WO1997012636A3 - Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope - Google Patents

Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope Download PDF

Info

Publication number
WO1997012636A3
WO1997012636A3 PCT/DE1996/001825 DE9601825W WO9712636A3 WO 1997012636 A3 WO1997012636 A3 WO 1997012636A3 DE 9601825 W DE9601825 W DE 9601825W WO 9712636 A3 WO9712636 A3 WO 9712636A3
Authority
WO
WIPO (PCT)
Prior art keywords
s2ny
radioisotopes
sulphide
bifunctional
forming agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1996/001825
Other languages
English (en)
French (fr)
Other versions
WO1997012636A2 (de
Inventor
Ludger Dinkelborg
Christoph Stephan Hilger
Wolfgang Kramp
Johannes Platzek
Bernd Raduechel
Sebastian Erber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Priority to AU14361/97A priority Critical patent/AU1436197A/en
Priority to EP96945141A priority patent/EP0851770A2/de
Publication of WO1997012636A2 publication Critical patent/WO1997012636A2/de
Publication of WO1997012636A3 publication Critical patent/WO1997012636A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft neue Verbindungen der allgemeinen Formel (I) M-L, worin M für ein Radioisotop von Tc oder Re und L für einen Liganden der allgemeinen Formel (II) R?1S-CR2R3-(CR4R5)¿n=1,2-S-CHR?6-CHR7-SO¿2-NH-(CR8R9)m=1,2-CO-B steht, worin R?1, R2, R3, R4, R5, R6, R7, R8, R9¿ unterschiedliche Bedeutung haben können und B für eine weitere Gruppe steht, die einerseits für die koordinative Bindung von Metallionen, andererseits für die Kopplung an sich selektiv anreichernde Verbindungen geeignet ist. Die neuen Verbindungen dienen zur Komplexierung von Technetium und Rhenium und werden in der medizinischen Diagnostik und Therapie eingesetzt.
PCT/DE1996/001825 1995-09-21 1996-09-19 Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope Ceased WO1997012636A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU14361/97A AU1436197A (en) 1995-09-21 1996-09-19 Bifunctional sulphide-containing sulphonamide s2ny-type chelate-forming agents for radioisotopes
EP96945141A EP0851770A2 (de) 1995-09-21 1996-09-19 Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s?2 ny für radioaktive isotope

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995136785 DE19536785A1 (de) 1995-09-21 1995-09-21 Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope
DE19536785.5 1995-09-21

Publications (2)

Publication Number Publication Date
WO1997012636A2 WO1997012636A2 (de) 1997-04-10
WO1997012636A3 true WO1997012636A3 (de) 1997-09-12

Family

ID=7773892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/001825 Ceased WO1997012636A2 (de) 1995-09-21 1996-09-19 Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ s2ny für radioaktive isotope

Country Status (5)

Country Link
EP (1) EP0851770A2 (de)
AU (1) AU1436197A (de)
CA (1) CA2232315A1 (de)
DE (1) DE19536785A1 (de)
WO (1) WO1997012636A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018497A2 (en) * 1996-10-28 1998-05-07 Nycomed Imaging As Contrast agents
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
ATE295369T1 (de) 1998-03-31 2005-05-15 Bristol Myers Squibb Pharma Co Pharmazeutika zur bildgebung der angiogenischen krankheiten
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349501A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (de) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Pharmazeutische zusammensetzungen, vitronectinrezeptor antagonisten enthaltend

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022493A1 (de) * 1993-03-31 1994-10-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Chelatbildner vom typ xn1s1x' für radioaktive isotope, deren metallkomplexe und ihre verwendung in diagnostik und therapie
WO1995003280A1 (en) * 1993-07-19 1995-02-02 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
WO1995005398A1 (en) * 1993-08-17 1995-02-23 Neorx Corporation S3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022493A1 (de) * 1993-03-31 1994-10-13 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Chelatbildner vom typ xn1s1x' für radioaktive isotope, deren metallkomplexe und ihre verwendung in diagnostik und therapie
WO1995003280A1 (en) * 1993-07-19 1995-02-02 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
WO1995005398A1 (en) * 1993-08-17 1995-02-23 Neorx Corporation S3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KWAMENA E BAIDOO ET AL: "SYNTHESIS OF A DIAMINEDITHIOL BIFUNCTIONAL CHELATING AGENT FOR INCORPORATION OF TECHNETIUM-99M INTO BIOMOLECULES", BIOCONJUGATE CHEMISTRY, vol. 1, no. 2, 1 January 1990 (1990-01-01), pages 132 - 137, XP000371813 *

Also Published As

Publication number Publication date
WO1997012636A2 (de) 1997-04-10
EP0851770A2 (de) 1998-07-08
AU1436197A (en) 1997-04-28
CA2232315A1 (en) 1997-04-10
DE19536785A1 (de) 1997-03-27

Similar Documents

Publication Publication Date Title
AU6129090A (en) Chelating agents for forming complexes with radioactive isotopes, metal complexes thereof and use thereof in diagnosis and therapy
UA32577C2 (uk) Радіомічена сполука для утворення зображення тромбів при радіонуклідній діагностиці, радіофармацевтичний препарат та радіофармацевтична композиція на їх основі та комплект для приготування радіофармацевтичних препаратів
IL109925A (en) Heteroatom-bearing dioxime derivatives, metal complexes thereof, methods for the preparation of suchcompounds and use of the complexes for the prepar ation of diagnostic pharmaceutical compositions
AU4299496A (en) Novel multiple-substituent dtpa derivatives and metal complexes thereof, pharmaceutical compositions containing such complexes, their use in diagnosis and therapy, methods ofpreparing the complexing agents and complexes and methods of preparing the pharmaceutical compositions
WO1997010852A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope
WO1997010853A3 (de) Bifunktionelle nicotinamid-chelatbildner vom typ n2s2 für radioaktive isotope
AU6501794A (en) Chelating agents of the type xn1s1o1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapy
DK0596586T3 (da) Fremgangsmåde til fremstilling af metalkomplekser af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyklododecan- og N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyklotetradecan-derivater.
AU2323197A (en) New ternary radiopharmaceutical complexes
IL110462A0 (en) Tris(isonitrile)copper(I) sulfate complexes and their preparation
AU6501894A (en) Chelators of type xn1s1x' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses
WO1997012850A3 (de) Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsny für radioaktive isotope
AU6501694A (en) Type s3n2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use
EP0588229A3 (en) Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
ZA851409B (en) Bis(aminomethyl)bicyclo(2.2.1)heptanes useful as metal ion control agents and radioactive metals complexed therewith
NO961743L (no) N-alkyl-peptid-chelatdannere, deres metallkomplekser med radionuklider, fremgangsmåte ved deres fremstilling og radiofarmasöytiske sammensetninger inneholdende disse forbindelser
NZ211192A (en) Bis(aminomethyl)bicyclo(2.2.1)heptane derivatives as chelating agents, as metal ion precipitating inhibitors and as radioactive bone seeking complexes
EP0431146A4 (en) Radionuclide metal chelates for the radiolabeling of proteins
HU9802311D0 (en) Chelating agents for complex formation with radioactive isotopes, their metal complexes and the use thereof for diagnostic and therapeutic purposes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA HU JP KR NO NZ US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1996945141

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2232315

Country of ref document: CA

Ref country code: CA

Ref document number: 2232315

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1996945141

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996945141

Country of ref document: EP