WO1996015149A3 - Methods and compositions for screening for presynaptic calcium channel blockers - Google Patents

Methods and compositions for screening for presynaptic calcium channel blockers Download PDF

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Publication number
WO1996015149A3
WO1996015149A3 PCT/US1995/014776 US9514776W WO9615149A3 WO 1996015149 A3 WO1996015149 A3 WO 1996015149A3 US 9514776 W US9514776 W US 9514776W WO 9615149 A3 WO9615149 A3 WO 9615149A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
screening
compositions
calcium channel
channel blockers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/014776
Other languages
French (fr)
Other versions
WO1996015149A2 (en
Inventor
William A Catterall
Zu-Hang Sheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Priority to AT95941385T priority Critical patent/ATE193542T1/en
Priority to EP95941385A priority patent/EP0791013B1/en
Priority to JP8516272A priority patent/JPH10509945A/en
Priority to AU42823/96A priority patent/AU4282396A/en
Priority to DE69517331T priority patent/DE69517331T2/en
Publication of WO1996015149A2 publication Critical patent/WO1996015149A2/en
Publication of WO1996015149A3 publication Critical patent/WO1996015149A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.
PCT/US1995/014776 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers Ceased WO1996015149A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT95941385T ATE193542T1 (en) 1994-11-10 1995-11-09 METHODS AND COMPOUNDS FOR SCREENING PRESYNAPTIC CALCIUM CHANNEL INHIBITORS
EP95941385A EP0791013B1 (en) 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers
JP8516272A JPH10509945A (en) 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers
AU42823/96A AU4282396A (en) 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers
DE69517331T DE69517331T2 (en) 1994-11-10 1995-11-09 METHOD AND CONNECTIONS FOR SCREENING PRESYNAPTIC CALCIUM CHANNEL INHIBITORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/337,602 1994-11-10
US08/337,602 US5623051A (en) 1994-11-10 1994-11-10 Methods and compositions for screening for presynaptic calcium channel blockers

Publications (2)

Publication Number Publication Date
WO1996015149A2 WO1996015149A2 (en) 1996-05-23
WO1996015149A3 true WO1996015149A3 (en) 1996-08-22

Family

ID=23321213

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/014776 Ceased WO1996015149A2 (en) 1994-11-10 1995-11-09 Methods and compositions for screening for presynaptic calcium channel blockers

Country Status (8)

Country Link
US (2) US5623051A (en)
EP (1) EP0791013B1 (en)
JP (1) JPH10509945A (en)
AT (1) ATE193542T1 (en)
AU (1) AU4282396A (en)
CA (1) CA2206110A1 (en)
DE (1) DE69517331T2 (en)
WO (1) WO1996015149A2 (en)

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* Cited by examiner, † Cited by third party
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US5638972A (en) * 1988-06-17 1997-06-17 Druitt; Rodney Malcolm Linerless closure for carbonated beverage container
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
WO1997020218A1 (en) * 1995-12-01 1997-06-05 The Board Of Trustees Of The Leland Stanford Junior University Calcium channel modulator compositions and methods
JP2001502535A (en) * 1996-10-07 2001-02-27 プレジデント アンド フェロウズ オブ ハーバード カレッジ Cross-reference of platelet secretion transport protein related applications
AU5900198A (en) * 1996-12-20 1998-07-17 Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulation of vesicular release
WO1998038210A2 (en) * 1997-02-26 1998-09-03 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulation of vesicular release
US20050009884A1 (en) * 1997-06-30 2005-01-13 Dreyer Evan B. Calcium blockers to treat proliferative retinal diseases
AU727080B2 (en) 1997-06-30 2000-11-30 Allergan, Inc. Calcium blockers to treat proliferative vitreoretinopathy
EP0996857B1 (en) * 1997-07-17 2009-09-09 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6310059B1 (en) 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
EP1092026A2 (en) * 1998-07-02 2001-04-18 Incyte Pharmaceuticals, Inc. Neurotransmission associated proteins
US6686147B1 (en) 1998-07-15 2004-02-03 Ludwig Institute For Cancer Research Cancer associated antigens and uses therefor
DE60024664T2 (en) 1999-10-13 2006-07-06 The University Of British Columbia, Vancouver METHOD FOR IDENTIFYING COMPOUNDS THAT MODULATE NEURONAL ACTIVITY
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US7049084B2 (en) * 2001-05-30 2006-05-23 Ortho-Mcneil Pharmaceutical, Inc. Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore
US20030092039A1 (en) * 2001-08-01 2003-05-15 Third Wave Technologies, Inc. Screening nutraceuticals
IL160229A0 (en) * 2001-08-10 2004-07-25 Genset Sa Polynucleotides, polypeptides encoded thereby and their use
WO2004105750A1 (en) * 2003-05-30 2004-12-09 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
US8362021B2 (en) * 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
KR20160138297A (en) * 2014-04-04 2016-12-02 마르코 펠리지오니 Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004083A1 (en) * 1991-08-15 1993-03-04 The Salk Institute Biotechnology/Industrial Associates, Inc. Human calcium channel compositions and methods
WO1993013128A1 (en) * 1991-12-30 1993-07-08 Neurex Corporation Methods of producing analgesia and enhancing opiate analgesia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424397B1 (en) * 1988-04-04 1996-06-19 The Salk Institute Biotechnology Industrial Associates, Inc. Calcium channel compositions and methods
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004083A1 (en) * 1991-08-15 1993-03-04 The Salk Institute Biotechnology/Industrial Associates, Inc. Human calcium channel compositions and methods
WO1993013128A1 (en) * 1991-12-30 1993-07-08 Neurex Corporation Methods of producing analgesia and enhancing opiate analgesia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.LÉVÊQUE ET AL.: "Purification of the N-type Calcium Cannel Associated with Syntaxin and Synaptotagmin", J.BIOL.CHEM, vol. 9, no. 4, March 1994 (1994-03-01), USA, pages 6306 - 12, XP002006136 *

Also Published As

Publication number Publication date
WO1996015149A2 (en) 1996-05-23
US6090631A (en) 2000-07-18
DE69517331D1 (en) 2000-07-06
JPH10509945A (en) 1998-09-29
EP0791013B1 (en) 2000-05-31
ATE193542T1 (en) 2000-06-15
EP0791013A2 (en) 1997-08-27
AU4282396A (en) 1996-06-06
CA2206110A1 (en) 1996-05-23
DE69517331T2 (en) 2001-01-04
US5623051A (en) 1997-04-22

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