WO1995006726A3 - Dna molecule encoding for cellular uptake of mycobacterium tuberculosis - Google Patents

Dna molecule encoding for cellular uptake of mycobacterium tuberculosis Download PDF

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Publication number
WO1995006726A3
WO1995006726A3 PCT/US1994/009863 US9409863W WO9506726A3 WO 1995006726 A3 WO1995006726 A3 WO 1995006726A3 US 9409863 W US9409863 W US 9409863W WO 9506726 A3 WO9506726 A3 WO 9506726A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterium tuberculosis
dna molecule
protein
molecule encoding
cellular uptake
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/009863
Other languages
French (fr)
Other versions
WO1995006726A2 (en
Inventor
Lee W Riley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Priority to EP94926657A priority Critical patent/EP0724635A1/en
Priority to CA002170148A priority patent/CA2170148A1/en
Priority to JP7508259A priority patent/JPH09502095A/en
Priority to BR9407527A priority patent/BR9407527A/en
Publication of WO1995006726A2 publication Critical patent/WO1995006726A2/en
Publication of WO1995006726A3 publication Critical patent/WO1995006726A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis an ability to enter mammalian cells and to survive within macrophages. The protein encoded by this gene fragment is useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.
PCT/US1994/009863 1993-09-02 1994-09-01 Dna molecule encoding for cellular uptake of mycobacterium tuberculosis Ceased WO1995006726A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP94926657A EP0724635A1 (en) 1993-09-02 1994-09-01 Dna molecule encoding for cellular uptake of mycobacterium tuberculosis
CA002170148A CA2170148A1 (en) 1993-09-02 1994-09-01 Dna molecule encoding for cellular uptake of mycobacterium tuberculosis
JP7508259A JPH09502095A (en) 1993-09-02 1994-09-01 DNA molecule encoding the cellular uptake of Mycobacterium tuberculosis
BR9407527A BR9407527A (en) 1993-09-02 1994-09-01 Isolated dna molecule isolated protein or polypeptide recombinant dna expression system host cell vaccine to prevent infection and disease in mammals isolated antibody or binding portion of it and product for uptake of materials into mammalian cells and mammalian vaccination processes against passive immunization infection of infected mammals for detection of mycobacterium tuberculosis in a sample and cell uptake

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11844293A 1993-09-02 1993-09-02
US08/118,442 1993-09-02

Publications (2)

Publication Number Publication Date
WO1995006726A2 WO1995006726A2 (en) 1995-03-09
WO1995006726A3 true WO1995006726A3 (en) 1995-04-27

Family

ID=22378619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/009863 Ceased WO1995006726A2 (en) 1993-09-02 1994-09-01 Dna molecule encoding for cellular uptake of mycobacterium tuberculosis

Country Status (6)

Country Link
EP (1) EP0724635A1 (en)
JP (1) JPH09502095A (en)
CN (1) CN1133063A (en)
BR (1) BR9407527A (en)
CA (1) CA2170148A1 (en)
WO (1) WO1995006726A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008201A (en) * 1993-09-02 1999-12-28 Cornell Research Foundation, Inc. DNA molecule encoding for cellular uptake of mycobacterium tuberculosis and uses thereof
US6509151B1 (en) * 1993-09-02 2003-01-21 Cornell Research Foundation, Inc. DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof
EP0907751A2 (en) * 1996-04-29 1999-04-14 Gesellschaft für Biotechnologische Forschung mbH (GBF) Dna, rna and a protein useful for detection of a mycobacterial infection
US6444444B1 (en) * 1996-07-10 2002-09-03 Aventis Pasteur Limited Genes encoding mycobacterial proteins associated with cell binding and cell entry and uses thereof
US6224881B1 (en) * 1996-08-07 2001-05-01 Cornell Research Foundation, Inc. DNA molecule fragments encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof
US6072048A (en) * 1997-03-10 2000-06-06 Cornell Research Foundation, Inc. DNA molecule encoding for cellular uptake of Mycobacterium tuberculosis and uses thereof
US6177086B1 (en) 1997-05-06 2001-01-23 Cornell Research Foundation, Inc. DNA molecule conferring on Mycobacterium tuberculosis resistance against antimicrobial reactive oxygen and nitrogen intermediates
FR2767337B1 (en) * 1997-08-14 2002-07-05 Pasteur Institut NUCLEIC SEQUENCES OF POLYPEPTIDES EXPORTED FROM MYCOBACTERI ES, VECTORS COMPRISING THEM AND APPLICATIONS TO DIAGNOSIS AND THE PREVENTION OF TUBERCULOSIS
US6136324A (en) 1997-08-21 2000-10-24 Connaught Laboratories Limited Attenuated strains of mycobacteria
CN112899329B (en) * 2021-02-02 2022-05-10 成都可恩生物科技有限公司 Method for producing tuberculin pure protein derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARRUDA S;BOMFIM G;JOHNSON W D JR;RILEY L W;: "CLONING OF A MYCOBACTERIUM-TUBERCULOSIS GENE NECESSARY FOR INVASION OF CULTURED EPITHELIAL CELLS", ABSTR GEN MEET AM SOC MICROBIOL, vol. 92, 1992, pages 41 *
ARRUDA S;BOMFIN G;KNIGHTS R;HUIMA-BYRON T;RILEY L W ;: "Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells", SCIENCE, vol. 261, 10 September 1993 (1993-09-10), LANCASTER, PA, pages 1454 - 1457 *

Also Published As

Publication number Publication date
WO1995006726A2 (en) 1995-03-09
EP0724635A1 (en) 1996-08-07
JPH09502095A (en) 1997-03-04
BR9407527A (en) 1997-11-11
CA2170148A1 (en) 1995-03-09
CN1133063A (en) 1996-10-09

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