WO1996016594A3 - Verfahren und vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens - Google Patents

Verfahren und vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens Download PDF

Info

Publication number
WO1996016594A3
WO1996016594A3 PCT/DE1995/001690 DE9501690W WO9616594A3 WO 1996016594 A3 WO1996016594 A3 WO 1996016594A3 DE 9501690 W DE9501690 W DE 9501690W WO 9616594 A3 WO9616594 A3 WO 9616594A3
Authority
WO
WIPO (PCT)
Prior art keywords
indicator
blood
blood flow
indicator component
intracerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1995/001690
Other languages
English (en)
French (fr)
Other versions
WO1996016594A2 (de
Inventor
Andreas Hoeft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP8518043A priority Critical patent/JPH10509629A/ja
Priority to DE59509190T priority patent/DE59509190D1/de
Priority to EP95940114A priority patent/EP0794729B1/de
Priority to US08/849,050 priority patent/US5865757A/en
Publication of WO1996016594A2 publication Critical patent/WO1996016594A2/de
Publication of WO1996016594A3 publication Critical patent/WO1996016594A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A61B5/028—Measuring blood flow using tracers, e.g. dye dilution by thermo-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Es wird ein Verfahren und eine Vorrichtung zur Ermittlung der Hirndurchblutung und des intracraniellen Blutvolumens beschrieben. Nach Injektion einer vorgegebenen Menge eines Doppelindikators in den Blutkreislauf werden arterielle und venöse Messungen der im Blutkreislauf resultierenden Indikatorverdünnungskurven durchgeführt. Als Doppelindikator dient eine in ihrer Temperatur von der Körpertemperatur abweichende Farbstofflösung, bei der Wärme oder Kälte eine hochdiffusible Indikatorkomponente und Farbstoff, vorzugsweise Indocyaningrün (ICG), eine intravasale Indikatorkomponente bilden. Die Hirndurchblutung (CBF) wird aus dem Quotienten aus einem Verteilungskoeffizienten μtherm der hochdiffusiblen Indikatorkomponente (Therm) zwischen Blut und dem Gehirngewebe und der mittleren Transitzeit mtttherm der hochdiffusiblen Indikatorkomponente (Therm) durch das Gehirn berechnet. Das intracranielle Blutvolumen (ICBV) wird aus dem Produkt aus Hirndurchblutung (CBF) und der mittleren Transitzeit mttICG der intravasalen Indikatorkomponente (ICG) berechnet.
PCT/DE1995/001690 1994-12-01 1995-11-29 Verfahren und vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens Ceased WO1996016594A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP8518043A JPH10509629A (ja) 1994-12-01 1995-11-29 脳血流量ｃｂｆ、および脳内血液量ｉｃｂｖを決定するための方法および装置
DE59509190T DE59509190D1 (de) 1994-12-01 1995-11-29 Vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens
EP95940114A EP0794729B1 (de) 1994-12-01 1995-11-29 Vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens
US08/849,050 US5865757A (en) 1994-12-01 1995-11-29 Process and a device for determining the cerebral blood flow CBF, and the intracerebral blood volume ICBV

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4442751.4 1994-12-01
DE4442751 1994-12-01

Publications (2)

Publication Number Publication Date
WO1996016594A2 WO1996016594A2 (de) 1996-06-06
WO1996016594A3 true WO1996016594A3 (de) 1996-08-29

Family

ID=6534614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1995/001690 Ceased WO1996016594A2 (de) 1994-12-01 1995-11-29 Verfahren und vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens

Country Status (5)

Country Link
US (1) US5865757A (de)
EP (1) EP0794729B1 (de)
JP (1) JPH10509629A (de)
DE (1) DE59509190D1 (de)
WO (1) WO1996016594A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19635038A1 (de) * 1996-08-29 1998-03-12 Pulsion Verwaltungs Gmbh & Co Verfahren zur nicht invasiven Bestimmung des zerebralen Blutflusses mittels Nah-Infrarot-Spektroskopie
AUPO676397A0 (en) * 1997-05-13 1997-06-05 Dunlop, Colin Method and apparatus for monitoring haemodynamic function
US6339714B1 (en) 1999-09-13 2002-01-15 Bo Chen Apparatus and method for measuring concentrations of a dye in a living organism
EP1385429B1 (de) * 2000-10-25 2008-09-03 The John P. Robarts Research Institute Verfahren und vorrichtung zur berechnung von blutflussparametern
US6546275B2 (en) 2001-06-25 2003-04-08 Wisconsin Alumni Research Foundation Determination of the arterial input function in dynamic contrast-enhanced MRI
DE10120980B4 (de) * 2001-05-01 2009-12-03 Pulsion Medical Systems Ag Verfahren, Vorrichtung und Computerprogramm zur Bestimmung des Blutflusses in einer Gewebe- oder Organregion
US7248356B2 (en) 2004-04-06 2007-07-24 Pulsion Medical Systems Ag Calibration aid
WO2007087311A2 (en) * 2006-01-25 2007-08-02 The Trustees Of Columbia University In The City Of New York Systems and methods for determining a cardiovascular parameter using temperature sensitive magnetic resonance imaging
US8527034B2 (en) * 2007-07-11 2013-09-03 The General Hospital Corporation Image derived input function for PET lung assessment
US20100016731A1 (en) * 2008-07-15 2010-01-21 Cardiox Corporation Hemodynamic Detection of Circulatory Anomalies
US20110224536A1 (en) * 2008-08-01 2011-09-15 The Trustees Of Columbia University In The City Of New York Systems and methods for determining a temperature differential using temperature sensitive magnetic resonance imaging
US20110196245A1 (en) * 2008-10-07 2011-08-11 Orsan Medical Technologies Ltd. Measurement of cerebral hemodynamic parameters
JP5695667B2 (ja) * 2009-12-30 2015-04-08 プウルジョン メディカル システムズ エスイー 生理的ボリューム量を決定するための装置
US20120203122A1 (en) 2011-02-09 2012-08-09 Opher Kinrot Devices and methods for monitoring cerebral hemodynamic conditions
DE102011083708B4 (de) * 2011-09-29 2025-09-18 Siemens Healthineers Ag Angiographisches Bildauswerteverfahren zur Bestimmung von Blutflussparametern
WO2015041312A1 (ja) 2013-09-20 2015-03-26 国立大学法人旭川医科大学 血管内血流動態の画像処理方法及びシステム
JP6761468B2 (ja) * 2015-07-17 2020-09-23 クァンティウム メディカル エスエレ 覚醒、鎮静及び全身麻酔中の意識、痛み及び侵害受容のレベルを評価するデバイス及び方法
JP6949329B2 (ja) * 2017-10-25 2021-10-13 国立研究開発法人国立循環器病研究センター 脳血流量の測定装置の作動方法及び測定装置
KR102502930B1 (ko) 2020-12-30 2023-02-23 숭실대학교 산학협력단 fNIRS 데이터에서 다항회귀를 활용한 뇌 활성화 지역 추출 방법, 이를 수행하기 위한 기록 매체 및 장치
CN112957023A (zh) * 2021-01-31 2021-06-15 华南师范大学 一种多参数脑功能测量方法及装置

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BÖCK ET AL.: "Thermal recovery after passage of pulmonary circulation assessed by deconvolution", JOURNAL OF APPLIED PHYSIOLOGY, vol. 64, no. 3, March 1988 (1988-03-01), US, pages 1210 - 1216, XP000570031 *
HOEFT ET AL.: "Messung der Koronardurchblutung mit einem Doppelfiberoptiksystem und rechnergestützter Entfaltung von transkoronaren Farbstoffdilutionssignalen", BIOMEDIZINISCHE TECHNIK, vol. 28, no. 10, October 1983 (1983-10-01), BERLIN, DE, pages 216 - 220, XP002002986 *
SCHRÖDER ET AL.: "Calculation of body transport function", PHYSICS IN MEDICINE AND BIOLOGY, vol. 37, no. 11, November 1992 (1992-11-01), BRISTOL, GB, pages 2059 - 2069, XP000309567 *
WILSON ET AL.: "Measurment of jugular venous flow by thermal dilution", IEEE PROCEEDINGS OF THE 23RD ANNUAL CONFERENCE ON ENGINEERING IN MEDICINE AND BIOLOGY, vol. 12, 16 November 1970 (1970-11-16), NEW YORK, US, pages 276, XP002002985 *

Also Published As

Publication number Publication date
JPH10509629A (ja) 1998-09-22
DE59509190D1 (de) 2001-05-17
US5865757A (en) 1999-02-02
WO1996016594A2 (de) 1996-06-06
EP0794729A2 (de) 1997-09-17
EP0794729B1 (de) 2001-04-11

Similar Documents

Publication Publication Date Title
WO1996016594A3 (de) Verfahren und vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens
Aaslid et al. Assessment of cerebral autoregulation dynamics from simultaneous arterial and venous transcranial Doppler recordings in humans.
Sinoway et al. Characteristics of flow-mediated brachial artery vasodilation in human subjects.
US7209780B2 (en) System and a computer program for the determination of quantities relating to the circulatory system of a patient
US8715200B2 (en) System for determining the blood flow in a coronary artery
Clapp III Acute exercise stress in the pregnant ewe
AU9302498A (en) Method and apparatus for determining the pressure inside the brain
Drapanas et al. Hemodynamics of the interposition mesocaval shunt
WO1995018564A1 (en) Apparatus and method for measuring blood pressure
Trivedi et al. Relative changes in cerebral blood flow during cardiac operations using xenon-133 clearance versus transcranial Doppler sonography
Sliwka et al. Part one: Effects of sustained low-level elevations of carbon dioxide on cerebral blood flow and autoregulation of the intracerebral arteries in humans
GB2369443A (en) Method and device for arterial blood pressure measurement
Barnes et al. Differntiation of primary from secondary varicose veins by Doppler ultrasound and strain gauge plethysmography
Nielsen et al. Thermostatted measurement of systolic blood pressure on cooled fingers
Seiler et al. Effect of nimodipine on cerebrovascular response to CO2 in asymptomatic individuals and patients with subarachnoid hemorrhage: a transcranial Doppler ultrasound study
Spetz Peripheral circulation during normal pregnancy
Pietilä et al. Accelerated tissue expansion with the “overfilling” technique
Miller et al. Carbon dioxide reactivity in the evaluation of cerebral ischemia
Kramer et al. Comparison of cerebral blood flow measured by laser-Doppler flowmetry and hydrogen clearance in cats after cerebral insult and hypervolemic hemodilution
Marshall et al. Analysis of vascular responses evoked in the cutaneous circulation of one hand by cooling the contralateral hand
WO2002043789A3 (en) Multi-site thermographic profiling catheter
Dodds et al. Effect of flow on the resistance of modelled femoral artery stenoses
Hashimoto et al. Monitoring of hemodynamics in subarachnoid hemorrhage using transcranial Doppler and laser Doppler
Edwards et al. Is cerebrovascular autoregulation impaired during neurally-mediated syncope?
Griffths et al. Impedance cardiography: non-invasive cardiac output measurement after burn injury

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1995940114

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 08849050

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1995940114

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1995940114

Country of ref document: EP