WO1997046308A1 - Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids - Google Patents
Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids Download PDFInfo
- Publication number
- WO1997046308A1 WO1997046308A1 PCT/SE1997/000965 SE9700965W WO9746308A1 WO 1997046308 A1 WO1997046308 A1 WO 1997046308A1 SE 9700965 W SE9700965 W SE 9700965W WO 9746308 A1 WO9746308 A1 WO 9746308A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liquid
- flow
- needle
- dosing device
- liquids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
Definitions
- the present invention relates to a dosing device or mixing device for mixing, in a continuous process, a flowing primary liquid with one or more added secondary liquids for obtaining a flowing liquid mixture at a per- manent, uniform mixing ratio of the mixed liquids.
- Espe ⁇ cially the processing industry and medicinal technology require access to dosing devices, by means of which two or more components in liquid state are continuously mix ⁇ ed with each other under conditions which yield uniform mixing ratios, i.e. uniform amounts of the components included, in a continuous mixing process.
- the device and the method according to the invention are especially applicable in the cases where one or some components, so-called secondary components, are to be admixed to a flow- ing primary component and where the amount of secondary components in terms of volume is comparatively small or very small compared with the amount of the primary compo ⁇ nent in the finished mixture.
- the con ⁇ tent of the added substances, the so-called secondary components can be as low as 0.05-1% of the flowing pri ⁇ mary component. It is possible by using the inventive method to obtain, with a uniform and continuous mixing ratio, a flow of liquid which can proceed to be packed with an equal content of additives in all packings.
- An example of such a process is, for instance, the prepara ⁇ tion of lactose-free sterile milk, where the untreated sterilised and lactose-containing milk is continuously mixed with a quantity of sterile-filtered lactase before packing, the proportions of lactose-containing milk/lac- tase being in the order of 5-10,000, about the same mix- ing ratio being required in all packings that are conti ⁇ nuously prepared. In some other cases, higher contents of secondary liquid are required as addition, for instance when colouring or flavouring foodstuffs.
- Dosing equipment for mixing flows of liquid having different flow ratios is known, but such equipment has essentially been directed to obtaining a constant mixing ratio by letting the combined flows of liquid being join ⁇ ed and conducted in a loop, i.e. a certain part of the flow of liquid is deflected from the main conduit and recirculated to a point in the flow conduit which is positioned downstream.
- the mixed liquid or parts thereof will in this manner circulate several times through the loop to obtain a good mixing when the loop has finally been passed.
- the present invention which operates with ⁇ out a mixing loop, is considerably simpler in its techni ⁇ cal design and permits great flexibility as regards the amount and type of additives and is, above all, easier to adjust between the use of different mixing components.
- the dosing device according to the invention preferably is adapted to be used in the foodstuff industry but may also be used in medicinal industry for continuous mixing of components in liquid state.
- Fig. 1 illustrates the dosing device
- Fig. 2 illustrates a special device with a plurality of needle-like nozzles for supplying a secondary liquid
- Fig. 3 shows a flexible plastic bag for storing steri- lised secondary liquid.
- the described device comprises a means for mixing, with great accuracy to volume, a first liquid, here called primary liquid, with the second liquid, here called secondary liquid, the mixing ratio being such that there is a very great difference between the individual volumes of the mixed liquids.
- primary liquid here called secondary liquid
- secondary liquid the mixing ratio being such that there is a very great difference between the individual volumes of the mixed liquids.
- the apparatus shown in Fig. 1 consists of a flow pipe 26 for primary liquid, the amount of passing primary liquid being controllable by means of a flow meter 22, which registers the amount of passing primary liquid and which by means of the regulator 20 controls the speed of the peristaltic pump 21.
- the secondary liquid is taken from a plastic bag 19 containing, in this case, sterilised secondary liquid 28.
- the secondary liquid 28 is passed via the conduit 27 to a peristaltic pump 21 controlled by the regulator 20 and being of known type, comprising a rotatable cylindrical body 29, which at its circumference supports rollers 30, which in the case shown are positioned diametrically opposite each other in the cylindrical body 29, and which with its rollers projects outside the periphery of the rotatable body 29.
- At least part 27' of the conduit 27 is made of a flexible material, e.g. rubber or plastic, and this part 27' of the conduit 27 is arranged in a duct 31 of the pump 21.
- the flexible conduit 27' is compressed by the rollers 30, the liquid contained in the conduit 27' between the rollers 30 being pressed forwards by the rollers 30 in the direc ⁇ tion of rotation of the cylindrical body 29 and thus being pumped forwards. Since the dimension of the tube
- a flow control device 23 is arranged at or in the vicinity of the terminal point of the con ⁇ duit 27.
- the secondary liquid 28 supplied as described above is added to the primary liquid by means of a spe ⁇ cially arranged inlet chamber 25 which is shown in detail in Fig. 2.
- the inlet chamber 25, which is connected to the conduit 26 for primary liquid, is provided with a connecting flange 32, which is located in the position where the conduit 26 in the case shown makes a bend and, in the bend of the conduit, has a liquid-flow-conducting labyrinth 31 for guiding the flow of primary liquid towards the inlet chamber 25.
- the inlet chamber 25 is provided with a connecting flange 33, which matches the conduit flange 32 and which is provided with seals 34 closely connected to each other.
- the inlet chamber 25 also has spaces 35, which can be kept sterile by means of a sterilising agent, e.g. vapour or a sterilising liquid, supplied through the conduit 10.
- the passing vapour or liquid sterilises the spaces 35 and all the objects that are present or may be present in the spaces 35.
- the inlet chamber 25 has one or more spaces 14, which are adapted to receive injection needles or syringe-like can- nulae comprising a hypodermic needle 12 and a connection 36 to the conduit 27.
- the inlet chamber 25 may be pro ⁇ vided with several spaces 14 for hypodermic needle ar- rangements which, adjacent to said connection 36, are sealed against the inlet chamber 25 by means of a sealing ring 37 of 0 ring type.
- the cannula 12 is thus displaceably movable in the chamber 14 by displacing the connection 36 with the seal- ing ring 37.
- That part of the inlet chamber 25 which con ⁇ nects to the primary liquid conduit 26 has a sealing wall 38 made of rubber or a rubber-like material, which can easily be penetrated by the cannula 12 and which, after retraction of the cannula 12 into the space 14, in a self-sealing manner attaches itself around the hole made by the cannula 14 in the sealing wall 38.
- the can- nula 12 can, when positioned in the space 14, be steril ⁇ ised and be made to retain its sterility to be passed through the sealing wall 38 into the conduit 26 for sup ⁇ plying, in an accurately predetermined dose, secondary liquid 28 to the flowing primary liquid.
- the cannula 12 can also be retracted into the space 14 without interrup ⁇ tion of the sterility.
- the connection 36 to the cannula 12, 13 is provided with a flange 39.
- the can ⁇ nula 12, 13 can be locked in the inserted position by a stop flange 40 being pushed over the flange 39, the posi ⁇ tion of the cannula 12 and the associated connection 36 being fixed.
- the conduit 26 ' for the mixed liquids is provided with a mixing cham- ber 24 having surfaces deflecting the flow of liquid to achieve, under turbulent flow, a homogeneous mixing of the joined liquids.
- the bag 19 for secondary liquid is provided with two connections 27, 3, the con- nection 3 constituting the filling conduit and the tube 27, as described above, constituting the discharge con ⁇ duit for secondary liquid.
- the tank for secon ⁇ dary liquid 19 need not necessarily be a plastic bag but may be a more dimensionally stable vessel made of plastic or metal, and it is not necessary to the invention that the supplied secondary liquid or, for that matter, the primary liquid be a sterile liquid.
- each secondary liquid 28 necessitates its own storage tank 19, its own pump 21 and its own regulator 20, unless the secondary liquids are not of such a nature that even in the storage tank they can be mixed to a common "secondary liquid mix ⁇ ture" .
- An inlet chamber with a number of cannula posi- tions may be practical to use with a view to making it possible to stop the process without shifting from a secondary liquid tank 19 to another when the first tank is empty. Such a "flying shift" of the secondary liquid tank 19 is possible to perform if the inlet chamber 25 is provided with several cannula spaces in the manner as described above.
- the device according to the present invention results in a permanent, very exact mix ⁇ ing ratio also during long continuous operation even if the volume ratio when mixing the liquids is extremely nonuniform.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Accessories For Mixers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nozzles (AREA)
Abstract
Description
Claims
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT97926350T ATE234667T1 (en) | 1996-06-03 | 1997-06-03 | DOSING DEVICE FOR MIXING A FLOWING FIRST LIQUID IN A CONTINUOUS PROCESS WITH ONE OR MORE ADDED SECOND LIQUID |
| CA002256650A CA2256650C (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
| PL97330364A PL185953B1 (en) | 1996-06-03 | 1997-06-03 | Dispensing device for continuously additing at least one additional secondary liquid to a continually flowing primary liquid and mixing these liquids with each other |
| DK97926350T DK0918562T3 (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing in a continuous process a flowing primary fluid with one or more supplied secondary fluids |
| EP97926350A EP0918562B1 (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
| AU31134/97A AU703969B2 (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
| DE69719995T DE69719995T2 (en) | 1996-06-03 | 1997-06-03 | DOSING DEVICE FOR MIXING A FLOWING FIRST LIQUID IN A CONTINUOUS METHOD WITH ONE OR MORE ADDED SECOND LIQUID |
| JP50049198A JP3654906B2 (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing primary liquid flowing in a continuous process with one or more secondary liquids added |
| NO19985632A NO317506B1 (en) | 1996-06-03 | 1998-12-03 | Dosage apparatus and method for mixing a flowing priming fluid with ± one or more added secondary liquids in a continuous process |
| US09/204,055 US6254269B1 (en) | 1996-06-03 | 1998-12-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602179A SE506791C2 (en) | 1996-06-03 | 1996-06-03 | Dosage device for mixing a flowing primary liquid with one or more secondary liquids and a method for mixing two or more liquids in a continuous process |
| SE9602179-5 | 1996-06-03 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/204,055 Continuation US6254269B1 (en) | 1996-06-03 | 1998-12-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1997046308A1 true WO1997046308A1 (en) | 1997-12-11 |
Family
ID=20402850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/SE1997/000965 Ceased WO1997046308A1 (en) | 1996-06-03 | 1997-06-03 | Dosing device for mixing in a continuous process a flowing primary liquid with one or more added secondary liquids |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6254269B1 (en) |
| EP (1) | EP0918562B1 (en) |
| JP (1) | JP3654906B2 (en) |
| CN (1) | CN1079692C (en) |
| AT (1) | ATE234667T1 (en) |
| AU (1) | AU703969B2 (en) |
| DE (1) | DE69719995T2 (en) |
| DK (1) | DK0918562T3 (en) |
| ES (1) | ES2189963T3 (en) |
| NO (1) | NO317506B1 (en) |
| PL (1) | PL185953B1 (en) |
| RU (1) | RU2181620C2 (en) |
| SE (1) | SE506791C2 (en) |
| WO (1) | WO1997046308A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10357861A1 (en) * | 2003-12-11 | 2005-07-14 | Schulz Gmbh Farben- Und Lackfabrik | Dosing plant for emulsion paints |
| EP2661180B1 (en) | 2011-01-05 | 2016-09-28 | MJN U.S. Holdings LLC | Composition comprising heat labile milk proteins and process for preparing same |
| US11666673B2 (en) | 2016-12-20 | 2023-06-06 | Tetra Laval Holdings & Finance S.A. | Food ingredient transfer device |
| US12263246B2 (en) | 2017-09-18 | 2025-04-01 | Ferring International Center S.A. | Manufacturing of pharmaceutical compositions |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE512503C2 (en) * | 1998-05-11 | 2000-03-27 | Arom Pak Ab | Dosing nozzle for continuous injection of a small amount of sterile, secondary fluid into a free-flowing sterile, primary fluid and ways of using the dosing nozzle |
| FR2856940B1 (en) * | 2003-07-04 | 2007-02-09 | Stedim Sa | CLOSED SYSTEM FOR SINGLE USE IN THE MIXING, STORAGE AND HOMOGENIZATION OF LIQUIDS UNDER OWN OR STERILE CONDITIONS |
| JP4633430B2 (en) * | 2004-10-06 | 2011-02-16 | 日本碍子株式会社 | Chemical liquid preparation device and chemical liquid preparation method |
| US8240908B2 (en) * | 2005-09-01 | 2012-08-14 | The Procter & Gamble Company | Control system for and method of combining materials |
| US20070219479A1 (en) * | 2006-03-20 | 2007-09-20 | Tasbas Hedy E | Tampon applicator for insertion of a lubricated tampon |
| SE529712C2 (en) * | 2006-03-31 | 2007-11-06 | Tetra Laval Holdings & Finance | Device for a dosing device |
| DE102007004036B4 (en) * | 2007-01-22 | 2017-08-03 | Martin Schmäh | Dosing device and method for producing a reagent mixture |
| BR112014029507B1 (en) | 2012-05-30 | 2020-12-15 | Mitsui Chemicals, Inc. | THREE COMPONENT MIXING EQUIPMENT AND THREE COMPONENT MIXING ADHESIVE KIT |
| US10485926B2 (en) | 2016-10-07 | 2019-11-26 | Carefusion 303, Inc. | Systems and methods for controlling an infusion pump |
| EP3339405A1 (en) | 2016-12-20 | 2018-06-27 | Alfa Laval Corporate AB | Separation of contaminants from a liquid mixture |
| DE102017216336A1 (en) | 2017-09-14 | 2019-03-14 | Henkel Ag & Co. Kgaa | "System and method for producing a liquid mixture" |
| JP6948602B2 (en) * | 2020-02-10 | 2021-10-13 | キスリー商事株式会社 | Diluting device and spraying device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016138A1 (en) * | 1990-04-23 | 1991-10-31 | S.C. Johnson & Son, Inc. | Precision-ratioed fluid-mixing device and system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE402980B (en) * | 1976-11-30 | 1978-07-24 | Gambro Ab | METHOD AND DEVICE FOR DELETING A CONCENTRATED SOLUTION, PREFERABLY IN CONNECTION WITH ANALYSIS, WHICH THE SOLUTION TOGETHER WITH THE DELIVERY IS SUCKED TO A PUMP DEVICE |
| DE2702566A1 (en) * | 1977-01-22 | 1978-07-27 | Schaur | Ejector pump as mixer for concentrate and liquid - has additional fluid inlets in suction line esp. for air |
| US4410321A (en) * | 1982-04-06 | 1983-10-18 | Baxter Travenol Laboratories, Inc. | Closed drug delivery system |
| US4585435A (en) * | 1984-05-31 | 1986-04-29 | The Telescope Folding Furniture Co., Inc. | Extension set for drug delivery |
| US5232437A (en) * | 1986-10-15 | 1993-08-03 | Baxter International Inc. | Mobile, self-contained blood collection system and method |
| JPH0312490A (en) * | 1989-06-09 | 1991-01-21 | Canon Inc | Ferroelectric chiral smectic liquid crystal composition and liquid crystal element containing same |
| DE3919534A1 (en) * | 1989-06-15 | 1990-12-20 | Merck Patent Gmbh | METHOD AND DEVICE FOR PREPARING BONE CEMENT |
| DE4211291C3 (en) * | 1992-04-03 | 2001-06-07 | Voith Gmbh J M | Mixing device and method for mixing two liquids at a constant mixture volume flow to supply the headbox of a paper machine |
| US5407269A (en) * | 1992-07-09 | 1995-04-18 | International Business Machine Corporation | Dynamic mixing chamber |
| US5378227A (en) * | 1992-08-11 | 1995-01-03 | Cobe Laboratories, Inc. | Biological/pharmaceutical method and apparatus for collecting and mixing fluids |
| CN2169155Y (en) * | 1993-10-22 | 1994-06-15 | 谢成龙 | Automatic adding apparatus for liquid proportion |
| US5544809A (en) * | 1993-12-28 | 1996-08-13 | Senercomm, Inc. | Hvac control system and method |
| US5670057A (en) * | 1995-04-28 | 1997-09-23 | Baxter International Inc. | Apparatus and method for automatically performing peritoneal equilibration tests |
| ATE190242T1 (en) * | 1995-10-05 | 2000-03-15 | Sulzer Chemtech Ag | MIXING DEVICE FOR MIXING A LOW VISCOSE FLUID INTO A HIGH VISCOSITY FLUID |
-
1996
- 1996-06-03 SE SE9602179A patent/SE506791C2/en not_active IP Right Cessation
-
1997
- 1997-06-03 ES ES97926350T patent/ES2189963T3/en not_active Expired - Lifetime
- 1997-06-03 DE DE69719995T patent/DE69719995T2/en not_active Expired - Lifetime
- 1997-06-03 JP JP50049198A patent/JP3654906B2/en not_active Expired - Lifetime
- 1997-06-03 PL PL97330364A patent/PL185953B1/en unknown
- 1997-06-03 WO PCT/SE1997/000965 patent/WO1997046308A1/en not_active Ceased
- 1997-06-03 RU RU99100094/12A patent/RU2181620C2/en active
- 1997-06-03 AT AT97926350T patent/ATE234667T1/en active
- 1997-06-03 DK DK97926350T patent/DK0918562T3/en active
- 1997-06-03 AU AU31134/97A patent/AU703969B2/en not_active Expired
- 1997-06-03 CN CN97196372A patent/CN1079692C/en not_active Expired - Lifetime
- 1997-06-03 EP EP97926350A patent/EP0918562B1/en not_active Expired - Lifetime
-
1998
- 1998-12-03 US US09/204,055 patent/US6254269B1/en not_active Expired - Lifetime
- 1998-12-03 NO NO19985632A patent/NO317506B1/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016138A1 (en) * | 1990-04-23 | 1991-10-31 | S.C. Johnson & Son, Inc. | Precision-ratioed fluid-mixing device and system |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10357861A1 (en) * | 2003-12-11 | 2005-07-14 | Schulz Gmbh Farben- Und Lackfabrik | Dosing plant for emulsion paints |
| DE10357861B4 (en) * | 2003-12-11 | 2005-11-24 | Schulz Gmbh Farben- Und Lackfabrik | Dosing plant for emulsion paints |
| US7942569B2 (en) | 2003-12-11 | 2011-05-17 | Schulz Gmbh Farben-Und Lackfabrik | Metering system for preparing emulsion paints from multiple aqueous paint components |
| EP2661180B1 (en) | 2011-01-05 | 2016-09-28 | MJN U.S. Holdings LLC | Composition comprising heat labile milk proteins and process for preparing same |
| US11666673B2 (en) | 2016-12-20 | 2023-06-06 | Tetra Laval Holdings & Finance S.A. | Food ingredient transfer device |
| US12263246B2 (en) | 2017-09-18 | 2025-04-01 | Ferring International Center S.A. | Manufacturing of pharmaceutical compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3113497A (en) | 1998-01-05 |
| RU2181620C2 (en) | 2002-04-27 |
| ES2189963T3 (en) | 2003-07-16 |
| DE69719995T2 (en) | 2003-09-04 |
| SE9602179L (en) | 1997-12-04 |
| US6254269B1 (en) | 2001-07-03 |
| DK0918562T3 (en) | 2003-07-14 |
| NO317506B1 (en) | 2004-11-08 |
| SE506791C2 (en) | 1998-02-09 |
| NO985632L (en) | 1999-01-29 |
| ATE234667T1 (en) | 2003-04-15 |
| JP3654906B2 (en) | 2005-06-02 |
| NO985632D0 (en) | 1998-12-03 |
| DE69719995D1 (en) | 2003-04-24 |
| EP0918562A1 (en) | 1999-06-02 |
| AU703969B2 (en) | 1999-04-01 |
| PL185953B1 (en) | 2003-09-30 |
| SE9602179D0 (en) | 1996-06-03 |
| JP2000513650A (en) | 2000-10-17 |
| PL330364A1 (en) | 1999-05-10 |
| CN1225038A (en) | 1999-08-04 |
| EP0918562B1 (en) | 2003-03-19 |
| CN1079692C (en) | 2002-02-27 |
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