WO1997025086A2 - Inhalation device - Google Patents

Inhalation device Download PDF

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Publication number
WO1997025086A2
WO1997025086A2 PCT/GB1996/003141 GB9603141W WO9725086A2 WO 1997025086 A2 WO1997025086 A2 WO 1997025086A2 GB 9603141 W GB9603141 W GB 9603141W WO 9725086 A2 WO9725086 A2 WO 9725086A2
Authority
WO
WIPO (PCT)
Prior art keywords
conduit
plates
pocket
outlet
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1996/003141
Other languages
French (fr)
Other versions
WO1997025086A3 (en
Inventor
Gregor John Mclennan Anderson
Richard Ian Walker
Michael Birsha Davies
Philip William Farr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9600044.3A external-priority patent/GB9600044D0/en
Priority claimed from GBGB9625134.3A external-priority patent/GB9625134D0/en
Priority to AT96942494T priority Critical patent/ATE209053T1/en
Priority to US09/101,102 priority patent/US6065472A/en
Priority to PL96327616A priority patent/PL327616A1/en
Priority to DE69618624T priority patent/DE69618624T2/en
Priority to BR9612410A priority patent/BR9612410A/en
Priority to AU11633/97A priority patent/AU725348B2/en
Priority to APAP/P/1998/001285A priority patent/AP9801285A0/en
Priority to EA199900400A priority patent/EA001237B1/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to NZ324374A priority patent/NZ324374A/en
Priority to EP96942494A priority patent/EP0883414B1/en
Priority to EA199800556A priority patent/EA001016B1/en
Priority to IL12518396A priority patent/IL125183A0/en
Priority to JP9524939A priority patent/JP2000503565A/en
Publication of WO1997025086A2 publication Critical patent/WO1997025086A2/en
Publication of WO1997025086A3 publication Critical patent/WO1997025086A3/en
Priority to IS4787A priority patent/IS4787A/en
Priority to NO983069A priority patent/NO983069L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
    • B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
    • B65D83/0454—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments the whole forming a circular container with rotating parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2583/00—Containers or packages with special means for dispensing contents
    • B65D2583/04—For dispensing annular, disc-shaped or spherical or like small articles or tablets
    • B65D2583/0404—Indications, e.g. directions for use
    • B65D2583/0409—Indications, e.g. directions for use of dates or follow-numbers

Definitions

  • This invention relates to an inhalation device by means of which metered doses of
  • medicament in the form of a powder can be dispensed to a user.
  • Inhalation devices are known to be used for local administration of drugs to the respiratory tract and lungs of patients.
  • a fresh blister is indexed to bring it into registration with a use station and then punctured with a puncturing member in two distinct actions to
  • Another inhalation device described in UK Patent No. 2242134 is for use with peelable medicament packs defining containers for holding the medicament
  • Medicament for administration by inhalation should be of a controlled particle
  • fine powders for example micronised powders
  • EP96.03274 describes how, by careful sizing of fine
  • agglomerates of powder can be easily handled and may be used to
  • baffles comprise a number of components rendering the device
  • GB 2191718 relates to aerosol devices for dispensing nicotine.
  • the nicotine dispensing device has an impaction means designed to separate the spray
  • PCT/EP93/00582 also describes a device comprising baffles which are acting
  • PCT/EP93/00582 is the high deposition of powder which can occur due to the baffles extending from the walls of the device at 90° to the direction of airflow.
  • an inhalation device According to the present invention there is provided an inhalation device
  • holder defining at least one pocket for containing a single dose of medicament
  • closure member in the form of a powder, a closure member having at least one closure pad
  • the device may also comprise
  • baffles comprise a plurality of staggered plates extending into the conduit from opposite sides of the conduit at an angle of less
  • the device contains at least 2 plates and more preferably 4 plates.
  • the said plates are inclined at an angle less than 70° to the
  • said plates are inclined at an angle in the range of 15° to 50°.
  • the penultimate baffle is shaped so that at some point along the plate it
  • conduit and a second face of which extends towards the outlet substantially parallel to the longitudinal axis of the conduit. This enables the airflow to exit
  • Figure 1 is a perspective view of an assembled device according to the invention
  • Figure 2 is an exploded perspective view of the device of Figure 1 showing the main body components and primary pack;
  • Figure 3 is an exploded perspective view of the device showing each component in disassembled form
  • Figure 4 is a plan view partly in section showing air flow through a preferred embodiment of the invention.
  • Figure 5 is a perspective view showing airflow through the device shown in Figure 4.
  • Figure 6 is a cut away view showing the pocket closure pad held in the raised position
  • the device shown in Figures 1 to 3 comprises a body 1 formed of a body base 2
  • Body top 3 is formed with window 4 the purpose of
  • the body 1 defines a main housing section adapted
  • a primary pack comprising a dose ring 6 and closure means in the form of a spider 7, and a mouthpiece section 8 forming an outlet through which
  • a user can inhale extending radially from the main housing section. As seen in
  • the mouthpiece section 8 of body base 2 is formed with a plurality of
  • baffles 9 which are explained below.
  • a medicament holder in the form of a disk or dose ring 6 comprises an upper
  • Each pocket 10 is
  • the dose ring shown is provided with
  • the dose ring might have more or fewer pockets depending on
  • Suitable powdered medicaments are, for example,
  • Preferred medicaments are salbutamol, salbutamol sulphate,
  • salmeterol salmeterol xinafoate, fluticasone propionate, beclomethasone dipropionate or solvates thereof and terbutaline sulphate.
  • fluticasone propionate fluticasone propionate
  • beclomethasone dipropionate or solvates thereof terbutaline sulphate.
  • powdered medicaments include antiviral medicaments, for example zanamivir
  • the powder medicament may, if desired, be a combination of two or more active ingredients.
  • a dose may be constituted from the contents of one or more
  • cavities and the size of each cavity will depend on the dose to be delivered. It is
  • the medicament powder may consist purely of one or
  • active ingredients or there may additionally be a carrier, for example
  • the dose ring 6 may be adapted for filling with agglomerated powder in
  • the dose ring 6 has a stepped peripheral edge the purpose of which is
  • the dose ring may also be moulded from a plastics material such as
  • the spider 7 comprises a central ring shaped section 11 from which extend a
  • Each radial arm 12 terminates in a
  • a plurality of short resilient hooked tabs 14 extend
  • the spider 7 may be moulded from a plastics material such as polycarbonate or any other engineering plastics which has the required
  • each pocket closure pad 13 is resiliently
  • the pocket closure pads may be moulded with a
  • ring 6 or raised lip 28 ( Figure 6), or alternatively may be provided with a soft
  • sealing material such as a thermoplastic elastomer, eg SANTOPRENE (Bayer),
  • the spider may be moulded with a channel 15 formed in the upper face of
  • each of the pocket closure pads 13 may have a number 17 or other
  • each pocket closure pad 13 is formed with a tab 16 adapted for engagement with a ramp 20 ( Figures 4 and 5) integrally formed with body top 3
  • the primary pack fits into the main housing section of the body 1 as shown in Figures 2 and 3 such that axle 21 of body base 2 is located within the hole in
  • Pawl 24 on body base 2 engages with teeth (not shown) on the underside of
  • Pockets 10 may be filled with agglomerated powder as described in PCT patent
  • respirable range that is smaller than 5 microns.
  • baffles can be formed in a single moulding with the body, so
  • baffles present will depend on the number and exact dimensions of baffles present
  • FIGS. 4 and 5 show a preferred arrangement of baffles 9 comprising of a plurality of staggered flat plates which extend into the conduit at angles of 30° to
  • baffles extend beyond the longitudinal axis of the conduit with the final baffle
  • a mouthpiece cover 22 is adapted to fit over the mouthpiece section 8 when the
  • mouthpiece cover has two pins 30 adapted to pass through two slots 23 into the main housing section of body 1 either side of the mouthpiece section 8 to
  • the user To operate the device the user first removes mouthpiece cover 22 thereby unlocking the primary pack. The user then indexes a pocket to bring it into
  • the pocket 10 engages with the sides of the exit channel 29 creating an
  • pocket closure pad 13 is in a raised position clear of the upper surface of the dose ring 6 as shown in Figure 6. In this position, pocket closure pad 13 is
  • medicament powder in the pocket is entrained in the turbulent air flow, drawn through the mouthpiece section 8 and inhaled by the user.
  • baffles 9 are arranged to disrupt the smooth flow of air
  • conduit attached to the penultimate baffle in the direction of airflow enables the

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manipulator (AREA)
  • Catching Or Destruction (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A powder inhalation device comprising a housing containing a pharmacologically active compound, a conduit (8) with an outlet extending into the housing through which a user can inhale to create an airflow through the conduit, a dosing unit (6, 7) for delivering a dose of the compound to the conduit and baffles (9) arranged within the said conduit to aid disintegration of powder agglomerates entrained in said airflow. The baffles (9) comprise a plurality of staggered plates extending into the conduit from opposite sides of the conduit at an angle of less than 90° to the sides of the conduit and are inclined towards the outlet to create a plurality of constrictions within the conduit and a plurality of changes in the direction of the said airflow through the conduit.

Description

INHALATION DEVICE
This invention relates to an inhalation device by means of which metered doses of
medicament in the form of a powder can be dispensed to a user.
Inhalation devices are known to be used for local administration of drugs to the respiratory tract and lungs of patients. One such device for use with blister
packs in which the medicament is held in powder form in the blisters thereof is
known as the DISKHALER inhalation device and is described in UK Patent No.
2178965. In use, a fresh blister is indexed to bring it into registration with a use station and then punctured with a puncturing member in two distinct actions to
enable the medicament to be inhaled therefrom.
Another inhalation device described in UK Patent No. 2242134 is for use with peelable medicament packs defining containers for holding the medicament
and includes a means for peeling the medicament pack apart to open each
container in turn as they are brought into registration with a use station. This
device is somewhat complex and contains many components.
Medicament for administration by inhalation should be of a controlled particle
size in order to achieve maximum penetration in to the lungs, preferably in the
range of 1 to 10 micrometers in diameter and more preferably 1 to 5
micrometers. Unfortunately, powders in this particle size range, hereinafter referred to as fine powders, for example micronised powders, usually have very
poor flow characteristics . due to the cohesive forces between the individual
particles which make them readily agglomerate together to form bridges which
are not readily broken apart to become free flowing. These characteristics
create handling and metering difficulties which adversely affect the accurate
dispensing of doses of the powder. However, co-pending PCT Patent
Application No. EP96.03274 describes how, by careful sizing of fine
agglomerated powder, it is possible to make use of the cohesive forces between
the particles to create agglomerates of powder which are free flowing. These
agglomerates of powder can be easily handled and may be used to
conveniently fill devices.
However, for efficient delivery to the lungs, the powder agglomerates must be
broken down before they leave such a device, back into a controlled size.
It has been found that it is possible to break up powder agglomerates in the
airflow as a user inhales by incorporating a series of baffles in the mouthpiece
of a powder inhalation device. EP 0 237 507 describes baffles which comprise
helical channel portions which give the airflow a rotating, helical pattern of
motion. However, one disadvantage associated with the baffles described in EP 0 237
507 in that the baffles comprise a number of components rendering the device
manufacturing process relatively complicated and expensive.
GB 2191718 relates to aerosol devices for dispensing nicotine. The nicotine dispensing device has an impaction means designed to separate the spray
allowing the smaller particles and vapour phase to flow around the baffle while
the larger particles are removed.
PCT/EP93/00582 also describes a device comprising baffles which are acting
as separators, but if the aerosol contains larger particles in the form of relatively
loose agglomerates, these agglomerates are reduced in size if their velocity of
impact against the baffles is sufficiently high.
One disadvantage of the two sets of baffles described in GB 2191718 and
PCT/EP93/00582 is the high deposition of powder which can occur due to the baffles extending from the walls of the device at 90° to the direction of airflow. This
may result in deposition of the larger agglomerates of powder occurring, which
agglomerates could become loose in subsequent inhalations and result in variations in dosage. It is an object of the invention to provide a device of the type just described which is
simple for a user to operate and which is not unduly complex in its assembly. It is a
further object to provide a device which may be filled with powder agglomerates but will deliver powder in a form suitable for administration by inhalation.
According to the present invention there is provided an inhalation device
comprising a housing, an outlet through which a user can inhale, a medicament
holder defining at least one pocket for containing a single dose of medicament
in the form of a powder, a closure member having at least one closure pad
resiliently urged into contact with the medicament holder to close the said at least one pocket, means for moving the pocket into registration with the outlet
and means for lifting the closure pad away from the medicament holder to open
the pocket when the pocket is brought into registration with the outlet.
Such a device is simple to operate requiring only one distinct action to enable
the medicament to be inhaled therefrom. The device may also comprise
relatively few components.
According to the invention there is also provided a powder inhalation device
comprising a housing containing a pharmacologically active compound or
medicament, a conduit with an outlet extending into the housing through which a user can inhale to create an airflow through the conduit, a dosing unit for delivering a dose of the compound to the conduit and baffles arranged within
the said conduit to aid disintegration of powder agglomerates entrained in said
airflow, characterised in that the baffles comprise a plurality of staggered plates extending into the conduit from opposite sides of the conduit at an angle of less
than 90° to the sides of the conduit and are inclined towards the outlet to create
a plurality of constrictions within the conduit and a plurality of changes in the
direction of the said airflow through the conduit.
By use of this arrangement it is possible to provide baffles which are simple to
manufacture and provide low deposition of powder, and yet which give good
results in breaking agglomerates down into discrete constituent particles to
create a powder of respirable size.
Preferably the device contains at least 2 plates and more preferably 4 plates.
Preferably the said plates are inclined at an angle less than 70° to the
longitudinal axis of the conduit in the direction of airflow and more preferably the
said plates are inclined at an angle in the range of 15° to 50°.
Suitably the penultimate baffle is shaped so that at some point along the plate it
divides into at least 2 faces, the first face of which continues to extend into the
conduit and a second face of which extends towards the outlet substantially parallel to the longitudinal axis of the conduit. This enables the airflow to exit
parallel to the said axis delivering the powder directly to the user's respiratory
tract and not into the cheek cavity of the user.
An embodiment of the invention is further described below with reference to the
accompanying drawings in which:
Figure 1 is a perspective view of an assembled device according to the invention;
Figure 2 is an exploded perspective view of the device of Figure 1 showing the main body components and primary pack;
Figure 3 is an exploded perspective view of the device showing each component in disassembled form;
Figure 4 is a plan view partly in section showing air flow through a preferred embodiment of the invention;
Figure 5 is a perspective view showing airflow through the device shown in Figure 4; and
Figure 6 is a cut away view showing the pocket closure pad held in the raised position
The device shown in Figures 1 to 3 comprises a body 1 formed of a body base 2
and a body top 3, both of which may be moulded from a plastics material such
as acryl-butyl styrene (ABS). Body top 3 is formed with window 4 the purpose of
which is described below. The body 1 defines a main housing section adapted
to contain a primary pack comprising a dose ring 6 and closure means in the form of a spider 7, and a mouthpiece section 8 forming an outlet through which
a user can inhale extending radially from the main housing section. As seen in
Figure 2, the mouthpiece section 8 of body base 2 is formed with a plurality of
baffles 9 which are explained below.
A medicament holder in the form of a disk or dose ring 6 comprises an upper
surface formed with a plurality of cavities or pockets 10 for containing inhalable
powdered medicament to be dispensed from the device. Each pocket 10 is
surrounded by a raised lip (not shown). The dose ring shown is provided with
ten pockets 10 which might be suitable for containing ten days' supply of
medicament or sufficient medicament for a single course of treatment. It will be
understood that the dose ring might have more or fewer pockets depending on
the medicament to be contained. Suitable powdered medicaments are, for
example, for the treatment of asthma, and include salbutamol, beclomethasone,
salmeterol, fluticasone, formoterol, terbutaline, budesonide and flunisolide, and
physiologically acceptable salts, solvates and esters or any combination
thereof. Preferred medicaments are salbutamol, salbutamol sulphate,
salmeterol, salmeterol xinafoate, fluticasone propionate, beclomethasone dipropionate or solvates thereof and terbutaline sulphate. Other suitable
powdered medicaments include antiviral medicaments, for example zanamivir
(4-guanidino-Neu-5-Ac-2-en). It will be appreciated by those skilled in the art
that the powder medicament, may, if desired, be a combination of two or more active ingredients. A dose may be constituted from the contents of one or more
cavities and the size of each cavity will depend on the dose to be delivered. It is
to be understood that the medicament powder may consist purely of one or
more active ingredients, or there may additionally be a carrier, for example
lactose powder.
The dose ring 6 may be adapted for filling with agglomerated powder in
accordance with the method and apparatus described in co-pending PCT Patent
Application No. EP96.03274
The dose ring 6 has a stepped peripheral edge the purpose of which is
explained below, and a splined hole in the centre for engagement with the
spider 7. The dose ring may also be moulded from a plastics material such as
ABS.
The spider 7 comprises a central ring shaped section 11 from which extend a
plurality of resilient radial arms 12, the number of which corresponds to the
number of pockets 10 in the dose ring 6. Each radial arm 12 terminates in a
pocket closure pad 13. A plurality of short resilient hooked tabs 14 extend
axially from the central ring shaped section 11 and are adapted to form a snap- fit with the dose ring 6 by engaging with the splined hole in the centre of the
dose ring 6. The spider 7 may be moulded from a plastics material such as polycarbonate or any other engineering plastics which has the required
resiliency characteristics. When the spider 7 is assembled to the dose ring 6 to
form the dosing unit or primary pack, the hooked tabs 14 tightly engage the
splined hole in the dose ring 6 and each pocket closure pad 13 is resiliently
urged into contact with a respective raised lip on the upper surface of the dose
ring 6 by means of the resilient radial arms 12 in such a position as to cover and
seal a respective pocket 10 to prevent loss of medicament from and ingression of moisture into the pocket. The pocket closure pads may be moulded with a
smooth flat contact face which seals directly on the upper surface of the dose
ring 6 or raised lip 28 (Figure 6), or alternatively may be provided with a soft
sealing material such as a thermoplastic elastomer, eg SANTOPRENE (Bayer),
formed on the contact face to improve the sealing characteristics. To
manufacture the spider 7 with a different sealing material on the pocket closure
pad the spider may be moulded with a channel 15 formed in the upper face of
the central ring shaped section 11 and in each radial arm 12, and a small hole
(not shown) leading from the end of the channel 15 in each arm 12 through to
the underside of the pocket closure pads 13. The sealing material in a molten
state may then be made to flow round channel 15 and through the holes to the
underside of each of the pocket closure pads 13 to form an integral cushion seal on each pad upon cooling. The upper faces of the pocket closure pads 13 may have a number 17 or other
indicating means moulded or printed thereon to give an indication as to how
many doses of medicament remain in the device as is explained further below.
An edge of each pocket closure pad 13 is formed with a tab 16 adapted for engagement with a ramp 20 (Figures 4 and 5) integrally formed with body top 3
to effect opening of the pocket as explained below.
The primary pack fits into the main housing section of the body 1 as shown in Figures 2 and 3 such that axle 21 of body base 2 is located within the hole in
the primary pack and the stepped peripheral edge of the dose ring protrudes
through two cut away sections on opposite sides of the main housing section. Pawl 24 on body base 2 engages with teeth (not shown) on the underside of
dose ring 6 to create a ratchet mechanism which only allows movement of the
dose ring in one direction.
Pockets 10 may be filled with agglomerated powder as described in PCT patent
application no. PCT EP96.03274. When so filled, for inhalation therapy it is
essential that the largest possible quantity of primary particles inhaled is in the
respirable range, that is smaller than 5 microns. In order to aid break-up of any
powder agglomerates entrained in the air flow a series of baffles 9 are located
in the mouthpiece section 8. As will be explained later, the position of the baffles are important. The baffles can be formed in a single moulding with the body, so
affording consistent, controlled and repeatable tolerance. It will be understood that the number and exact dimensions of baffles present will depend on the
powder being used and the strength of the forces holding the agglomerates
together. For example, it has been found that four baffles achieved the required
break up of powder agglomerates of zanamivir. It would be entirely straight forward for a skilled person to experiment with the baffle dimensions to obtain
desired flow resistance for a particular powder.
Figures 4 and 5 show a preferred arrangement of baffles 9 comprising of a plurality of staggered flat plates which extend into the conduit at angles of 30° to
the longitudinal axis of the conduit from opposite sides of the housing. Most of
the baffles extend beyond the longitudinal axis of the conduit with the final baffle
25 in the direction of airflow stopping short of the axis. The penultimate baffle
26 in the direction of the airflow has an extended flat face 27 running parallel to
the longitudinal axis of the conduit and extending towards the outlet. This
enables the airflow to exit parallel to the said axis delivering the powder directly
to the user's respiratory tract and not into the cheek cavity of the user.
A mouthpiece cover 22 is adapted to fit over the mouthpiece section 8 when the
device is not in use to prevent contamination of the mouthpiece by dust The
mouthpiece cover has two pins 30 adapted to pass through two slots 23 into the main housing section of body 1 either side of the mouthpiece section 8 to
engage the stepped peripheral edge of the dose ring and so lock the primary
pack to prevent accidental movement thereof when the device is not in use.
To operate the device the user first removes mouthpiece cover 22 thereby unlocking the primary pack. The user then indexes a pocket to bring it into
registration with the mouthpiece by holding the stepped peripheral edge of the
dose ring where it protrudes through the cut away sections of the main housing
section and rotating the dose ring 6 relative to the body 1. The ratchet
mechanism described above allows rotation of the primary pack in one direction only. As the primary pack rotates, tab 16 of the next pocket closure pad 13
engages ramp 20 and pocket closure pad 13 is lifted away from the upper
surface of the dose ring 6 as the tab rides over the ramp. As the pocket comes
into registration with the mouthpiece, the raised lip 28 (Figure 6) surrounding
the pocket 10 engages with the sides of the exit channel 29 creating an
increased resistance to motion of the dose ring, so giving a clear indication to
the user that the dose ring is in position ready for delivery of medicament.
As the raised lip 28 surrounding the pocket 10 engages with the exit channel 29
the pocket closure pad 13 is in a raised position clear of the upper surface of the dose ring 6 as shown in Figure 6. In this position, pocket closure pad 13 is
situated directly beneath window 4 in body top 3 such that the number 17 or
other dose indicating means moulded or printed on the upper face of the pocket closure pad 13 is clearly visible through window 4. This allows the user to see
how many doses remain in the device.
The dose of medicament contained in pocket 10 is now ready for delivery. The
user inhales through mouthpiece 8. Air is drawn into the device via slots 23 and
directed over the open pocket 10 as seen in Figures 4 and 5. As the air flows
over pocket 10, medicament powder in the pocket is entrained in the turbulent air flow, drawn through the mouthpiece section 8 and inhaled by the user.
As seen in Figure 5, baffles 9 are arranged to disrupt the smooth flow of air
through the mouthpiece to create additional turbulence, cause the air flow to change direction several times to cause any agglomerates of powder to collide
with the baffles, walls and other agglomerates, and constrict the air flow to
increase the flow velocity. The air circulation produces eddy currents in the
back waters of the baffles creating further collisions to aid in the break up of the powder agglomerates. This is shown by the arrows representing air flow in
Figure 5. All of these effects promote the disintegration of powder agglomerates
entrained in the air flow to render the powder in a form suitable for inhalation therapy. The extended flat face 27 running parallel to the longitudinal axis of the
conduit attached to the penultimate baffle in the direction of airflow enables the
airflow to exit parallel to the said axis delivering the powder directly to the user's
respiratory tract and not into the cheek cavity of the user. After inhalation the user replaces mouthpiece cover 22 to protect and lock the
device until the next dose is required to be delivered.
It will be understood that the present disclosure is for the purpose of illustration only and the invention extends to modifications, variations and improvements
thereto.

Claims

Claims
1. An inhalation device comprising a housing, an outlet through which a user
can inhale, a medicament holder defining at least one pocket for containing a
single dose of medicament in the form of a powder, a closure member having at
least one closure pad resiliently urged into contact with the medicament holder
to close the said at least one pocket, means for moving the pocket into registration with the outlet and means for lifting the closure pad away from the
medicament holder to open the pocket when the pocket is brought into
registration with the outlet.
2. A device as claimed in claim 1 , wherein said medicament holder comprises a
disk which is rotatably mounted in the device with the at least one pocket
arranged on one face of the said disk.
3. A device as claimed in claims 1 or 2, wherein each said closure pad is resiliently urged into contact with the medicament holder by means of a
respective resilient arm.
4. A device as claimed in claim 3 comprising a plurality of closure pads, wherein
the closure member comprises a plurality of resilient arms connected together in the form of a spider..
5. A device as claimed in claim 4, wherein said spider is made from
polycarbonate.
6. A device as claimed in any one of the preceding claims, wherein said closure
pad comprises a thermoplastic elastomer.
7. A device as claimed in any of claims 2 to 6, wherein the said disk protrudes from the body of the device to provide means for moving the at least one pocket
into registration with the outlet.
8. A device as claimed in claim 7, wherein the said disk is provided with grips at
its periphery.
9. A device as claimed in any one of claims 7 or 8, further comprising a ratchet
mechanism to allow movement of the disk in only one direction
10. A device as claimed in any one of the preceding claims, wherein the pocket
closure pad is lifted away from the surface of the said disk by engagement with a ramp.
11. A device as claimed in any one of the preceding claims, further comprising a
removable mouthpiece cover which, when in place, engages with the medicament holder to prevent movement thereof.
12. A device as claimed in any one of the preceding claims, wherein the outlet
comprises a conduit in which are arranged a plurality of staggered plates extending into the conduit from opposite sides of the conduit at an angle of less
than 90° to the sides of the conduit and which plates are inclined towards the
outlet to create a plurality of constrictions within the conduit and a plurality of
changes in the direction of the airflow through the conduit.
13. A device as claimed in claim 12 comprising at least 2 plates.
14. A device as claimed in claim 13 comprising 4 plates.
15. A device as claimed in any of claims 12 to 14, wherein the said plates are
inclined at an angle less than 70° to the longitudinal axis of the conduit in the direction of airflow.
16. A device as claimed in claim 15, wherein the said plates are inclined at an
angle in the range of 15° to 50°.
17. A device as claimed in claim 16, wherein the said plates are inclined at an
angle of 30°.
18. A device as claimed in any of claims 12 to 17, wherein the penultimate
baffle is shaped so that at some point along the plate it divides into at least 2
faces, the first face of which continues to extend into the conduit and a second
face of which extends towards the outlet substantially parallel to the longitudinal
axis of the conduit.
19. A device as claimed in any preceding claim, wfierein the said pockets are
filled with medicament.
20. A powder inhalation device comprising a housing containing a medicament,
a conduit with an outlet extending into the housing through which a user can
inhale to create an airflow through the conduit, a dosing unit for delivering a
dose of the compound to the conduit and baffles arranged within the said
conduit to aid disintegration of powder agglomerates entrained in said airflow,
wherein the baffles comprise a plurality of staggered plates extending into the
conduit from opposite sides of the conduit at an angle of less than 90° to the
sides of the conduit and are inclined towards the outlet to create a plurality of
constrictions within the conduit and a plurality of changes in the direction of the
said airflow through the conduit
21. A device as claimed in claim 20, comprising at least 2 plates.
22. A device as claimed in claim 21 , comprising 4 plates.
23. A device as claimed in any one of claims 20 to 22 wherein the said plates
are inclined at an angle less than 70° to the longitudinal axis of the conduit in
the direction of airflow.
24. A device as claimed in claim 23, wherein the said plates are inclined at an
angle in the range of 15° to 50°.
25. A device as claimed in claim 24 wherein the said plates are inclined at an
angle of 30°.
26. A device as claimed in any one of claims 20 to 25, wherein the penultimate
baffle is shaped so that at some point along the plate it divides into at least 2
faces, the first face of which continues to extend into the conduit and a second
face of which extends towards the outlet substantially parallel to the longitudinal axis of the conduit.
27. A device as claimed in any preceding claim, wherein the medicament is
zanamivir.
PCT/GB1996/003141 1996-01-03 1996-12-19 Inhalation device Ceased WO1997025086A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL12518396A IL125183A0 (en) 1996-01-03 1996-12-19 Inhalation device
JP9524939A JP2000503565A (en) 1996-01-03 1996-12-19 Inhaler
NZ324374A NZ324374A (en) 1996-01-03 1996-12-19 Inhalation device
PL96327616A PL327616A1 (en) 1996-01-03 1996-12-19 Inhaler
DE69618624T DE69618624T2 (en) 1996-01-03 1996-12-19 inhaler
BR9612410A BR9612410A (en) 1996-01-03 1996-12-19 Inhalation device
AU11633/97A AU725348B2 (en) 1996-01-03 1996-12-19 Inhalation device
APAP/P/1998/001285A AP9801285A0 (en) 1996-01-03 1996-12-19 Inhalation device.
EA199900400A EA001237B1 (en) 1996-01-03 1996-12-19 Inhalation device
AT96942494T ATE209053T1 (en) 1996-01-03 1996-12-19 INHALER DEVICE
US09/101,102 US6065472A (en) 1996-01-03 1996-12-19 Multidose powder inhalation device
EP96942494A EP0883414B1 (en) 1996-01-03 1996-12-19 Inhalation device
EA199800556A EA001016B1 (en) 1996-01-03 1996-12-19 Inhalation device
IS4787A IS4787A (en) 1996-01-03 1998-06-29 inhalation equipment
NO983069A NO983069L (en) 1996-01-03 1998-07-02 Inhalation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9600044.3A GB9600044D0 (en) 1996-01-03 1996-01-03 Inhalatiion device
GBGB9625134.3A GB9625134D0 (en) 1996-12-03 1996-12-03 Powder inhalation device
GB9625134.3 1996-12-03
GB9600044.3 1996-12-03

Publications (2)

Publication Number Publication Date
WO1997025086A2 true WO1997025086A2 (en) 1997-07-17
WO1997025086A3 WO1997025086A3 (en) 1997-09-04

Family

ID=26308412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/003141 Ceased WO1997025086A2 (en) 1996-01-03 1996-12-19 Inhalation device

Country Status (22)

Country Link
US (1) US6065472A (en)
EP (2) EP0883414B1 (en)
JP (1) JP2000503565A (en)
KR (1) KR19990077014A (en)
CN (1) CN1213974A (en)
AP (1) AP9801285A0 (en)
AT (2) ATE209939T1 (en)
AU (1) AU725348B2 (en)
BR (1) BR9612410A (en)
CA (1) CA2241880A1 (en)
CZ (1) CZ212598A3 (en)
DE (2) DE69617754T2 (en)
EA (2) EA001237B1 (en)
ES (2) ES2166473T3 (en)
IL (1) IL125183A0 (en)
IS (1) IS4787A (en)
MX (1) MX9805409A (en)
NO (1) NO983069L (en)
NZ (1) NZ324374A (en)
PL (1) PL327616A1 (en)
TR (1) TR199801265T2 (en)
WO (1) WO1997025086A2 (en)

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