al. Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C
EP1985705A3 (en) Nucleotide sequences of pestivirus strains, polypeptides encoded by these sequences and use thereof for diagnosis and prevention of pestivirus infections
Bernier et al. Identification of numerous hepatitis C virus genotypes in Montreal, Canada
Driesel et al. Hepatitis C virus (HCV) genotype distribution in German isolates: studies on the sequence variability in the E2 and NS5 region
Fukushi et al. Nucleotide sequence of the 5′ noncoding region of hepatitis G virus isolated from Japanese patients: comparison with reported isolates
KR970703425A (en) Hepatitis G virus and its molecular cloning method (HEPATITIS G VIRUS AND MO-LECULAR CLONING THEREOF)
Forns et al. Comparative study of three methods for genotyping hepatitis C virus strains in samples from Spanish patients
Yu et al. Proton NMR resonance assignment of the active site residues of paramagnetic proteins by 2D bond correlation spectroscopy: metcyanomyoglobin
Weaver et al. Identification of Acinetobacter species
KR950704509A (en) Probe Diagnosis Probe
Lindstrom et al. Nuclear magnetic resonance and spin-label studies of hemoglobin Kempsey
ATE185377T1 (en) GENOMIC GENE MAPPING METHOD BY DIRECT DETECTION OF HAPLOTYPES USING INTRON SEQUENCE ANALYSIS
Vizmanos et al. Degree and distribution of variability in the 5'untranslated, E1, E2/NS1 and NS5 regions of the hepatitis C virus (HCV)
Li et al. Thermal denaturation of calf thymus DNA: existence of a GC-richer fraction
Sugiyama et al. Novel genotypes of hepatitis C virus in Thailand
Toniutto et al. Discordant results from hepatitis C virus genotyping by procedures based on amplification of different genomic regions
Castelain et al. Direct blotting electrophoresis for sequencing and genotyping hepatitis C virus

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AT AU BB BG BR BY CA CH CZ DE DK ES FI GB HU JP KP KR KZ LK LU LV MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 08256568

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2128528

Country of ref document: CA

AK Designated states

Kind code of ref document: A3

Designated state(s): AT AU BB BG BR BY CA CH CZ DE DK ES FI GB HU JP KP KR KZ LK LU LV MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1994901891

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 1994901891

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 1994901891

Country of ref document: EP