WO1995002326A1 - Solutions for tissue preservation and bloodless surgery and methods using same - Google Patents

Solutions for tissue preservation and bloodless surgery and methods using same Download PDF

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Publication number
WO1995002326A1
WO1995002326A1 PCT/US1994/007872 US9407872W WO9502326A1 WO 1995002326 A1 WO1995002326 A1 WO 1995002326A1 US 9407872 W US9407872 W US 9407872W WO 9502326 A1 WO9502326 A1 WO 9502326A1
Authority
WO
WIPO (PCT)
Prior art keywords
ions
solutions
solution
maintenance
atp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/007872
Other languages
French (fr)
Inventor
Michael Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolife Solutions Inc
Original Assignee
Cryomedical Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryomedical Sciences Inc filed Critical Cryomedical Sciences Inc
Priority to EP94923461A priority Critical patent/EP0708595A4/en
Priority to JP7504696A priority patent/JPH09500380A/en
Priority to AU73320/94A priority patent/AU680928B2/en
Publication of WO1995002326A1 publication Critical patent/WO1995002326A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A blood substitute which contains a purge solution and a maintenance solution, the latter of which is useful for organ preservation is disclosed. The purge solution contains an aqueous solution of electrolytes at physiological concentrations, a macromolecular oncotic agent, a biological pH buffer, a simple sugar, and a substrate for the regeneration of ATP. The maintenance solution contains a second aqueous solution of electrolytes containing potassium ions (35-45 mM), sodium ions (80-120 mM), magnesium ions (2-10 mM), chloride ions (15-20 mM), and calcium ions (0.01-0.1 mM), an impermeant anion, mannitol, a macromolecular oncotic agent, at least one simple sugar, a substrate for the regeneration of ATP, and a biological pH buffer. Glutathione is an optional additive. The blood substitute solutions are also useful for preserving organs for later transplantation in subjects. Skin may be preserved in the maintenance solutions for extended periods under refrigeration.
PCT/US1994/007872 1993-07-16 1994-07-14 Solutions for tissue preservation and bloodless surgery and methods using same Ceased WO1995002326A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94923461A EP0708595A4 (en) 1993-07-16 1994-07-14 TISSUE PRESERVATION AND BLOOD SUBSTITUTION SOLUTIONS AND METHODS USING THE SAME
JP7504696A JPH09500380A (en) 1993-07-16 1994-07-14 Solution for tissue preservation and bloodless surgery, and method using the same
AU73320/94A AU680928B2 (en) 1993-07-16 1994-07-14 Solutions for tissue preservation and bloodless surgery and methods using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US092,456 1993-07-16
US08/092,456 US5405742A (en) 1993-07-16 1993-07-16 Solutions for tissue preservation and bloodless surgery and methods using same

Publications (1)

Publication Number Publication Date
WO1995002326A1 true WO1995002326A1 (en) 1995-01-26

Family

ID=22233307

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/007872 Ceased WO1995002326A1 (en) 1993-07-16 1994-07-14 Solutions for tissue preservation and bloodless surgery and methods using same

Country Status (6)

Country Link
US (2) US5405742A (en)
EP (1) EP0708595A4 (en)
JP (1) JPH09500380A (en)
AU (1) AU680928B2 (en)
CA (1) CA2167409A1 (en)
WO (1) WO1995002326A1 (en)

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CA2167409A1 (en) 1995-01-26
AU7332094A (en) 1995-02-13
US5405742A (en) 1995-04-11
AU680928B2 (en) 1997-08-14
US5514536A (en) 1996-05-07
JPH09500380A (en) 1997-01-14
EP0708595A1 (en) 1996-05-01
EP0708595A4 (en) 1997-11-19

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