WO1995003414A3 - Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor - Google Patents

Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor Download PDF

Info

Publication number
WO1995003414A3
WO1995003414A3 PCT/NL1994/000168 NL9400168W WO9503414A3 WO 1995003414 A3 WO1995003414 A3 WO 1995003414A3 NL 9400168 W NL9400168 W NL 9400168W WO 9503414 A3 WO9503414 A3 WO 9503414A3
Authority
WO
WIPO (PCT)
Prior art keywords
cav
virus
vaccines
antibodies
chicken anemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL1994/000168
Other languages
French (fr)
Other versions
WO1995003414A2 (en
Inventor
Mathieu Hubertus Maria Noteborn
Guus Koch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aesculaap BV
Original Assignee
Aesculaap BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT94925638T priority Critical patent/ATE236980T1/en
Priority to DE69432486T priority patent/DE69432486T2/en
Priority to JP50507295A priority patent/JP3829290B2/en
Priority to US08/454,121 priority patent/US6071520A/en
Priority to DK01205103T priority patent/DK1253201T3/en
Priority to CA002167578A priority patent/CA2167578C/en
Priority to AU75473/94A priority patent/AU703187B2/en
Priority to EP94925638A priority patent/EP0784685B1/en
Application filed by Aesculaap BV filed Critical Aesculaap BV
Priority to DK94925638T priority patent/DK0784685T3/en
Publication of WO1995003414A2 publication Critical patent/WO1995003414A2/en
Publication of WO1995003414A3 publication Critical patent/WO1995003414A3/en
Anticipated expiration legal-status Critical
Priority to US09/403,213 priority patent/US7253150B1/en
Priority to US09/740,676 priority patent/US7427658B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Novel proteins of the Chicken Anemia Virus are discribed and compositions for preventing or treating infections with that virus (CAV), in particular vaccines less pathogenic than the CAV itself, but yet leading to neutralizing antibodies in the immunized animal. Besides, there are described compositions containing antibodies against parts of the CAV for the control of infections with CAV and anti-idiotype antibodies. The invention also provides antibodies and test kits for the detection of CAV. Recombinant DNA molecules derived from CAV and host cells transfected therewith and vaccines based on these host cells are made possible by this invention. The invention also comprises living virus vaccines in which a piece of DNA is brought into a virus infectious to the host. Besides, the invention provides uses of proteins of CAV in the induction of apoptosis, in particular in tumor cells. It further provides the induction of cell death by means of gene therapy.
PCT/NL1994/000168 1990-09-12 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor Ceased WO1995003414A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU75473/94A AU703187B2 (en) 1993-07-20 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
JP50507295A JP3829290B2 (en) 1993-07-20 1994-07-19 Chicken anemia virus variants and vaccines and uses for them based on viral proteins VP1, VP2 and VP3 or viral coding sequences
US08/454,121 US6071520A (en) 1990-09-12 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
DK01205103T DK1253201T3 (en) 1993-07-20 1994-07-19 Chicken anemia virus mutants and vaccines based on the viral protein VP3 or sequences of this virus encoding therefore
CA002167578A CA2167578C (en) 1993-07-20 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor
EP94925638A EP0784685B1 (en) 1993-07-20 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor
DK94925638T DK0784685T3 (en) 1993-07-20 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or therefore coding virus sequences
AT94925638T ATE236980T1 (en) 1993-07-20 1994-07-19 CHICKEN ANAEMIA VIRUS MUTANT, VACCINES, AND USE BASED ON VIRUS PROTEINS VP1, VP2 AND VP3, OR VIRUS SEQUENCES CODING THEREOF
DE69432486T DE69432486T2 (en) 1993-07-20 1994-07-19 CHICKEN ANAEMY VIRUS MUTANTE, VACCINE, AND USE BASED ON VIRUS PROTEINS VP1, VP2 AND VP3, OR VIRUS-ENCODING VIRUS SEQUENCES
US09/403,213 US7253150B1 (en) 1991-09-11 1998-04-15 Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin
US09/740,676 US7427658B2 (en) 1990-09-12 2000-12-18 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9301272A NL9301272A (en) 1993-07-20 1993-07-20 Chicken Anemia Virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or coding sequences of that virus.
NL9301272 1993-07-20

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
PCT/NL1991/000165 Continuation-In-Part WO1992004446A1 (en) 1990-09-12 1991-09-11 Cloning of chicken anaemia dna
US08030335 Continuation-In-Part 1991-09-11
US08/030,335 Continuation-In-Part US5491073A (en) 1990-09-12 1991-09-11 Cloning of chicken anaemia DNA

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US08454121 A-371-Of-International 1994-07-19
US08/489,666 Continuation-In-Part US5922600A (en) 1990-09-12 1995-06-07 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1 VP2 and VP3 or sequences of that virus coding therefor
US08/482,161 Continuation-In-Part US6162461A (en) 1990-09-12 1995-06-07 Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor

Publications (2)

Publication Number Publication Date
WO1995003414A2 WO1995003414A2 (en) 1995-02-02
WO1995003414A3 true WO1995003414A3 (en) 1995-03-02

Family

ID=19862681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1994/000168 Ceased WO1995003414A2 (en) 1990-09-12 1994-07-19 Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor

Country Status (13)

Country Link
US (1) US5952002A (en)
EP (2) EP1253201B1 (en)
JP (1) JP3829290B2 (en)
AT (2) ATE401406T1 (en)
AU (1) AU703187B2 (en)
CA (1) CA2167578C (en)
DE (2) DE69435117D1 (en)
DK (2) DK1253201T3 (en)
ES (2) ES2196032T3 (en)
NL (1) NL9301272A (en)
PT (2) PT784685E (en)
WO (1) WO1995003414A2 (en)
ZA (1) ZA945275B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162461A (en) * 1990-09-12 2000-12-19 Leadd B.V. Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
US20080234466A1 (en) * 1990-09-12 2008-09-25 Noteborn Mathieu H M Delivery method for the tumor-specific apoptosis-inducing activity of apoptin
EP0878546A1 (en) * 1997-04-15 1998-11-18 Leadd B.V. A gene delivery vehicle expressing the apoptosis-inducing proteins VP2 and/or apoptin
EP0872552A1 (en) * 1997-04-15 1998-10-21 Leadd B.V. A gene delivery vehicle expressing the apoptosis-inducing proteins VP2 and/or Apoptin
US5789567A (en) * 1994-07-06 1998-08-04 Cornell Research Foundation, Inc. Chicken infectious anemia virus vaccine
GB9414888D0 (en) * 1994-07-23 1994-09-14 Univ Belfast Method and composition
DE69628431T2 (en) * 1995-06-07 2004-05-06 Leadd B.V. USES OF APOPTIN
WO1996040931A1 (en) * 1995-06-07 1996-12-19 Aesculaap B.V. Neutralizing conformational epitopes of chicken anemia virus
EP0927757A1 (en) * 1997-12-03 1999-07-07 Leadd B.V. Methods and means for inducing apoptosis by interfering with Bip-like proteins
US7361730B1 (en) * 1999-03-15 2008-04-22 University Of Maryland Surface localized colligin/Hsp47 in carcinoma cells
EP1199363A1 (en) * 2000-10-20 2002-04-24 Leadd B.V. Phosphorylation modifications of apoptin
AUPR567401A0 (en) * 2001-06-14 2001-07-12 University Of Melbourne, The Circovirus vaccines
DK2275132T3 (en) 2005-12-29 2021-05-17 Boehringer Ingelheim Animal Health Usa Inc MULTIVALENT PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PREPARING THEM
CA2635430A1 (en) 2005-12-29 2007-08-23 Boehringer Ingelheim Vetmedica, Inc. Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs
CN102311928B (en) * 2011-08-25 2013-04-24 中国农业科学院哈尔滨兽医研究所 Recombinant yeast engineering strain coexpressed by proteins of chicken anaemia viruses VP1 and VP2, construction method thereof and application thereof
RU2744193C2 (en) 2015-10-16 2021-03-03 Канзас Стейт Юниверсити Рисерч Фаундейшн Immunogenic compositions for immunization of pigs against circovirus type 3 and methods of prduction and application thereof
WO2017187131A1 (en) * 2016-04-26 2017-11-02 London School Of Hygiene & Tropical Medicine Reoviridae vaccine
CN113980146B (en) * 2021-11-11 2022-09-27 扬州优邦生物药品有限公司 Trimerization duck flavivirus E protein domainIII, and preparation method and application thereof
CN122167540B (en) * 2026-05-13 2026-07-07 华中农业大学 Recombinant protein combination of chicken infectious anemia virus VP1 and VP2 proteins and application thereof in preparation of subunit vaccine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004446A1 (en) * 1990-09-12 1992-03-19 Aesculaap B.V. Cloning of chicken anaemia dna
EP0483911A2 (en) * 1990-10-31 1992-05-06 Akzo N.V. Chicken anemia virus vaccine and diagnostic reagent
EP0533294A1 (en) * 1991-09-20 1993-03-24 Akzo Nobel N.V. Chicken anaemia agent vaccine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004446A1 (en) * 1990-09-12 1992-03-19 Aesculaap B.V. Cloning of chicken anaemia dna
EP0483911A2 (en) * 1990-10-31 1992-05-06 Akzo N.V. Chicken anemia virus vaccine and diagnostic reagent
EP0533294A1 (en) * 1991-09-20 1993-03-24 Akzo Nobel N.V. Chicken anaemia agent vaccine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NOTEBORN ET AL.: "Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle", JOURNAL OF VIROLOGY, vol. 65, no. 6, June 1991 (1991-06-01), pages 3131 - 3139 *

Also Published As

Publication number Publication date
EP1253201A2 (en) 2002-10-30
CA2167578A1 (en) 1995-02-02
DK0784685T3 (en) 2003-08-04
JPH09504941A (en) 1997-05-20
EP0784685B1 (en) 2003-04-09
EP0784685A2 (en) 1997-07-23
ES2311005T3 (en) 2009-02-01
JP3829290B2 (en) 2006-10-04
NL9301272A (en) 1995-02-16
DE69432486D1 (en) 2003-05-15
PT1253201E (en) 2008-10-27
ZA945275B (en) 1995-02-24
ES2196032T3 (en) 2003-12-16
WO1995003414A2 (en) 1995-02-02
DE69435117D1 (en) 2008-08-28
DK1253201T3 (en) 2008-11-17
PT784685E (en) 2003-08-29
CA2167578C (en) 2007-03-13
AU703187B2 (en) 1999-03-18
DE69432486T2 (en) 2004-03-04
EP1253201A3 (en) 2003-01-08
US5952002A (en) 1999-09-14
ATE236980T1 (en) 2003-04-15
ATE401406T1 (en) 2008-08-15
EP1253201B1 (en) 2008-07-16
AU7547394A (en) 1995-02-20

Similar Documents

Publication Publication Date Title
CA2167578A1 (en) Chicken anemia virus mutants and vaccines and uses based on the viral proteins vp1, vp2 and vp3 or sequences of that virus coding therefor
BR9712592A (en) Process to generate an infectious clone, recombinant nucleic acid, its molecule, modified RNA virus, cell infected with it, vaccine, protein and / or antigen, and diagnostic test
EP0837928A4 (en) RECOMBINANT CYTOMEGALOVIRUS-POXVIRUS, COMPOSITIONS AND USES
DE69536039D1 (en) A host cell containing a recombinant virus expressing an antigen and a recombinant virus expressing an immunostimulatory molecule
DE69519521D1 (en) COMPOSITION CONTAINING AN ANTIQUE-EXPRESSING RECOMBINANT VIRUS AND AN IMMUNE-STIMULATING MOLECULE-EXPRESSING RECOMBINANT VIRUS
ATE335831T1 (en) NUCLEIC ACID VECTOR, COMPOUND CONTAINING SUCH A VECTOR AND VACCINE FOR IMMUNIZATION AGAINST HEPATITIS
MX9700817A (en) Vr-2332 viral nucleotide sequence and methods of use.
WO2020223362A8 (en) Compositions useful for treatment of pompe disease
AU571128B2 (en) Expression of immunologically reactive aids viral protein
CN105899684B (en) Method and kit for quantifying pseudoviral particles removed from purified solution
NO994967L (en) Gene delivery vehicles expressing the apoptosis-inducing proteins VP2 and / or apoptin
NZ309172A (en) Neutralizing conformational epitopes of chicken anemia virus
AU686000B2 (en) Infectious peritonitis vaccine
WO1998023752A3 (en) Papilloma viruses, agents for detecting the same and for treating diseases caused by such viruses
WO1992014818A3 (en) Entomopoxvirus expression system comprising spheroidin or thymidine-kinase sequences
WO2000043514A3 (en) Human acid sensing ion channel and uses thereof
DE60136832D1 (en) ATCR-1, A HUMAN ACYLTRANSFERASE AND USES THEREOF
MX9709851A (en) Neutralizing conformational epitopes of chicken anemia virus.
CN1428427A (en) Endoplasmic target polypeptide expression box
WO2000017236A3 (en) Apoptosis related protein and uses therefor
WO2001083762A3 (en) 26343, a novel human oxidoreductase and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN HU JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 08485001

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 08454121

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2167578

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1994925638

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1994925638

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 1997 911092

Country of ref document: US

Date of ref document: 19970814

Kind code of ref document: A

WWG Wipo information: grant in national office

Ref document number: 1994925638

Country of ref document: EP