WO1997006255A3 - Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods - Google Patents

Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods Download PDF

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Publication number
WO1997006255A3
WO1997006255A3 PCT/IB1996/001022 IB9601022W WO9706255A3 WO 1997006255 A3 WO1997006255 A3 WO 1997006255A3 IB 9601022 W IB9601022 W IB 9601022W WO 9706255 A3 WO9706255 A3 WO 9706255A3
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WO
WIPO (PCT)
Prior art keywords
primers
probes
detection methods
protein gene
gene family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1996/001022
Other languages
French (fr)
Other versions
WO1997006255A2 (en
Inventor
Robert G Korneluk
Alexander E Mackenzie
Stephen Baird
Peter Liston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Ottawa
Original Assignee
University of Ottawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/511,485 external-priority patent/US5919912A/en
Priority to EP96931191A priority Critical patent/EP0837939B1/en
Priority to US09/011,356 priority patent/US6656704B1/en
Priority to DE69635482T priority patent/DE69635482T2/en
Priority to CA002228635A priority patent/CA2228635C/en
Priority to JP50827797A priority patent/JP4458551B2/en
Application filed by University of Ottawa filed Critical University of Ottawa
Priority to AT96931191T priority patent/ATE310819T1/en
Publication of WO1997006255A2 publication Critical patent/WO1997006255A2/en
Publication of WO1997006255A3 publication Critical patent/WO1997006255A3/en
Anticipated expiration legal-status Critical
Priority to US09/201,936 priority patent/US6541457B2/en
Priority to US11/316,539 priority patent/US20070009971A1/en
Priority to US11/334,902 priority patent/US20060205021A1/en
Priority to US11/492,113 priority patent/US20070026470A1/en
Priority to US11/492,112 priority patent/US20070031904A1/en
Priority to US11/492,111 priority patent/US20070031903A1/en
Priority to US11/492,867 priority patent/US20070027304A1/en
Priority to US11/492,862 priority patent/US20070048772A1/en
Priority to US11/492,868 priority patent/US20070026494A1/en
Priority to US11/498,244 priority patent/US7776552B2/en
Priority to US11/498,897 priority patent/US20070066524A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract

Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
PCT/IB1996/001022 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods Ceased WO1997006255A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
AT96931191T ATE310819T1 (en) 1995-08-04 1996-08-05 MAMMAL APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, SAMPLES AND METHODS OF DETECTION
US09/011,356 US6656704B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
DE69635482T DE69635482T2 (en) 1995-08-04 1996-08-05 MOWERING APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, SAMPLES AND PROCEDURE FOR PROOF
CA002228635A CA2228635C (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
JP50827797A JP4458551B2 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitory protein gene family, primers, probes and detection methods
EP96931191A EP0837939B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
US09/201,936 US6541457B2 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
US11/316,539 US20070009971A1 (en) 1995-08-04 2005-12-22 Mammalian IAP gene family, primers, probes, and detection methods
US11/334,902 US20060205021A1 (en) 1995-08-04 2006-01-19 Mammalian IAP gene family, primers, probes and detection methods
US11/492,113 US20070026470A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,111 US20070031903A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,112 US20070031904A1 (en) 1995-08-04 2006-07-25 Mammalian IAP gene family, primers, probes and detection methods
US11/492,868 US20070026494A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/492,862 US20070048772A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/492,867 US20070027304A1 (en) 1995-08-04 2006-07-26 Mammalian IAP gene family, primers, probes and detection methods
US11/498,244 US7776552B2 (en) 1995-08-04 2006-08-03 Mammalian IAP gene family, primers, probes and detection methods
US11/498,897 US20070066524A1 (en) 1995-08-04 2006-08-04 Mammalian IAP gene family, primers, probes and detection methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/511,485 1995-08-04
US08/511,485 US5919912A (en) 1995-08-04 1995-08-04 Mammalian IAP antibodies and diagnostic kits
US08/576,956 US6156535A (en) 1995-08-04 1995-12-22 Mammalian IAP gene family, primers, probes, and detection methods
US08/576,956 1995-12-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08/576,956 Continuation-In-Part US6156535A (en) 1995-08-04 1995-12-22 Mammalian IAP gene family, primers, probes, and detection methods

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/011,356 A-371-Of-International US6656704B1 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods
US09011356 A-371-Of-International 1996-08-05
US09/201,932 Division US6689562B1 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
US09/201,936 Division US6541457B2 (en) 1995-08-04 1998-12-01 Mammalian IAP gene family, primers, probes and detection methods
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