WO1996013598A3 - Hybrid adenovirus-aav virus and method of use thereof - Google Patents

Hybrid adenovirus-aav virus and method of use thereof Download PDF

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Publication number
WO1996013598A3
WO1996013598A3 PCT/US1995/014018 US9514018W WO9613598A3 WO 1996013598 A3 WO1996013598 A3 WO 1996013598A3 US 9514018 W US9514018 W US 9514018W WO 9613598 A3 WO9613598 A3 WO 9613598A3
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WO
WIPO (PCT)
Prior art keywords
hybrid
aav
transgene
host cell
aav virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/014018
Other languages
French (fr)
Other versions
WO1996013598A2 (en
Inventor
James M Wilson
William M Kelley
Krishna J Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK00103600T priority Critical patent/DK1046711T3/en
Priority to JP8514801A priority patent/JPH10507928A/en
Priority to EP95942840A priority patent/EP0797678B1/en
Priority to DE69520448T priority patent/DE69520448T2/en
Priority to US08/836,087 priority patent/US5871982A/en
Priority to CA 2203808 priority patent/CA2203808C/en
Priority to DK95942840T priority patent/DK0797678T3/en
Priority to AT95942840T priority patent/ATE199938T1/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority to AU44055/96A priority patent/AU695811B2/en
Publication of WO1996013598A2 publication Critical patent/WO1996013598A2/en
Publication of WO1996013598A3 publication Critical patent/WO1996013598A3/en
Anticipated expiration legal-status Critical
Priority to GR20010400694T priority patent/GR3035845T3/en
Ceased legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2810/00—Vectors comprising a targeting moiety
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5' and 3' ITR sequences from an AAV, and a selected transgene. Also provided is a hybrid virus linked via a polycation conjugate to an AAV rep gene to form a single particle. These trans-infection particles are characterized by high titer transgene delivery to a host cell and the ability to stably integrate the transgene into the host cell chromosome. Also disclosed is the use of the hybrid vectors and viruses to produce large quantities of recombinant AAV.
PCT/US1995/014018 1994-10-28 1995-10-27 Hybrid adenovirus-aav virus and method of use thereof Ceased WO1996013598A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK95942840T DK0797678T3 (en) 1994-10-28 1995-10-27 Hybrid adenovirus AAV virus and methods for using it
EP95942840A EP0797678B1 (en) 1994-10-28 1995-10-27 Hybrid adenovirus-aav virus and method of use thereof
DE69520448T DE69520448T2 (en) 1994-10-28 1995-10-27 ADENOVIRUS-AAV SECOND VIRUS AND METHODS FOR USE THEREOF
US08/836,087 US5871982A (en) 1994-10-28 1995-10-27 Hybrid adenovirus-AAV virus and methods of use thereof
CA 2203808 CA2203808C (en) 1994-10-28 1995-10-27 Hybrid adenovirus-aav virus and method of use thereof
DK00103600T DK1046711T3 (en) 1994-10-28 1995-10-27 Recombinant adenophilic virus
JP8514801A JPH10507928A (en) 1994-10-28 1995-10-27 Hybrid adenovirus-AAV virus and methods of use thereof
AT95942840T ATE199938T1 (en) 1994-10-28 1995-10-27 ADENOVIRUS-AAV ZWITTERVIRUS AND METHODS OF USE THEREOF
AU44055/96A AU695811B2 (en) 1994-10-28 1995-10-27 Hybrid adenovirus-AAV virus and methods of use thereof
GR20010400694T GR3035845T3 (en) 1994-10-28 2001-05-11 Hybrid adenovirus-aav virus and method of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/331,384 US5856152A (en) 1994-10-28 1994-10-28 Hybrid adenovirus-AAV vector and methods of use therefor
US08/331,384 1994-10-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/246,320 Continuation US6251677B1 (en) 1997-08-25 1999-02-08 Hybrid adenovirus-AAV virus and methods of use thereof

Publications (2)

Publication Number Publication Date
WO1996013598A2 WO1996013598A2 (en) 1996-05-09
WO1996013598A3 true WO1996013598A3 (en) 1996-08-15

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Application Number Title Priority Date Filing Date
PCT/US1995/014018 Ceased WO1996013598A2 (en) 1994-10-28 1995-10-27 Hybrid adenovirus-aav virus and method of use thereof

Country Status (11)

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US (2) US5856152A (en)
EP (2) EP0797678B1 (en)
JP (1) JPH10507928A (en)
AT (2) ATE199938T1 (en)
AU (1) AU695811B2 (en)
DE (2) DE69520448T2 (en)
DK (2) DK0797678T3 (en)
ES (2) ES2278556T3 (en)
GR (1) GR3035845T3 (en)
PT (2) PT797678E (en)
WO (1) WO1996013598A2 (en)

Cited By (6)

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US7052881B2 (en) 1995-06-15 2006-05-30 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US7344883B2 (en) 2000-11-15 2008-03-18 Crucell Holland B.V. Complementing cell lines
US7468181B2 (en) 2002-04-25 2008-12-23 Crucell Holland B.V. Means and methods for the production of adenovirus vectors
US7790449B2 (en) 2001-12-17 2010-09-07 The Trustees Of The University Of Pennsylvania Adeno-associated virus (AAV) serotype 8 sequences, vectors containing the same, and uses therefor
US8524446B2 (en) 2001-11-13 2013-09-03 The Trustees Of The University Of Pennsylvania Method for detecting adeno-associated virus
US9890365B2 (en) 2014-03-09 2018-02-13 The Trustees Of The University Of Pennsylvania Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency

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US5856152A (en) * 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
DE69534166T2 (en) 1994-10-28 2006-03-09 Trustees Of The University Of Pennsylvania RECOMBINANT ADENOVIRUS AND METHODS OF USE THEREOF
US6924128B2 (en) * 1994-12-06 2005-08-02 Targeted Genetics Corporation Packaging cell lines for generation of high titers of recombinant AAV vectors
US5843742A (en) * 1994-12-16 1998-12-01 Avigen Incorporated Adeno-associated derived vector systems for gene delivery and integration into target cells
US5652224A (en) * 1995-02-24 1997-07-29 The Trustees Of The University Of Pennsylvania Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
US5756283A (en) * 1995-06-05 1998-05-26 The Trustees Of The University Of Pennsylvania Method for improved production of recombinant adeno-associated viruses for gene therapy
US6281010B1 (en) 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
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US20030027250A1 (en) * 1995-12-15 2003-02-06 Mitchell Lloyd G. Methods and compositions for use in spliceosome mediated RNA trans-splicing
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US6258595B1 (en) 1999-03-18 2001-07-10 The Trustees Of The University Of Pennsylvania Compositions and methods for helper-free production of recombinant adeno-associated viruses
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