WO1994016675A1 - Pharmaceutical and dermocosmetic compositions containing equine colostrum - Google Patents

Pharmaceutical and dermocosmetic compositions containing equine colostrum Download PDF

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Publication number
WO1994016675A1
WO1994016675A1 PCT/EP1993/003655 EP9303655W WO9416675A1 WO 1994016675 A1 WO1994016675 A1 WO 1994016675A1 EP 9303655 W EP9303655 W EP 9303655W WO 9416675 A1 WO9416675 A1 WO 9416675A1
Authority
WO
WIPO (PCT)
Prior art keywords
colostrum
milk
equine
pharmaceutical
compositions according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1993/003655
Other languages
French (fr)
Inventor
Rosa Maria Gobbi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Horse Vitality Ltd
Original Assignee
Horse Vitality Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI930118 external-priority patent/IT1263819B/en
Priority claimed from IT93MI001417A external-priority patent/IT1264637B1/en
Priority to AU58339/94A priority Critical patent/AU5833994A/en
Priority to AT94904173T priority patent/ATE151278T1/en
Priority to EP94904173A priority patent/EP0675708B1/en
Priority to DE69309712T priority patent/DE69309712T2/en
Application filed by Horse Vitality Ltd filed Critical Horse Vitality Ltd
Priority to JP6516595A priority patent/JPH08505630A/en
Priority to CA002154652A priority patent/CA2154652C/en
Priority to US08/464,904 priority patent/US5750149A/en
Publication of WO1994016675A1 publication Critical patent/WO1994016675A1/en
Anticipated expiration legal-status Critical
Priority to GR970401677T priority patent/GR3024022T3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/986—Milk; Derivatives thereof, e.g. butter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/13—Burn treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Definitions

  • the present invention refers to pharmaceutical,, dermatological and cosmetic compositions containing equine colostrum optionally in admixture with equine milk or derivatives of equine colostrum or milk.
  • equine preferably refers to horses although other equine spe ⁇ cies can be used as sources of colostrum (or milk) ac ⁇ cording to the invention.
  • Colostrum is defined according to the invention as the mammary secretion occurring in the period starting from some days before delivery until some days after delivery, characterized by an immunoglobulin content of at least 1000 mg/dl. In certain phases of the secretion, this content may be remarkably higher.
  • the pharmaceutical and/or dermocosmetological and cosmetic compositions of the invention contain there ⁇ fore either equine colostrum as above defined or mixtu ⁇ res of colostrum and milk, in weight ratios ranging from 1:10 to 3:1, preferably from 1:9 to 2:1.
  • compositions of the in ⁇ vention when topically applied on the skin, are parti ⁇ cularly effective in the treatment of burns (caused by fire or sunlight) , contact lesions (caused by jelly fi ⁇ shes or, generally by vescicant agents), of cutaneous diseases such as acne, seborrhoic dermatitis, irrita ⁇ tions, dyscheratosis and dysmetabolic, dyspepsic forms, such as vascular cutaneous dystrophy, keratinization defects (psoriasis, ichtyosis) , chronic photodamages, atopic dermatitis, senile itching, photoerythema and other common dermatological diseases.
  • burns caused by fire or sunlight
  • contact lesions caused by jelly fi ⁇ shes or, generally by vescicant agents
  • dyspepsic forms such as vascular cutaneous dystrophy, keratinization defects (psoriasis, ichtyosis) , chronic photodamages,
  • equine colostrum and milk may also be formulated, in the above specified ra- tios , into cosmetic compositions having anti-burn, anti-lines, antiaging, moisturizing, protective, ten- sio-distensive, tonic, anti-relaxant, smoothing, anti- irritant, emollient, decongestionant, sun filtering, bleaching, lenitive sebum normalizing activities, repairing activity of damages by sun or radiant rays or generally by physical a chemical damages.
  • compositions of the invention may be effectively used, for instance, in cases of irritation of infants or children's skin caused by diapers, irritation after shave, and in all cases of irritation caused by atmo ⁇ spheric agents (sun, wind, cold etc).
  • the compositions of the invention may be effecti- vely used for the treatment of aging processes of the skin (antiaging action) caused both by physiological and by exogenous causes, such as noxious UV radiations, atmospheric agents, pollution etc. Thanks to their nu ⁇ tritive and sebumnormalizing action, the compositions of the invention may also be used in the treatment of diseases of the scalp and of hair, particularly of se- borrhoic dermatitis and consequent alopecia; dandruff; fragility, dryness of the hair and split hairs due to decoloration or perm processes or the like. The compositions of the invention are also useful for the prevention and treatment of cellulitis, coupe- rouse and hair loss and, because of their healing and antiallergic action, for the treatment of burns, erythemas etc.
  • compositions of the invention comprise creams, lotions, tonic lotions, emulsions, ointments, gels, masks, foams, milks, detergent milks, aspersory pourders, sun- and after-sun creams, oils, shampoos, hair conditioners, packs lipsticks, after-shave creams and lotions, and the like.
  • the compositions of the invention typically con ⁇ tain from 1 to 50% by weight of equine colostrum (or mixtures thereof with equine milk in the above specified ratios) according to the intended uses, with suitable excipients and adjuvants.
  • Formulations consisting of pure equine colostrum may also be provided.
  • Extractive or semi-synthetic derivatives of colo ⁇ strum may also be used.
  • the compositions of the invention may also optionally contain other active agents, having complementary or anyhow useful activity, such as anti- inflammatory, antibacterial, moisturizing, emollients, healing, repairing agents such as, for instance: Hedera elix, Centella asiatica, borage, calendula, sage, rose ⁇ mary, vegetable oils, pineapple, sea weeds, papaya, blackberry, domestic chestnut, red vine, malva, jaluro- nic acid, elastine, collagene, hamamelis, wheat germ, carrot, green clay, thymus, propolis, etc.
  • active agents having complementary or anyhow useful activity, such as anti- inflammatory, antibacterial, moisturizing, emollients, healing, repairing agents such as, for instance: Hedera elix, Centella asiatica, borage, calendula, sage, rose ⁇ mary, vegetable oils
  • the administration route and frequency will depend of course on the kind of formulation and of the desired effect but generally will be those typical for the kind of used formulations (creams 1 to 3 times a day; after ⁇ shave after each shaving; beauty mask once or more ti ⁇ mes a week; anti-irritating creams after each diaper change; shampoo and balsam once or more times a week and so on) .
  • Equine colostrum or milk can be used either fresh, e.g. immediately after milking, or in lyophilized or spray-dried form.
  • sterility of the formu ⁇ lation may be a necessary requisite; in this case, co ⁇ lostrum or milk may be subjected to gamma rays sterili ⁇ zation without alteration of their characteristics.
  • Equine colostrum can be frozen for its long-term preservation and thawed before its formulation in the final administration forms.
  • compositions of the invention may also contain conventional excipients usually used in the preparation of pharmaceutical and cosmetic formulations, such as thickening agents, emulsifiers, detergents, sufactants, preserving agents, hair-conditioners, perfumees, etc.
  • the formulations of the invention have been clini ⁇ cally tested in a variety of conditions. The results are reported hereinafter. Acne. Twelve 16-27 years old patients, affected by se- borroic acne, were treated twice a day with topi ⁇ cal application of cream containing 30% of horse colostrum in hydrosoluble base. In each case, the cutaneous lesions completely disappeared and re- stitutio ad integrum of the cutis took place within 6-12 days. Contact lesions.
  • Atopic dermatitis Seven patients affected by atopic dermatitis of medium degree, were treated with 20% emulsion of equine colostrum twice a day for 30 days. 10 Healthy subjects were treated analogously as a control group. The treatment turned out to be well tolerated also on dermatitic cutis and to be endowed with emollient, lenitive, anti-inflammato- ry activities higher than that of commonly availa ⁇ ble emulsions. No cases of sensitization or side- effect have been reported. The dryness of the skin was considerably reduced together with decrease of erythema and itching. Ulcerative cutaneous lesions.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Pharmaceutical and/or dermocosmetic compositions contain equine colostrum, preferably horse colostrum, optionally in admixture with milk.

Description

PHARMACEUTICAL AND DERMOCOSMETIC COMPOSITIONS CONTAI¬ NING EQUINE COLOSTRUM
The present invention refers to pharmaceutical,, dermatological and cosmetic compositions containing equine colostrum optionally in admixture with equine milk or derivatives of equine colostrum or milk. In the following description, the term "equine" preferably refers to horses although other equine spe¬ cies can be used as sources of colostrum (or milk) ac¬ cording to the invention.
Colostrum is defined according to the invention as the mammary secretion occurring in the period starting from some days before delivery until some days after delivery, characterized by an immunoglobulin content of at least 1000 mg/dl. In certain phases of the secretion, this content may be remarkably higher. The pharmaceutical and/or dermocosmetological and cosmetic compositions of the invention contain there¬ fore either equine colostrum as above defined or mixtu¬ res of colostrum and milk, in weight ratios ranging from 1:10 to 3:1, preferably from 1:9 to 2:1. It has been found that the compositions of the in¬ vention, when topically applied on the skin, are parti¬ cularly effective in the treatment of burns (caused by fire or sunlight) , contact lesions (caused by jelly fi¬ shes or, generally by vescicant agents), of cutaneous diseases such as acne, seborrhoic dermatitis, irrita¬ tions, dyscheratosis and dysmetabolic, dyspepsic forms, such as vascular cutaneous dystrophy, keratinization defects (psoriasis, ichtyosis) , chronic photodamages, atopic dermatitis, senile itching, photoerythema and other common dermatological diseases.
According to the invention, equine colostrum and milk may also be formulated, in the above specified ra- tios , into cosmetic compositions having anti-burn, anti-lines, antiaging, moisturizing, protective, ten- sio-distensive, tonic, anti-relaxant, smoothing, anti- irritant, emollient, decongestionant, sun filtering, bleaching, lenitive sebum normalizing activities, repairing activity of damages by sun or radiant rays or generally by physical a chemical damages.
Thanks to their lenitive and anti-irritant action, the compositions of the invention may be effectively used, for instance, in cases of irritation of infants or children's skin caused by diapers, irritation after shave, and in all cases of irritation caused by atmo¬ spheric agents (sun, wind, cold etc).
Thanks to their tonic, distensive action on wrink¬ les, the compositions of the invention may be effecti- vely used for the treatment of aging processes of the skin (antiaging action) caused both by physiological and by exogenous causes, such as noxious UV radiations, atmospheric agents, pollution etc. Thanks to their nu¬ tritive and sebumnormalizing action, the compositions of the invention may also be used in the treatment of diseases of the scalp and of hair, particularly of se- borrhoic dermatitis and consequent alopecia; dandruff; fragility, dryness of the hair and split hairs due to decoloration or perm processes or the like. The compositions of the invention are also useful for the prevention and treatment of cellulitis, coupe- rouse and hair loss and, because of their healing and antiallergic action, for the treatment of burns, erythemas etc.
Examples of compositions of the invention comprise creams, lotions, tonic lotions, emulsions, ointments, gels, masks, foams, milks, detergent milks, aspersory pourders, sun- and after-sun creams, oils, shampoos, hair conditioners, packs lipsticks, after-shave creams and lotions, and the like. The compositions of the invention typically con¬ tain from 1 to 50% by weight of equine colostrum (or mixtures thereof with equine milk in the above specified ratios) according to the intended uses, with suitable excipients and adjuvants. Formulations consisting of pure equine colostrum (distributed, for instance, in vials or bottles) may also be provided.
Extractive or semi-synthetic derivatives of colo¬ strum may also be used. Moreover, the compositions of the invention may also optionally contain other active agents, having complementary or anyhow useful activity, such as anti- inflammatory, antibacterial, moisturizing, emollients, healing, repairing agents such as, for instance: Hedera elix, Centella asiatica, borage, calendula, sage, rose¬ mary, vegetable oils, pineapple, sea weeds, papaya, blackberry, domestic chestnut, red vine, malva, jaluro- nic acid, elastine, collagene, hamamelis, wheat germ, carrot, green clay, thymus, propolis, etc. The administration route and frequency will depend of course on the kind of formulation and of the desired effect but generally will be those typical for the kind of used formulations (creams 1 to 3 times a day; after¬ shave after each shaving; beauty mask once or more ti¬ mes a week; anti-irritating creams after each diaper change; shampoo and balsam once or more times a week and so on) .
Equine colostrum or milk can be used either fresh, e.g. immediately after milking, or in lyophilized or spray-dried form. For certain applications, sterility of the formu¬ lation may be a necessary requisite; in this case, co¬ lostrum or milk may be subjected to gamma rays sterili¬ zation without alteration of their characteristics. Equine colostrum can be frozen for its long-term preservation and thawed before its formulation in the final administration forms.
The compositions of the invention may also contain conventional excipients usually used in the preparation of pharmaceutical and cosmetic formulations, such as thickening agents, emulsifiers, detergents, sufactants, preserving agents, hair-conditioners, parfumes, etc.
The formulations of the invention have been clini¬ cally tested in a variety of conditions. The results are reported hereinafter. Acne. Twelve 16-27 years old patients, affected by se- borroic acne, were treated twice a day with topi¬ cal application of cream containing 30% of horse colostrum in hydrosoluble base. In each case, the cutaneous lesions completely disappeared and re- stitutio ad integrum of the cutis took place within 6-12 days. Contact lesions. Five cases of cutaneous lesions with contact vesicles (jelly-fish) were topically tre¬ ated with two applications, at 12 hours intervals, of a cream containing 20% horse colostrum and 10% horse milk in hydrosoluble base, also containing peppermint and benzocaine. Pain immediately disap¬ peared and the lesions recovered within 24 hours. Sun burns. Thirty patients affected by sun burns with hyperthermia were treated twice a day with the same cream as used for contact lesions. Pain always immediately disappeared, with decrease of the cutaneous tension within 24 hours, followed in the subsequent days by normal sun-tan without de- squamation. (Children were treated with the same cream, containing camomille extract instead of peppermint) .
Fire burns Six cases of 2° degree fire burns and two of
3° degree burns were treated with the same cream and modalities as for sun burns. Again, pain di- sappearance was very fast and the complete resti- tutio ad integrum of epithelium occurred with one week.
Atopic dermatitis. Seven patients affected by atopic dermatitis of medium degree, were treated with 20% emulsion of equine colostrum twice a day for 30 days. 10 Healthy subjects were treated analogously as a control group. The treatment turned out to be well tolerated also on dermatitic cutis and to be endowed with emollient, lenitive, anti-inflammato- ry activities higher than that of commonly availa¬ ble emulsions. No cases of sensitization or side- effect have been reported. The dryness of the skin was considerably reduced together with decrease of erythema and itching. Ulcerative cutaneous lesions. Ten patients affected by cutaneous ulcerative lesions following to impair¬ ment of blood perfusion of primitive (vasculopathic) or secondary origin were treated twice a day for 20 days with a liposomial gel con¬ taining 20% of horse colostrum. No phlogistic ef- feet occurred upon application of the gel. The completely or partially impaired healing processes improved, starting from the third day of treatment in 7 patients. A significant repair of the cutane¬ ous lesion occurred in most cases. The following examples further illustrate the in¬ vention.
Example 1 Body cream Contents: Composition:
Horse Colostrum 3%
Horse Milk 20%
Maize Germ Oil 10%
Karite Butter 10% Sodium Lactate 2%
Glycerol 2%
Water q.s. Example 2
Face cream
Contents: Composition: Horse Colostrum 10%
Horse Milk 20%
Squalene 10%
Maize Germ Oil 10%
Karite Butter 10% Sodium Lactate 2%
Water q.s.
Example 3 Anti-ulcer and anti-burn cream Contents: Composition:
Horse Colostrum 20%
Horse Milk 10%
Beeswax 10%
Maize Germ Oil 10% Zinc oxide 7%
Panthenol 3%
Water q.s.

Claims

1. Pharmaceutical, dermatological and cosmetic compo¬ sitions containing equine colostrum optionally in ad- mixture with milk or derivatives of equine colostrum or milk.
2. Compositions according to claim 1 containing equine colostrum optionally in admixture with equine milk.
3. Compositions according to claim 2 containing horse colostrum.
4. Compositions according to any one of the preceding claims containing mixtures of milk and colostrum in ra¬ tios from 1:10 to 3:1.
5. Compositions according to any one of the preceding claims in form of creams, lotions, tonic lotions, emul¬ sions, ointments, gels, masks, foams, milks, detergent milks, aspersory pourders, sun- and after-sun creams, oils, shampoos, hair conditioners, packs lipsticks, af- ter-shave creams and lotions, and the like.
6. Use of equine colostrum or milk for the prepara¬ tion of a medicament for the treatment of dermatologi¬ cal diseases.
7. A method of cosmetic treatment comprising the to- pical application of equine colostrum optionally in ad¬ mixture with milk.
PCT/EP1993/003655 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum Ceased WO1994016675A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US08/464,904 US5750149A (en) 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum
CA002154652A CA2154652C (en) 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum
AT94904173T ATE151278T1 (en) 1993-01-26 1993-12-22 PHARMACEUTICAL AND DERMOCOSMETIC PRODUCTS CONTAINING HORSE ECOLOSTRUM
EP94904173A EP0675708B1 (en) 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum
DE69309712T DE69309712T2 (en) 1993-01-26 1993-12-22 PHARMACEUTICAL AND DERMOCOSMETIC AGENTS CONTAINING HORSE DECOLOSTRUM
AU58339/94A AU5833994A (en) 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum
JP6516595A JPH08505630A (en) 1993-01-26 1993-12-22 Pharmaceutical and skin cosmetic compositions containing equine colostrum
GR970401677T GR3024022T3 (en) 1993-01-26 1997-07-08 Pharmaceutical and dermocosmetic compositions containing equine colostrum.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI93A000118 1993-01-26
ITMI930118 IT1263819B (en) 1993-01-26 1993-01-26 Pharmaceutical, dermatological and cosmetic compsns contg. equine colostrum - opt. mixed with milk, for topical use e.g. in the treatment of burns, contact lesions and dermatological diseases
IT93MI001417A IT1264637B1 (en) 1993-07-01 1993-07-01 Pharmaceutical and/or dermocosmetological and cosmetic compositions containing equine colostrum
ITMI93A001417 1993-07-01

Publications (1)

Publication Number Publication Date
WO1994016675A1 true WO1994016675A1 (en) 1994-08-04

Family

ID=26330951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/003655 Ceased WO1994016675A1 (en) 1993-01-26 1993-12-22 Pharmaceutical and dermocosmetic compositions containing equine colostrum

Country Status (11)

Country Link
US (1) US5750149A (en)
EP (1) EP0675708B1 (en)
JP (1) JPH08505630A (en)
AT (1) ATE151278T1 (en)
AU (1) AU5833994A (en)
CA (1) CA2154652C (en)
DE (1) DE69309712T2 (en)
DK (1) DK0675708T3 (en)
ES (1) ES2102813T3 (en)
GR (1) GR3024022T3 (en)
WO (1) WO1994016675A1 (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026900A1 (en) * 1996-01-26 1997-07-31 Sylvie Limited Gastro-resistant pharmaceutical formulations containing colostrum and the use of colostrum for the treatment of erectile dysfunctions
WO1997026899A1 (en) * 1996-01-24 1997-07-31 Sylvie Limited Use of colostrum for the treatment of constipation
WO1997026898A1 (en) * 1996-01-24 1997-07-31 Sylvie Limited Gastro-resistant pharmaceutical formulations containing colostrum and the use of colostrum for the treatment of insomnia
WO1998036759A1 (en) * 1997-02-18 1998-08-27 Horse Vitality Ltd. Pharmaceutical compositions containing colostrum and the use of colostrum for the treatment of hair loss
WO1998051316A1 (en) * 1997-05-09 1998-11-19 Vander Way Limited Pharmaceutical formulations containing colostrum and the use of colostrum for the treatment of affections of the oral cavity
WO1998053836A1 (en) * 1997-05-27 1998-12-03 Anderson Michael R Improved gelled oxygen products
FR2781150A1 (en) * 1998-07-17 2000-01-21 Jean Noel Thorel Topical composition containing milk components in a carrier for treatment of greasy skins and especially acne
FR2783172A1 (en) * 1998-09-15 2000-03-17 Petit Leon Antoine Georges Le Lyophilized equine milk for the prevention and treatment of bucco-dental disorders such as gingivitis and periodontitis
US6202546B1 (en) 1995-11-08 2001-03-20 Northfield Laboratories Pty. Ltd Liquid colostrum for dairy products
SG83647A1 (en) * 1995-04-28 2001-10-16 Sara Lee De Nv Mouth-care products
EP1151754A1 (en) * 2000-05-05 2001-11-07 François Ballestra Use of a equine milk fraction for the inhibition of interleukin-1 production
WO2007000648A1 (en) * 2005-06-29 2007-01-04 You Biomedical Research S.R.L Pharmaceutical formulations containing colostrum and calcium folinate for te treatment of disorders of the oral cavity
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FR2808444A1 (en) * 2000-05-05 2001-11-09 Francois Ballestra USE OF A FRACTION OF EQUINE MILK FOR THE MANUFACTURE OF A COMPOSITION HAVING AN ACTIVITY OF INHIBITION OF THE PRODUCTION OF INTERLEUKIN-1 AND THE COMPOSITION THUS OBTAINED
EP1631243A4 (en) * 2003-04-09 2009-06-03 Dolhay Klinika Egeszseguegyi K Sexual hygienic composition
WO2007000648A1 (en) * 2005-06-29 2007-01-04 You Biomedical Research S.R.L Pharmaceutical formulations containing colostrum and calcium folinate for te treatment of disorders of the oral cavity
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KR20190060556A (en) * 2017-11-24 2019-06-03 주식회사 팜스킨 A cosmetic composition of fermented colostrum product for anti-acne
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US11413321B2 (en) 2017-12-26 2022-08-16 Hirotaro FUKUOKA Pharmaceutical composition for use in increasing hair, modifying scalp or skin, healing a wound, promoting osteogenesis, or modifying hair
US12343369B2 (en) 2017-12-26 2025-07-01 Hirotaro FUKUOKA Pharmaceutical composition for use in increasing hair, modifying scalp or skin, healing a wound, promoting osteogenesis, or modifying hair

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US5750149A (en) 1998-05-12
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ATE151278T1 (en) 1997-04-15
JPH08505630A (en) 1996-06-18
CA2154652C (en) 2005-05-03
DE69309712D1 (en) 1997-05-15
DK0675708T3 (en) 1997-10-20
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GR3024022T3 (en) 1997-10-31
DE69309712T2 (en) 1997-10-23

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