WO1995021382A3 - Molecular analyzer and method of use - Google Patents

Molecular analyzer and method of use Download PDF

Info

Publication number
WO1995021382A3
WO1995021382A3 PCT/US1995/001591 US9501591W WO9521382A3 WO 1995021382 A3 WO1995021382 A3 WO 1995021382A3 US 9501591 W US9501591 W US 9501591W WO 9521382 A3 WO9521382 A3 WO 9521382A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
sample
test sample
target
detection reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/001591
Other languages
French (fr)
Other versions
WO1995021382A2 (en
Inventor
Robert E Fields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9401849A external-priority patent/GB9401849D0/en
Priority claimed from GB9402357A external-priority patent/GB9402357D0/en
Priority claimed from GB9404758A external-priority patent/GB9404758D0/en
Priority claimed from GB9413641A external-priority patent/GB9413641D0/en
Priority to AT95909512T priority Critical patent/ATE265686T1/en
Priority to EP95909512A priority patent/EP0752105B1/en
Priority to US08/687,589 priority patent/US5840573A/en
Priority to DE69532953T priority patent/DE69532953T8/en
Application filed by Individual filed Critical Individual
Priority to AU17454/95A priority patent/AU699986B2/en
Priority to JP52082095A priority patent/JP3383310B2/en
Publication of WO1995021382A2 publication Critical patent/WO1995021382A2/en
Publication of WO1995021382A3 publication Critical patent/WO1995021382A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

A molecular analyzer and method of use for sensitive, rapid and accurate detection of specific, or target, molecules or specific parts of molecules in a liquid sample to be detected without the use of radioisotopes. Apparatus for sealingly holding any number of sample tubes (23) containing a test sample and having pre-incorporated, internally contained detection reagents for removing unbound molecules from the sample tubes, as well as means for rapidly changing the temperature of the test sample and means for quantitating the target molecules without allowing molecules in the sample tube to contact the environment is provided. Alternatively, the apparatus may be adapted to receive detection reagents that are not preincorporated without exposing them or the test sample to the atmosphere.
PCT/US1995/001591 1994-02-01 1995-02-01 Molecular analyzer and method of use Ceased WO1995021382A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP52082095A JP3383310B2 (en) 1994-02-01 1995-02-01 Molecular analyzer and method of use
AU17454/95A AU699986B2 (en) 1994-02-01 1995-02-01 Molecular analyzer and method of use
AT95909512T ATE265686T1 (en) 1994-02-01 1995-02-01 MOLECULAR ANALYZER AND METHOD OF USE THEREOF
DE69532953T DE69532953T8 (en) 1994-02-01 1995-02-01 MOLECULAR ANALYZER AND METHOD FOR ITS USE
EP95909512A EP0752105B1 (en) 1994-02-01 1995-02-01 Molecular analyzer and method of use
US08/687,589 US5840573A (en) 1994-02-01 1995-02-01 Molecular analyzer and method of use

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB9401849A GB9401849D0 (en) 1994-02-01 1994-02-01 Reaction-chamber cassette
GB9402357A GB9402357D0 (en) 1994-02-08 1994-02-08 Sample processor
GB9404758A GB9404758D0 (en) 1994-03-11 1994-03-11 PCR workstation
GB9405565A GB9405565D0 (en) 1994-02-08 1994-03-21 Capillary tube holder and method of use
GB9413641A GB9413641D0 (en) 1994-07-06 1994-07-06 Tube holder and dispenser
GB9402357.9 1994-10-24
GB9421378A GB9421378D0 (en) 1994-02-01 1994-10-24 Molecular analyzer and method of use
GB9404758.6 1994-10-24
GB9401849.6 1994-10-24
GB9421378.2 1994-10-24
GB9413641.3 1994-10-24
GB9405565.4 1994-10-24

Publications (2)

Publication Number Publication Date
WO1995021382A2 WO1995021382A2 (en) 1995-08-10
WO1995021382A3 true WO1995021382A3 (en) 1995-11-09

Family

ID=27547213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/001591 Ceased WO1995021382A2 (en) 1994-02-01 1995-02-01 Molecular analyzer and method of use

Country Status (7)

Country Link
EP (1) EP0752105B1 (en)
JP (1) JP3383310B2 (en)
AT (1) ATE265686T1 (en)
AU (1) AU699986B2 (en)
CA (1) CA2182513A1 (en)
DE (1) DE69532953T8 (en)
WO (1) WO1995021382A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5976896A (en) * 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US5830657A (en) * 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
JP2000507350A (en) * 1996-03-19 2000-06-13 ユニバーシティー オブ ユタ リサーチ ファンデーション System for determining analyte concentration
US6126899A (en) * 1996-04-03 2000-10-03 The Perkins-Elmer Corporation Device for multiple analyte detection
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
CA2252571A1 (en) * 1996-05-01 1997-11-06 Visible Genetics Inc. Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
JP4281877B2 (en) * 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション System and method for performing and monitoring biological processes
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6025189A (en) * 1997-05-14 2000-02-15 3M Innovative Properties Company Apparatus for reading a plurality of biological indicators
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
GB9719673D0 (en) * 1997-09-17 1997-11-19 Glaxo Group Ltd Novel apparatus
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
DE10011529T1 (en) 1998-05-01 2011-09-01 Gen-Probe Incorporated Automatic diagnostic analyzer and method
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
US8409508B2 (en) 2002-04-23 2013-04-02 Biofire Diagnostics, Inc. Sample withdrawal and dispensing device
AU2003283064B2 (en) * 2002-11-20 2009-06-04 Qiagen Gmbh Centrifugal device and method for performing binding assays
AU2002952797A0 (en) * 2002-11-20 2002-12-05 Bio-Molecular Holdings Pty Limited Centrifugal device and method using same
DE60330045D1 (en) * 2002-12-20 2009-12-24 Corning Inc CAPILLARY ASSAY DEVICE AND METHOD
FR2938063B1 (en) * 2008-11-05 2014-09-19 Commissariat Energie Atomique DEVICE FOR PREPARING AND / OR PROCESSING A BIOLOGICAL SAMPLE
US8196479B2 (en) * 2009-10-20 2012-06-12 Midwest Research Institute, Inc. Portable multi-tube air sampler unit
CN105044320B (en) 2010-03-25 2017-02-22 艾博生物医药(杭州)有限公司 Detection apparatus for testing to-be-analyzed substance in liquid sample
KR20130029128A (en) 2010-07-23 2013-03-21 베크만 컬터, 인코포레이티드 Vessel for real time pcr
JP6062449B2 (en) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド Specimen container detection
BR112014011044A2 (en) 2011-11-07 2017-04-25 Beckman Coulter Inc magnetic damping for specimen transport system
BR112014010955A2 (en) 2011-11-07 2017-06-06 Beckman Coulter Inc system and method for processing samples
EP2776846B1 (en) 2011-11-07 2019-08-21 Beckman Coulter, Inc. Aliquotter system and workflow
KR20140092375A (en) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 Centrifuge system and workflow
KR102040996B1 (en) 2011-11-07 2019-11-05 베크만 컬터, 인코포레이티드 Robotic arm
JP2013230117A (en) * 2012-04-27 2013-11-14 Yokohama National Univ Heating and cooling device and heating and cooling method using same
GB201615320D0 (en) * 2016-09-09 2016-10-26 Invitron Ltd Point of care platform test
WO2020118255A1 (en) * 2018-12-07 2020-06-11 Element Biosciences, Inc. Flow cell device and use thereof
EP3992633B1 (en) 2020-10-28 2025-04-16 Tecan Trading Ag Robotic liquid handling system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998719A (en) * 1974-08-21 1976-12-21 Ceskoslovenska Akademie Ved Isotachophoretic columns
US4747919A (en) * 1987-01-16 1988-05-31 Large Scale Biology Corporation Apparatus and method for electrophoresis in tubes
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998719A (en) * 1974-08-21 1976-12-21 Ceskoslovenska Akademie Ved Isotachophoretic columns
US4747919A (en) * 1987-01-16 1988-05-31 Large Scale Biology Corporation Apparatus and method for electrophoresis in tubes
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control

Also Published As

Publication number Publication date
EP0752105B1 (en) 2004-04-28
DE69532953D1 (en) 2004-06-03
WO1995021382A2 (en) 1995-08-10
AU1745495A (en) 1995-08-21
JP3383310B2 (en) 2003-03-04
CA2182513A1 (en) 1995-08-10
ATE265686T1 (en) 2004-05-15
JPH09511572A (en) 1997-11-18
AU699986B2 (en) 1998-12-17
DE69532953T2 (en) 2005-06-02
DE69532953T8 (en) 2005-10-06
EP0752105A1 (en) 1997-01-08

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