WO1994029456A3 - Herpes simplex virus type-2 protease - Google Patents

Herpes simplex virus type-2 protease Download PDF

Info

Publication number
WO1994029456A3
WO1994029456A3 PCT/US1994/005920 US9405920W WO9429456A3 WO 1994029456 A3 WO1994029456 A3 WO 1994029456A3 US 9405920 W US9405920 W US 9405920W WO 9429456 A3 WO9429456 A3 WO 9429456A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
herpes simplex
simplex virus
virus type
hsv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/005920
Other languages
French (fr)
Other versions
WO1994029456A2 (en
Inventor
Kevin R Steffy
Warren M Kati
Leonard Katz
Thomas P Mcgonigal
Aparna V Sarthy
Sharon E Schoen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to JP7501849A priority Critical patent/JPH08510918A/en
Priority to CA002164601A priority patent/CA2164601A1/en
Priority to EP94920039A priority patent/EP0708833A1/en
Publication of WO1994029456A2 publication Critical patent/WO1994029456A2/en
Publication of WO1994029456A3 publication Critical patent/WO1994029456A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/085—Orthoherpesviridae (F), e.g. pseudorabies virus or Epstein-Barr virus
    • C07K16/087—Herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Protease activity associated with herpes simplex virus (HSV) type 2 was identified. The complete nucleotide and amino acid sequence of the protease was determined. The HSV-2 nucleic acid segment encoding the protease substrate ICP35 was also sequenced. Recombinant vectors and host cells for expressing the protease are also described.
PCT/US1994/005920 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease Ceased WO1994029456A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP7501849A JPH08510918A (en) 1993-06-08 1994-05-25 Herpes simplex virus type 2 protease
CA002164601A CA2164601A1 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease
EP94920039A EP0708833A1 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7381993A 1993-06-08 1993-06-08
US24539094A 1994-05-23 1994-05-23
US08/073,819 1994-05-23
US08/245,390 1994-05-23

Publications (2)

Publication Number Publication Date
WO1994029456A2 WO1994029456A2 (en) 1994-12-22
WO1994029456A3 true WO1994029456A3 (en) 1995-03-02

Family

ID=26754923

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/005920 Ceased WO1994029456A2 (en) 1993-06-08 1994-05-25 Herpes simplex virus type-2 protease

Country Status (4)

Country Link
EP (1) EP0708833A1 (en)
JP (1) JPH08510918A (en)
CA (1) CA2164601A1 (en)
WO (1) WO1994029456A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714399A4 (en) * 1993-08-20 1999-01-27 Smithkline Beecham Corp Hsv-2 ul26 gene, capsid proteins, immunoassays and protease inhibitors
EP3756684A1 (en) 2009-05-22 2020-12-30 Genocea Biosciences, Inc. Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
JP6055776B2 (en) 2010-11-24 2016-12-27 ジェノセア バイオサイエンシーズ， インコーポレイテッド Vaccines against herpes simplex virus type 2: Compositions and methods for inducing an immune response
AU2012340712B2 (en) 2011-11-23 2017-09-14 Genocea Biosciences, Inc. Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response
US10350288B2 (en) 2016-09-28 2019-07-16 Genocea Biosciences, Inc. Methods and compositions for treating herpes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514830A2 (en) * 1991-05-24 1992-11-25 Arch Development Corporation Methods and compositions of a preparation and use of a herpes protease
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying

Also Published As

Publication number Publication date
WO1994029456A2 (en) 1994-12-22
EP0708833A1 (en) 1996-05-01
CA2164601A1 (en) 1994-12-22
JPH08510918A (en) 1996-11-19

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