WO1997005170A3 - Broad specificity antibodies - Google Patents

Broad specificity antibodies Download PDF

Info

Publication number
WO1997005170A3
WO1997005170A3 PCT/GB1996/001889 GB9601889W WO9705170A3 WO 1997005170 A3 WO1997005170 A3 WO 1997005170A3 GB 9601889 W GB9601889 W GB 9601889W WO 9705170 A3 WO9705170 A3 WO 9705170A3
Authority
WO
WIPO (PCT)
Prior art keywords
generic
antibodies
broad specificity
receptor
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1996/001889
Other languages
French (fr)
Other versions
WO1997005170A2 (en
Inventor
Michael Robert Anthony Morgan
Colin Malcolm Ward
Andrew Philip Wilkinson
Heather Avril Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minister of Agriculture Fisheries and Food UK
Original Assignee
Minister of Agriculture Fisheries and Food UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minister of Agriculture Fisheries and Food UK filed Critical Minister of Agriculture Fisheries and Food UK
Priority to EP96926469A priority Critical patent/EP0842197A2/en
Priority to AU66638/96A priority patent/AU6663896A/en
Priority to JP9507384A priority patent/JPH11510691A/en
Priority to CA002227599A priority patent/CA2227599A1/en
Publication of WO1997005170A2 publication Critical patent/WO1997005170A2/en
Publication of WO1997005170A3 publication Critical patent/WO1997005170A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method for producing broad specificity, generic, antibodies having a specific binding affinity for two or more of a class of compounds demonstrating a common mode of biological activity (e.g. organophosphate pesticides) comprising selecting a receptor or enzyme through which the class of compounds exert the biological activity, raising intermediate monoclonal antibodies against the recognition site of the receptor or enzyme, inoculating an animal with these iMABs or fragments thereof and recovering the generic antibodies from a body fluid or tissues of the animal. Also disclosed are generic polysera, generic antibodies, and cell lines for producing them, and also methods and kits for screening a sample for the presence or absence of compounds demonstrating a common mode of activity using generic antibodies.
PCT/GB1996/001889 1995-08-02 1996-08-01 Broad specificity antibodies Ceased WO1997005170A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP96926469A EP0842197A2 (en) 1995-08-02 1996-08-01 Broad specificity antibodies
AU66638/96A AU6663896A (en) 1995-08-02 1996-08-01 Broad specificity antibodies
JP9507384A JPH11510691A (en) 1995-08-02 1996-08-01 Broad specificity antibodies
CA002227599A CA2227599A1 (en) 1995-08-02 1996-08-01 Broad specificity antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9515850.7 1995-08-02
GBGB9515850.7A GB9515850D0 (en) 1995-08-02 1995-08-02 Broad specificity antibodies

Publications (2)

Publication Number Publication Date
WO1997005170A2 WO1997005170A2 (en) 1997-02-13
WO1997005170A3 true WO1997005170A3 (en) 1997-03-13

Family

ID=10778655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001889 Ceased WO1997005170A2 (en) 1995-08-02 1996-08-01 Broad specificity antibodies

Country Status (6)

Country Link
EP (1) EP0842197A2 (en)
JP (1) JPH11510691A (en)
AU (1) AU6663896A (en)
CA (1) CA2227599A1 (en)
GB (1) GB9515850D0 (en)
WO (1) WO1997005170A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252050B1 (en) 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
CN113049812B (en) * 2021-03-26 2024-03-19 信达安检测技术(天津)有限公司 ELISA method for detecting carbofuran and kit thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000472A1 (en) * 1986-07-23 1988-01-28 Aphton Corporation Immunogens and improved methods of making immunogens
WO1993017030A1 (en) * 1992-02-27 1993-09-02 The Horticulture And Food Research Institute Of New Zealand Limited Immunological detection of organophosphates
WO1994027149A1 (en) * 1993-05-18 1994-11-24 The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Methods, agents and kits for detection of organophosphorus compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000472A1 (en) * 1986-07-23 1988-01-28 Aphton Corporation Immunogens and improved methods of making immunogens
WO1993017030A1 (en) * 1992-02-27 1993-09-02 The Horticulture And Food Research Institute Of New Zealand Limited Immunological detection of organophosphates
WO1994027149A1 (en) * 1993-05-18 1994-11-24 The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Methods, agents and kits for detection of organophosphorus compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. WILKINSON ET AL.: "Antibodies to the pesticide interaction sites of parathion hydrolase and cutinase.", FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 7, no. 3, 1995, ABINGDON, GB, pages 273 - 281, XP000614947 *
C. SPINKS ET AL.: "Production and characterization of monoclonal anti-idiotype mimics for the pyrethroid insecticides and the herbicide paraquat.", FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 5, no. 1, 1993, ADINGDON, GB, pages 13 - 25, XP000614951 *
E. HELDMAN ET AL.: "A novel immunoassay with direct relevance to protection against organophosphate poisoning.", FEBS LETTERS, vol. 180, no. 2, January 1985 (1985-01-01), AMSTERDAM, NL, pages 243 - 248, XP002023908 *
J. SKERRITT ET AL.: "Testing cereal products and samples by immunoassay. Tests for organophosphate, carbamate, and pyrethroid grain protectants.", ACS SYMPOSIUM SERIES, vol. 451, 1991, WASHINGTON, DC, USA, pages 124 - 138, XP002023909 *

Also Published As

Publication number Publication date
JPH11510691A (en) 1999-09-21
AU6663896A (en) 1997-02-26
EP0842197A2 (en) 1998-05-20
CA2227599A1 (en) 1997-02-13
GB9515850D0 (en) 1995-10-04
WO1997005170A2 (en) 1997-02-13

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