WO1997048408A3 - Method for the prevention and treatment of mastitis - Google Patents

Method for the prevention and treatment of mastitis Download PDF

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Publication number
WO1997048408A3
WO1997048408A3 PCT/EP1997/003212 EP9703212W WO9748408A3 WO 1997048408 A3 WO1997048408 A3 WO 1997048408A3 EP 9703212 W EP9703212 W EP 9703212W WO 9748408 A3 WO9748408 A3 WO 9748408A3
Authority
WO
WIPO (PCT)
Prior art keywords
micrococcin
mastitis
infection
antibiotics
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/003212
Other languages
French (fr)
Other versions
WO1997048408A2 (en
Inventor
Bruno Suri
Catherine Georges
John Edmondson Peel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Priority to BR9709812A priority Critical patent/BR9709812A/en
Priority to DE69711661T priority patent/DE69711661T2/en
Priority to DK97929226T priority patent/DK0934075T3/en
Priority to JP10502296A priority patent/JP2000513348A/en
Priority to US09/202,650 priority patent/US6187800B1/en
Priority to EP97929226A priority patent/EP0934075B1/en
Priority to AT97929226T priority patent/ATE215378T1/en
Priority to IL12648997A priority patent/IL126489A0/en
Priority to AU33410/97A priority patent/AU720243B2/en
Publication of WO1997048408A2 publication Critical patent/WO1997048408A2/en
Publication of WO1997048408A3 publication Critical patent/WO1997048408A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/05—Treating milk before coagulation; Separating whey from curd
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A method for treating or preventing mastitis in mammals is disclosed. The method contemplates the intramammary injection or dipping the teat with micrococcin antibiotics, preferably micrococcin P1 or P2, which do not interfere with the production of cheese and yoghurt using milk from treated animals. Hydrophobic antibiotics such as micrococcin P1 or P2 can be administered prior to infection to effectively suppress the rate, severity, and duration of subsequent bacterial infection, or can be administered subsequent to infection to effectively treat mastitis.
PCT/EP1997/003212 1996-06-20 1997-06-19 Method for the prevention and treatment of mastitis Ceased WO1997048408A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BR9709812A BR9709812A (en) 1996-06-20 1997-06-19 Process for mastitis prevention and treatment
DE69711661T DE69711661T2 (en) 1996-06-20 1997-06-19 MICROCOCCIN ANTIBIOTICS FOR THE PREVENTION AND THERAPY OF MASTITIS
DK97929226T DK0934075T3 (en) 1996-06-20 1997-06-19 Micrococcin antibiotic for the prevention and treatment of mastitis
JP10502296A JP2000513348A (en) 1996-06-20 1997-06-19 How to prevent and treat mastitis
US09/202,650 US6187800B1 (en) 1996-06-20 1997-06-19 Method for the prevention and treatment of mastitis
EP97929226A EP0934075B1 (en) 1996-06-20 1997-06-19 Micrococcin atibiotic for the prevention and treatment of mastitis
AT97929226T ATE215378T1 (en) 1996-06-20 1997-06-19 MICROCOCCIN ANTIBIOTICS FOR THE PREVENTION AND THERAPY OF MASTITIS
IL12648997A IL126489A0 (en) 1996-06-20 1997-06-19 Method for the prevention and treatment of mastitis
AU33410/97A AU720243B2 (en) 1996-06-20 1997-06-19 Method for the prevention and treatment of mastitis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96810415.8 1996-06-20
EP96810415 1996-06-20

Publications (2)

Publication Number Publication Date
WO1997048408A2 WO1997048408A2 (en) 1997-12-24
WO1997048408A3 true WO1997048408A3 (en) 1998-02-19

Family

ID=8225635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/003212 Ceased WO1997048408A2 (en) 1996-06-20 1997-06-19 Method for the prevention and treatment of mastitis

Country Status (14)

Country Link
US (1) US6187800B1 (en)
EP (1) EP0934075B1 (en)
JP (1) JP2000513348A (en)
CN (1) CN1119170C (en)
AT (1) ATE215378T1 (en)
AU (1) AU720243B2 (en)
BR (1) BR9709812A (en)
CA (1) CA2251779A1 (en)
DE (1) DE69711661T2 (en)
DK (1) DK0934075T3 (en)
ES (1) ES2175425T3 (en)
IL (1) IL126489A0 (en)
PT (1) PT934075E (en)
WO (1) WO1997048408A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
US6638902B2 (en) * 2001-02-01 2003-10-28 Ecolab Inc. Stable solid enzyme compositions and methods employing them
US7030085B2 (en) 2001-03-13 2006-04-18 Astellas Pharma Inc Thiopeptide compounds
DE10161077A1 (en) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Highly concentrated stable meloxicam solutions for needleless injection
WO2004002451A1 (en) * 2002-06-28 2004-01-08 Fang Chen Controllable released suppository used in milk-secreting channel
US8992980B2 (en) * 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004021281A1 (en) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
DE102004030409A1 (en) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh New use of meloxicam in veterinary medicine
NZ539076A (en) * 2005-03-29 2008-05-30 Blis Technologies Ltd Skin treatment compositions
CN100368016C (en) * 2005-04-01 2008-02-13 北京大北农农业科技研究院 Udder perfusate for treating dairy cow mastitis and preparation method thereof
SG166115A1 (en) * 2005-09-30 2010-11-29 Boehringer Ingelheim Vetmed Pharmaceutical preparation containing meloxicam
CN100448480C (en) * 2005-11-09 2009-01-07 北京大北农科技集团股份有限公司 Udder aseptic powder injection preparation for treating cow mastitis and preparation method thereof
EP2079477B1 (en) * 2006-10-10 2017-07-26 Wisconsin Alumni Research Foundation Intra-mammary teat sealant formulation and method of using same to reduce or eliminate visual defects in aged cheeses
KR20120005497A (en) 2009-04-08 2012-01-16 위스콘신 얼럼나이 리서어치 화운데이션 Intra-mammary nipple sealing formulations and methods of using the same to reduce or eliminate visual defects in aged cheese
US9101529B2 (en) 2009-10-12 2015-08-11 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
EP2361632B1 (en) * 2010-02-19 2014-03-19 Protectimmun GmbH Specific environmental bacteria for the protection from and/or the treatment of allergic, chronic inflammatory and/or autoimmune diseases
WO2011107150A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
US9943500B2 (en) * 2013-02-08 2018-04-17 Luoda Pharma Pty Ltd Methods of treating topical microbial infections
MX375254B (en) * 2013-02-08 2025-03-06 Luoda Pharma Ltd AN INTRAMAMARY PHARMACEUTICAL OR VETERINARY ANTIMICROBIAL COMPOSITION COMPRISING A POLYETHER IONOPHORE, OR A USE THEREOF FOR TREATING MASTITIS.
TW201607534A (en) * 2013-10-31 2016-03-01 皮拉馬爾企業有限公司 Use of a thiopeptide compound in the treatment of clostridium difficile associated infections
CN110139638A (en) * 2016-12-27 2019-08-16 高露洁-棕榄公司 Antiperspirant/deodorant compositions
GB202014427D0 (en) * 2020-09-14 2020-10-28 Norwegian Univ Of Life Sciences Composition and use
WO2022245150A1 (en) * 2021-05-21 2022-11-24 주식회사 에이엔제이사이언스 Pharmaceutical composition comprising macrocosine compound and method for preparing macrocosine compound
CN117597138A (en) * 2021-05-21 2024-02-23 A&J科学有限公司 Pharmaceutical compositions containing micrococcin compounds and methods for preparing micrococcin compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005844A1 (en) * 1993-08-20 1995-03-02 Ciba-Geigy Ag Method for the prevention and treatment of bovine mastitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005844A1 (en) * 1993-08-20 1995-03-02 Ciba-Geigy Ag Method for the prevention and treatment of bovine mastitis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B.W. BYCROFT ET AL.: "THE STRUCTURES OF THE HIGHLY MODIFIED PEPTIDE ANTIBIOTICS MICROCOCCIN P1 AND P2.", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., no. 6, 15 March 1978 (1978-03-15), LETCHWORTH GB, pages 256 - 258, XP002043056 *
E.P. ABRAHAM ET AL.: "PROBABLE IDENTITY OF AN ANTIBIOTIC PRODUCED BY A SPORE-BEARING BACILLUS OF THE B. pumilus GROUP WITH MICROCOCCIN.", NATURE, vol. 178, 7 July 1956 (1956-07-07), LONDON GB, pages 44 - 45, XP002043055 *
J.D. LEVIN ET AL.: "AN AGAR DIFFUSION MICROBIOLOGICAL ASSAY FOR THIOSTREPTON", ANTIBIOTICS AND CHEMOTHERAPY, vol. 10, no. 7, July 1960 (1960-07-01), BASEL, CH, pages 422 - 429, XP002018735 *
S. BUDAVARI ET AL, EDITORS: "THE MERCK INDEX, 11th. EDITION", 1989, MERCK & CO., INC., RAHWAY, N.J., U.S.A., XP002018736 *

Also Published As

Publication number Publication date
AU720243B2 (en) 2000-05-25
CN1119170C (en) 2003-08-27
JP2000513348A (en) 2000-10-10
CA2251779A1 (en) 1997-12-24
IL126489A0 (en) 1999-08-17
PT934075E (en) 2002-08-30
BR9709812A (en) 1999-08-10
ES2175425T3 (en) 2002-11-16
DE69711661T2 (en) 2002-10-17
CN1222081A (en) 1999-07-07
ATE215378T1 (en) 2002-04-15
DK0934075T3 (en) 2002-06-10
DE69711661D1 (en) 2002-05-08
EP0934075A2 (en) 1999-08-11
US6187800B1 (en) 2001-02-13
EP0934075B1 (en) 2002-04-03
AU3341097A (en) 1998-01-07
WO1997048408A2 (en) 1997-12-24

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