WO1997041225A3 - Mammalian mixed lymphocyte receptors, chemokine receptors [mmlr-ccr] - Google Patents

Mammalian mixed lymphocyte receptors, chemokine receptors [mmlr-ccr] Download PDF

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Publication number
WO1997041225A3
WO1997041225A3 PCT/US1997/006993 US9706993W WO9741225A3 WO 1997041225 A3 WO1997041225 A3 WO 1997041225A3 US 9706993 W US9706993 W US 9706993W WO 9741225 A3 WO9741225 A3 WO 9741225A3
Authority
WO
WIPO (PCT)
Prior art keywords
ccr
mmlr
mphg
receptors
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/006993
Other languages
French (fr)
Other versions
WO1997041225A2 (en
Inventor
Janice Au-Young
Olga Bandman
Roger Coleman
Craig G Wilde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Priority to EP97922475A priority Critical patent/EP0906424A2/en
Priority to JP09539067A priority patent/JP2000510690A/en
Priority to AU28132/97A priority patent/AU2813297A/en
Publication of WO1997041225A2 publication Critical patent/WO1997041225A2/en
Publication of WO1997041225A3 publication Critical patent/WO1997041225A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides polynucleotides (mmlr-ccr or mphg-ccr) which encode novel chemokine receptors (MMLR-CCR or MPHG-CCR). The present invention provides for screening methods for the detection of molecules that modulate receptor activity. The present invention also provides for antisense molecules, diagnostic molecules, genetically engineered expression vectors and host cells for the production of purified MMLR-CCR or MPHG-CCR; antibodies, agonists, antagonists and inhibitors of MMLR-CCR or MPHG-CCR; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention further provides diagnostic and therapeutic compositions for the detection and treatment of infection, inflammation, proliferative disease, solid tumors and cardiovascular disease.
PCT/US1997/006993 1996-04-26 1997-04-25 Mammalian mixed lymphocyte receptors, chemokine receptors [mmlr-ccr] Ceased WO1997041225A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97922475A EP0906424A2 (en) 1996-04-26 1997-04-25 Mammalian mixed lymphocyte receptors, chemokine receptors mmlr-ccr]
JP09539067A JP2000510690A (en) 1996-04-26 1997-04-25 Mammalian mixed lymphocyte receptor, chemokine receptor (MMLR-CCR)
AU28132/97A AU2813297A (en) 1996-04-26 1997-04-25 Mammalian mixed lymphocyte receptors, chemokine receptors {mmlr-ccr}

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63808196A 1996-04-26 1996-04-26
US08/638,081 1996-04-26

Publications (2)

Publication Number Publication Date
WO1997041225A2 WO1997041225A2 (en) 1997-11-06
WO1997041225A3 true WO1997041225A3 (en) 1998-04-23

Family

ID=24558570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/006993 Ceased WO1997041225A2 (en) 1996-04-26 1997-04-25 Mammalian mixed lymphocyte receptors, chemokine receptors [mmlr-ccr]

Country Status (6)

Country Link
US (1) US20030148294A1 (en)
EP (1) EP0906424A2 (en)
JP (1) JP2000510690A (en)
AU (1) AU2813297A (en)
CA (1) CA2252432A1 (en)
WO (1) WO1997041225A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
EP1199360A3 (en) * 1996-03-01 2002-05-02 Euroscreen S.A. Active and inactive CC-chemokine receptors and nucleic acid molecules encoding said receptor
EP0859787B1 (en) * 1996-07-22 2001-10-10 Smithkline Beecham Corporation G-protein coupled receptor hnfds78
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
CA2235420A1 (en) * 1998-06-17 1999-12-17 Paolo Renzi Antisense oligonucleotides for treating or preventing atopic diseases and neoplastic cell proliferation
DE19842363A1 (en) * 1998-09-16 2000-03-30 Forssmann Wolf Georg Use of chemokines, especially HCC-2 for mobilising haematopoietic stem cells, progenitor cells and mature leukocytes from the bone marrow into the blood stream
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
WO2005105841A2 (en) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
NZ554723A (en) 2004-10-29 2009-12-24 Topigen Pharmaceuticals Inc Antisense oligonucleotides against CCR3 chemokine receptor
WO2007055636A1 (en) * 2005-11-08 2007-05-18 Astrazeneca Ab Single nucleotide polymorphisms in the ckrx gene associated with respiratory disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019436A1 (en) * 1994-01-13 1995-07-20 The Regents Of The University Of California Mammalian monocyte chemoattractant protein receptors
WO1996039437A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human g-protein chemokine receptor hdgnr10
WO1997022698A2 (en) * 1995-12-20 1997-06-26 Icos Corporation Chemokine receptors 88-2b[ckr-3] and 88c and their antibodies
WO1997032019A2 (en) * 1996-03-01 1997-09-04 Euroscreen S.A. C-c ckr-5, cc-chemikines receptor, derivatives thereof and their uses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019436A1 (en) * 1994-01-13 1995-07-20 The Regents Of The University Of California Mammalian monocyte chemoattractant protein receptors
WO1996039437A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human g-protein chemokine receptor hdgnr10
WO1997022698A2 (en) * 1995-12-20 1997-06-26 Icos Corporation Chemokine receptors 88-2b[ckr-3] and 88c and their antibodies
WO1997032019A2 (en) * 1996-03-01 1997-09-04 Euroscreen S.A. C-c ckr-5, cc-chemikines receptor, derivatives thereof and their uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BORING L ET AL: "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.", J BIOL CHEM, MAR 29 1996, 271 (13) P7551-8, UNITED STATES, XP002043124 *
CHARO, I.F. ET AL.: "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 91, 1994, WASHINGTON US, pages 2752 - 2756, XP002043550 *

Also Published As

Publication number Publication date
WO1997041225A2 (en) 1997-11-06
AU2813297A (en) 1997-11-19
JP2000510690A (en) 2000-08-22
EP0906424A2 (en) 1999-04-07
US20030148294A1 (en) 2003-08-07
CA2252432A1 (en) 1997-11-06

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