WO1995020602A3 - ANALOGS OF THYMOSIN α¿1? - Google Patents

ANALOGS OF THYMOSIN α¿1? Download PDF

Info

Publication number
WO1995020602A3
WO1995020602A3 PCT/US1995/000617 US9500617W WO9520602A3 WO 1995020602 A3 WO1995020602 A3 WO 1995020602A3 US 9500617 W US9500617 W US 9500617W WO 9520602 A3 WO9520602 A3 WO 9520602A3
Authority
WO
WIPO (PCT)
Prior art keywords
glu
lys
val
asn
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/000617
Other languages
French (fr)
Other versions
WO1995020602A2 (en
Inventor
Su-Sun Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha 1 Biomedicals Inc
Original Assignee
Alpha 1 Biomedicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha 1 Biomedicals Inc filed Critical Alpha 1 Biomedicals Inc
Priority to DE69534740T priority Critical patent/DE69534740T2/en
Priority to JP7520088A priority patent/JPH09508387A/en
Priority to AU15689/95A priority patent/AU1568995A/en
Priority to HK98114130.5A priority patent/HK1013296B/en
Priority to EP95907463A priority patent/EP0741746B1/en
Priority to CA002181477A priority patent/CA2181477C/en
Publication of WO1995020602A2 publication Critical patent/WO1995020602A2/en
Publication of WO1995020602A3 publication Critical patent/WO1995020602A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compression, Expansion, Code Conversion, And Decoders (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compounds of formula (I), wherein X is an acetyl or pyroglutamyl group and Z is -NH2, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Pro-NH2, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH2, or -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn with the proviso that when X is a pyroglutamyl group, Z is -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, and when X is an acetyl group, Z is other than -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn and methods for the production thereof.
PCT/US1995/000617 1994-01-28 1995-01-18 ANALOGS OF THYMOSIN α¿1? Ceased WO1995020602A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69534740T DE69534740T2 (en) 1994-01-28 1995-01-18 ANALOG OF THYMOSINE ALPHA 1
JP7520088A JPH09508387A (en) 1994-01-28 1995-01-18 Thymosin α (1) analogue
AU15689/95A AU1568995A (en) 1994-01-28 1995-01-18 Analogs of thymosin alpha1
HK98114130.5A HK1013296B (en) 1994-01-28 1995-01-18 Analogs of thymosin alpha 1
EP95907463A EP0741746B1 (en) 1994-01-28 1995-01-18 Analogs of thymosin alpha 1
CA002181477A CA2181477C (en) 1994-01-28 1995-01-18 Analogs of thymosin .alpha.1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/188,232 US6262230B1 (en) 1994-01-28 1994-01-28 Analogs of thymosin α1
US08/188,232 1994-01-28

Publications (2)

Publication Number Publication Date
WO1995020602A2 WO1995020602A2 (en) 1995-08-03
WO1995020602A3 true WO1995020602A3 (en) 1995-10-12

Family

ID=22692289

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/000617 Ceased WO1995020602A2 (en) 1994-01-28 1995-01-18 ANALOGS OF THYMOSIN α¿1?

Country Status (15)

Country Link
US (1) US6262230B1 (en)
EP (2) EP1688431A3 (en)
JP (2) JPH09508387A (en)
AT (1) ATE315583T1 (en)
AU (1) AU1568995A (en)
CA (1) CA2181477C (en)
DE (1) DE69534740T2 (en)
DK (1) DK0741746T3 (en)
ES (1) ES2259439T3 (en)
MY (1) MY114151A (en)
PE (1) PE29797A1 (en)
PT (1) PT741746E (en)
TW (1) TW396161B (en)
WO (1) WO1995020602A2 (en)
ZA (1) ZA95669B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006008781D1 (en) * 2005-05-04 2009-10-08 Lonza Ag SOLID PHASE-BONDED THYMOSINE-ALPHA1 AND ITS SYNTHESIS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002560A1 (en) * 1979-05-15 1980-11-27 Max Planck Gesellschaft Process for producing polypeptide alpha -thymosine and derivatives therefrom
DE3100974A1 (en) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Medicaments having immunoregulating action which contain thymosin alpha 1 fragments, and thymosin alpha 1 fragments
EP0200404A2 (en) * 1985-04-11 1986-11-05 Alpha-1 Biomedicals, Inc. Solid phase process for synthesizing peptides
US4659694A (en) * 1983-10-27 1987-04-21 Hoffmann-La Roche Inc. Prothymosin alpha
EP0341935A2 (en) * 1988-05-10 1989-11-15 Alpha-1 Biomedicals, Inc. A solid phase process for synthesizing Thymosin alpha 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL176255C (en) * 1971-07-01 1985-03-18 Hoechst Ag METHOD FOR PREPARING PEPTIDES
US4079127A (en) 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
CH641152A5 (en) * 1977-04-22 1984-02-15 Hoffmann La Roche Process for preparing thymosin alpha-1 and an analogue
US4116951A (en) 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
US4148788A (en) 1978-01-23 1979-04-10 Hoffmann-La Roche Inc. Synthesis of thymosin α1
US4612365A (en) * 1980-03-25 1986-09-16 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002560A1 (en) * 1979-05-15 1980-11-27 Max Planck Gesellschaft Process for producing polypeptide alpha -thymosine and derivatives therefrom
DE3100974A1 (en) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Medicaments having immunoregulating action which contain thymosin alpha 1 fragments, and thymosin alpha 1 fragments
US4659694A (en) * 1983-10-27 1987-04-21 Hoffmann-La Roche Inc. Prothymosin alpha
EP0200404A2 (en) * 1985-04-11 1986-11-05 Alpha-1 Biomedicals, Inc. Solid phase process for synthesizing peptides
EP0341935A2 (en) * 1988-05-10 1989-11-15 Alpha-1 Biomedicals, Inc. A solid phase process for synthesizing Thymosin alpha 1

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABIKO, TAKASHI ET AL: "Synthesis and immunological effect of deacetyl-thymosin.alpha.11 on low E-rosette-forming cells of a rheumatoid arthritis patient", CHEM. PHARM. BULL. (1985), 33(12), 5419-27 CODEN: CPBTAL;ISSN: 0009-2363 *
BARLOS, KLEOMENIS ET AL: "Synthesis of prothymosin.alpha. (Pro T.alpha.), a 109 amino acid residue protein", ANGEW. CHEM. (1991), 103(5), 572-5 (SEE ALSO ANGEW. CHEM., INT. ED. ENGL., 1991, 30(5), 590-3) CODEN: ANCEAD;ISSN: 0044-8249 *

Also Published As

Publication number Publication date
DE69534740T2 (en) 2006-11-02
AU1568995A (en) 1995-08-15
JPH09508387A (en) 1997-08-26
JP2006160751A (en) 2006-06-22
EP1688431A3 (en) 2006-11-29
ES2259439T3 (en) 2006-10-01
US6262230B1 (en) 2001-07-17
CA2181477C (en) 2002-01-01
HK1013296A1 (en) 1999-08-20
PE29797A1 (en) 1997-09-01
ZA95669B (en) 1996-07-29
EP1688431A2 (en) 2006-08-09
WO1995020602A2 (en) 1995-08-03
ATE315583T1 (en) 2006-02-15
EP0741746B1 (en) 2006-01-11
MY114151A (en) 2002-08-30
DK0741746T3 (en) 2006-05-29
EP0741746A1 (en) 1996-11-13
CA2181477A1 (en) 1995-08-03
DE69534740D1 (en) 2006-04-06
PT741746E (en) 2006-05-31
TW396161B (en) 2000-07-01
JP3931194B2 (en) 2007-06-13

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